Forced expression of heat-shock protein 70 increases the secretion of Hsp70 and provides protection against tumour growth

British Journal of Cancer

Volumn 90, Issue 4, 2004, Pages 926-931

  Wang, M H ^a   Grossmann, M E ^a   Young, C Y F ^a  

^a MAYO CLINIC   (United States)

Author keywords

Gene therapy; Heat shock protein 70; Prostate cancer; Secretion; Transgenic adenocarcinoma mouse prostate

Indexed keywords

COMPLEMENTARY DNA; HEAT SHOCK PROTEIN 70; LUCIFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROSTATE CANCER; REPORTER GENE; SURVIVAL RATE; TRANSGENIC MOUSE; WESTERN BLOTTING; ADENOCARCINOMA; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CHEMOPROPHYLAXIS; CYTOPLASM; GENETICS; PATHOPHYSIOLOGY; PROSTATE TUMOR; SECRETION;

ADENOCARCINOMA; ANIMALS; BLOTTING, WESTERN; CHEMOPREVENTION; CYTOPLASM; DNA, COMPLEMENTARY; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MALE; MICE; MICE, TRANSGENIC; PROSTATIC NEOPLASMS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 1642400682     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601583     Document Type: Article

References (39)

1. Bello D, Webber MM, Kleinman HK, Wartinger DD, Rhim JS (1997) Acinar differentiation by non-malignant immortalized human prostate epithelial cells and its loss by malignant cells. Carcinogenesis 18: 1225-1231
2. Binder RJ, Han DK, Srivastava P (2000) CD91 is a receptor for heat shock protein gp96. Nat Immunol 1: 151-155
3. Botzler C, Li G, Issels RD, Multhoff G (1998) Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response. Cell Stress Chaperon 3: 6-11
4. Cavallo F, Pierro FD, Giovarelli M, Gulino A, Vacca A, Stoppacciaro A, Forni M, Modesti A, Forni G (1993) Protective and curative potential of vaccination with interleukin-2 gene transfected cells from a spontaneous mouse mammary adenocarcinoma. Cancer Res 53: 5067-5070
5. Cayeux S, Richter G, Noffz G, Dorken B, Blankenstein T (1997) Influence of gene modified (IL-7, IL-4, and B7) tumor cell vaccines on tumor antigen presentation. J Immunol 158: 2834-2841
6. Chen X, Tao QT, Yu H, Zhang L, Cao X (2002) Tumor cell membrane bound heat shock protein 70 elicits antitumor immunity. Immunol Lett 84: 81-87
7. Cleves AE (1997) Protein transports: the nonclassical ins and outs. Curr Biol 7: R318-20
8. Fearon ER, Pardoll DM, Itaya T, Golumbek P, Levitsky HI, Simons JW, Karasuyama H, Vogelstein B, Frost P (1990) Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell 60: 397-403
9. Foster BA, Gingrich JR, Kwon ED, Madias C, Greenberg NM (1997) Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model. Cancer Res 57: 3325-3330
10. Gau JT, Salter RD, Krill D, Gove ML, Becich MJ (1997) The biosynthesis and secretion of prostate-specific antigen in LNCaP cells. Cancer Res 57: 3830-3834
11. Gething MJ, Sambrook J (1992) Protein folding in the cell. Nature 355: 33-45
12. Greenberg N, DeMayo F, Finegold M, Tilley W, Aspinall J (1995) Prostate cancer in a transgenic mouse model. Proc Natl Acad Sci USA 92: 3439
13. Guzhova I, Kislyakova K, Moskaliova O, Fridlanskaya I, Tytell M, Cheetham M, Margulis B (2001) In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance. Brain Res 914: 66-73
14. Hightower LE, Guidon Jr PT (1989) Selective release from cultured mammalian cells of heat-shock (stress) proteins that resemble glia-axon transfer proteins. J Cell Physiol 138: 257-266
15. Houghton AN (1994) Cancer antigens: immune recognition of self and altered self. [comment]. J Exp Med 180: 1-4
16. Ishii T, Udono H, Yamano T, Ohta H, Uenaka A, Ono T, Hizuta A, Tanaka N, Srivastava PK, Nakayama E (1999) Isolation of MHC class I-restricted tumor antigen peptide and its precursors associated with heat shock proteins hsp70, hsp90, and gp96. J Immunol 162: 1303-1309
17. Konno S, Mordente JA, Chen YP, Wu JM, Tazaki H, Mallouh C (1998) Effects of brefeldin A on androgen receptor-mediated cellular responses in human prostatic carcinoma LNCaP cells. Mol Urol 2: 7-11
18. Lebret T, Watson RW, Fitzpatrick JM (2003) Heat shock proteins: their role in urological tumors. J Urol 169: 338-346
19. Mahler C, Denis L (1992) Management of relapsing disease in prostate cancer. Cancer 70: 334-329
20. Matsutake T, Srivastava P (1999) CC91 is involved in MHC class II presentation of gp96 chaperoned peptides. Cell Stress Chaperon 5: 378
21. Melcher A, Todryk S, Hardwick N, Ford M, Jacobson M, Vile RG (1998) Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression. Nat Med 4: 581-587
22. Murtha P, Tindall DJ, Young C (1993) Androgen induction of a human prostate specific kallikrein, hKLK2: characterization of an androgen response element in the 5′ region of the gene. Biochemistry 32: 6459-6464
23. Nylandsted J, Brand K, Jaattela M (2000a) Heat shock protein 70 is required for the survival of cancer cells. Ann NY Acad Sci 926: 122-125
24. Nylandsted J, Rohde M, Brand K, Bastholm L, Elling F, Jaattela M (200Ob) Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2. Proc Natl Acad Sci USA 97: 7871-7876
25. Panjwani N, Popova L, Febbraio M, Srivastava P (2000) The CD36 scavenger receptor as a receptor for gp96. Cell Stress Chaperon 5: 391
26. Parsell DA, Lindquist S (1993) The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins. Annu Rev Genet 27: 437-496
27. Ponomarev ED, Tarasenko TN, Sapozhnikov AM (2000) Splenic cytotoxic cells recognize surface HSP70 on culture-adapted EL-4 mouse lymphoma cells. Immunol Lett 74: 133-139
28. Russo P, Kalkkinen N, Sareneva H, Paakkola J, Makarow M (1992) A heat shock gene from Saccharomyces cerevisiae encoding a secretory glycoprotein. Proc Natl Acad Sci USA 89: 8857
29. Sanda MG, Ayyagari SR, Jaffee EM, Epstein JI, Clift SL, Cohen LK, Dranoff G, Pardoll DM, Mulligan RC, Simons JW (1994) Demonstration of a rational strategy for human prostate cancer gene therapy. J Urol 151: 622-628
30. Schatz G, Dobberstein B (1996) Common principles of protein translocation across membranes. Science 271: 1519-1526
31. Srivastava PK, Menoret A, Basu S, Binder RJ, McQuade KL (1998) Heat shock proteins come of age: primitive functions acquire new roles in an adaptive world. Immunity 8: 657-665
32. Suto R, Srivastava P (1995) A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 269: 1585-1588
33. Vanaja DK, Grossmann ME, Celis E, Young CY (2000) Tumor prevention and antitumor immunity with heat shock protein 70 induced by 15-deoxy-delta12,14- prostaglandin J2 in transgenic adenocarcinoma of mouse prostate cells. Cancer Res 60: 4714-4718
34. Vieweg J, Rosenthal FM, Bannerji R, Heston WD, Fair WR, Gansbacher B, Gilboa E (1994) Immunotherapy of prostate cancer in the Dunning rat model: use of cytokine gene modified tumor vaccines. Cancer Res 54: 1760-1765
35. Vile RG, Castleden S, Marshall J, Camplejohn R, Upton C, Chong H (1997) Generation of an anti-tumor immune response in a non-immunogenic tumor:HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoral cytokine expression. Intl J Cancer 71: 267-274
36. Wang XY, Li Y, Manjili MH, Repasky EA, Pardoll DM, Subjeck JR (2002) HspllO over-expression increases the immunogenicity of the murine CT26 colon tumor. Cancer Immunol Immunother 51: 311-319
37. Wang Y, Kelly CG, Karttunen JT, Whittall T, Lehner PJ, Duncan L, MacAry P, Yonnson JS, Singh M, Oelmann W, Cheng G, Bergmeier L, Lehner T (2001) CD40 is a cellular receptor mediating mycobaterial heat shock protein 70 stimulation of CC chemokines. Immunity 15: 971-983
38. Wu WZ, Liu KD, Xie Q, Wu HS (1999) The study on the expression of membrane HSP70 protein in H22 cell and its immunoprotective mechanism against carcinoma. J Exp Clin Cancer Res 18: 543-548
39. Yamazaki K, Nguyen T, Podack ER (1999) Cutting edge: tumor secreted heat shock-fusion protein elicits CD8 cells for rejection. J Immunol 163: 5178-5182