Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues

Bioorganic Chemistry

Volumn 35, Issue 3, 2007, Pages 221-232

  Zhang, Xinying ^a   Amer, Adel ^a   Fan, Xuesen ^a   Balzarini, Jan ^b   Neyts, Johan ^b   De Clercq, Erik ^b   Prichard, Mark ^c   Kern, Earl ^c   Torrence, Paul F ^a  

^a NORTHERN ARIZONA UNIVERSITY   (United States)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

Cowpox virus; Smallpox; Thymidine kinase; Vaccinia virus

Indexed keywords

1 (2 HYDROXYETHOXYMETHYL) 5 (2,2 DICYANOVINYL)URACIL; 1 (2 HYDROXYETHOXYMETHYL) 5 (DIMETHOXYMETHYL)URACIL; 1 [(2 ACETOXYETHOXY)METHYL] 5 (2 AMINO 3 CYANO 5 OXO 5,6,7,8 TETRAHYDRO 4H CHROMEN 4 YL)URACIL; 1 [(2 ACETOXYETHOXY)METHYL] 5 (2,2 DICYANOVINYL)URACIL; 1 [(2 ACETOXYETHOXY)METHYL]THYMINE; 1 [(2 HYDROXYETHOXY)METHYL] 5 (2 AMINO 3 CYANO 5 OXO 5,6,7,8 TETRAHYDRO 4H CHROMEN 4 YL)URACIL; 1 [(ACETOXYETHOXY)METHYL] 5 FORMYLURACIL; ACYCLOTHYMIDINE; NUCLEOSIDE ANALOG; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; COWPOX VIRUS; DNA VIRUS; DRUG EFFICACY; DRUG SYNTHESIS; HERPES VIRUS; HUMAN; HUMAN CELL; NONHUMAN; ORTHOPOXVIRUS; PRIORITY JOURNAL; RNA VIRUS; STRUCTURE ACTIVITY RELATION; VACCINIA VIRUS;

ANTIVIRAL AGENTS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NUCLEOSIDES; ORTHOPOXVIRUS; RNA VIRUSES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

COWPOX VIRUS; HERPESVIRIDAE; RNA VIRUSES; VACCINIA VIRUS; VARIOLA VIRUS;

EID: 34247495922     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2006.11.003     Document Type: Article

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