메뉴 건너뛰기




Volumn 251, Issue 2, 2007, Pages 211-219

Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion

Author keywords

Cervical intraepithelial neoplasia (CIN); DNA methylation; DNA methyltransferase 1 (DNMT1); Proliferating cell nuclear antigen (PCNA); Squamous cell carcinoma; Uterine cervix

Indexed keywords

DNA METHYLTRANSFERASE 1;

EID: 34247567828     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2006.11.023     Document Type: Article
Times cited : (48)

References (45)
  • 1
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones P.A., and Baylin S.B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3 (2002) 415-428
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 2
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G., Liang G., Aparicio A., and Jones P.A. Epigenetics in human disease and prospects for epigenetic therapy. Nature 429 (2004) 457-463
    • (2004) Nature , vol.429 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 3
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?
    • Baylin S.B., and Ohm J.E. Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?. Nat. Rev. Cancer. 6 (2006) 107-116
    • (2006) Nat. Rev. Cancer. , vol.6 , pp. 107-116
    • Baylin, S.B.1    Ohm, J.E.2
  • 4
    • 0030830914 scopus 로고    scopus 로고
    • DNA hypermethylation at the D17S5 locus in non-small cell lung cancers: its association with smoking history
    • Eguchi K., Kanai Y., Kobayashi K., and Hirohashi S. DNA hypermethylation at the D17S5 locus in non-small cell lung cancers: its association with smoking history. Cancer Res. 57 (1997) 4913-4915
    • (1997) Cancer Res. , vol.57 , pp. 4913-4915
    • Eguchi, K.1    Kanai, Y.2    Kobayashi, K.3    Hirohashi, S.4
  • 5
    • 0032498296 scopus 로고    scopus 로고
    • DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis
    • Kanai Y., Ushijima S., Ochiai A., Eguchi K., Hui A.M., and Hirohashi S. DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis. Cancer Lett. 122 (1998) 135-141
    • (1998) Cancer Lett. , vol.122 , pp. 135-141
    • Kanai, Y.1    Ushijima, S.2    Ochiai, A.3    Eguchi, K.4    Hui, A.M.5    Hirohashi, S.6
  • 7
    • 33745213611 scopus 로고    scopus 로고
    • Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues
    • Arai E., Kanai Y., Ushijima S., Fujimoto H., Mukai K., and Hirohashi S. Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues. Int. J. Cancer 119 (2006) 288-296
    • (2006) Int. J. Cancer , vol.119 , pp. 288-296
    • Arai, E.1    Kanai, Y.2    Ushijima, S.3    Fujimoto, H.4    Mukai, K.5    Hirohashi, S.6
  • 8
    • 0026697174 scopus 로고
    • Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain
    • Bestor T.H. Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain. EMBO J. 11 (1992) 2611-2617
    • (1992) EMBO J. , vol.11 , pp. 2611-2617
    • Bestor, T.H.1
  • 9
    • 0030770835 scopus 로고    scopus 로고
    • Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1
    • Chuang L.S., Ian H.I., Koh T.W., Ng H.H., Xu G., and Li B.F. Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. Science 277 (1997) 1996-2000
    • (1997) Science , vol.277 , pp. 1996-2000
    • Chuang, L.S.1    Ian, H.I.2    Koh, T.W.3    Ng, H.H.4    Xu, G.5    Li, B.F.6
  • 10
    • 0029973718 scopus 로고    scopus 로고
    • De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase
    • Vertino P.M., Yen R.W., Gao J., and Baylin S.B. De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase. Mol. Cell. Biol. 16 (1996) 4555-4565
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4555-4565
    • Vertino, P.M.1    Yen, R.W.2    Gao, J.3    Baylin, S.B.4
  • 12
    • 0242523715 scopus 로고    scopus 로고
    • Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder
    • Nakagawa T., Kanai Y., Saito Y., Kitamura T., Kakizoe T., and Hirohashi S. Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder. J. Urol. 170 (2003) 2463-2466
    • (2003) J. Urol. , vol.170 , pp. 2463-2466
    • Nakagawa, T.1    Kanai, Y.2    Saito, Y.3    Kitamura, T.4    Kakizoe, T.5    Hirohashi, S.6
  • 13
    • 0037598752 scopus 로고    scopus 로고
    • Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas
    • Saito Y., Kanai Y., Nakagawa T., Sakamoto M., Saito H., Ishii H., and Hirohashi S. Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. Int. J. Cancer 105 (2003) 527-532
    • (2003) Int. J. Cancer , vol.105 , pp. 527-532
    • Saito, Y.1    Kanai, Y.2    Nakagawa, T.3    Sakamoto, M.4    Saito, H.5    Ishii, H.6    Hirohashi, S.7
  • 14
    • 1542319832 scopus 로고    scopus 로고
    • Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers
    • Etoh T., Kanai Y., Ushijima S., Nakagawa T., Nakanishi Y., Sasako M., Kitano S., and Hirohashi S. Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am. J. Pathol. 164 (2004) 689-699
    • (2004) Am. J. Pathol. , vol.164 , pp. 689-699
    • Etoh, T.1    Kanai, Y.2    Ushijima, S.3    Nakagawa, T.4    Nakanishi, Y.5    Sasako, M.6    Kitano, S.7    Hirohashi, S.8
  • 15
    • 23844472366 scopus 로고    scopus 로고
    • Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas
    • Peng D.F., Kanai Y., Sawada M., Ushijima S., Hiraoka N., Kosuge T., and Hirohashi S. Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas. Cancer Sci. 96 (2005) 403-408
    • (2005) Cancer Sci. , vol.96 , pp. 403-408
    • Peng, D.F.1    Kanai, Y.2    Sawada, M.3    Ushijima, S.4    Hiraoka, N.5    Kosuge, T.6    Hirohashi, S.7
  • 16
    • 0035863455 scopus 로고    scopus 로고
    • DNA methyltransferase expression and DNA methylation of CpG islands and peri-centromeric satellite regions in human colorectal and stomach cancers
    • Kanai Y., Ushijima S., Kondo Y., Nakanishi Y., and Hirohashi S. DNA methyltransferase expression and DNA methylation of CpG islands and peri-centromeric satellite regions in human colorectal and stomach cancers. Int. J. Cancer 91 (2001) 205-212
    • (2001) Int. J. Cancer , vol.91 , pp. 205-212
    • Kanai, Y.1    Ushijima, S.2    Kondo, Y.3    Nakanishi, Y.4    Hirohashi, S.5
  • 17
    • 17144413410 scopus 로고    scopus 로고
    • DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis
    • Nakagawa T., Kanai Y., Ushijima S., Kitamura T., Kakizoe T., and Hirohashi S. DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis. J. Urol. 173 (2005) 1767-1771
    • (2005) J. Urol. , vol.173 , pp. 1767-1771
    • Nakagawa, T.1    Kanai, Y.2    Ushijima, S.3    Kitamura, T.4    Kakizoe, T.5    Hirohashi, S.6
  • 18
    • 33745627069 scopus 로고    scopus 로고
    • DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas
    • Peng D.F., Kanai Y., Sawada M., Ushijima S., Hiraoka N., Kitazawa S., and Hirohashi S. DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas. Carcinogenesis 27 (2006) 1160-1168
    • (2006) Carcinogenesis , vol.27 , pp. 1160-1168
    • Peng, D.F.1    Kanai, Y.2    Sawada, M.3    Ushijima, S.4    Hiraoka, N.5    Kitazawa, S.6    Hirohashi, S.7
  • 19
    • 10344260184 scopus 로고    scopus 로고
    • CpG island methylator phenotype in cancer
    • Issa J.P. CpG island methylator phenotype in cancer. Nat. Rev. Cancer 4 (2004) 988-993
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 988-993
    • Issa, J.P.1
  • 21
    • 0034772724 scopus 로고    scopus 로고
    • Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix
    • Dong S.M., Kim H.S., Rha S.H., and Sidransky D. Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. Clin. Cancer Res. 7 (2001) 1982-1986
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1982-1986
    • Dong, S.M.1    Kim, H.S.2    Rha, S.H.3    Sidransky, D.4
  • 24
    • 18744385545 scopus 로고    scopus 로고
    • The hypermethylation and protein expression of p16 INK4A and DNA repair gene O6-methylguanine-DNA methyltransferase in various uterine cervical lesions
    • Lin Z., Gao M., Zhang X., Kim Y.S., Lee E.S., Kim H.K., and Kim I. The hypermethylation and protein expression of p16 INK4A and DNA repair gene O6-methylguanine-DNA methyltransferase in various uterine cervical lesions. J. Cancer Res. Clin. Oncol. 131 (2005) 364-370
    • (2005) J. Cancer Res. Clin. Oncol. , vol.131 , pp. 364-370
    • Lin, Z.1    Gao, M.2    Zhang, X.3    Kim, Y.S.4    Lee, E.S.5    Kim, H.K.6    Kim, I.7
  • 25
    • 0015568709 scopus 로고
    • Cervical intraepithelial neoplasia
    • Richart R. Cervical intraepithelial neoplasia. Pathol. Annu. 8 (1973) 301-328
    • (1973) Pathol. Annu. , vol.8 , pp. 301-328
    • Richart, R.1
  • 27
    • 0029868154 scopus 로고    scopus 로고
    • Cervical intraepithelial neoplasia, cervical cancer, and HPV
    • Holly E.A. Cervical intraepithelial neoplasia, cervical cancer, and HPV. Annu. Rev. Public. Health 17 (1996) 69-84
    • (1996) Annu. Rev. Public. Health , vol.17 , pp. 69-84
    • Holly, E.A.1
  • 28
    • 0032169416 scopus 로고    scopus 로고
    • Coexistence of low and high grade squamous intraepithelial lesions of the cervix: morphologic progression or multiple papillomaviruses?
    • Park J., Sun D., Genest D.R., Trivijitsilp P., Suh I., and Crum C.P. Coexistence of low and high grade squamous intraepithelial lesions of the cervix: morphologic progression or multiple papillomaviruses?. Gynecol. Oncol. 70 (1998) 386-391
    • (1998) Gynecol. Oncol. , vol.70 , pp. 386-391
    • Park, J.1    Sun, D.2    Genest, D.R.3    Trivijitsilp, P.4    Suh, I.5    Crum, C.P.6
  • 30
    • 0031442751 scopus 로고    scopus 로고
    • Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis
    • Sun L., Hui A.M., Kanai Y., Sakamoto M., and Hirohashi S. Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis. Jpn. J. Cancer Res. 88 (1997) 1165-1170
    • (1997) Jpn. J. Cancer Res. , vol.88 , pp. 1165-1170
    • Sun, L.1    Hui, A.M.2    Kanai, Y.3    Sakamoto, M.4    Hirohashi, S.5
  • 31
    • 0033052844 scopus 로고    scopus 로고
    • DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis
    • Kanai Y., Hui A.M., Sun L., Ushijima S., Sakamoto M., Tsuda H., and Hirohashi S. DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis. Hepatology 29 (1999) 703-709
    • (1999) Hepatology , vol.29 , pp. 703-709
    • Kanai, Y.1    Hui, A.M.2    Sun, L.3    Ushijima, S.4    Sakamoto, M.5    Tsuda, H.6    Hirohashi, S.7
  • 32
    • 0033988602 scopus 로고    scopus 로고
    • Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis
    • Kanai Y., Ushijima S., Tsuda H., Sakamoto M., and Hirohashi S. Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis. Cancer Lett. 148 (2000) 73-80
    • (2000) Cancer Lett. , vol.148 , pp. 73-80
    • Kanai, Y.1    Ushijima, S.2    Tsuda, H.3    Sakamoto, M.4    Hirohashi, S.5
  • 33
    • 0033765496 scopus 로고    scopus 로고
    • Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis-A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma
    • Kondo Y., Kanai Y., Sakamoto M., Mizokami M., Ueda R., and Hirohashi S. Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis-A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology 32 (2000) 970-979
    • (2000) Hepatology , vol.32 , pp. 970-979
    • Kondo, Y.1    Kanai, Y.2    Sakamoto, M.3    Mizokami, M.4    Ueda, R.5    Hirohashi, S.6
  • 34
    • 0035127794 scopus 로고    scopus 로고
    • Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis
    • Saito Y., Kanai Y., Sakamoto M., Saito H., Ishii H., and Hirohashi S. Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology 33 (2001) 561-568
    • (2001) Hepatology , vol.33 , pp. 561-568
    • Saito, Y.1    Kanai, Y.2    Sakamoto, M.3    Saito, H.4    Ishii, H.5    Hirohashi, S.6
  • 35
    • 0037162542 scopus 로고    scopus 로고
    • Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis
    • Saito Y., Kanai Y., Sakamoto M., Saito H., Ishii H., and Hirohashi S. Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc. Natl. Acad. Sci. USA 99 (2002) 10060-10065
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10060-10065
    • Saito, Y.1    Kanai, Y.2    Sakamoto, M.3    Saito, H.4    Ishii, H.5    Hirohashi, S.6
  • 37
    • 0029812553 scopus 로고    scopus 로고
    • Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation
    • Lee P.J., Washer L.L., Law D.J., Boland C.R., Horon I.L., and Feinberg A.P. Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation. Proc. Natl. Acad. Sci. USA 93 (1996) 10366-10370
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 10366-10370
    • Lee, P.J.1    Washer, L.L.2    Law, D.J.3    Boland, C.R.4    Horon, I.L.5    Feinberg, A.P.6
  • 38
    • 0142250909 scopus 로고    scopus 로고
    • p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding
    • Peterson E.J., Bogler O., and Taylor S.M. p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. Cancer Res. 63 (2003) 6579-6582
    • (2003) Cancer Res. , vol.63 , pp. 6579-6582
    • Peterson, E.J.1    Bogler, O.2    Taylor, S.M.3
  • 41
    • 0037162536 scopus 로고    scopus 로고
    • The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases
    • Tsai C.N., Tsai C.L., Tse K.P., Chang H.Y., and Chang Y.S. The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases. Proc. Natl. Acad. Sci. USA 99 (2002) 10084-10089
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10084-10089
    • Tsai, C.N.1    Tsai, C.L.2    Tse, K.P.3    Chang, H.Y.4    Chang, Y.S.5
  • 42
    • 0030846298 scopus 로고    scopus 로고
    • Tying it all together: epigenetics, genetics, cell cycle, and cancer
    • Baylin S.B. Tying it all together: epigenetics, genetics, cell cycle, and cancer. Science 277 (1997) 1948-1949
    • (1997) Science , vol.277 , pp. 1948-1949
    • Baylin, S.B.1
  • 43
    • 0037363349 scopus 로고    scopus 로고
    • E-cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours
    • Chen C.L., Liu S.S., Ip S.M., Wong L.C., Ng T.Y., and Ngan H.Y. E-cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours. Eur. J. Cancer 39 (2003) 517-523
    • (2003) Eur. J. Cancer , vol.39 , pp. 517-523
    • Chen, C.L.1    Liu, S.S.2    Ip, S.M.3    Wong, L.C.4    Ng, T.Y.5    Ngan, H.Y.6
  • 44
  • 45
    • 0033945861 scopus 로고    scopus 로고
    • DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
    • Rountree M.R., Bachman K.E., and Baylin S.B. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat. Genet. 25 (2000) 269-277
    • (2000) Nat. Genet. , vol.25 , pp. 269-277
    • Rountree, M.R.1    Bachman, K.E.2    Baylin, S.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.