Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu

Toxicon

Volumn 49, Issue 7, 2007, Pages 1063-1069

  Pérez, Aida Verónica ^a,b   Saravia, Patricia ^c   Rucavado, Alexandra ^b   Sant'Ana, Carolina D ^d   Soares, Andreimar M ^d   Gutiérrez, José María ^b  

^a University of El Salvador   (El Salvador)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^c UNIVERSIDAD DE SAN CARLOS DE GUATEMALA   (Guatemala)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bothrops jararacussu; Defibrin(ogen)ation; MMPs; Serine proteinase; Thrombin like

Indexed keywords

BJUSSUSP I TOXIN; D DIMER; FIBRIN; FIBRINOGEN; GELATINASE A; GELATINASE B; PHOSPHOLIPASE A2; SERINE PROTEINASE; SNAKE VENOM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD CLOTTING; CONTROLLED STUDY; CREMASTER MUSCLE; DISSEMINATED INTRAVASCULAR CLOTTING; EDEMA; ENZYME ACTIVATION; ENZYME SYNTHESIS; FIBRINOGEN BLOOD LEVEL; MICROANGIOPATHY; MOUSE; MUSCLE NECROSIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SNAKE; SYSTEMIC DISEASE;

ANIMALS; BOTHROPS; CROTALID VENOMS; EDEMA; ENZYME ACTIVATION; ENZYME PRECURSORS; GELATINASES; HEMORRHAGE; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; MICE; MUSCLES; NECROSIS; SERINE ENDOPEPTIDASES; TOXICITY TESTS;

ANIMALIA; BOTHROPS JARARACUSSU; MUS;

EID: 34247571875     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2006.12.011     Document Type: Article

References (26)

1. Alexander G., Grothusen J., Zepeda H., and Schwartzman R.J. Gyroxin, a toxin from the venom of Crotalus durissus terrificus, is a thrombin-like enzyme. Toxicon 26 (1988) 953-960
2. Baramova E.N., Bajou K., Remacle A., L'Hoir C., Krell H.W., Weidle U.H., Noel A., and Foidart J.M. Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activation. FEBS Lett. 405 (1997) 157-162
3. Cidade D.A., Simao T.A., Davila A.M., Wagner G., Junqueira-de-Azevedo I., Ho P.L., Bon C., Zingali R., and Albano R.M. Bothrops jararaca venom gland transcriptome: analysis of the gene expression pattern. Toxicon 48 (2006) 437-461
4. Fan H.W., and Cardoso J.L. Clinical toxicology of snake bites in South America. In: Meier J., and White J. (Eds). Handbook of Clinical Toxicology of Animal Venoms and Poisons (1995), CRC Press, Boca Raton, FL 667-688
5. França F.O.S., and Málaque C.M.S. Acidente botrópico. In: Cardoso J.L.C., França F.O.S., Wen F.H., Málaque C.M.S., and Haddad V. (Eds). Animais Peçonhentos no Brasil (2003), Biologia, Clínica e Terapêutica dos Acidentes, Sarvier, Sao Paulo 72-86
6. Francischetti I.M., My-Pham V., Harrison J., Garfield M.K., and Ribeiro J.M. Bitis gabonica (Gaboon viper) snake venom gland: toward a catalog for the full-length transcripts (cDNA) and proteins. Gene 337 (2004) 55-69
7. Gutiérrez J.M. Clinical toxicology of snakebite in Central America. In: Meier J., and White J. (Eds). Handbook of Clinical Toxicology of Animal Venoms and Poisons (1995), CRC Press, Boca Raton, FL 645-665
8. Gutiérrez J.M., and Lomonte B. Efectos locales en el envenenamiento ofídico en América Latina. In: In: Cardoso J.L.C., França F.O.S., Wen F.H., Málaque C.M.S., and Haddad V. (Eds). Animais Peçonhentos no Brasil (2003), Biologia, Clínica e Terapêutica dos Acidentes, Sarvier, Sao Paulo 310-323
9. Gutiérrez J.M., Romero M., Díaz C., Borkow G., and Ovadia M. Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo). Toxicon 33 (1995) 19-29
10. 2. Biochimie 86 (2004) 211-219
11. Kini R.M. The intriguing world of prothrombin activators from snake venom. Toxicon 45 (2005) 1133-1145
12. Lafleur M.A., Hollenberg M.D., Atkinson S.J., Knauper V., Murphy G., and Edwards D.R. Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species. Biochem. J. 357 (2001) 107-115
13. Lomonte B., and Gutiérrez J.M. A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo). Toxicon 27 (1989) 725-733
14. Lomonte B., Tarkowski A., and Hanson L.A. Host response to Bothrops asper snake venom: analysis of edema formation, inflammatory cells and cytokine release in a mouse model. Inflammation 17 (1993) 93-105
15. Lomonte B., Lundgren J., Johansson B., and Bagge U. The dynamics of local tissue damage induced by Bothrops asper snake venom and myotoxin II on the mouse cremaster muscle: an intravital and electron microscopic study. Toxicon 32 (1994) 41-55
16. Markland F.S. Snake venoms and the hemostatic system. Toxicon 36 (1998) 1749-1800
17. Monea S., Lehti K., Keski-Oja J., and Mignatti P. Plasmin activates pro-matrix metalloproteinase-2 with a membrane-type 1 matrix metalloproteinase-dependent mechanism. J. Cell Physiol. 192 (2002) 160-170
18. Moreira L., Gutiérrez J.M., Borkow G., and Ovadia M. Ultrastructural alterations in mouse capillary blood vessels after experimental injection of venom from the snake Bothrops asper (terciopelo). Exp. Mol. Pathol. 57 (1992) 124-133
19. Nagase H., and Woessner J.F. Matrix metalloproteinases. J. Biol. Chem. 274 (1999) 21491-21494
20. Rucavado A., Escalante T., Teixeira C.F., Fernandes C.M., Díaz C., and Gutiérrez J.M. Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper. Mediators Inflamm. 11 (2002) 121-128
21. Rucavado A., Soto M., Escalante T., Loría G.D., Arni R., and Gutiérrez J.M. Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage. Thromb. Haemost. 94 (2005) 123-131
22. Sant'Ana, C.D., Ticli, F.K., Oliveira, L.L., Giglio, J.R., Rechia, C.G.V., Fuly, A.L., Selistre-de-Araújo, H.S., Franco, J.J., Stábeli, R.G., Soares, A.M., Sampaio, S.V., 2007. BjussuSP-I, a new thrombin-like enzyme isolated from Bothrops jararacussu snake venom. Comp. Biochem. Physiol., in press.
23. Saravia-Otten P., Frisan T., Thelestam M., and Gutiérrez J.M. Membrane-independent activation of fibroblast proMMP-2 by snake venom: novel roles for venom proteinases. Toxicon 44 (2004) 749-764
24. Serrano S.M.T., and Maroun R.C. Snake venom serine proteinases: sequence homology vs. substrate specificity, a paradox to be solved. Toxicon 45 (2005) 1115-1132
25. Serrano S.M.T., Shannon J.D., Wang D., Camargo A.C., and Fox J.W. A multifaceted analysis of viperid snake venoms by two-dimensional gel electrophoresis: an approach to understand venom proteomics. Proteomics 5 (2005) 501-510
26. White J. Snake venoms and coagulopathy. Toxicon 45 (2005) 951-967