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Volumn 3, Issue 5, 2007, Pages 422-429

Mechanisms of disease: Molecular genetics of childhood thyroid cancers

Author keywords

Childhood thyroid cancer; Molecular genetics; Papillary thyroid carcinoma; Radiation

Indexed keywords

A KINASE ANCHOR PROTEIN 9; B RAF KINASE; NEUROTROPHIC TYROSINE KINASE RECEPTOR 1; ONCOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN P53; PROTEIN RET; RAS PROTEIN; TRANSCRIPTION FACTOR PAX8; TUMOR PROTEIN; UNCLASSIFIED DRUG;

EID: 34247500375     PISSN: 17458366     EISSN: 17458374     Source Type: Journal    
DOI: 10.1038/ncpendmet0499     Document Type: Review
Times cited : (78)

References (67)
  • 1
    • 0026638813 scopus 로고
    • Thyroid nodules in the population living around Chernobyl
    • Mettler FA Jr et al. (1992) Thyroid nodules in the population living around Chernobyl. JAMA 268: 616-619
    • (1992) JAMA , vol.268 , pp. 616-619
    • Mettler Jr, F.A.1
  • 3
    • 33645468926 scopus 로고    scopus 로고
    • Comprehensive clinical assessment of 740 cases of surgically treated thyroid cancer in children of Belarus
    • Demidchik YE et al. (2006) Comprehensive clinical assessment of 740 cases of surgically treated thyroid cancer in children of Belarus. Ann Surg 243: 525-532
    • (2006) Ann Surg , vol.243 , pp. 525-532
    • Demidchik, Y.E.1
  • 4
    • 0028963996 scopus 로고
    • Thyroid cancer after exposure to external radiation: A pooled analysis of seven studies
    • Ron E et al. (1995) Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiat Res 141: 259-277
    • (1995) Radiat Res , vol.141 , pp. 259-277
    • Ron, E.1
  • 5
    • 0035830303 scopus 로고    scopus 로고
    • 15 years after Chernobyl: New evidence of thyroid cancer
    • Shibata Y et al. (2001) 15 years after Chernobyl: new evidence of thyroid cancer. Lancet 358: 1965-1966
    • (2001) Lancet , vol.358 , pp. 1965-1966
    • Shibata, Y.1
  • 7
    • 34247533259 scopus 로고    scopus 로고
    • DeLellis RA et al. (Eds; 2004) Pathology and Genetics of Tumors of Endocrine Organs. In World Health Organization Classification of Tumors, 49-133 (Eds Kleihues P and Sobin LH ) Lyon: International Agency for Research on Cancer Press
    • DeLellis RA et al. (Eds; 2004) Pathology and Genetics of Tumors of Endocrine Organs. In World Health Organization Classification of Tumors, 49-133 (Eds Kleihues P and Sobin LH ) Lyon: International Agency for Research on Cancer Press
  • 8
    • 0026475739 scopus 로고
    • Pathomorphological findings in thyroid cancers of children from the Republic of Belarus: A study of 86 cases occurring between 1986 ('post-Chernobyl') and 1991
    • Furmanchuk AW et al. (1992) Pathomorphological findings in thyroid cancers of children from the Republic of Belarus: a study of 86 cases occurring between 1986 ('post-Chernobyl') and 1991. Histopathology 21: 401-408
    • (1992) Histopathology , vol.21 , pp. 401-408
    • Furmanchuk, A.W.1
  • 9
    • 7144242326 scopus 로고    scopus 로고
    • Shirahige Y et al. (1998) Childhood thyroid cancer: comparison of Japan and Belarus. Endocr J 45: 203-209
    • Shirahige Y et al. (1998) Childhood thyroid cancer: comparison of Japan and Belarus. Endocr J 45: 203-209
  • 10
    • 3042785163 scopus 로고    scopus 로고
    • Thyroid carcinoma after Chernobyl latent period, morphology and aggressiveness
    • Williams ED et al. (2004) Thyroid carcinoma after Chernobyl latent period, morphology and aggressiveness. Br J Cancer 90: 2219-2224
    • (2004) Br J Cancer , vol.90 , pp. 2219-2224
    • Williams, E.D.1
  • 11
    • 0035186167 scopus 로고    scopus 로고
    • Solid variant of papillary thyroid carcinoma: Incidence, clinical-pathologic characteristics, molecular analysis, and biologic behavior
    • Nikiforov YE et al. (2001) Solid variant of papillary thyroid carcinoma: incidence, clinical-pathologic characteristics, molecular analysis, and biologic behavior. Am J Surg Pathol 25: 1478-1484
    • (2001) Am J Surg Pathol , vol.25 , pp. 1478-1484
    • Nikiforov, Y.E.1
  • 12
    • 13444278643 scopus 로고    scopus 로고
    • Poorly differentiated thyroid carcinoma: Introduction to the issue, its landmarks, and clinical impact
    • Rosai J (2004) Poorly differentiated thyroid carcinoma: introduction to the issue, its landmarks, and clinical impact. Endocr Pathol 15: 293-296
    • (2004) Endocr Pathol , vol.15 , pp. 293-296
    • Rosai, J.1
  • 13
    • 0029150495 scopus 로고
    • Childhood thyroid cancer in England and Wales
    • Harach HR et al. (1995) Childhood thyroid cancer in England and Wales. Br J Cancer 72: 777-783
    • (1995) Br J Cancer , vol.72 , pp. 777-783
    • Harach, H.R.1
  • 14
    • 0028291920 scopus 로고
    • Pediatric thyroid cancer after the Chernobyl disaster: Pathomorphologic study of 84 cases (1991-1992) from the Republic of Belarus
    • Nikiforov Y et al. (1994) Pediatric thyroid cancer after the Chernobyl disaster: pathomorphologic study of 84 cases (1991-1992) from the Republic of Belarus. Cancer 74: 748-766
    • (1994) Cancer , vol.74 , pp. 748-766
    • Nikiforov, Y.1
  • 15
    • 0033089247 scopus 로고    scopus 로고
    • Pathomorphology of thyroid gland lesions associated with radiation exposure: The Chernobyl experience and review of the literature
    • Nikiforov YE et al. (1999) Pathomorphology of thyroid gland lesions associated with radiation exposure: the Chernobyl experience and review of the literature. Adv Anat Pathol 6: 78-91
    • (1999) Adv Anat Pathol , vol.6 , pp. 78-91
    • Nikiforov, Y.E.1
  • 16
    • 0034016275 scopus 로고    scopus 로고
    • Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-Chernobyl papillary thyroid carcinomas: Biological, phenotypic, and clinical implications
    • Rabes HM et al. (2000) Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-Chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications. Clin Cancer Res 6: 1093-1103
    • (2000) Clin Cancer Res , vol.6 , pp. 1093-1103
    • Rabes, H.M.1
  • 17
    • 0035986363 scopus 로고    scopus 로고
    • RET/PTC rearrangement in thyroid tumors
    • Nikiforov YE (2002) RET/PTC rearrangement in thyroid tumors. Endocr Pathol 13: 3-16
    • (2002) Endocr Pathol , vol.13 , pp. 3-16
    • Nikiforov, Y.E.1
  • 18
    • 22544456020 scopus 로고    scopus 로고
    • RET tyrosine kinase signaling in development and cancer
    • Arighi E et al. (2005) RET tyrosine kinase signaling in development and cancer. Cytokine Growth Factor Rev 16: 441-467
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 441-467
    • Arighi, E.1
  • 19
    • 0030941779 scopus 로고    scopus 로고
    • Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children
    • Nikiforov YE et al. (1997) Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. Cancer Res 57: 1690-1694
    • (1997) Cancer Res , vol.57 , pp. 1690-1694
    • Nikiforov, Y.E.1
  • 20
    • 0033331028 scopus 로고    scopus 로고
    • High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: A strong correlation between RET/PTC3 and the solid-follicular variant
    • Thomas GA et al. (1999) High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant. J Clin Endocrinol Metab 84: 4232-4238
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 4232-4238
    • Thomas, G.A.1
  • 21
    • 0034453001 scopus 로고    scopus 로고
    • The RET/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults
    • Fenton CL et al. (2000) The RET/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults. J Clin Endocrinol Metab 85: 1170-1175
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1170-1175
    • Fenton, C.L.1
  • 22
    • 0031792561 scopus 로고    scopus 로고
    • Distinct multiple RET/PTC gene rearrangements in multifocal papillary thyroid neoplasia
    • Sugg SL et al. (1998) Distinct multiple RET/PTC gene rearrangements in multifocal papillary thyroid neoplasia. J Clin Endocrinol Metab 83: 4116-4122
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 4116-4122
    • Sugg, S.L.1
  • 23
    • 23844491862 scopus 로고    scopus 로고
    • RET gene rearrangements (RET/PTC1 and RET/PTC3) in papillary thyroid carcinomas from an iodine-rich country (Japan)
    • Nakazawa T et al. (2005) RET gene rearrangements (RET/PTC1 and RET/PTC3) in papillary thyroid carcinomas from an iodine-rich country (Japan). Cancer 104: 943-951
    • (2005) Cancer , vol.104 , pp. 943-951
    • Nakazawa, T.1
  • 24
    • 0036144208 scopus 로고    scopus 로고
    • Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tallcell variant of papillary thyroid carcinoma
    • Basolo F et al. (2002) Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tallcell variant of papillary thyroid carcinoma. Am J Pathol 160: 247-254
    • (2002) Am J Pathol , vol.160 , pp. 247-254
    • Basolo, F.1
  • 25
    • 3643067689 scopus 로고    scopus 로고
    • The RET/PTC3 oncogene: Metastatic solid-type papillary carcinomas in murine thyroids
    • Powell DJ Jr et al. (1998) The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids. Cancer Res 58: 5523-5528
    • (1998) Cancer Res , vol.58 , pp. 5523-5528
    • Powell Jr, D.J.1
  • 26
    • 0029671246 scopus 로고    scopus 로고
    • Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas
    • Jhiang SM et al. (1996) Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas. Endocrinology 137: 375-378
    • (1996) Endocrinology , vol.137 , pp. 375-378
    • Jhiang, S.M.1
  • 27
    • 85047691154 scopus 로고    scopus 로고
    • Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer
    • Ciampi R et al. (2005) Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer. J Clin Invest 115: 94-101
    • (2005) J Clin Invest , vol.115 , pp. 94-101
    • Ciampi, R.1
  • 28
    • 18544375569 scopus 로고    scopus 로고
    • RET expression in papillary thyroid cancer from patients irradiated in childhood for benign conditions
    • Collins BJ et al. (2002) RET expression in papillary thyroid cancer from patients irradiated in childhood for benign conditions. J Clin Endocrinol Metab 87: 3941-3946
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3941-3946
    • Collins, B.J.1
  • 29
    • 2442697906 scopus 로고    scopus 로고
    • The PAX8/PPARγ fusion oncoprotein transforms immortalized human thyrocytes through a mechanism probably involving wild-type PPARγ inhibition
    • Powell JG et al. (2004) The PAX8/PPARγ fusion oncoprotein transforms immortalized human thyrocytes through a mechanism probably involving wild-type PPARγ inhibition. Oncogene 23: 3634-3641
    • (2004) Oncogene , vol.23 , pp. 3634-3641
    • Powell, J.G.1
  • 30
    • 23644459338 scopus 로고    scopus 로고
    • A subset of the follicular variant of papillary thyroid carcinoma harbors the PAX8-PPARγ translocation
    • Castro P et al. (2005) A subset of the follicular variant of papillary thyroid carcinoma harbors the PAX8-PPARγ translocation. Int J Surg Pathol 13: 235-238
    • (2005) Int J Surg Pathol , vol.13 , pp. 235-238
    • Castro, P.1
  • 31
    • 0036344885 scopus 로고    scopus 로고
    • Expression of PAX8-PPARγ1 rearrangements in both follicular thyroid carcinomas and adenomas
    • Marques AR et al. (2002) Expression of PAX8-PPARγ1 rearrangements in both follicular thyroid carcinomas and adenomas. J Clin Endocrinol Metab 87: 3947-3952
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3947-3952
    • Marques, A.R.1
  • 32
    • 0031890864 scopus 로고    scopus 로고
    • Absence of ras and p53 mutations in thyroid carcinomas of children after Chernobyl in contrast to adult thyroid tumours
    • Suchy B et al. (1998) Absence of ras and p53 mutations in thyroid carcinomas of children after Chernobyl in contrast to adult thyroid tumours. Br J Cancer 77: 952-955
    • (1998) Br J Cancer , vol.77 , pp. 952-955
    • Suchy, B.1
  • 33
    • 0032705678 scopus 로고    scopus 로고
    • Ras mutations are uncommon in sporadic thyroid cancer in children and young adults
    • Fenton C et al. (1999) Ras mutations are uncommon in sporadic thyroid cancer in children and young adults. J Endocrinol Invest 22: 781-789
    • (1999) J Endocrinol Invest , vol.22 , pp. 781-789
    • Fenton, C.1
  • 34
    • 27244459732 scopus 로고    scopus 로고
    • Biology of RAS in thyroid cells
    • Meinkoth JL (2004) Biology of RAS in thyroid cells. Cancer Treat Res 122: 131-148
    • (2004) Cancer Treat Res , vol.122 , pp. 131-148
    • Meinkoth, J.L.1
  • 35
    • 0012683188 scopus 로고    scopus 로고
    • RAS point mutations and PAX8-PPARγ rearrangement in thyroid tumors: Evidence for distinct molecular pathways in thyroid follicular carcinoma
    • Nikiforova MN et al. (2003) RAS point mutations and PAX8-PPARγ rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma. J Clin Endocrinol Metab 88: 2318-2326
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2318-2326
    • Nikiforova, M.N.1
  • 36
    • 28444485337 scopus 로고    scopus 로고
    • Molecular pathology of well-differentiated thyroid carcinomas
    • Sobrinho-Simoes M et al. (2005) Molecular pathology of well-differentiated thyroid carcinomas. Virchows Arch 447: 787-793
    • (2005) Virchows Arch , vol.447 , pp. 787-793
    • Sobrinho-Simoes, M.1
  • 37
    • 4544324693 scopus 로고    scopus 로고
    • BRAF mutations are not a major event in post-Chernobyl childhood thyroid carcinomas
    • Lima J et al. (2004) BRAF mutations are not a major event in post-Chernobyl childhood thyroid carcinomas. J Clin Endocrinol Metab 89: 4267-4271
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4267-4271
    • Lima, J.1
  • 38
    • 4544314992 scopus 로고    scopus 로고
    • Low frequency of BRAFT1796A mutations in childhood thyroid carcinomas
    • Kumagai A et al. (2004) Low frequency of BRAFT1796A mutations in childhood thyroid carcinomas. J Clin Endocrinol Metab 89: 4280-4284
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4280-4284
    • Kumagai, A.1
  • 39
    • 18744402183 scopus 로고    scopus 로고
    • BRAF mutations are uncommon in papillary thyroid cancer of young patients
    • Penko K et al. (2005) BRAF mutations are uncommon in papillary thyroid cancer of young patients. Thyroid 15: 320-325
    • (2005) Thyroid , vol.15 , pp. 320-325
    • Penko, K.1
  • 40
    • 17144394374 scopus 로고    scopus 로고
    • Frequency of BRAF T1796A mutation in papillary thyroid carcinoma relates to age of patient at diagnosis and not to radiation exposure
    • Powell N et al. (2005) Frequency of BRAF T1796A mutation in papillary thyroid carcinoma relates to age of patient at diagnosis and not to radiation exposure. J Pathol 205: 558-564
    • (2005) J Pathol , vol.205 , pp. 558-564
    • Powell, N.1
  • 41
    • 23044455248 scopus 로고    scopus 로고
    • Mutational activation of BRAF is not a major event in sporadic childhood papillary thyroid carcinoma
    • Rosenbaum E et al. (2005) Mutational activation of BRAF is not a major event in sporadic childhood papillary thyroid carcinoma. Mod Pathol 18: 898-902
    • (2005) Mod Pathol , vol.18 , pp. 898-902
    • Rosenbaum, E.1
  • 42
    • 2442642971 scopus 로고    scopus 로고
    • Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas
    • Nikiforova MN et al. (2004) Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas. Cancer Lett 209: 1-6
    • (2004) Cancer Lett , vol.209 , pp. 1-6
    • Nikiforova, M.N.1
  • 43
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • Xing M (2005) BRAF mutation in thyroid cancer. Endocr Relat Cancer 12: 245-262
    • (2005) Endocr Relat Cancer , vol.12 , pp. 245-262
    • Xing, M.1
  • 44
    • 0030909107 scopus 로고    scopus 로고
    • Absence of Gs? gene mutations in childhood thyroid tumors after Chernobyl in contrast to sporadic adult thyroid neoplasia
    • Waldmann V et al. (1997) Absence of Gs? gene mutations in childhood thyroid tumors after Chernobyl in contrast to sporadic adult thyroid neoplasia. Cancer Res 57: 2358-2361
    • (1997) Cancer Res , vol.57 , pp. 2358-2361
    • Waldmann, V.1
  • 45
    • 0029933129 scopus 로고    scopus 로고
    • Mutations in the p53 tumour suppressor gene in thyroid tumours of children from areas contaminated by the Chernobyl accident
    • Hillebrandt S et al. (1996) Mutations in the p53 tumour suppressor gene in thyroid tumours of children from areas contaminated by the Chernobyl accident. Int J Radiat Biol 69: 39-45
    • (1996) Int J Radiat Biol , vol.69 , pp. 39-45
    • Hillebrandt, S.1
  • 46
    • 0030060619 scopus 로고    scopus 로고
    • Thyroid lesions in children and adolescents after the Chernobyl disaster: Implications for the study of radiation tumorigenesis
    • Nikiforov Y et al. (1996) Thyroid lesions in children and adolescents after the Chernobyl disaster: implications for the study of radiation tumorigenesis. J Clin Endocrinol Metab 81: 9-14
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 9-14
    • Nikiforov, Y.1
  • 47
    • 0031564214 scopus 로고    scopus 로고
    • p53 mutations in childhood thyroid tumours from Belarus and in thyroid tumours without radiation history
    • Smida J et al. (1997) p53 mutations in childhood thyroid tumours from Belarus and in thyroid tumours without radiation history. Int J Cancer 73: 802-807
    • (1997) Int J Cancer , vol.73 , pp. 802-807
    • Smida, J.1
  • 48
    • 0034613291 scopus 로고    scopus 로고
    • Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells
    • Nikiforova MN et al. (2000) Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells. Science 290: 138-141
    • (2000) Science , vol.290 , pp. 138-141
    • Nikiforova, M.N.1
  • 49
    • 0024816270 scopus 로고
    • Papillary thyroid carcinoma in Iceland. A study of the occurrence in families and the coexistence of other primary tumours
    • Hrafnkelsson J et al. (1989) Papillary thyroid carcinoma in Iceland. A study of the occurrence in families and the coexistence of other primary tumours. Acta Oncol 28: 785-788
    • (1989) Acta Oncol , vol.28 , pp. 785-788
    • Hrafnkelsson, J.1
  • 50
    • 0022972560 scopus 로고
    • Familial papillary carcinoma of the thyroid
    • Stoffer SS et al. (1986) Familial papillary carcinoma of the thyroid. Am J Med Genet 25: 775-782
    • (1986) Am J Med Genet , vol.25 , pp. 775-782
    • Stoffer, S.S.1
  • 51
    • 0030896374 scopus 로고    scopus 로고
    • Familial nonmedullary thyroid carcinoma: A meta-review of case series
    • Loh KC (1997) Familial nonmedullary thyroid carcinoma: a meta-review of case series. Thyroid 7: 107-113
    • (1997) Thyroid , vol.7 , pp. 107-113
    • Loh, K.C.1
  • 52
    • 2442570712 scopus 로고    scopus 로고
    • Familial concordance of thyroid and other head and neck tumors in an irradiated cohort: Analysis of contributing factors
    • Momani MS et al. (2004) Familial concordance of thyroid and other head and neck tumors in an irradiated cohort: analysis of contributing factors J Clin Endocrinol Metab 89: 2185-2191
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2185-2191
    • Momani, M.S.1
  • 53
    • 0025814851 scopus 로고
    • Familial nonmedullary thyroid cancer
    • Ron E et al. (1991) Familial nonmedullary thyroid cancer. Oncology 48: 309-311
    • (1991) Oncology , vol.48 , pp. 309-311
    • Ron, E.1
  • 54
    • 0028143018 scopus 로고
    • Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands
    • Goldgar DE et al. (1994) Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands. J Natl Cancer Inst 86: 1600-1608
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1600-1608
    • Goldgar, D.E.1
  • 55
    • 17944369099 scopus 로고    scopus 로고
    • Increased risk for nonmedullary thyroid cancer in the first degree relatives of prevalent cases of nonmedullary thyroid cancer: A hospital-based study
    • Pal T et al. (2001) Increased risk for nonmedullary thyroid cancer in the first degree relatives of prevalent cases of nonmedullary thyroid cancer: a hospital-based study. J Clin Endocrinol Metab 86: 5307-5312
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5307-5312
    • Pal, T.1
  • 56
    • 26944500520 scopus 로고    scopus 로고
    • High incidence of thyroid cancer in long-standing goiters with thyroglobulin mutations
    • Hishinuma A et al. (2005) High incidence of thyroid cancer in long-standing goiters with thyroglobulin mutations. Thyroid 15: 1079-1084
    • (2005) Thyroid , vol.15 , pp. 1079-1084
    • Hishinuma, A.1
  • 57
    • 0023909011 scopus 로고
    • Radiation-induced thyroid neoplasms: Evidence for familial susceptibility factors
    • Perkel VS et al. (1988) Radiation-induced thyroid neoplasms: evidence for familial susceptibility factors. J Clin Endocrinol Metab 66: 1316-1322
    • (1988) J Clin Endocrinol Metab , vol.66 , pp. 1316-1322
    • Perkel, V.S.1
  • 58
    • 0027305591 scopus 로고
    • In vitro irradiation is able to cause RET oncogene rearrangement
    • Ito T et al. (1993) In vitro irradiation is able to cause RET oncogene rearrangement. Cancer Res 53: 2940-2943
    • (1993) Cancer Res , vol.53 , pp. 2940-2943
    • Ito, T.1
  • 59
    • 17844394699 scopus 로고    scopus 로고
    • Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to γ-radiation: A model of carcinogenic chromosomal rearrangement induced by ionizing radiation
    • Caudill CM et al. (2005) Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to γ-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiation. J Clin Endocrinol Metab 90: 2364-2369
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2364-2369
    • Caudill, C.M.1
  • 60
    • 0034688338 scopus 로고    scopus 로고
    • Preferential induction of RET/PTC1 rearrangement by X-ray irradiation
    • Mizuno T et al. (2000) Preferential induction of RET/PTC1 rearrangement by X-ray irradiation. Oncogene 19: 438-443
    • (2000) Oncogene , vol.19 , pp. 438-443
    • Mizuno, T.1
  • 61
    • 0031172072 scopus 로고    scopus 로고
    • Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas
    • Bongarzone I et al. (1997) Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas. Genomics 42: 252-259
    • (1997) Genomics , vol.42 , pp. 252-259
    • Bongarzone, I.1
  • 62
    • 0035870623 scopus 로고    scopus 로고
    • RET rearrangements in radiation-induced papillary thyroid carcinomas: High prevalence of topoisomerase I sites at breakpoints and microhomology-mediated end joining in ELE1 and RET chimeric genes
    • Klugbauer S et al. (2001) RET rearrangements in radiation-induced papillary thyroid carcinomas: high prevalence of topoisomerase I sites at breakpoints and microhomology-mediated end joining in ELE1 and RET chimeric genes. Genomics 73: 149-160
    • (2001) Genomics , vol.73 , pp. 149-160
    • Klugbauer, S.1
  • 63
    • 0033524002 scopus 로고    scopus 로고
    • Chromosomal breakpoint positions suggest a direct role for radiation in inducing illegitimate recombination between the ELE1 and RET genes in radiation-induced thyroid carcinomas
    • Nikiforov YE et al. (1999) Chromosomal breakpoint positions suggest a direct role for radiation in inducing illegitimate recombination between the ELE1 and RET genes in radiation-induced thyroid carcinomas. Oncogene 18: 6330-6334
    • (1999) Oncogene , vol.18 , pp. 6330-6334
    • Nikiforov, Y.E.1
  • 64
    • 14844293859 scopus 로고    scopus 로고
    • Investigation of loss of heterozygosity and SNP frequencies in the RET gene in papillary thyroid carcinoma
    • Stephens LA et al. (2005) Investigation of loss of heterozygosity and SNP frequencies in the RET gene in papillary thyroid carcinoma. Thyroid 15: 100-104
    • (2005) Thyroid , vol.15 , pp. 100-104
    • Stephens, L.A.1
  • 65
    • 33746401185 scopus 로고    scopus 로고
    • TP53 codon 72 polymorphism in radiation-associated human papillary thyroid cancer
    • Rogounovitch TI et al. (2006) TP53 codon 72 polymorphism in radiation-associated human papillary thyroid cancer. Oncol Rep 15: 949-956
    • (2006) Oncol Rep , vol.15 , pp. 949-956
    • Rogounovitch, T.I.1
  • 66
    • 33745767098 scopus 로고    scopus 로고
    • Proliferative activity of human thyroid cells in various age groups and its correlation with the risk of thyroid cancer after radiation exposure
    • Saad AG et al. (2006) Proliferative activity of human thyroid cells in various age groups and its correlation with the risk of thyroid cancer after radiation exposure. J Clin Endocrinol Metab 91: 2672-2677
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2672-2677
    • Saad, A.G.1
  • 67
    • 33645307434 scopus 로고    scopus 로고
    • Pathogenetic mechanisms in thyroid follicular-cell neoplasia
    • Kondo T et al. (2006) Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nat Rev Cancer 6: 292-306
    • (2006) Nat Rev Cancer , vol.6 , pp. 292-306
    • Kondo, T.1


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