Synthesis, hydrolysis kinetics and anti-platelet effects of isosorbide mononitrate derivatives of aspirin

European Journal of Pharmaceutical Sciences

Volumn 14, Issue 3, 2001, Pages 221-227

  Gilmer, John F ^a   Moriarty, Louise M ^a   McCafferty, Dermot F ^b   Clancy, John M ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Aspirin; ISMN; Nitric oxide; Platelet inhibition; Prodrug

Indexed keywords

DERIVATIVES; HYDROLYSIS; PH; PHOSPHATES; REACTION KINETICS;

RABBIT PLASMA;

SYNTHESIS (CHEMICAL);

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID DERIVATIVE; CHYMOTRYPSIN A; ESTER; ISOSORBIDE DERIVATIVE; NITRIC OXIDE; PHYSOSTIGMINE; PRODRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG SYNTHESIS; KINETICS; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; THROMBOCYTE AGGREGATION INHIBITION;

ANIMALS; ASPIRIN; BLOOD; HYDROLYSIS; ISOSORBIDE DINITRATE; NITRIC OXIDE DONORS; PLATELET AGGREGATION INHIBITORS; RABBITS;

EID: 0034822731     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(01)00183-X     Document Type: Article

References (29)

1. Synthesis, properties and prodrug potential of 2-methyl-2-oxy- and 2-methyl-2-thio-4H-1,3-benzodioxinones
2. Collaborative overview of randomised trial of antiplatelet therapy- I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients
3. Aggregation of blood platelets by adenosine diphosphate and its reversal
4. Effects of very low doses of aspirin (ASA) on gastric, duodenal and rectal prostaglandins (PGs) and mucosal injury
5. Does non-acetylated salicylate inhibit thromboxane synthesis on human platelets?
6. NO-aspirins: a class of new anti-inflammatory and antithrombotic agents
7. Chemical feasibility studies concerning potential prodrugs of acetylsalicylic acid
8. Aspirin prodrugs:2-methyl-2-aryloxy-4H-1,3-benzodioxin-4-ones acting as true aspirin prodrugs
9. Enzymatic and nonenzymatic in vitro hydrolysis of 2-methyl-2-[2-(methoxy)phenoxy]-4H-1,3-benzodioxin-4-one and 2-methoxyphenyl O-acetylsalicylate
10. Risk of aspirin-associated major upper-gastrointestinal bleeding with enteric-coated or buffered product
11. The effect of chronic aspirin use on duodenal and gastric ulcer hospitalisation
12. NO-aspirins: anti-thrombotic activity of derivatives of acetylsalicylic acid releasing nitric oxide
13. Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice
14. Aspirin prodrugs: synthesis of 2-substituted 2-methyl-4H-1,3-benzodioxin-4-ones and their screening for prodrug potential
15. Evaluation of glycolamide esters and various other esters of aspirin as true aspirin prodrugs
16. Glycerides as prodrugs. 2. 1,3-Dialkanoyl-2-(2-methyl-4-oxo-1,3-benzodioxan-2-yl)glycerides (cyclic aspirin triglycerides) as antiinflammatory agents
17. 2 production in healthy subjects
18. m and the rate of endogenous substrate production (R) from substrate depletion data
19. Acetylation of prostaglandin synthase by aspirin
20. Intramolecular catalysis in the reactions of nucleophilic reagents with aspirin
21. Effect of nitric oxide-releasing aspirin derivative on gastric functional and ulcerogenic responses in rats: comparison with plain aspirin
22. Lack of gastric toxicity of nitric oxide releasing aspirin, NCX-4016, in the stomach of diabetic rats
23. Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: role of neutrophils
24. In vivo antithrombotic effects of a nitric oxide-releasing aspirin derivative, NCX-4016
25. 14C-isosorbide-5-monitrate in humans
26. Effect of organic nitrates on ex vivo platelet aggregation and fibrinolysis in man
27. The potential of aspirin in prodrug synthesis: a new potential delivery system of AZT and FLT