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Volumn 48, Issue 3, 2005, Pages 299-306

Expression of the p16INK4a gene product, methylation of the p16INK4a promoter region and expression of the polycomb-group gene BMI-1 in squamous cell lung carcinoma and premalignant endobronchial lesions

Author keywords

Cancer; Lung; MSP; p16INK4a; Polycomb; Premalignant

Indexed keywords

PROTEIN P16;

EID: 18844374833     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2004.11.026     Document Type: Article
Times cited : (61)

References (35)
  • 2
    • 0035691670 scopus 로고    scopus 로고
    • The new World Health Organization classification of lung tumours
    • E. Brambilla, W.D. Travis, T.V. Colby, B. Corrin, and Y. Shimosato The new World Health Organization classification of lung tumours Eur Respir J 18 6 2001 1059 1068
    • (2001) Eur Respir J , vol.18 , Issue.6 , pp. 1059-1068
    • Brambilla, E.1    Travis, W.D.2    Colby, T.V.3    Corrin, B.4    Shimosato, Y.5
  • 4
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 1 2000 57 70
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 5
    • 0037075887 scopus 로고    scopus 로고
    • Cyclin D-dependent kinases, INK4 inhibitors and cancer
    • S. Ortega, M. Malumbres, and M. Barbacid Cyclin D-dependent kinases, INK4 inhibitors and cancer Biochim Biophys Acta 1602 1 2002 73 87
    • (2002) Biochim Biophys Acta , vol.1602 , Issue.1 , pp. 73-87
    • Ortega, S.1    Malumbres, M.2    Barbacid, M.3
  • 6
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • M. Serrano, G.J. Hannon, and D. Beach A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 Nature 366 6456 1993 704 707
    • (1993) Nature , vol.366 , Issue.6456 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 7
    • 0028121279 scopus 로고
    • A cell cycle regulator potentially involved in genesis of many tumor types
    • A. Kamb, N.A. Gruis, J. Weaver-Feldhaus, Q. Liu, K. Harshman, and S.V. Tavtigian A cell cycle regulator potentially involved in genesis of many tumor types Science 264 5157 1994 436 440
    • (1994) Science , vol.264 , Issue.5157 , pp. 436-440
    • Kamb, A.1    Gruis, N.A.2    Weaver-Feldhaus, J.3    Liu, Q.4    Harshman, K.5    Tavtigian, S.V.6
  • 8
    • 0032786446 scopus 로고    scopus 로고
    • Alterations of expression of Rb, p16(INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance
    • E. Brambilla, D. Moro, S. Gazzeri, and C. Brambilla Alterations of expression of Rb, p16(INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance J Pathol 188 4 1999 351 360
    • (1999) J Pathol , vol.188 , Issue.4 , pp. 351-360
    • Brambilla, E.1    Moro, D.2    Gazzeri, S.3    Brambilla, C.4
  • 9
    • 0032576630 scopus 로고    scopus 로고
    • Mechanisms of p16INK4A inactivation in non small-cell lung cancers
    • S. Gazzeri, V. Gouyer, C. Vour'ch, C. Brambilla, and E. Brambilla Mechanisms of p16INK4A inactivation in non small-cell lung cancers Oncogene 16 4 1998 497 504
    • (1998) Oncogene , vol.16 , Issue.4 , pp. 497-504
    • Gazzeri, S.1    Gouyer, V.2    Vour'Ch, C.3    Brambilla, C.4    Brambilla, E.5
  • 10
    • 0036145156 scopus 로고    scopus 로고
    • Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours
    • M. Esteller, and J.G. Herman Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours J Pathol 196 1 2002 1 7
    • (2002) J Pathol , vol.196 , Issue.1 , pp. 1-7
    • Esteller, M.1    Herman, J.G.2
  • 11
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycomb-group gene BMI-1 regulates cell proliferation and senescence through the ink4a locus
    • J.J. Jacobs, K. Kieboom, S. Marino, R.A. DePinho, and M. van Lohuizen The oncogene and Polycomb-group gene BMI-1 regulates cell proliferation and senescence through the ink4a locus Nature 397 6715 1999 164 168
    • (1999) Nature , vol.397 , Issue.6715 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    Depinho, R.A.4    Van Lohuizen, M.5
  • 12
    • 0035906853 scopus 로고    scopus 로고
    • The BMI-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression
    • S. Vonlanthen, J. Heighway, H.J. Altermatt, M. Gugger, A. Kappeler, and M.M. Borner The BMI-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression Br J Cancer 84 10 2001 1372 1376
    • (2001) Br J Cancer , vol.84 , Issue.10 , pp. 1372-1376
    • Vonlanthen, S.1    Heighway, J.2    Altermatt, H.J.3    Gugger, M.4    Kappeler, A.5    Borner, M.M.6
  • 13
    • 0001299387 scopus 로고    scopus 로고
    • Early detection of preinvasive lesions in high-risk patients: A comparison of conventional flexible and fluorescence bronchoscopy
    • B.J. Venmans, J.C. Linden van der, Boxem van AJM, P.E. Postmus, E.F. Smit, and T.G. Sutedja Early detection of preinvasive lesions in high-risk patients: a comparison of conventional flexible and fluorescence bronchoscopy J. Bronchology 5 1998 280 283
    • (1998) J. Bronchology , vol.5 , pp. 280-283
    • Venmans, B.J.1    Linden Vander, J.C.2    Boxem Van, A.J.M.3    Postmus, P.E.4    Smit, E.F.5    Sutedja, T.G.6
  • 14
    • 0034492916 scopus 로고    scopus 로고
    • Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin's disease
    • F.M. Raaphorst, F.J. van Kemenade, T. Blokzijl, E. Fieret, K.M. Hamer, and D.P. Satijn Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin's disease Am J Pathol 157 3 2000 709 715
    • (2000) Am J Pathol , vol.157 , Issue.3 , pp. 709-715
    • Raaphorst, F.M.1    Van Kemenade, F.J.2    Blokzijl, T.3    Fieret, E.4    Hamer, K.M.5    Satijn, D.P.6
  • 15
    • 0035871985 scopus 로고    scopus 로고
    • Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri
    • R. Klaes, T. Friedrich, D. Spitkovsky, R. Ridder, W. Rudy, and U. Petry Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri Int J Cancer 92 2 2001 276 284
    • (2001) Int J Cancer , vol.92 , Issue.2 , pp. 276-284
    • Klaes, R.1    Friedrich, T.2    Spitkovsky, D.3    Ridder, R.4    Rudy, W.5    Petry, U.6
  • 17
    • 0029843950 scopus 로고    scopus 로고
    • Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
    • J.G. Herman, J.R. Graff, S. Myohanen, B.D. Nelkin, and S.B. Baylin Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proc Natl Acad Sci USA 93 18 1996 9821 9826
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.18 , pp. 9821-9826
    • Herman, J.G.1    Graff, J.R.2    Myohanen, S.3    Nelkin, B.D.4    Baylin, S.B.5
  • 18
    • 0037051666 scopus 로고    scopus 로고
    • Alterations of the p16(ink4a) gene in resected nonsmall cell lung tumors and exfoliated cells within sputum
    • J.T. Chen, Y.C. Chen, Y.C. Wang, R.C. Tseng, and C.Y. Chen Alterations of the p16(ink4a) gene in resected nonsmall cell lung tumors and exfoliated cells within sputum Int J Cancer 98 5 2002 724 731
    • (2002) Int J Cancer , vol.98 , Issue.5 , pp. 724-731
    • Chen, J.T.1    Chen, Y.C.2    Wang, Y.C.3    Tseng, R.C.4    Chen, C.Y.5
  • 19
    • 0035870282 scopus 로고    scopus 로고
    • P16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer
    • D.H. Kim, H.H. Nelson, J.K. Wiencke, S. Zheng, D.C. Christiani, and J.C. Wain p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer Cancer Res 61 8 2001 3419 3424
    • (2001) Cancer Res , vol.61 , Issue.8 , pp. 3419-3424
    • Kim, D.H.1    Nelson, H.H.2    Wiencke, J.K.3    Zheng, S.4    Christiani, D.C.5    Wain, J.C.6
  • 20
    • 0030765323 scopus 로고    scopus 로고
    • Prognostic value of the immunohistochemical detection of p16INK4 expression in nonsmall cell lung carcinoma
    • S. Taga, T. Osaki, A. Ohgami, H. Imoto, T. Yoshimatsu, and I. Yoshino Prognostic value of the immunohistochemical detection of p16INK4 expression in nonsmall cell lung carcinoma Cancer 80 3 1997 389 395
    • (1997) Cancer , vol.80 , Issue.3 , pp. 389-395
    • Taga, S.1    Osaki, T.2    Ohgami, A.3    Imoto, H.4    Yoshimatsu, T.5    Yoshino, I.6
  • 22
    • 0032578509 scopus 로고    scopus 로고
    • Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
    • S.A. Belinsky, K.J. Nikula, W.A. Palmisano, R. Michels, G. Saccomanno, and E. Gabrielson Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis Proc Natl Acad Sci USA 95 20 1998 11891 11896
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.20 , pp. 11891-11896
    • Belinsky, S.A.1    Nikula, K.J.2    Palmisano, W.A.3    Michels, R.4    Saccomanno, G.5    Gabrielson, E.6
  • 23
    • 0037054936 scopus 로고    scopus 로고
    • Aberrant methylation of the CDKN2a/p16INK4a gene promoter region in preinvasive bronchial lesions: A prospective study in high-risk patients without invasive cancer
    • A. Lamy, R. Sesboue, J. Bourguignon, B. Dautreaux, J. Metayer, and T. Frebourg Aberrant methylation of the CDKN2a/p16INK4a gene promoter region in preinvasive bronchial lesions: A prospective study in high-risk patients without invasive cancer Int J Cancer 100 2 2002 189 193
    • (2002) Int J Cancer , vol.100 , Issue.2 , pp. 189-193
    • Lamy, A.1    Sesboue, R.2    Bourguignon, J.3    Dautreaux, B.4    Metayer, J.5    Frebourg, T.6
  • 24
    • 0035875049 scopus 로고    scopus 로고
    • Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies
    • D.J. Smiraglia, L.J. Rush, M.C. Fruhwald, Z. Dai, W.A. Held, and J.F. Costello Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies Hum Mol Genet 10 13 2001 1413 1419
    • (2001) Hum Mol Genet , vol.10 , Issue.13 , pp. 1413-1419
    • Smiraglia, D.J.1    Rush, L.J.2    Fruhwald, M.C.3    Dai, Z.4    Held, W.A.5    Costello, J.F.6
  • 25
    • 0033970457 scopus 로고    scopus 로고
    • Cutting edge: Polycomb gene expression patterns reflect distinct B cell differentiation stages in human germinal centers
    • F.M. Raaphorst, F.J. van Kemenade, E. Fieret, K.M. Hamer, D.P. Satijn, and A.P. Otte Cutting edge: polycomb gene expression patterns reflect distinct B cell differentiation stages in human germinal centers J Immunol 164 1 2000 1 4
    • (2000) J Immunol , vol.164 , Issue.1 , pp. 1-4
    • Raaphorst, F.M.1    Van Kemenade, F.J.2    Fieret, E.3    Hamer, K.M.4    Satijn, D.P.5    Otte, A.P.6
  • 26
    • 0035873747 scopus 로고    scopus 로고
    • Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation
    • F.M. Raaphorst, A.P. Otte, F.J. van Kemenade, T. Blokzijl, E. Fieret, and K.M. Hamer Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation J Immunol 166 10 2001 5925 5934
    • (2001) J Immunol , vol.166 , Issue.10 , pp. 5925-5934
    • Raaphorst, F.M.1    Otte, A.P.2    Van Kemenade, F.J.3    Blokzijl, T.4    Fieret, E.5    Hamer, K.M.6
  • 27
    • 0035655540 scopus 로고    scopus 로고
    • Polycomb-group genes as regulators of mammalian lymphopoiesis
    • F.M. Raaphorst, A.P. Otte, and C.J. Meijer Polycomb-group genes as regulators of mammalian lymphopoiesis Trends Immunol 22 12 2001 682 690
    • (2001) Trends Immunol , vol.22 , Issue.12 , pp. 682-690
    • Raaphorst, F.M.1    Otte, A.P.2    Meijer, C.J.3
  • 28
    • 0035866814 scopus 로고    scopus 로고
    • BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas
    • S. Bea, F. Tort, M. Pinyol, X. Puig, L. Hernandez, and S. Hernandez BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas Cancer Res 61 6 2001 2409 2412
    • (2001) Cancer Res , vol.61 , Issue.6 , pp. 2409-2412
    • Bea, S.1    Tort, F.2    Pinyol, M.3    Puig, X.4    Hernandez, L.5    Hernandez, S.6
  • 29
    • 0033569429 scopus 로고    scopus 로고
    • BMI-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
    • J.J. Jacobs, B. Scheijen, J.W. Voncken, K. Kieboom, A. Berns, and M. van Lohuizen BMI-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF Genes Dev 13 20 1999 2678 2690
    • (1999) Genes Dev , vol.13 , Issue.20 , pp. 2678-2690
    • Jacobs, J.J.1    Scheijen, B.2    Voncken, J.W.3    Kieboom, K.4    Berns, A.5    Van Lohuizen, M.6
  • 30
    • 0033569427 scopus 로고    scopus 로고
    • Functional antagonism of the polycomb-group genes eed and BMI-1 in hemopoietic cell proliferation
    • J. Lessard, A. Schumacher, U. Thorsteinsdottir, M. van Lohuizen, T. Magnuson, and G. Sauvageau Functional antagonism of the polycomb-group genes eed and BMI-1 in hemopoietic cell proliferation Genes Dev 13 20 1999 2691 2703
    • (1999) Genes Dev , vol.13 , Issue.20 , pp. 2691-2703
    • Lessard, J.1    Schumacher, A.2    Thorsteinsdottir, U.3    Van Lohuizen, M.4    Magnuson, T.5    Sauvageau, G.6
  • 31
    • 0030747208 scopus 로고    scopus 로고
    • Homeobox genes in embryogenesis and pathogenesis
    • M. Mark, F.M. Rijli, and P. Chambon Homeobox genes in embryogenesis and pathogenesis Pediatr Res 42 4 1997 421 429
    • (1997) Pediatr Res , vol.42 , Issue.4 , pp. 421-429
    • Mark, M.1    Rijli, F.M.2    Chambon, P.3
  • 32
    • 0035877978 scopus 로고    scopus 로고
    • Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma
    • F.J. van Kemenade, F.M. Raaphorst, T. Blokzijl, E. Fieret, K.M. Hamer, and D.P. Satijn Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma Blood 97 12 2001 3896 3901
    • (2001) Blood , vol.97 , Issue.12 , pp. 3896-3901
    • Van Kemenade, F.J.1    Raaphorst, F.M.2    Blokzijl, T.3    Fieret, E.4    Hamer, K.M.5    Satijn, D.P.6
  • 33
    • 0141515537 scopus 로고    scopus 로고
    • Evidence for at least three alternative mechanisms targeting the p16INK4A/cyclin D/Rb pathway in penile carcinoma, one of which is mediated by high-risk human papillomavirus
    • E. Ferreux, A.P. Lont, S. Horenblas, M.P. Gallee, F.M. Raaphorst, and D.M. von Knebel Evidence for at least three alternative mechanisms targeting the p16INK4A/cyclin D/Rb pathway in penile carcinoma, one of which is mediated by high-risk human papillomavirus J Pathol 201 1 2003 109 118
    • (2003) J Pathol , vol.201 , Issue.1 , pp. 109-118
    • Ferreux, E.1    Lont, A.P.2    Horenblas, S.3    Gallee, M.P.4    Raaphorst, F.M.5    Von Knebel, D.M.6
  • 34
    • 1242316271 scopus 로고    scopus 로고
    • Unique polycomb gene expression pattern in Hodgkin's lymphoma and Hodgkin's lymphoma derived cell lines
    • D.F. Dukers, J. van Galen, C. Giroth, P. Jansen, R.G. Sewalt, and A.P. Otte Unique polycomb gene expression pattern in Hodgkin's lymphoma and Hodgkin's lymphoma derived cell lines Am J Pathol 164 2004 873 881
    • (2004) Am J Pathol , vol.164 , pp. 873-881
    • Dukers, D.F.1    Van Galen, J.2    Giroth, C.3    Jansen, P.4    Sewalt, R.G.5    Otte, A.P.6


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