Synthesis and anti-inflammatory activity of a series of N-substituted naproxen glycolamides: Nitric oxide-donor naproxen prodrugs

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 8, 2006, Pages 2589-2599

  Ranatunge, Ramani R ^a   Augustyniak, Michael E ^a   Dhawan, Vijay ^a   Ellis, James L ^a   Garvey, David S ^a   Janero, David R ^a   Letts, L Gordon ^a   Richardson, Stewart K ^a   Shumway, Mathew J ^a   Trocha, A Mark ^a   Young, Delano V ^a   Zemtseva, Irina S ^a  

^a NitroMed Inc   (United States)

Author keywords

Anit inflammatory; CINOD; Cyclo oxygenase; Naproxen; Nitric oxide; Non steroidal anti inflammatory drug (NSAID)

Indexed keywords

(TERT BUTYLOXYCARBONYL)METHYL 2 [6 METHOXY(2 NAPHTHYL)]PROPANOIC ACID; 2 [2 [2 [6 METHOXY (2 NAPHTHYL)PROPANOYLOXY] N METHYLACETYLAMINO]ACETIC ACID; 2 [2 [6 METHOXY (2 NAPHTHYL)]PROPANOYLOXY]ACETIC ACID; 2 [4 [(NITROOXY)METHYL]PIPERIDYL] 2 OXOETHYL 2 [6 METHOXY(2 NAPHTHYL)]PROPANOIC ACID; 2 [4 [2 (NITROOXY)ETHYL]PIPERAZINYL] 2 OXOETHYL 2 [6 METHOXY(2 NAPHTHYL)]PROPANOIC ACID; 2 [4 [2 (NITROOXY)ETHYL]PIPERAZINYL] 2 OXOETHYL 2 [6 METHOXY(2 NAPHTHYL)]PROPANOIC ACID HYDROGEN CHLORIDE; 2 [4 [2 (NITROOXY)ETHYL]PIPERIDYL] 2 OXOETHYL 2 [6 METHOXY(2 NAPHTHYL)]PROPANOIC ACID; [N [[(3 HYDROXYPROPYL)OXYCARBONYL]METHYL] N CARBAMOYL]METHYL 2 [6 METHOXY (2 NAPHTHYL)]PROPANOIC ACID; [N [[TERTBUTYL0OXYCARBONYL]METHYL] N METHYLCARBAMOYL]METHYL 2 [6 METHOXY (2 NAPHTHYL)]PROPANOIC ACID; [N CYCLOHEXYL N [2 (NITROOXY)ETHYL]CARBAMOYL]METHYL 2 [6 METHOXY (2 NAPHTHYL)PROPANOIC ACID; [N ETHYL N [2 (NITROOXY)ETHYL]CARBAMOYL]METHYL 2 [6 METHOXY (2 NAPHTHYL)PROPANOIC ACID; [N METHYL N [2 (NITROOXY)ETHYL]CARBAMOYL]METHYL 2 [6 METHOXY (2 NAPHTHYL)PROPANOIC ACID; [N METHYL N [[[2 (NITROOXY)ETHYL]OXYCARBONYL]METHOXY]CARBAMOYL]METHYL 2 [6 METHOXY (2 NAPHTHYL)]PROPANOIC ACID; [N METHYL N [[[3 (NITROOXY)PROPYL]OXYCARBONYL]METHOXY]CARBAMOYL]METHYL 2 [6 METHOXY (2 NAPHTHYL)]PROPANOIC ACID; [N METHYL N [[N [2 (NITROOXY)ETHYL]CARBAMOYL]METHOXY]CARBAMOYL]METHYL 2 [6 METHOXY (2 NAPHTHYL)]PROPANOIC ACID; [N METHYL N [[N METHYL N [2 (NITROOXY)ETHYL]CARBAMOYL]METHYL]CARBAMOYL] METHYL 2 [6 METHOXY (2 NAPHTHYL)]PROPANOIC ACID; [N PROPYL N [2 (NITROOXY)ETHYL]CARBAMOYL]METHYL 2 [6 METHOXY (2 NAPHTHYL)PROPANOIC ACID; NAPROXEN DERIVATIVE; NITRIC OXIDE DONOR; NITRONAPROXEN; PRODRUG; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG RELEASE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERANCE; MALE; NONHUMAN; PAW EDEMA; RAT; STOMACH; STOMACH LESION; STRUCTURE ANALYSIS;

AMIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; GASTRITIS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; NAPROXEN; NITRIC OXIDE DONORS; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 33644760312     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.11.040     Document Type: Article

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