Treatment of aerosolized cowpox virus infection in mice with aerosolized cidofovir

Antiviral Research

Volumn 54, Issue 3, 2002, Pages 129-142

  Bray, Mike ^a   Martinez, Mark ^a   Kefauver, Deborah ^a   West, Michael ^a   Roy, Chad ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

Aerosol; Antiviral therapy; Cidofovir; Cowpox virus; Cyclic HPMPC; HPMPC; Orthopoxvirus; Smallpox

Indexed keywords

CIDOFOVIR;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BRONCHOPNEUMONIA; CONTROLLED STUDY; COWPOX; COWPOX VIRUS; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG DELIVERY SYSTEM; FEMALE; LUNG WEIGHT; MOUSE; MOUSE STRAIN; NONHUMAN; POXVIRUS INFECTION; PRIORITY JOURNAL; PROPHYLAXIS; RESPIRATORY SYSTEM; SMALLPOX; SURVIVAL; VIRUS INFECTION; VIRUS STRAIN;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; ANTIVIRAL AGENTS; BODY WEIGHT; BRONCHOPNEUMONIA; COWPOX; COWPOX VIRUS; CYTOSINE; FEMALE; INJECTIONS, SUBCUTANEOUS; LUNG; MICE; MICE, INBRED BALB C; ORGAN SIZE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; STATISTICS, NONPARAMETRIC;

ANIMALIA; COWPOX VIRUS; MONKEYPOX VIRUS; ORTHOPOXVIRUS; POXVIRIDAE; VARIOLA VIRUS;

EID: 0036226416     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(01)00220-0     Document Type: Article

References (35)

1. 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo
2. Standard samplier for assay of airborne microorganisms
3. Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge
4. Drug delivery via the respiratory tract
5. Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir
6. Pharmacokinetics, bioavailability, metabolism and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats
7. Clinical pharmacokinetics of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine in hunman immunodeficiency virus-infected patients
8. Aerosol administration of antiviral agents to treat lung infection due to murine cytomegalovirus
9. Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections
10. Pharmacokinetics of ribavirin aerosol in mice
11. SP-303 small-particle aerosol treatment of influenza A virus infection in mice and respiratory syncytial virus infection in cotton rats
12. Measurement of the respiratory volumes of laboratory animals
13. Inhaled zanamavir for the prevention of influenza in families
14. Bioterrorism as a public health threat
15. Cidofovir, a new agent with potent anti-herpesvirus activity
16. Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy) propyl]cytosine
17. Outbreak of human monkeypox, Democratic Republic of Congo, 1996-1997
18. Antiviral therapy with small particle aerosols
19. A mouse model of aerosol-transmitted orthopoxviral disease
20. The collison nebulizer: Description, performance and application
21. Prevention and treatment of respiratory syncytial virus infections
22. Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza A and B virus infections
23. Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine for the treatment of lethal vaccinia virus infections in severe combined immune deficiency (SCID) mice
24. HPMPC (cidofovir), PMEA (adefovir) and related acyclic nucleoside phosphonate analogues: A review of their pharmacology and clinical potential in the treatment of viral infections
25. Aryl ester prodrugs of cyclic HPMPC. I: Physicochemical characterization and in vitro biological stability
26. Smallpox: An attack scenario
27. Treatment of cowpox virus respiratory infections in mice with ribavirin as a single agent or followed sequentially by cidofovir
28. Evaluation of infrequent dosing regimens with (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine (S-HPMPC) on simian varicella infection in monkeys
29. Efficacy of RD3-0028 aerosol treatment against respiratory syncytial virus infection in immunosuppressed mice
30. Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in human immunodeficiency virus-infected subjects
31. An airborne outbreak of smallpox in a German hospital and its significance with respect to other recent outbreaks in Europe
32. Amantadine and ribavirin aerosol treatment of influenza A and B infection in mice