Mitochondrial creatine kinase is critically necessary for normal myocardial high-energy phosphate metabolism

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 283, Issue 2 52-2, 2002, Pages

  Spindler, Matthias ^a,b   Niebler, Reinhard ^a   Remkes, Helga ^b   Horn, Michael ^b   Lanz, Titus ^a   Neubauer, Stefan ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Creatine kinase; Energy metabolism; Nuclear magnetic resonance spectroscopy; Transgenic mouse

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE KINASE; CREATINE KINASE MB; CREATINE PHOSPHATE; MITOCHONDRIAL ENZYME;

ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; ENERGY TRANSFER; ENZYME ACTIVITY; GENE DELETION; HEART LEFT VENTRICLE PERFORMANCE; HEART MUSCLE METABOLISM; HIGH ENERGY PHOSPHATE; MOUSE; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0036073201     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00800.2001     Document Type: Article

References (29)

1. Transport of energy in muscle: The phosphorylcreatine shuttle
2. 31p NMR surface coil studies in brain, heart, and skeletal muscle of the living rat
3. Maintained coupling of oxidative phosphorylation to creatine kinase activity in sarcomeric mitochondrial creatine kinase-deficient mice
4. The cytoplasmic phosphorylation potential. Its possible role in the control of myocardial respiration and cardiac contractility
5. 31P nuclear magnetic resonance spectroscopy
6. Is cardiac failure a consequence of decreased energy reserve?
7. Energetic crosstalk between organelles: Architectural integration of energy production and utilization
8. Microassay of free and total creatine from tissue extracts by combination of chromatographic and fluorometric methods
9. eq of the creatine kinase reaction and other phosphate hydrolyses and phosphate transfer reactions
10. Decreased energy reserve in an animal model of dilated cardiomyopathy. Relationship to contractile performance
11. Protein measurement with the Folin phenol reagent
12. Creatine kinase system in failing and nonfailing human myocardium
13. Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy
14. Impairment of energy metabolism in intact residual myocardium of rat hearts with chronic myocardial infarction
15. +-creatine cotransporter in failing human myocardium and in experimental heart failure
16. Expansion of extracellular tracer spaces in the isolated heart perfused with crystalloid solutions: Expansion of extracellular space, trans-sarcolemmal leakage, or both?
17. An improved procedure for serum creatine phosphokinase determination
18. Metabolic compartmentation and substrate channelling in muscle cells. Role of coupled creatine kinases in in vivo regulation of cellular respiration - A synthesis
19. Kinetic, thermodynamic, and developmental consequences of deleting creatine kinase isoenzymes from the heart. Reaction kinetics of the creatine kinase isoenzymes in the intact heart
20. Impaired cardiac energetics in mice lacking muscle-specific isoenzymes of creatine kinase
21. Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy
22. 2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies
23. Use of gene targeting for compromising energy homeostasis in neuro-muscular tissues: The role of sarcomeric mitochondrial creatine kinase
24. Cytoarchitectural and metabolic adaptations in muscles with mitochondrial and cytosolic creatine kinase deficiencies
25. Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity
26. 31P NMR studies of creatine kinase flux in M-creatine kinase-deficient mouse heart
27. Muscle creatine kinase-deficient mice. II. Cardiac and skeletal muscles exhibit tissue-specific adaptation of the mitochondrial function
28. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The "phosphocreatine circuit" for cellular energy homeostasis
29. Mitochondrial creatine kinase: A key enzyme of aerobic energy metabolism