In vivo effects of the 5-HT3 antagonist alosetron on basal and cholera toxin-induced secretion in the human jejunum: A segmental perfusion study

Alimentary Pharmacology and Therapeutics

Volumn 11, Issue 6, 1997, Pages 1109-1114

  Bearcroft, C P ^a   Andre E A ^a   Farthing, M J G ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALOSETRON; CHOLERA TOXIN; PLACEBO; SEROTONIN 3 ANTAGONIST;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ELECTROLYTE TRANSPORT; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INTESTINE ABSORPTION; JEJUNUM; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REGIONAL PERFUSION;

EID: 0030833013     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1997.d01-1389.x     Document Type: Article

References (26)

1. Sharp GWG, Hynie S. Stimulation of intestinal adenyl cyclase by choiera toxin. Nature 1971: 229: 266-9.
2. Kimberg DV. Field M, Johnson J. Hendcrson A, Gershon E. Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins. J Clin Invest 1971: 50: 1218-30.
3. Cassuto J, Jodal M, Tuttle R. Lundgren 0. 5-hydroxytryptamine and cholera secretion. Physiological and pharmacological studies in cats and rats. Scand J Gastroenterol 1982; 17: 695-703.
4. Donowitz M. Charney A, Hefferman JM. Effect of serotonin treatment on intestinal transport in the in vivo rabbit small intestine. Am J Physiol 1977: 232 (Endocrinol Metab Gastrointest Physiol): E85-94.
5. Hardcastle J. Hardcastle PT, Redfren JS. Action of 5-hydroxytryptamine on intestinal ion transport in the rat. J Physiol 1981: 320:41-55.
6. Uonowitz M. Binder Hj. Jejunal fluid and electrolyte secretion in carcinoid syndrome. Dig Dis Sei 1975; 20: 1115-22.
7. Beubler E, Bukhave K. Rask-Madsen J. Colonie secretion mediated by prostaglandin E > and 5-hydroxytryptamine may contribute to diarrhoea due to morphine withdrawal in the rat. Gastroenterology 1984: 87: 1042-8.
8. Nilsson O, Cassuto J, Larsson P-A. et al. 5-Hydroxytryptamine and cholera secretion: a histochemical and physiological study in cats. Gut 1983; 24: 542-8.
9. Turvill JL. Mourad FH, Perrett D, Farthing MJG. Tissue 5-hydroxytryptamine (5-HT) content in rat small intestine in absorptive and secretory states. Gut 1994; 35(5): S54.
10. 2. and cyclic adenosine monophosphate in cholera toxin-induced fluid secretion in the small intestine of the rat in vivo. Gastroenterology 1989; 96: 368-76.
11. 3 receptor subtypes mediate cholera toxin-induced intestinal fluid secretion in the rat. Gastroenterology 1990: 99: 83-9.
12. Bearcroft CP, Perrett D, Farthing MJG. Cholera toxin stimulates 5-hydroxytryptamine release into human jejunum. Gut 1994: 35(5): 213.
13. Mourad F. O'Donnell LJD, Dias J, Ogutu E. Andre EA, Farthing MJG. Role of 5-hydroxytryptamine type 3 receptors in cholera toxin and Escherichia coli enterotoxins induced intestinal secretion. Gut 1995; 37: 340-5.
14. Bucheit KII. Inhibition of cholera toxin-induced intestinal secretion by the 5-HT3 receptor antagonist ICS205-930. Naunyn Schmiedeberg's Arch Pharmacol 1989: 339: 704-5.
15. Bradley PB, Engel G, Feniuk W. et al. Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacology 1986; 25: 563-76.
16. Siriwardena AK. Smith EH. Borum EH, Kellum JM. Identification of a 5-hydroxytryptamine (5-HT2) receptor on guinea pig small intestinal crypt cells. Am J Physiol 1993: 265(2 pt 1): G339-46.
17. Cassuto J, Fahrenkrug J, Jodal M, Tuttle R, Lundgren O. Release of vasoactive intestinal polypeptide from the cat small intestine exposed to cholera toxin. Gut 1981; 22: 958-63.
18. 4 receptor in Cl~ secretion in human jejunal mucosa. Eur J Pharmacol 1996: 314: 109-14.
19. Turvill JL, Mourad FH, Farthing MJG. 5-Hydroxytryptamine type 3 receptor antagonist, granisetron reverses secretion in human cholera model. Gastroenterology 1996: 110: A336 (Abstract).
20. Eherer AJ, Hinterleitner TA, Petritsch VV, Holzer-Petsche U, Beubler E, Krejs GJ. Effect of 5-hydroxytryptamine antagonists on cholera toxin-induced secretion in the human jejunum. Eur J Clin Invest 1994; 24: 664-8.
21. Hunt JB, Thillainayagam AV. Carnaby S, Fairclough PD, Clark ML, Farthing MJG. A new model of human secretory diarrhoea using cholera toxin. Aliment Pharmacol Ther 1992: 6: 619-27.
22. Cooper H. Levitan R, Fordtran JS, Ingelfinger FJ. A method for studying absorption of water and solute from the human small intestine. Gastroenterology 1966; 50: 1-7.
23. Hunt JB. Assessment of experimental hypotonie oral rehydration solutions in secreting animal and normal and secreting human intestine. University of London, 1990. MD thesis.
24. Hunt JB, Elliot EJ, Farthing MJG. Efficacy of a standard United Kingdom oral rehydration solution (ORS) and a hypotonie ORS assessed by human intestinal perfusion. Aliment Pharmacol Ther 1989; 3: 565-71.
25. Hicks T, Turnberg LA. The influence of secretin on ion transport in the human jejunum. Gut 1973; 14: 485-90.
26. Bardham K, Bodemar G, Geldof H, Schutz E, Snell C, Darekar B. A double-blind placebo-controlled study to evaluate the efficacy of alosetron in the treatment of irritable bowel syndrome (IBS). Gastroenterology 1996; 110: A630(Abstract).