Inactivation of LLC1 gene in nonsmall cell lung cancer

International Journal of Cancer

Volumn 120, Issue 11, 2007, Pages 2353-2358

  Hong, Kyeong Man ^a,b   Yang, Sei Hoon ^a   Chowdhuri, Sinchita Roy ^a   Player, Audrey ^a   Hames, Megan ^a   Fukuoka, Junya ^a,d   Meerzaman, Daoud ^a   Dracheva, Tatiana ^a   Sun, Zhifu ^c   Yang, Ping ^c   Jen, Jin ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b National Cancer Center   (South Korea)

^c MAYO CLINIC CANCER CENTER   (United States)

^d TOYAMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

LLC1; Nonsmall cell lung cancer; Promoter methylation; Serial analysis of gene expression

Indexed keywords

5 AZA 2' DEOXYCYTIDINE;

ARTICLE; CARCINOGENESIS; CHROMOSOME 20Q; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPITHELIUM CELL; EXON; GENE; GENE INACTIVATION; GENE LLC1; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; SERIAL ANALYSIS OF GENE EXPRESSION; SQUAMOUS CELL CARCINOMA;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CARCINOMA, NON-SMALL-CELL LUNG; CATTLE; DNA PRIMERS; DOGS; GENE EXPRESSION PROFILING; GENE SILENCING; HUMANS; LUNG NEOPLASMS; MICE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 34247370949     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.22577     Document Type: Article

References (32)

1. Cancer Statistics. www.cancer.gov/statistics/ (2005).
2. Sanchez-Cespedes M, Ahrendt SA, Piantadosi S, Rosell R, Monzo M, Wu L, Westra WH, Yang SC, Jen J, Sidransky D. Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers. Cancer Res 2001;61:1309-13.
3. Pei J, Balsara BR, Li W, Litwin S, Gabrielson E, Feder M, Jen J, Testa JR. Genomic imbalances in human lung adenocarcinomas and squamous cell carcinomas. Genes Chromosomes Cancer 2001;31: 282-7.
4. Hibi K, Liu Q, Beaudry GA, Madden SL, Westra WH, Wehage SL, Yang SC, Heitmiller RF, Bertelsen AH, Sidransky D, Jen J. Serial analysis of gene expression in non-small cell lung cancer. Cancer Res 1998;58:5690-4.
5. Nacht M, Dracheva T, Gao Y, Fujii T, Chen Y, Player A, Akmaev V, Cook B, Dufault M, Zhang M, Zhang W, Guo M, et al. Molecular characteristics of non-small cell lung cancer. Proc Natl Acad Sci USA 2001;98:15203-8.
6. Koga T, Horio Y, Mitsudomi T, Takahashi T, Yatabe Y. Identification of MGB1 as a marker in the differential diagnosis of lung tumors in patients with a history of breast cancer by analysis of publicly available SAGE data. J Mol Diagn 2004;6:90-5.
7. Sasaki H, Moriyama S, Mizuno K, Yukiue H, Yano M, Fukai I, Yamakawa Y, Fujii Y. SAGE mRNA expression in advanced-stage lung cancers. Eur J Surg Oncol 2003;29:900-3.
8. He P, Varticovski L, Bowman ED, Fukuoka J, Welsh JA, Miura K, Jen J, Gabrielson E, Brambilla E, Travis WD, Harris CC. Identification of carboxypeptidase E and γ-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. Hum Pathol 2004;35:1196-209.
9. Fukuoka J, Fujii T, Shih JH, Dracheva T, Meerzaman D, Player A, Hong K, Settnek S, Gupta A, Buetow K, Hewitt S, Travis WD, et al. Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer. Clin Cancer Res 2004;10:4314-24.
10. Beer DG, Kardia SL, Huang CC, Giordano TJ, Levin AM, Misek DE. Lin L, Chen G, Gharib TG, Thomas DG, Lizyness ML, Kuick R, et al. Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat Med 2002;8:816-24.
11. Talbot SG, Estilo C, Maghami E, Sarkaria IS, Pham DK, O-Charoenrat P, Socci ND, Ngai I, Carlson D, Ghossein R, Viale A, Park BJ, et al. Gene expression profiling allows distinction between primary and metastatic squamous cell carcinomas in the lung. Cancer Res 2005;65:3063-71.
12. Bhattacharjee A, Richards WG, Staunton J, Li C, Monti S, Vasa P, Ladd C, Beheshti J, Bueno R, Gillette M, Loda M, Weber G, et al. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci USA 2001;98:13790-5.
13. Raponi M, Zhang Y, Yu J, Chen G, Lee G, Taylor JM, Macdonald J, Thomas D, Moskaluk C, Wang Y, Beer DG. Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung. Cancer Res 2006;66:7466-72.
14. Hibi K, Westra WH, Borges M, Goodman S, Sidransky D, Jen J. PGP9.5 as a candidate tumor marker for non-small-cell lung cancer. Am J Pathol 1999;155:711-5.
15. Player A, Gillespie J, Fujii T, Fukuoka J, Dracheva T, Meerzaman D, Hong KM, Curran J, Attoh G, Travis W, Jen J. Identification of TDE2 gene and its expression in non-small cell lung cancer. Int J Cancer 2003;107:238-43.
16. Yang P, Allen MS, Aubry MC, Wampfler JA, Marks RS, Edell ES, Thibodeau S, Adjei AA, Jett J, Deschamps C. Clinical features of 5,628 primary lung cancer patients: experience at Mayo Clinic from 1997 to 2003. Chest 2005;128:452-62.
17. Yang SH, Mechanic LE, Yang P, Landi MT, Bowman ED, Wampfler J, Meerzaman D, Hong KM, Mann F, Dracheva T, Fukuoka J, Travis W, et al. Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer. Clin Cancer Res 2005;11:2106-10.
18. Fujii T, Dracheva T, Player A, Chacko S, Clifford R, Strausberg RL, Buetow K, Azumi N, Travis WD, Jen J. A preliminary transcriptome map of non-small cell lung cancer. Cancer Res 2002;62:3340-6.
19. Hong KM, Yang SH, Guo M, Herman JG, Jen J. Semi-automatic detection of DNA methylation at CpG islands. Biotechniques 2005; 38:354, 356, 358.
20. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996;93:9821-6.
21. Iwao K, Watanabe T, Fujiwara Y, Takami K, Kodama K, Higashiyama M, Yokouchi H, Ozaki K, Monden M, Tanigami A. Isolation of a novel human lung-specific gene, PLUNC, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Int J Cancer 2001;91:433-7.
22. Wang T, Fan L, Watanabe Y, McNeill P, Fanger GR, Persing DH, Reed SG. L552S, an alternatively spliced isoform of XAGE1, is over-expressed in lung adenocarcinoma. Oncogene 2001;20:7699-709.
23. Velculescu VE, Zhang L, Vogelstein B, Kinzler KW. Serial analysis of gene expression. Science 1995;270:484-7.
24. Zhang L, Zhou W, Velculescu VE, Kern SE, Hruban RH, Hamilton SR, Vogelstein B, Kinzler KW. Gene expression profiles in normal and cancer cells. Science 1997;276:1268-72.
25. Hodgson JG, Chin K, Collins C, Gray JW. Genome amplification of chromosome 20 in breast cancer. Breast Cancer Res Treat 2003; 78:337-45.
26. Dammann R, Schagdarsurengin U, Seidel C, Strunnikova M, Rastetter M, Baier K, Pfeifer GP. The tumor suppressor RASSF1A in human carcinogenesis. Histol Histopathol 2005;20:645-63.
27. Holst CR, Nuovo GJ, Esteller M, Chew K, Baylin SB, Herman JG, Tlsty TD. Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res 2003; 63:1596-601.
28. Breuer RH, Snijders PJ, Sutedja GT, Sewalt RG, Otte AP, Postmus PE, Meijer CJ, Raaphorst FM, Smit EF. Expression of the p16(INK4a) gene product, methylation of the p16(INK4a) promoter region and expression of the polycomb-group gene BMI-1 in squamous cell lung carcinoma and premalignant endobronchial lesions. Lung Cancer 2005;48:299-306.
29. Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003;349:2042-54.
30. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995;1:686-92.
31. Zochbauer-Muller S, Fong KM, Virmani AK, Geradts J, Gazdar AF, Minna JD. Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res 2001;61:249-55.
32. Agathanggelou A, Dallol A, Zochbauer-Muller S, Morrissey C, Honorio S, Hesson L, Martinsson T, Fong KM, Kuo MJ, Yuen PW, Maher ER, Minna JD, et al. Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers. Oncogene 2003;22: 1580-8.