Cholesteryl esters of aggregated LDL are internalized by selective uptake in human vascular smooth muscle cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 26, Issue 1, 2006, Pages 117-123

  Llorente Cortés, Vicenta ^a   Otero Viñas, Marta ^a   Camino López, Sandra ^a   Costales, Paula ^a   Badimon, Lina ^a  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

Author keywords

Adipophilin; Aggregated LDL; Cholesteryl ester; LRP1; Selective uptake

Indexed keywords

ADIPOPHILIN; AGGREGATED LOW DENSITY LIPOPROTEIN; APOLIPOPROTEIN; APOLIPOPROTEIN B100; CHOLESTEROL ESTER; CYTOPLASM PROTEIN; CYTOSKELETON PROTEIN; FAT DROPLET; HIGH DENSITY LIPOPROTEIN; IODINE 125; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; PROTEOGLYCAN; SMALL INTERFERING RNA; TRITIUM; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; APOLIPOPROTEIN B; CHLOROQUINE; DIAGNOSTIC AGENT; ENZYME INHIBITOR; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROTEIN KINASE INHIBITOR; RADIOACTIVE IODINE;

ARTERY INTIMA; ARTICLE; CELL MEMBRANE TRANSPORT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENE SILENCING; HUMAN; HUMAN CELL; INTERNALIZATION; ISOTOPE LABELING; LIPID STORAGE; PRIORITY JOURNAL; PROTEIN DEGRADATION; RNA INTERFERENCE; SELECTIVE UPTAKE; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; CELL CULTURE; CORONARY BLOOD VESSEL; CYTOLOGY; CYTOSKELETON; DRUG EFFECT; LYSOSOME; METABOLISM; PHAGOCYTOSIS; PHYSIOLOGY;

ANTIMALARIALS; APOLIPOPROTEIN B-100; APOLIPOPROTEINS B; CELLS, CULTURED; CHLOROQUINE; CHOLESTEROL ESTERS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CORONARY VESSELS; CYTOSKELETON; ENZYME INHIBITORS; HUMANS; IODINE RADIOISOTOPES; LDL-RECEPTOR RELATED PROTEIN 1; LYSOSOMES; MUSCLE, SMOOTH, VASCULAR; PHAGOCYTOSIS; PROTEIN KINASE INHIBITORS; TRITIUM;

EID: 33644816611     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000193618.32611.8b     Document Type: Article

References (39)

1. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (part I). N Engl J Med. 1992;326:242-250.
2. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (part II). N Engl J Med. 1992;326:310-318.
3. Steinberg D, Parthasarathy S, Carew T, Khoo J, Witztum J. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989;320:915-924.
4. Camejo G, Hurt-Camejo E, Wiklund O, Bondjers G. Association of apoB lipoproteins with arterial proteoglycans: Pathological significance and molecular basis. Atherosclerosis. 1998;139:205-222.
5. Llorente-Cortés V, Martínez-González J, Badimon L. Esterified cholesterol accumulation induced by aggregated LDL uptake in human vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitors. Arterioscler Thromb Vasc Biol. 1998;18:738-746.
6. Llorente-Cortés V, Martínez-González J, Badimon L. LDL receptor-related protein mediates uptake of aggregated LDL in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2000;20:1572-1579.
7. Llorente-Cortés V, Otero-Viñas M, Hurt-Camejo E, Martínez-González J, Badimon L. Human coronary smooth muscle cells internalize versican-modified LDL through LDL receptor-related protein and LDL receptors. Arterioscler Thromb Vasc Biol. 2002;22:387-393.
8. Llorente-Cortés V, Otero-Viñas M, Sánchez S, Rodríguez C, Badimon L. Low density lipoprotein upregulates low density lipoprotein receptor-related protein expression in vascular smooth muscle cells. Circulation. 2002;106:3104-3110.
9. Kounnas MZ, Chappell DA, Wong H, Argraves WS, Strickland DK. The cellular intemalization and degradation of hepatic lipase is mediated by low density lipoprotein receptor-related protein and requires cell surface proteoglycans. J Biol Chem. 1995;270:9307-9312.
10. Rohlmann A, Gotthardt M, Hammer RE, Herz J. Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnant. J Clin Invest. 1998;101:689-695.
11. Llorente-Cortés V, Otero-Viñas M, Badimon L. Differential role of heparan sulfate proteoglycans on aggregated LDL uptake in human vascular smooth muscle cells and mouse embryonic fibroblasts. Arterioscler Thromb Vasc Biol. 2002;22:1905-1911.
12. Goldstein JL, Basu SK, Brown MS. Receptor-mediated endocytosis of Low-density lipoprotein in cultured cells. Method Enzimol. 1983;98:241-260.
13. Herz J, Strickland DK. LRP: a multifunctional scavenger and signaling receptor. J Clin Invest. 2001;108:779-784.
14. Patel M, Morrow J, Maxfields FR, Strickland DK, Greenberg S, Tabas I. The cytoplasmic domain of the low density lipoprotein (LDL) Receptor-related protein, but not that of the LDL receptor, triggers phagocytosis. J Biol Chem. 2003;278:44799-44807.
15. Vassiliou G, Benois F, Lau P, Kavaslar KN, McPherson R. The low density lipoprotein receptor-related protein contributes to selective uptake of high density lipoprotein cholesteryl esters by SW872 liposarcoma cells and primary human adipocytes. J Biol Chem. 2001;276:48823-48830.
16. 2-macroglobulin receptor. J Biol Chem. 2001;276:21121-21128.
17. Temel RE, Walzem RL, Banka CL, Williams DL. Apolipoprotein A-I is necessary for the in vivo formation of high density lipoprotein competent for scavenger receptor BI-mediated cholesteryl ester-selective uptake. J Biol Chem. 2002;277:26565-26572.
18. Seo T, Al-Haideri M, Treskova E, Worgall TS, Kako Y, Goldberg IJ, Deckelbaum RJ. Lipoprotein lipase-mediated selective uptake from low density lipoprotein requires cell surface proteoglycans and is dependent of scavenger receptor class B type 1. J Biol Chem. 2000;275:30355-30362.
19. Kadowaki H, Patton GM, Robins SJ. Metabolism of high density lipoprotein lipids by the rat liver: evidence for participation of hepatic lipase in the uptake of cholesteryl ester. J Lipid Res. 1992;33:1689-1698.
20. Williams DL, Connelly MA, Temel RE, Swarnakar S, Phillips MC, de la Llera-Moya M, Rothblat GH. Scavenger receptor BI and cholesterol trafficking. Curr Opin Lipidol. 1999;10:329-339.
21. Misra UK, Gawdi G, Gonzalez-Gronow M, Pizzo SV. Coordinate regulation of the α2-macroglobulin signaling receptor and the low density lipoprotein receptor-related protein/α2-macroglobulin receptor by Insulin. J Biol Chem. 1999;274:25785-25791.
22. Kancha RK, Hussain MM. Regulation of the low density lipoprotein receptor-related protein by dexamethasone in HepG2 cells.Biochim Biophys Acta. 1996;1301:213-220.
23. Heid HW, Moll R, Schwetlick I, Rackwitz HR, Keenan TW. Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. Cell Tissue Res. 1998;294:309-321.
24. Brasaemle DL, Barber T, Wolins NE, Serrero G, Blanchette-Mackie EJ, Londos C. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J Lipid Res. 1997;38: 2249-2263.
25. Ji Z-S, Brecht WJ, Miranda RD, Hussain MM, Innerarity TL, Mahley RW. Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoprotein in cultured cells. J Biol Chem. 1993;268:10160-10167.
26. Ji Z-S, Dichek HL, Miranda RD, Mahley RW. Heparan sulfate proteoglycans participate in hepatic lipase- and apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins. J Biol Chem. 1997;272:31285-31292.
27. Mahley RW, Ji Z-S. Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E. J Lipid Res 1999;40:1-16.
28. Mortimer BC, Beveridge DJ, Martins IJ, Redgrave TG. Intracellular localization and metabolism of chylomicron remnants in the livers of low density lipoprotein receptor-deficient mice and apoE-deficient mice. Evidence for slow metabolism via an alternative apoE-dependent pathway. J Biol Chem. 1995;270:28767-28776.
29. Landschulz KT, Pathak RK, Rigotti A, Krieger M, Hobbs HH. Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat. J Clin Invest. 1996;98:984-995.
30. Sakr SW, Eddy RJ, Barth H, Wang F, Greenberg S, Maxfield FR, Tabas I. The uptake and degradation of matrix-bound lipoproteins by macrophages require an intact actin cytoskeleton, Rho family GTPases, and myosin ATPase activity. J Biol Chem. 2001;276:37649-37658.
31. Reaven E, Tsai L, Azhar S. Intracellular events in the "selective" transport of lipoprotein-derived cholesteryl esters. J Biol Chem. 1996; 271:16208-16217.
32. Liscum L, Underwood KW. Intracellular cholesterol transport and compartmentation. J Biol Chem. 1995;270:15443-15446.
33. Van Meer G, Sprong H. Membrane lipids and vesicular traffic. Curr Opinion In Cell Biol. 2004;16:373-378.
34. Llorente-Cortes V, Otero-Vinas M, Camino-Lopez S, Llampayas O, Badimon L. Aggregated low-density lipoprotein uptake induces membrane tissue factor procoagulant activity and microparticle release in human vascular smooth muscle cells. Circulation. 2004;110:452-459.
35. Okwu AK, Xu XX, Shiratori Y, Tabas I. Regulation of the threshold for lipoprotein-induced acyl-CoA:cholesterol O-acyltransferase stimulation in macrophages by cellular sphingomyelin content. J Lipid Res. 1994;35:644-655.
36. Xu XX, Tabas I. Sphingomyelinase enhances low density lipoprotein uptake and ability to induce cholesteryl ester accumulation in macrophages. J Biol Chem. 1991;266:24849-24858.
37. Deeney JT, Valivullah HM, Dapper CH, Dylewski DP, Keenan TW. Microlipid droplets in milk secreting mammary epithelial cells: evidence that they originate from endoplasmic reticulum and are precursors of milk lipid globules. Eur J Cell Biol. 1985;38:16-26.
38. Li Q, Komaba A, Yokoyama S. Cholesterol is poorly available for free apolipoprotein-mediated cellular lipid efflux from smooth muscle cells. Biochemistry: 1993;32:4597-4603.
39. Larigauderie G, Furman F, Larigauderie G, Furman C, Jaye M, Lasselin C, Copin C, Fruchart JC, Castro G, Rouis M. Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 Macrophages: Potential role in atherogenesis. Arterioscler Thromb Vasc Biol. 2004;24:504-510.