Synthesis and biological evaluation of 2-epi-paclitaxel

Journal of Organic Chemistry

Volumn 61, Issue 2, 1996, Pages 799-801

  Chordia, Mahendra D ^a   Kingston, David G I ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 EPIPACLITAXEL; PACLITAXEL DERIVATIVE; TAXANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030070853     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo951530u     Document Type: Article

References (15)

1. (a) Chaudhary, A. G.; Chordia, M. D.; Kingston, D. G. I. J. Org. Chem. 1995, 60, 3260-3262.
2. (b) Chaudhary, A. G.; Gharpure, M. M.; Rimoldi, J. M.; Chordia, M. D.; Gunatilaka, A. A. L.; Kingston, D. G. I.; Grover, S.; Lin, C. M.; Hamel, E. J. Am. Chem. Soc. 1994, 116, 4097-4098.
3. (c) Grover, S.; Rimoldi, J. M.; Molinero, A. A.; Chaudhary, A. G., Kingston, D. G. I; Hamel, E. Biochemistry 1995, 34, 3927-3934.
4. (a) Chen, S.-H.; Wei, J.-M.; Farina, V. Tetrahedron Lett. 1993, 34, 3205-3206.
5. (b) Chen, S.-H.; Huang, S.; Gao, Q.; Golik, J.; Farina, V. J. Org. Chem. 1994, 59, 1475-1484.
6. (c) Boge, T. C.; Himes, R. H.; Vander Velde, D. G.; Georg, G. I. J. Med. Chem. 1994, 37, 3337-3343.
7. (d) Georg, G. I.; Ali, S. M.; Boge, T. C.; Datta, A; Falborg, L.; Himes, R. H. Tetrahedron Lett. 1994, 35, 8931-8934.
8. (e) Chen, S.-H.; Farina, V.; Wei, J.-M.; Long, B.; Fairchild, C.; Mamber, S. W.; Kadow, J. F.; Vyas, D.; Doyle, T. W. Bioorg. Med. Chem. Lett. 1994, 4, 479-482.
9. (f) Nicolaou, K. C.; Couladouras, E. A.; Nantermet, P. G.; Renaud, J.; Guy, R. K.; Wrasidlo, W. Angew. Chem., Int. Ed. Engl. 1994, 33, 1581-1583.
10. (g) Pulicani, J.-P.; Bézard, D.; Bourzat, J.-D.; Bouchard, H.; Zucco, M.; Deprez, D.; Commerçon, A. Tetrahedron Lett. 1994, 32, 9717-9720.
11. (h) Georg, G. I.; Ali, S. M.; Boge, T. C.; Datta, A.; Falborg, L.; Park, H.; Mejillano, M.; Himes, R. H. Bioorg. Med. Chem. Lett. 1995, 5, 259-264.
12. (a) Paloma, L. G.; Guy, R. K; Wrasidlo, W.; Nicolaou, K. C. Chem. Biol. 1994, 1, 107-112.
13. (b) Vander Velde, D. G.; Georg, G. I.; Grunewald, G. L.; Gunn, C. W.; Mitscher, L. A. J. Am. Chem. Soc. 1993, 115, 11650-11651.
14. (c) Dubois, J.; Guénard, D.; Guéritte-Voegelein, F.; Guerida, N.; Potier, P.; Gillet, B.; Beloeil, J.-C. Tetrahedron 1993, 49, 6533-6544.
15. (d) Williams, H. J.; Scott, A. I.; Dieden, R. A.; Swindell, C. S.; Chirlian, L. E.; Francl, M. M.; Heerding, J. M.; Krauss, N. E. Tetrahedron 1993, 49, 6545-6560.