Alopecia areata, primary sclerosing cholangitis, and ulcerative colitis: Autoimmunity and apoptosis as common links?

Digestive Diseases and Sciences

Volumn 52, Issue 5, 2007, Pages 1288-1292

  Katsinelos, Panagiotis ^a   Kountouras, Jannis ^b,c   Paroutoglou, George ^a   Zavos, Christos ^b  

^a AHEPA UNIVERSITY HOSPITAL   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^c NONE   (Greece)

Author keywords

Alopecia areata; Apoptosis; Autoimmunity; Primary sclerosing cholangitis; Ulcerative colitis

Indexed keywords

BETAMETHASONE; METHYLPREDNISOLONE;

ABDOMINAL SCINTISCANNING; ADULT; ALOPECIA AREATA; ANAMNESIS; APOPTOSIS; ARTICLE; AUTOIMMUNITY; BLOODY DIARRHEA; CASE REPORT; COLONOSCOPY; DISEASE ASSOCIATION; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; HISTOLOGY; HUMAN; HUMAN TISSUE; LABORATORY TEST; LIVER BIOPSY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; ULCERATIVE COLITIS; ULTRASOUND;

ADULT; ALOPECIA AREATA; APOPTOSIS; AUTOIMMUNITY; CHOLANGITIS, SCLEROSING; COLITIS, ULCERATIVE; HUMANS; MALE; T-LYMPHOCYTES; TIME FACTORS;

EID: 34247384298     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-006-9265-3     Document Type: Article

References (44)

1. Kountouras J, Zavos C, Chatzopoulos D (2004) Immunomodulatory benefits of cyclosporine A in inflammatory bowel disease. J Cell Mol Med 8:317-328
2. Snook JA, de Silva HJ, Jewell DP (1989) The association of autoimmune disorders with inflammatory bowel disease. Q J Med 72:835-840
3. Tan RS (1974) Ulcerative colitis,myasthenia gravis, atypical lichen planus, alopecia areata, vitiligo. Proc R Soc Med 67:195-19
4. Thompson DM, Robinson TW, Lennard-Jones J (1974) Alopecia areata, vitiligo, scleroderma and ulcerative colitis. Proc R Soc Med 67:1010-1012
5. Martinez-Mir A, Zlotogorski A, Ott J, Gordon D, Christiano AM (2003) Genetic linkage studies in alopecia areata. J Invest Dermatol Symp Proc 8:199-203
6. Treem WR, Veligati LN, Rotter JI, Targan SR, Hyams JS (1993) Ulcerative colitis and total alopecia in a mother and her son. Gastroenterology 104:1187-1191
7. Christodoulou DK, Katsanos KH, Kitsanou M, Stergiopoulou C, Hatzis J, Tsianos EV (2002) Frequency of extraintestinal manifestations in patients with inflammatory bowel disease in Northwest Greece and review of the literature. Dig Liver Dis 34:781-786
8. Muller SA, Winkelmann RK (1963) Alopecia areata. An evaluation of 736 patients. Arch Dermatol 88:290-29
9. Tang L, Cao L, Bernardo O, Chen Y, Sundberg JP, Lui H, Chung S, Shapiro J (2003) Topical mechlorethamine restores autoimmune-arrested follicular activity in mice with an alopecia areata-like disease by targeting infiltrated lymphocytes. J Invest Dermatol 120:400-406
10. Gilhar A, Ullmann Y, Berkutzki T, Assy B, Kalish RS (1998) Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. J Clin Invest 101:62-67
11. Sato-Kawamura M, Aiba S, Tagami H (2003) Strong expression of CD40, CD54 and HLA-DR antigen and lack of evidence for direct cellular cytotoxicity are unique immunohistopathological features in alopecia areata. Arch Dermatol Res 294:536-543
12. McElwee KJ, Freyschmidt-Paul P, Hoffmann R, Kissling S, Hummel S, Vitacolonna M, Zoller M (2005) Transfer of CD8(+) cells induces localized hair loss whereas CD4(+)/CD25(-) cells promote systemic alopecia areata and CD4(+)/CD25(+) cells blockade disease onset in the C3H/HeJ mouse model. J Invest Dermatol 124:947-957
13. Zoller M, McElwee KJ, Vitacolonna M, Hoffmann R (2004) Apoptosis resistance in peripheral blood lymphocytes of alopecia areata patients. J Autoimmun 23:241-256
14. Bodemer C, Peuchmaur M, Fraitaig S, Chatenoud L, Brousse N, De Prost Y (2000) Role of cytotoxic T cells in chronic alopecia areata. J Invest Dermatol 114:112-116
15. McElwee KJ, Freyschmidt-Paul P, Zoller M, Hoffmann R (2003) Alopecia areata susceptibility in rodent models. J Invest Dermatol Symp Proc 8:182-187
16. Christoph T, Muller-Rover S, Audring H, Tobin DJ, Hermes B, Cotsarelis G, Ruckert R, Paus R (2000) The human hair follicle immune system: cellular composition and immune privilege. Br J Dermatol 142:862-873
17. Gilhar A, Shalaginov R, Assy B, Serafimovich S, Kalish RS (1999) Alopecia areata is a T-lymphocyte mediated autoimmune disease: lesional human T-lymphocytes transfer alopecia areata to human skin grafts on SCID mice. J Invest Dermatol Symp Proc 4:207-210
18. Benichou G, Price VH (1999) T cell repertoire in mice with alopecia areata. J Invest Dermatol Symp Proc 4:224-225
19. Namazi MR (2003) Nitric oxide donors as potential additions to anti-alopecia areata armamentarium. Inflamm Res 52:227-229
20. Gilhar A, Landau M, Assy B, Ullmann Y, Shalaginov R, Serafimovich S, Kalish RS (2003) Transfer of alopecia areata in the human scalp graft/Prkdc(scid) (SCID) mouse system is characterized by a TH1 response. Clin Immunol 106:181-187
21. Brajac I, Gruber F, Petrovecki M, Malnar-Dragojevic D (2004) Interleukin-2 receptor alpha-chain expression in patients with alopecia areata. Acta Dermatovenerol Croat 12:154-156
22. Gupta AK, Ellis CN, Cooper KD, Nickoloff BJ, Ho VC, Chan LS, Hamilton TA, Tellner DC, Griffiths CE, Voorhees JJ (1990) Oral cyclosporine for the treatment of alopecia areata. A clinical and immunohistochemical analysis. J Am Acad Dermatol 22(2; Pt 1):242-250
23. Lazarous MC, Kerdel FA (2002) Topical tacrolimus Protopic. Drugs Today (Barc) 38:7-15
24. Nunzi E, Hamerlinck F, Cormane RH (1980) Immunopathological studies on alopecia areata. Arch Dermatol Res 269:1-11
25. McElwee KJ, Freyschmidt-Paul P, Sundberg JP, Hoffmann R (2003) The pathogenesis of alopecia areata in rodent models. J Invest Dermatol Symp Proc 8:6-11
26. Carroll JM, McElwee KJE, King L, Byrne MC, Sundberg JP (2002) Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mousemodel and humans. J Invest Dermatol 119:392-402
27. Bo X, Broome U, Remberger M, Sumitran-Holgersson S (2001) Tumour necrosis factor alpha impairs function of liver derived T lymphocytes and natural killer cells in patients with primary sclerosing cholangitis. Gut 49:131-141
28. Tinmouth J, Lee M, Wanless IR, Tsui FW, Inman R, Heathcote EJ (2002) Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis. Liver 22:228-234
29. Ludwig J, Barham SS, LaRusso NF, Elveback LR, Wiesner RH, McCall JT (1981) Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis. Hepatology 1:632-640
30. Whiteside TL, Lasky S, Si L, Van Thiel DH (1985) Immunologic analysis of mononuclear cells in liver tissues and blood of patients with primary sclerosing cholangitis. Hepatology 5:468-474
31. Lindor KD, Wiesner RH, LaRusso NF, Homburger HA (1987) Enhanced autoreactivity of T-lymphocytes in primary sclerosing cholangitis. Hepatology 7:884-888
32. Panasiuk A, Prokopowicz D, Zak J, Panasiuk B, Wysocka J (2004) Lymphocyte subpopulations in peripheral blood in primary sclerosing cholangitis. Hepatogastroenterology 51:1289-1291
33. Broome U, Hultcrantz R, Lefvert AK, Yi Q (1998) Cytokine production from colonic T cells in patients with ulcerative colitis with and without primary sclerosing cholangitis. Dis Colon Rectum 41:1543-1549
34. Tjandra K, Le T, Swain MG (2003) Glucocorticoid receptors are downregulated in hepatic T lymphocytes in rats with experimental cholangitis. Gut 52:1363-1370
35. Kyokane K, Ichihara T, Horisawa M, Suzuki N, Ichihara S, Suga S, Nakao A, Morise K (1994) Successful treatment of primary sclerosing cholangitis with cyclosporine and corticosteroid. Hepatogastroenterology 41:449-452
36. Van Thiel DH, Carroll P, Abu-Elmagd K, Rodriguez-Rilo H, Irish W, McMichael J, Starzl TE (1995) Tacrolimus (FK 506), a treatment for primary sclerosing cholangitis: results of an open-label preliminary trial. Am J Gastroenterol 90:455-459
37. Xu B, Broome U, Ericzon BG, Sumitran-Holgersson S (2002) High frequency of autoantibodies in patients with primary sclerosing cholangitis that bind biliary epithelial cells and induce expression of CD44 and production of interleukin 6. Gut 51:120-127
38. Wen Z, Fiocchi C (2004) Inflammatory bowel disease: Autoimmune or immune-mediated pathogenesis? Clin Dev Immunol 11:195-204
39. Shanahan F, Targan S (1994) Mechanisms of tissue injury in inflammatory bowel disease. In Inflammatory bowel disease: from bench to bedside. Targan S, Shanahan F (eds). Williams & Wilkins, Baltimore, MD, pp 78-88
40. Groux H, Powrie F (1999) Regulatory T cells and inflammatory bowel disease. Immunol Today 20:442-445
41. Fiocchi C (1998) Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115:182-205
42. Kountouras J, Kouklakis G, Zavos C, Chatzopoulos D, Moschos J, Molyvas E, Zavos N (2003) Apoptosis, inflammatory bowel disease and carcinogenesis: overview of international and Greek experiences. Can J Gastroenterol 17:249-258
43. Souza HS, Tortori CJ, Castelo-Branco MT, Carvalho AT, Margallo VS, Delgado CF, Dines I, EliaCC (2005) Apoptosis in the intestinal mucosa of patients with inflammatory bowel disease: evidence of altered expression of FasL and perforin cytotoxic pathways. Int J Colorectal Dis 20:277-286
44. Kountouras J, Zavos C, Chatzopoulos D (2005) Anti-tumor necrosis factor therapy for ulcerative colitis. Gastroenterology 129:1138-1139