Evaluation of nitrate-substituted pseudocholine esters of aspirin as potential nitro-aspirins

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 11, 2007, Pages 3217-3220

  Gilmer, John F ^a   Moriarty, Louise M ^a   Clancy, John M ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Nitroaspirin

Indexed keywords

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; CHOLINESTERASE; ESTER DERIVATIVE; ETHANOLAMINE; NITRATE; NITRIC OXIDE; PSEUDOCHOLINE ESTER DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DEGRADATION KINETICS; DRUG ABSORPTION; DRUG DESIGN; DRUG DETERMINATION; DRUG SYNTHESIS; ENZYME ACTIVITY; ESTERIFICATION; HUMAN; HYDROLYSIS; IN VIVO STUDY; NONHUMAN;

ASPIRIN; BUTYRYLCHOLINESTERASE; CHOLINE; DRUG DESIGN; ESTERS; HUMANS; HYDROLYSIS; NITRATES; NITRIC OXIDE DONORS; PRODRUGS; SERUM;

EID: 34247847900     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.009     Document Type: Article

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