Effects of triflusal on oxidative stress, prostaglandin production and nitric oxide pathway in a model of anoxia-reoxygenation in rat brain slices

Brain Research

Volumn 1011, Issue 2, 2004, Pages 148-155

  Gonzalez Correa J A ^a   Arrebola, M M ^a   Urena I M ^a   Guerrero, A ^a   Munoz Marin J ^a   Ruiz Villafranca, D ^a   Sanchez De La Cuesta F ^a   De La Cruz, J P ^a  

^a UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

Antiplatelet agent; Brain anoxia; Disorders of the nervous system; Ischemia; Nitric oxide; Oxidative stress; Salicylate; Triflusal

Indexed keywords

ACETYLSALICYLIC ACID; ANTIOXIDANT; GLUTATHIONE; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTATE DEHYDROGENASE; NEUROPROTECTIVE AGENT; NITRATE; NITRIC OXIDE; PROSTAGLANDIN; PROSTAGLANDIN E2; TRIFLUSAL;

ANIMAL MODEL; ANIMAL TISSUE; ANOXIA; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN HYPOXIA; BRAIN SLICE; BRAIN TISSUE; CELL DAMAGE; CELL DEATH; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; LIPID PEROXIDATION; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT; REOXYGENATION;

ANALYSIS OF VARIANCE; ANIMALS; ANOXIA; ASPIRIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; MALE; NITRATES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; OXYGEN; PLATELET AGGREGATION INHIBITORS; PROSTAGLANDINS; RATS; RATS, WISTAR; SALICYLATES;

EID: 2442595662     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.02.069     Document Type: Article

References (33)

1. Acarin L., González B., Castellano B. Oral administration of the anti-inflammatory substance triflusal results in the downregulation of constitutive transcription factor NF-κB in the postnatal rat brain. Neurosci Lett. 288:2000;41-44
2. Acarin L., González B., Castellano B. Triflusal posttreatment inhibits glial nuclear factor-κB, downregulates the glial response, and is neuroprotective in an excitotoxic injury model in postnatal brain. Stroke. 32:2001;2394-2402
3. Acarin L., González B., Castellano B. Decrease of proinflammatory molecules correlates with neuroprotective effect of the fluorinated salicylate triflusal after postnatal excitotoxic damage. Stroke. 33:2002;2499-2505
4. Antithrombotic Trialists' Collaboration Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. Br. Med. J. 324:2002;71-86
5. Bosmann H.B., Hemsworth B.A. Intraneural mitochondria. J. Biol. Chem. 245:1970;363-371
6. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254
7. De La Cruz J.P., Pavía J., García-Arnés J., Sánchez de la Cuesta F. Effects of triflusal and aspirin on platelet aggregation in whole blood and platelet-rich plasma of diabetic patients. Eur. J. Haematol. 40:1987;232-236
8. De La Cruz J.P., Carrasco T., Ortega G., Sánchez De La Cuesta F. Inhibition of ferrous-induced lipid peroxidation by pyrimido-pyrimidine derivatives in human liver membranes. Lipids. 27:1992;192-194
9. De La Cruz J.P., Mata J.M., Sánchez De la Cuesta F. Triflusal vs. Aspirin on the inhibition of human platelet and vascular cyclooxygenase. Gen. Pharmacol. 23:1992;297-300
10. De La Cruz J.P., Blanco E., Sánchez De La Cuesta F. Effect of dipyridamole and aspirin on the platelet-neutrophil interaction via the nitric oxide pathway. Eur. J. Pharmacol. 397:2000;35-41
11. De La Cruz J.P., Guerrero A., Paniego M.J., Arranz I., Moreno A., Sánchez De La Cuesta F. Effect of aspirin on prostanoids and nitric oxide production in streptozotocin-diabetic rats with ischemic retinopathy. Naunyn-Schmiedeberg's Arch. Pharmacol. 365:2002;96-101
12. Flohé L., Gunzler W.A. Assays of glutathione peroxidasa. Methods Enzymol. 105:1985;114-121
13. Gálvez J., De la Cruz J.P., Zarzuelo A., Sánchez-Medina F., Jiménez J., Sánchez De La Cuesta F. Oral administration of quercitrin modifies intestinal oxidative status in rats. Gen. Pharmacol. 25:1994;1237-1243
14. Grilli M., Pizzi M., Memo M., Spano P. Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappa B activation. Science. 274:1996;1383-1385
15. Grotta J.C., Lemak N.A., Gary H., Fields W.S., Vital D. Does platelet antiaggregant therapy lessen the severity of stroke? Neurology. 35:1985;632-636
16. Hall E.D., Andrus P.K., Althaus J.S., Von Voigtlander P.F. Hydroxyl radical production and lipid peroxidation parallel selective post-ischemic vulnerability in gerbil brain. J. Neurosci. Res. 34:1993;107-112
17. Hissin P.J., Hill R. A fluorimetric method of determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74:1976;214-226
18. Khayyam N., Thavendiranathan P., Carmichael F.J., Kus B., Jay B., Burnham W.M. Neuroprotective effects of acetylsalicylic acid in an animal model of focal brain ischemia. NeuroReport. 10:1999;371-374
19. Kim S.J., Kim Y.K., Takagi G., Huang C.H., Geng Y.J., Vatner S.F. Enhanced iNOS function in myocytes one day after brief ischemic episode. Am. J. Physiol. Heart Circ. Physiol. 282:2002;H423-H428
20. Kontos H.A. Oxygen radicals in cerebral ischemia: the 2001 Willis Lecture. Stroke. 32:2001;2712-2716
21. Li P.A., Liu G.J., He Q.P., Floyd R.A., Siesjo B.K. Production of hydroxyl free radicals by brain tissues in hyperglycemic rats subjected to transient forebrain ischemia. Free Radic. Biol. Med. 27:1999;1033-1040
22. Lobner D. Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? J. Neurosci. Methods. 96:2000;147-152
23. Lopez-Farré A., Caramelo C., Esteban A., Alberola M.L., Millas I., Monton M., Casado S. Effect of aspirin on platelet-neutrophil interaction. Role of nitric oxide and endothelin-1. Circulation. 91:1995;2080-2088
24. Matias-Guiu J., Ferro J.M., Alvarez-Sabin J., Tores F., Jiménez M.D., Lago A., Melo T., TACIP Investigators Comparison of triflusal and aspirin for prevention of vascular events in patients after cerebral infarction: the TACIP study: a randomised, double-blind, multicenter trial. Stroke. 34:2003;840-848
25. Moro M.A., De Alba J., Leza J.C., Lorenzo P., Fernández A.P., Ventura M.L., Boscá L., Rodrigo J., Lizasoain I. Neuronal expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices. Eur. J. Neurosci. 10:1998;445-456
26. Moro M.A., De Alba J., Cárdenas A., De Cristóbal J., Leza J.C., Lizasoain I., Díaz-Guerra M.J.M., Boscá L., Lorenzo P. Mechanisms of the neuroprotective effect of aspirin after oxygen and glucose deprivation in rat forebrain slices. Neuropharmacology. 39:2000;1309-1318
27. Murdoch J., Hall R. Brain protection: physiological and pharmacological considerations. Part I: the physiology of brain injury. Can. J. Anaesth. 37:1990;663-671
28. Piantadosi C.A., Zhang J., Demchenko I.Y. Production of hydroxyl radical in the hippocampus after CO hypoxia or hypoxia in the rat. Free Radic. Biol. Med. 22:1997;725-732
29. Sagone A.L., Husney R.M. Oxidation of salicylates by stimulated granulocytes: evidence that these drugs act as free radical scavengers in biological systems. J. Immunol. 138:1987;2177-2183
30. Sánchez de Miguel L., Casado S., Farré J., García-Durán M., Rico L.A., Montón M., Romero J., Bellver T., Sierra M.P., Guerra J.I., Mata P., Esteban A., López-Farré A. Comparison of in vitro effects of triflusal and acetylsalicylic acid on nitric oxide synthesis by human neutrophils. Eur. J. Pharmacol. 343:1998;547-565
31. Sánchez de Miguel L., Jiménez A., Montón M., Farré J., Arriero M.M., Rodríguez-Feo J.A., García- Cañete J., Rico L., Gómez J., Núñez A., Casado S., López-Farré A. A 4-trifluoromethyl derivative of salicylate, triflusal, stimulates nitric oxide production by human neutrophils: role in platelet function. Eur. J. Clin. Investig. 30:2000;811-817
32. Volhardt K.P.C. Química Orgánica. 1992;1090-1145 Ediciones Omega S.A. Barcelona, Spain
33. Warholm M., Guthenberg C., Von Bahr C., Mannervik B. Glutathione transferases from human liver. Methods Enzymol. 113:1985;449-503