Synthesis, biological evaluations, and tubulin binding poses of C-2α sulfur linked taxol analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 11, 2007, Pages 3191-3194

  Wang, Lei ^a,e   Alcaraz, Ana A ^c   Matesanz, Ruth ^d   Yang, Chun Gang ^a   Barasoain, Isabel ^d   Díaz, J Fernando ^d   Li, Ye Zhi ^e   Snyder, James P ^c   Fang, Wei Shuo ^a,b  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

^c EMORY UNIVERSITY   (United States)

^d CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^e JILIN UNIVERSITY   (China)

Author keywords

Binding conformation; Paclitaxel; SAR studies; Taxol analogues

Indexed keywords

PACLITAXEL; PACLITAXEL DERIVATIVE; SULFUR; TOXOID; TUBULIN;

ARTICLE; CHEMICAL MODIFICATION; COMPUTER SIMULATION; DRUG STRUCTURE; DRUG SYNTHESIS; PROTEIN BINDING; PROTEIN INTERACTION;

HUMANS; MOLECULAR CONFORMATION; PACLITAXEL; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR; TAXOIDS; TUBULIN; TUBULIN MODULATORS;

EID: 34247855036     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.026     Document Type: Article

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