Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 46, 2006, Pages 17396-17401

  Du, Zhijun ^a   Podsypanina, Katrina ^b   Huang, Shixia ^a   McGrath, Amanda ^a   Toneff, Michael J ^a   Bogoslovskaia, Ekaterina ^a   Zhang, Xiaomei ^a   Moraes, Ricardo C ^a   Fluck, Michele ^c   Allred, D Craig ^a   Lewises, Michael T ^a   Varmus, Harold E ^b   Li, Yi ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c Michigan State University ^*  (United States)

Author keywords

Breast cancer; ErbB2; Polyoma middle T antigen; Tumor virus A; Wnt

Indexed keywords

CYCLIN D1; KI 67 ANTIGEN; MYC PROTEIN; RCAS PYMT; UNCLASSIFIED DRUG; VIRUS MIDDLE T ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVIAN LEUKOSIS ONCOVIRUS; BREAST CARCINOGENESIS; CELL HETEROGENEITY; CELL PROLIFERATION; CONTROLLED STUDY; GENE TRANSFER; GFP GENE; IN VITRO STUDY; MAMMARY GLAND; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; ONCOGENE C MYC; ONCOGENE NEU; PRIORITY JOURNAL; PYMT GENE; REPLICATION COMPETENT AVIAN SARCOMA LEUKOMA VIRUS LTR SPLICE ACCEPTOR; RETROVIRUS VECTOR; SOMATIC GENE THERAPY; TRANSGENIC MOUSE; VIRUS GENE;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; AVIAN SARCOMA VIRUSES; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN D1; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; GENETIC VECTORS; MAMMARY GLANDS, ANIMAL; MICE; MICE, TRANSGENIC; ONCOGENIC VIRUSES; PROTO-ONCOGENE PROTEINS C-MYC; SURVIVAL RATE;

ANIMALIA; AVES; AVIAN LEUKOSIS VIRUS; MOUSE MAMMARY TUMOR VIRUS; MUS MUSCULUS; SUBGROUP A;

EID: 33751244557     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0608607103     Document Type: Article

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