SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo

European Journal of Pharmacology

Volumn 237, Issue 2-3, 1993, Pages 299-309

  Bachy, André ^a   Héaulme, Michel ^a   Giudice, Antonina ^b   Michaud, Jean Claude ^a   Lefevre, Isabelle A ^a   Souilhac, Josiane ^a   Manara, Luciano ^b   Emerit, Michel B ^c   Gozlan, Henri ^c   Hamon, Michel ^c   Keane, Peter E ^a   Soubrié, Philippe ^a   Le Fur, Gérard ^a  

^a SANOFI   (France)

^b Research Center Sanofi Midy   (Italy)

^c INSERM   (France)

Author keywords

(Ex vivo binding); 5 HT3 receptors; Bezold Jarisch reflex; Cortical firing rate; Ileum; Turning behaviour; 14C Guanidinium; 3H Granisetron; 3H Zacopride

Indexed keywords

1 (3 CHLOROPHENYL)BIGUANIDE; 2 METHYLSEROTONIN; 4 AMINO 1 (6 CHLORO 2 PYRIDYL)PIPERIDINE; GLUTAMIC ACID; GRANISETRON; GUANIDINE; METHYSERGIDE; ONDANSETRON; PHENYLBIGUANIDE; RADIOLIGAND; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN 3 RECEPTOR; SEROTONIN AGONIST; SUBSTANCE P; TROPISETRON; ZACOPRIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN; BRAIN CORTEX; CARDIOVASCULAR REFLEX; CIRCLING BEHAVIOR; CONTROLLED STUDY; CORPUS STRIATUM; DRUG ANTAGONISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG UPTAKE; ELECTROPHYSIOLOGY; GUINEA PIG; ILEUM; INTRACEREBRAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ANIMAL; BLOOD-BRAIN BARRIER; BRAIN; CELLS, CULTURED; CEREBRAL CORTEX; CORPUS STRIATUM; GUINEA PIGS; ILEUM; INDOLES; MALE; MICE; MUSCLE CONTRACTION; PIPERIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SUBSTANCE P;

EID: 0027325088     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(93)90282-M     Document Type: Article

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