메뉴 건너뛰기




Volumn 24, Issue 1, 2006, Pages 11-24

Triflusal: An antiplatelet drug with a neuroprotective effect?

Author keywords

Neuroprotection; Platelets; Stroke; Triflusal

Indexed keywords

ACENOCOUMAROL; ACETYLSALICYLIC ACID; ANTIHYPERTENSIVE AGENT; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; CYCLIC AMP; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPYRIDAMOLE; NITRIC OXIDE; THROMBOXANE; TRIFLUSAL; NEUROPROTECTIVE AGENT; SALICYLIC ACID DERIVATIVE;

EID: 34247853343     PISSN: 08975957     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3466.2006.00011.x     Document Type: Review
Times cited : (18)

References (60)
  • 1
    • 0036790816 scopus 로고    scopus 로고
    • Decrease of proinflammatory molecules correlates with neuroprotective effect of the fluorinated salicylate triflusal alter postnatal excitotoxic damage
    • Acarín L, González B, Castellano B. Decrease of proinflammatory molecules correlates with neuroprotective effect of the fluorinated salicylate triflusal alter postnatal excitotoxic damage. Stroke 2002 33 : 2499 2505.
    • (2002) Stroke , vol.33 , pp. 2499-2505
    • Acarín, L.1    González, B.2    Castellano, B.3
  • 2
    • 0343081535 scopus 로고    scopus 로고
    • Oral administration of the anti-inflammatory substance triflusal results in the downregulation of constitutive transcription factor NF-ÊB in the postnatal rat brain
    • Acarín L, González B, Castellano B. Oral administration of the anti-inflammatory substance triflusal results in the downregulation of constitutive transcription factor NF-ÊB in the postnatal rat brain. Neurosci Lett 2000 288 : 41 44.
    • (2000) Neurosci Lett , vol.288 , pp. 41-44
    • Acarín, L.1    González, B.2    Castellano, B.3
  • 3
    • 0034797396 scopus 로고    scopus 로고
    • Triflusal posttreatment inhibits glial nuclear factor ÊB, downregulates the glial response, and is neuroprotective in an excitotoxic injury in postnatal brain
    • Acarín L, González B, Castellano B. Triflusal posttreatment inhibits glial nuclear factor ÊB, downregulates the glial response, and is neuroprotective in an excitotoxic injury in postnatal brain. Stroke 2001 32 : 2394 2402.
    • (2001) Stroke , vol.32 , pp. 2394-2402
    • Acarín, L.1    González, B.2    Castellano, B.3
  • 4
    • 16844376360 scopus 로고    scopus 로고
    • Guidelines for the early management of patients with ischemic stroke. 2005 update. a scientific statement from the Stroke Council of the American Heart Association/([a-z])merican Stroke Association
    • Adams H, Adams R, Del Zoppo G, Goldstein LB. Guidelines for the early management of patients with ischemic stroke. 2005 update. A scientific statement from the Stroke Council of the American Heart Association/([a-z])merican Stroke Association. Stroke 2005 36 : 916 921.
    • (2005) Stroke , vol.36 , pp. 916-921
    • Adams, H.1    Adams, R.2    Del Zoppo, G.3    Goldstein, L.B.4
  • 5
    • 0023197255 scopus 로고
    • Inhibition of thromboxane production and platelet function by triflusal in healthy volunteers
    • Albors M, Castellarnau C, Vila L, Sola J, Rutllant M. Inhibition of thromboxane production and platelet function by triflusal in healthy volunteers. Rev Farmacol Clin Exp 1987 4 : 11 16.
    • (1987) Rev Farmacol Clin Exp , vol.4 , pp. 11-16
    • Albors, M.1    Castellarnau, C.2    Vila, L.3    Sola, J.4    Rutllant, M.5
  • 6
    • 0031011512 scopus 로고    scopus 로고
    • Secondary prevention of ischemic strokes: Effect of dosage of aspirin
    • Alvarez Sabin J, Calvo G, Morros R. Secondary prevention of ischemic strokes: effect of dosage of aspirin. Rev Neurol 1997 25 : 541 544.
    • (1997) Rev Neurol , vol.25 , pp. 541-544
    • Alvarez Sabin, J.1    Calvo, G.2    Morros, R.3
  • 7
    • 0028120906 scopus 로고
    • Collaborative overview of randomised trials of antiplatelets therapy. Prevention of death, myocardial infarction and stroke by prolonged antiplatelet therapy in various categories of patients
    • Antiplatelets Trialists' Collaboration.
    • Antiplatelets Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelets therapy. Prevention of death, myocardial infarction and stroke by prolonged antiplatelet therapy in various categories of patients. Br Med J 1994 308 : 81 106.
    • (1994) Br Med J , vol.308 , pp. 81-106
  • 8
    • 0037065502 scopus 로고    scopus 로고
    • Collaborative meta-analysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
    • Antithrombotic Trialists' Collaboration.
    • Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. Br Med J 2002 324 : 71 86.
    • (2002) Br Med J , vol.324 , pp. 71-86
  • 9
    • 17844403223 scopus 로고    scopus 로고
    • Triflusal vs. oral anticoagulation for primary prevention of thromboembolism after bioprosthetic valve replacement (TRAC): Prospective, randomized, co-operative trial
    • Aramendi JI, Mestres CA, Martinez-Leon J, Campos V, Munoz G, Navas C. Triflusal vs. oral anticoagulation for primary prevention of thromboembolism after bioprosthetic valve replacement (TRAC): Prospective, randomized, co-operative trial. Eur J Cardiothorac Surg 2005 27 : 54 60.
    • (2005) Eur J Cardiothorac Surg , vol.27 , pp. 54-60
    • Aramendi, J.I.1    Mestres, C.A.2    Martinez-Leon, J.3    Campos, V.4    Munoz, G.5    Navas, C.6
  • 10
    • 0033002191 scopus 로고    scopus 로고
    • 4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor κb activation
    • Bayón Y, Alonso A, Sánchez Crespo, M. 4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor κB activation. Br J Pharmacol 1999 126 : 1359 1366.
    • (1999) Br J Pharmacol , vol.126 , pp. 1359-1366
    • Bayón, Y.1    Alonso, A.2    Sánchez Crespo, M.3
  • 11
    • 0030590746 scopus 로고    scopus 로고
    • A randomized, blinded trial of clopidogrel versus aspirin in patients at risk of ischemic events (Caprie)
    • CAPRIE Steering Committee.
    • CAPRIE Steering Committee. A randomized, blinded trial of clopidogrel versus aspirin in patients at risk of ischemic events (Caprie). Lancet 1996 348 : 1329 1339.
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 14
    • 0342288676 scopus 로고    scopus 로고
    • Randomized comparative trial of triflusal and aspirin following acute myocardial infarction
    • Cruz-Fernandez JM, Lopez-Bescos L, Garcia-Dorado D, et al. Randomized comparative trial of triflusal and aspirin following acute myocardial infarction. Eur Heart J 2000 21 : 457 465.
    • (2000) Eur Heart J , vol.21 , pp. 457-465
    • Cruz-Fernandez, J.M.1    Lopez-Bescos, L.2    Garcia-Dorado, D.3
  • 15
    • 11144356190 scopus 로고    scopus 로고
    • TAPIRSS investigadors. Triflusal vs aspirin for prevention of cerebral infarction: A randomized stroke study
    • Culebras A, Rotta-Escalante R, Vila J, et al. TAPIRSS investigadors. Triflusal vs aspirin for prevention of cerebral infarction: a randomized stroke study. Neurology 2004 62 : 1073 1080.
    • (2004) Neurology , vol.62 , pp. 1073-1080
    • Culebras, A.1    Rotta-Escalante, R.2    Vila, J.3
  • 17
    • 0023908470 scopus 로고
    • Effect of triflusal and acetylsalicylic acid on platelet aggregation in human whole blood: Influence of red blood cells and leukocytes
    • De La Cruz JP, Pavía J, Bellido, I, Sánchez de la Cuesta, F. Effect of triflusal and acetylsalicylic acid on platelet aggregation in human whole blood: Influence of red blood cells and leukocytes. Meth Find Exp Clin Pharmacol 1988 10 : 363 367.
    • (1988) Meth Find Exp Clin Pharmacol , vol.10 , pp. 363-367
    • De La Cruz, J.P.1    Pavía, J.2    Bellido, I.3    Sánchez De La Cuesta, F.4
  • 18
    • 0023900087 scopus 로고
    • Effects of triflusal and acetylsalicylic acid on platelet aggregation in whole blood of diabetic patients
    • De La Cruz JP, Pavía J, García-Arnés, J, Sánchez de la Cuesta, F. Effects of triflusal and acetylsalicylic acid on platelet aggregation in whole blood of diabetic patients. Eur J Haematol 1988 40 : 232 236.
    • (1988) Eur J Haematol , vol.40 , pp. 232-236
    • De La Cruz, J.P.1    Pavía, J.2    García-Arnés, J.3    Sánchez De La Cuesta, F.4
  • 20
    • 0026548502 scopus 로고
    • Mata JM, Sánchez de la Cuesta F. Triflusal vs aspirin on the inhibition of human platelet and vascular cyclooxygenase
    • De La Cruz JP Mata JM, Sánchez de la Cuesta F. Triflusal vs aspirin on the inhibition of human platelet and vascular cyclooxygenase. Gen Pharmacol 1992 23 : 297 300.
    • (1992) Gen Pharmacol , vol.23 , pp. 297-300
    • De La Cruz, J.P.1
  • 21
    • 3242770664 scopus 로고    scopus 로고
    • MATCH investigators. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): Randomized, double-blind, placebo-controlled trial
    • Diener HC, Bogousslavsky J, Brass LM, et al. MATCH investigators. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): Randomized, double-blind, placebo-controlled trial. Lancet 2004 364 : 331 337.
    • (2004) Lancet , vol.364 , pp. 331-337
    • Diener, H.C.1    Bogousslavsky, J.2    Brass, L.M.3
  • 22
    • 0030274360 scopus 로고    scopus 로고
    • Cerebral infarct (in Spanish)
    • Diez Tejedor E Cerebral infarct (in Spanish). Rev Clin Esp 1996 196 (Suppl 3 1 2.
    • (1996) Rev Clin Esp , vol.196 , Issue.SUPPL. 3 , pp. 1-2
    • Diez Tejedor, E.1
  • 23
    • 0026072561 scopus 로고
    • Dutch TIA Trial Study Group. a comparison of two doses aspirin (30 mg vs 283 mg a day) in patients after a transient ischemic attack or minor ischemic stroke
    • Dutch TIA Trial Study Group. A comparison of two doses aspirin (30 mg vs 283 mg a day) in patients after a transient ischemic attack or minor ischemic stroke. N Engl J Med 1991 325 : 1261 1266.
    • (1991) N Engl J Med , vol.325 , pp. 1261-1266
  • 24
    • 0026355123 scopus 로고
    • UK-TIA Study Group. United Kingdom transient ischemic attack (UK-TIA) aspirin trial: Final reports
    • Farrel B, Godwin J, Richards S, et al. UK-TIA Study Group. United Kingdom transient ischemic attack (UK-TIA) aspirin trial: Final reports. J Neurol Neurosurg Psychiatr 1991 54 : 1044 1054.
    • (1991) J Neurol Neurosurg Psychiatr , vol.54 , pp. 1044-1054
    • Farrel, B.1    Godwin, J.2    Richards, S.3
  • 25
    • 17144462683 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase-2, expression by 4-trifluoromethyl derivatives of salicylate, triflusal and its deacetylated metabolite, 2-hydroxy-4-trifluoromethyl-benzoic acid
    • Fernández de Arriba A, Cavalcanti F, Miralles A, et al. Inhibition of cyclooxygenase-2, expression by 4-trifluoromethyl derivatives of salicylate, triflusal and its deacetylated metabolite, 2-hydroxy-4-trifluoromethyl-benzoic acid. Mol Pharmacol 1999 55 : 753 760.
    • (1999) Mol Pharmacol , vol.55 , pp. 753-760
    • Fernández De Arriba, A.1    Cavalcanti, F.2    Miralles, A.3
  • 27
    • 0035512676 scopus 로고    scopus 로고
    • Association between aspirin and upper gastrointestinal complications: Systematic review of epidemiological studies
    • García LA, Hernández-Díaz S, de Abajo FJ. Association between aspirin and upper gastrointestinal complications: Systematic review of epidemiological studies. Br J Clin Pharmacol 2001 52 : 563 571.
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 563-571
    • García, L.A.1    Hernández-Díaz, S.2    De Abajo, F.J.3
  • 28
    • 0032970421 scopus 로고    scopus 로고
    • Interaction between antiplatelet agents and ACE inhibitors in patients with acute myocardial infarction
    • García-Dorado D, Rami, JV Lamela, A5. Interaction between antiplatelet agents and ACE inhibitors in patients with acute myocardial infarction. Eur Heart J Suppl 1999 1 (Suppl F 24 28.
    • (1999) Eur Heart J Suppl , vol.1 , Issue.SUPPL. F , pp. 24-28
    • García-Dorado, D.1    Rami, J.V.2    Lamela, A.3
  • 29
    • 0018348567 scopus 로고
    • Comparison of the inhibitory effects of acetylsalicylic acid and triflusal on enzymes related to thrombosis
    • García-Rafanell J, Planas JM, Puig-Parellada P. Comparison of the inhibitory effects of acetylsalicylic acid and triflusal on enzymes related to thrombosis. Arch Int Pharmacodyn Ther 1979 237 : 343 350.
    • (1979) Arch Int Pharmacodyn Ther , vol.237 , pp. 343-350
    • García-Rafanell, J.1    Planas, J.M.2    Puig-Parellada, P.3
  • 30
    • 0022845256 scopus 로고
    • Effect of triflusal and other salicylic acid derivatives on cyclic AMP levels in rat platelets
    • García-Rafanell J, Ramis J, Gómez L, Forn J. Effect of triflusal and other salicylic acid derivatives on cyclic AMP levels in rat platelets. Arch Int Pharmacodyn Ther 1986 284 : 155 165.
    • (1986) Arch Int Pharmacodyn Ther , vol.284 , pp. 155-165
    • García-Rafanell, J.1    Ramis, J.2    Gómez, L.3    Forn, J.4
  • 31
    • 0035830392 scopus 로고    scopus 로고
    • Primary prevention of ischemic stroke. a statement for healthcare professionals from the stroke council of the American Heart Association
    • Goldstein LB, Adams R, Becker K, et al. Primary prevention of ischemic stroke. A statement for healthcare professionals from the stroke council of the American Heart Association. Stroke 2001 103 : 163 182.
    • (2001) Stroke , vol.103 , pp. 163-182
    • Goldstein, L.B.1    Adams, R.2    Becker, K.3
  • 32
    • 0023092126 scopus 로고
    • Prospective effect of triflusal and acetylsalicylic acid against arachido-nic acid-induced cerebrovascular occlusion in anaesthetized rats
    • Gomez L, García-Rafanell J, Forn J. Prospective effect of triflusal and acetylsalicylic acid against arachido-nic acid-induced cerebrovascular occlusion in anaesthetized rats. Meth Find Exp Clin Pharmacol 1987 9 : 13 17.
    • (1987) Meth Find Exp Clin Pharmacol , vol.9 , pp. 13-17
    • Gomez, L.1    García-Rafanell, J.2    Forn, J.3
  • 33
    • 2442595662 scopus 로고    scopus 로고
    • Effects of triflusal on oxidative stress, prostaglandin production ad nitric oxide pathway in a model of anoxia-reoxygenation in rat brain slices
    • González-Correa JA, Arrebola MM, Ureña MI, et al. Effects of triflusal on oxidative stress, prostaglandin production ad nitric oxide pathway in a model of anoxia-reoxygenation in rat brain slices. Brain Res 2004 102 : 148 155.
    • (2004) Brain Res , vol.102 , pp. 148-155
    • González-Correa, J.A.1    Arrebola, M.M.2    Ureña, M.I.3
  • 34
    • 15044340682 scopus 로고    scopus 로고
    • P rotective effect of triflusal and its main metabolite HTB in an in vitro model of anoxia-reoxygenation in rat brain slices: Comparison with acetylsalicylic and salicylic acids
    • González-Correa JA, Arrebola MM, Ureña MI, et al. P rotective effect of triflusal and its main metabolite HTB in an in vitro model of anoxia-reoxygenation in rat brain slices: Comparison with acetylsalicylic and salicylic acids. Naunyn-Schmiedeberg's Arch Pharmacol 2005 371 : 81 88.
    • (2005) Naunyn-Schmiedeberg's Arch Pharmacol , vol.371 , pp. 81-88
    • González-Correa, J.A.1    Arrebola, M.M.2    Ureña, M.I.3
  • 35
    • 0034012218 scopus 로고    scopus 로고
    • Aspirin for the primary prevention of stroke and other major vascular events. Meta-analysis and hypotheses
    • Hart RG, Halperin JL, McBride BS, Benavente O, Man-Son-Hing M, Kronmal RA. Aspirin for the primary prevention of stroke and other major vascular events. Meta-analysis and hypotheses. Arch Neurol 2000 57 : 326 332.
    • (2000) Arch Neurol , vol.57 , pp. 326-332
    • Hart, R.G.1    Halperin, J.L.2    McBride, B.S.3    Benavente, O.4    Man-Son-Hing, M.5    Kronmal, R.A.6
  • 36
    • 0034745254 scopus 로고    scopus 로고
    • Atrial fibrillation and stroke. Concepts and controversies
    • Hart RG, Halperin JL. Atrial fibrillation and stroke. Concepts and controversies. Stroke 2001 32 : 803 808.
    • (2001) Stroke , vol.32 , pp. 803-808
    • Hart, R.G.1    Halperin, J.L.2
  • 37
    • 0035126395 scopus 로고    scopus 로고
    • Effect of 4-tri-fluoromethyl derivatives of salicylate on nuclear factor κb-dependent transcription in human astrocytoma cells
    • Hernandez, M, Fernández de Arriba, A, Merlos M, Fuentes L, Sánchez Crespo M, Nieto ML. Effect of 4-tri-fluoromethyl derivatives of salicylate on nuclear factor κB-dependent transcription in human astrocytoma cells. Br J Pharmacol 2001 132 : 547 555.
    • (2001) Br J Pharmacol , vol.132 , pp. 547-555
    • Hernandez, M.1    Fernández De Arriba, A.2    Merlos, M.3    Fuentes, L.4    Sánchez Crespo, M.5    Nieto, M.L.6
  • 38
    • 0026013037 scopus 로고
    • Effects of triflusal and acetylsalicylic acid on micro-thrombi formation in experimental brain ischemia
    • Heye N, Campos A, Kannuki S, Cervós-Navarro J. Effects of triflusal and acetylsalicylic acid on micro-thrombi formation in experimental brain ischemia. Exp Pathol 1991 41 : 31 36.
    • (1991) Exp Pathol , vol.41 , pp. 31-36
    • Heye, N.1    Campos, A.2    Kannuki, S.3    Cervós-Navarro, J.4
  • 40
    • 11144246091 scopus 로고    scopus 로고
    • Dipyridamole in Stroke Collaboration (DISC). Dipyridamole for preventing recurrent ischemic stroke and other vascular events: A meta-analysis of individual patient data from randomized controlled trials
    • Leonardi-Bee J, Bath PM, Bousser MG, et al. Dipyridamole in Stroke Collaboration (DISC). Dipyridamole for preventing recurrent ischemic stroke and other vascular events: A meta-analysis of individual patient data from randomized controlled trials. Stroke 2005 36 : 162 168.
    • (2005) Stroke , vol.36 , pp. 162-168
    • Leonardi-Bee, J.1    Bath, P.M.2    Bousser, M.G.3
  • 42
    • 34247888121 scopus 로고    scopus 로고
    • TACIP investigators. Comparison of triflusal and aspirin in prevention of vascular events in patients after cerebral infarction: The TACIP Study: A randomized, double-blind multicenter trial
    • Matías-Guiu J, Ferro, JM, Aacutelvarez-Sabín, J, et al. TACIP investigators. Comparison of triflusal and aspirin in prevention of vascular events in patients after cerebral infarction: the TACIP Study: A randomized, double-blind multicenter trial. Stroke 2003 34 : 84 848.
    • (2003) Stroke , vol.34 , pp. 84-848
    • Matías-Guiu, J.1    Ferro, J.M.2    Aacutelvarez-Sabín, J.3
  • 43
    • 0026502736 scopus 로고
    • Binding of a metabolite of triflusal (HTB) to serum protein in rat and man
    • Mis R, Ramis J, Conte L, Forn J. Binding of a metabolite of triflusal (HTB) to serum protein in rat and man. Eur J Clin Pharmacol 1992 42 : 175 179.
    • (1992) Eur J Clin Pharmacol , vol.42 , pp. 175-179
    • Mis, R.1    Ramis, J.2    Conte, L.3    Forn, J.4
  • 44
    • 0026465015 scopus 로고
    • In vitro protein binding interaction between a metabolite of triflusal, 2-hydroxy-4-trifluoromethylbenzoic acid and other drugs
    • Mis R, Ramis J, Conte L, Forn J. In vitro protein binding interaction between a metabolite of triflusal, 2-hydroxy-4-trifluoromethylbenzoic acid and other drugs. J Pharm Pharmacol 1992 44 : 935 937.
    • (1992) J Pharm Pharmacol , vol.44 , pp. 935-937
    • Mis, R.1    Ramis, J.2    Conte, L.3    Forn, J.4
  • 45
    • 28244459634 scopus 로고    scopus 로고
    • Low dose aspirin for the prevention of atherothrombosis
    • Patrono C, García LA, Landolfi R, Baigent C. Low dose aspirin for the prevention of atherothrombosis. N Engl J Med 2005 353 : 2373 2383.
    • (2005) N Engl J Med , vol.353 , pp. 2373-2383
    • Patrono, C.1    García, L.A.2    Landolfi, R.3    Baigent, C.4
  • 46
    • 5644295138 scopus 로고    scopus 로고
    • NASPEAF Investigators. Comparative effects of antiplatelet, anticoagulant, or combined therapy in patients with valvular and nonvalvular atrial fibrillation: A randomized multicenter study
    • Perez-Gomez F, Alegria E, Berjon J, et al. NASPEAF Investigators. Comparative effects of antiplatelet, anticoagulant, or combined therapy in patients with valvular and nonvalvular atrial fibrillation: A randomized multicenter study. J Am Coll Cardiol 2004 44 : 1557 1566.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 1557-1566
    • Perez-Gomez, F.1    Alegria, E.2    Berjon, J.3
  • 47
    • 0025118840 scopus 로고
    • Rat and human plasma protein binding of the main metabolite of triflusal
    • Ramis J, Mis R, Conte L, Forn J. Rat and human plasma protein binding of the main metabolite of triflusal. Eur J Pharmacol 1990 183 : 1867 1868.
    • (1990) Eur J Pharmacol , vol.183 , pp. 1867-1868
    • Ramis, J.1    Mis, R.2    Conte, L.3    Forn, J.4
  • 48
    • 0026356115 scopus 로고
    • Pharmacokinetics of triflusal and its main metabolite HTB in healthy subjects following a single oral dose
    • Ramis J, Mis R, Forn J, Torrent J, Gorina E, Jané F. Pharmacokinetics of triflusal and its main metabolite HTB in healthy subjects following a single oral dose. Eur J Drug Metab Pharmacokinet 1991 16 : 169 273.
    • (1991) Eur J Drug Metab Pharmacokinet , vol.16 , pp. 169-273
    • Ramis, J.1    Mis, R.2    Forn, J.3    Torrent, J.4    Gorina, E.5    Jané, F.6
  • 49
    • 0026341278 scopus 로고
    • Pharmacokinetics of triflusal and its main metabolite in rats and dogs
    • Ramis J, Mis R, Forn J. Pharmacokinetics of triflusal and its main metabolite in rats and dogs. Eur J Drug Metab Pharmacokinet 1991 16 : 261 268.
    • (1991) Eur J Drug Metab Pharmacokinet , vol.16 , pp. 261-268
    • Ramis, J.1    Mis, R.2    Forn, J.3
  • 50
    • 4243296633 scopus 로고
    • Iatrogenic cerebrovascular disease
    • Rey A, Martí-Villalta JL. Iatrogenic cerebrovascular disease. Rev Neurol 1995 23 (Suppl 1 S131 S146.
    • (1995) Rev Neurol , vol.23 , Issue.SUPPL. 1
    • Rey, A.1    Martí-Villalta, J.L.2
  • 51
    • 15744378579 scopus 로고    scopus 로고
    • A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women
    • Ridker PM, Cook NR, Lee IM, et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med 2995 : 352 : 1293 1304.
    • N Engl J Med , vol.2995 , Issue.352 , pp. 1293-1304
    • Ridker, P.M.1    Cook, N.R.2    Lee, I.M.3
  • 53
    • 0003699301 scopus 로고    scopus 로고
    • Royal College of Physicians (RCP): The Intercollegiate Working Party. London (UK): RCP. June
    • Royal College of Physicians (RCP): The Intercollegiate Working Party. National Clinical Guidelines for Stroke. London (UK) : RCP June 2004.
    • (2004) National Clinical Guidelines for Stroke.
  • 54
    • 0032484950 scopus 로고    scopus 로고
    • C omparison of in vitro effects of truflusal and acetylsalicylic acid on nitric oxide syntaxis by human neutrophils
    • Sánchez de Miguel L, Casado S, Farré J, et al. C omparison of in vitro effects of truflusal and acetylsalicylic acid on nitric oxide syntaxis by human neutrophils. Eur J Pharmacol 1998 343 : 57 65.
    • (1998) Eur J Pharmacol , vol.343 , pp. 57-65
    • Sánchez De Miguel, L.1    Casado, S.2    Farré, J.3
  • 55
    • 0033811717 scopus 로고    scopus 로고
    • A 4-trifluoromethyl derivative of salicylate, triflusal, stimulates nitric oxide production by human neutrophils: Role in platelet function
    • Sánchez de Miguel L, Jimenez A, Montón M, et al. A 4-trifluoromethyl derivative of salicylate, triflusal, stimulates nitric oxide production by human neutrophils: Role in platelet function. Eur J Clin Invest 2000 30 : 82 817.
    • (2000) Eur J Clin Invest , vol.30 , pp. 82-817
    • Sánchez De Miguel, L.1    Jimenez, A.2    Montón, M.3
  • 56
    • 0025751563 scopus 로고
    • Swedish aspirin low doses trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular secondary events
    • The SALT Collaborative Group.
    • The SALT Collaborative Group. Swedish aspirin low doses trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular secondary events. Lancet 1991 338 : 1345 1349.
    • (1991) Lancet , vol.338 , pp. 1345-1349
  • 57
    • 18744367545 scopus 로고    scopus 로고
    • Access of HTB, main metabolite of triflusal, to cerebrospinal fluid in healthy volunteers
    • Valle M, Barbanoj MJ, Donner A, et al. Access of HTB, main metabolite of triflusal, to cerebrospinal fluid in healthy volunteers. Eur J Clin Pharmacol 2005 61 : 103 3.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 103-3
    • Valle, M.1    Barbanoj, M.J.2    Donner, A.3
  • 58
    • 16344380237 scopus 로고    scopus 로고
    • Adverse effects and drug interactions of antithrombotic agents used in prevention of ischaemic stroke
    • Weinberger J. Adverse effects and drug interactions of antithrombotic agents used in prevention of ischaemic stroke. Drugs 2005 65 : 461 471.
    • (2005) Drugs , vol.65 , pp. 461-471
    • Weinberger, J.1
  • 59
    • 23244448320 scopus 로고    scopus 로고
    • Interaction between a rat model of cerebral ischemia and β-amyloid toxicity
    • Whitehead S, Cheng G, Hachinski V, Cechetto DF. Interaction between a rat model of cerebral ischemia and β-amyloid toxicity. Stroke 2005 36 : 1782 1789.
    • (2005) Stroke , vol.36 , pp. 1782-1789
    • Whitehead, S.1    Cheng, G.2    Hachinski, V.3    Cechetto, D.F.4
  • 60
    • 0035899289 scopus 로고    scopus 로고
    • Effect of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation: The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators
    • Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK. Effect of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation: The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. N Engl J Med 2001 345 : 494 502.
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.