A subset of the follicular variant of papillary thyroid carcinoma harbors the PAX8-PPARγ translocation

International Journal of Surgical Pathology

Volumn 13, Issue 3, 2005, Pages 235-238

  Castro, Patrícia ^a   Roque, Lúcia ^b,c   Magalhães, João ^a,d,e   Sobrinho Simões, Manuel ^a,d,e,f  

^a UNIVERSITY OF PORTO   (Portugal)

^b Center for Immunology and Molecular   (Portugal)

^c Portuguese Cancer Institute   (Portugal)

^d H S João   (Portugal)

^e University of Porto   (Portugal)

^f Rua Dr Roberto Frias   (Portugal)

Author keywords

Follicular variant; Papillary carcinoma; PAX8 PPAR translocation; Thyroid

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR PAX8;

ARTICLE; CANCER CLASSIFICATION; CLINICAL ARTICLE; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN TRANSPORT; THYROID PAPILLARY CARCINOMA;

EID: 23644459338     PISSN: 10668969     EISSN: None     Source Type: Journal    
DOI: 10.1177/106689690501300301     Document Type: Article

References (12)

1. Kroll TG, Sarraf P, Pecciarini L, Chen CJ, Mueller E, Spiegelman BM, Fletcher JA. PAX8-PPARgamma 1 fusion oncogene in human thyroid carcinoma. Science 289:1357-1360, 2000
2. Marques AR, Espadinha C, Catarino AL, Moniz S, Pereira T, Sobrinho LG, Leite V. Expression of PAX8-PPAR gamma 1 rearrangements in both follicular thyroid carcinomas and adenomas. J Clin Endocrinol Metab 87:3947-3952, 2002
3. Nikiforova MN, Biddinger PW, Caudill CM, Kroll TG, Nikiforov YE. PAX8-PPARgamma rearrangement in thyroid tumors: RT-PCR and immunohistochemical analyses. Am J Surg Pathol 26:1016-1023, 2002
4. Cheung L, Messina M, Gill A, Clarkson A, Learoyd D, Delbridge L, Wentworth J, Philips J, Clifton-Bligh R, Robinson BG. Detection of the PAX8-PPAR gamma fusion oncogene in both follicular thyroid carcinomas and adenomas. J Clin Endocrinol Metab 88:354-357, 2003
5. Marques AR, Espadinha C, Frias MJ, Roque L, Catarino AL, Sobrinho LG, Leite V. Underexpression of peroxisome proliferator-activated receptor (PPAR)gamma in PAX8/PPARgamma-negaiive thyroid tumors. Br J Cancer 91:732-738, 2004
6. Zhu Z, Gandhi M, Nikiforova MN, Fischer AH, Nikiforov YE. Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations. Am J Clin Pathol 120:71-77, 2003
7. Roque L, Nunes VM, Ribeiro C, Martins C, Soares J. Karyotypic characterization of papillary thyroid carcinomas. Cancer 92:2529-2538, 2001
8. Wreesmann VB, Ghossein RA, Hezel M, Banerjee D, Shaha AR, Tuttle RM, Shah JP, Rao PH, Singh B. Follicular variant of papillary thyroid carcinoma: Genome-wide appraisal of a controversial entity. Genes Chromosomes Cancer 40:355-364, 2004
9. Nikiforova MN, Lynch RA, Biddinger PW, Alexander EK, Dom GW II, Tallini G, Kroll TG, Nikiforov YE. RAS-point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: Evidence for distinct molecular pathways in thyroid follicular carcinoma. J Clin Endocrinol Metab 88:2318-2326, 2003
10. Soares P, Trovisco V, Rocha AS, Lima J, Castro P, Preto A, Maximo V, Botelho T, Seruca R, Sobrinho-Simoes M. BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC. Oncogene 22:4578-4580, 2003
11. Trovisco V, Vieira de Castro I, Soares P, Maximo V, Silva P, Magalhaes J, Abrosimov A, Guiu XM, Sobrinho-Simoes M. BRAF mutations are associated with some histological types of papillary thyroid carcinoma. J Pathol 202:247-251, 2004
12. Lima J, Trovisco V, Soares P, Maximo V, Magalhaes J, Salvatore G, Santoro M, Bogdanova T, Tronko M, Abrosimov A, Jeremiah S, Thomas G, Williams D, Sobrinho-Simoes M. BRAF mutations are not a major event in post-Chernobyl childhood thyroid carcinomas. J Clin Endocrinol Metab 89:4267-4271, 2004