Incremental retinal-defocus theory of myopia development-Schematic analysis and computer simulation

Computers in Biology and Medicine

Volumn 37, Issue 7, 2007, Pages 930-946

  Hung, George K ^a   Ciuffreda, Kenneth J ^b  

^a RUTGERS UNIVERSITY   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Computer simulation; Constant light; IRDT model; Myopia; Nearwork induced transient myopia; Refraction; Retinal defocus; Under correction

Indexed keywords

COMPUTER SIMULATION; EYE MOVEMENTS; MATHEMATICAL MODELS; OPHTHALMOLOGY; REFRACTION; SCHEMATIC DIAGRAMS;

CONSTANT LIGHT; INCREMENTAL RETINAL DEFOCUS THEORY (IRDT) MODELS; NEARWORK INDUCED TRANSIENT MYOPIA; RETINAL DEFOCUS; UNDER CORRECTION;

MEDICAL COMPUTING;

PROTEOGLYCAN;

ARTICLE; CHROMATIN; COMPUTER SIMULATION; CORRELATION ANALYSIS; DARKNESS; DISEASE COURSE; EYE AXIS LENGTH; EYE DEVELOPMENT; EYE MOVEMENT; EYE REFRACTION; HUMAN; LENS; LIGHT EXPOSURE; MEDICAL LITERATURE; MYOPIA; NEUROMODULATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RETINA IMAGE; SCLERA; SIGNAL TRANSDUCTION; SPATIAL FREQUENCY DISCRIMINATION;

ANIMALS; BIOMEDICAL ENGINEERING; COMPUTER SIMULATION; EYE; FIXATION, OCULAR; HUMANS; MODELS, BIOLOGICAL; MYOPIA; RETINA;

EID: 34247278282     PISSN: 00104825     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.compbiomed.2006.10.004     Document Type: Article

References (119)

1. Goldschmidt E. On the etiology of myopia-an epidemiological study. Acta Ophthalmol. (Suppl.) (1968) 1-72
2. Sperduto R.D., Seigel D., Roberts J., and Rowland M. Prevalence of myopia in the United States. Arch. Ophthalmol. 101 (1983) 405-407
3. Lin L.L.K., Shih Y.F., Lee Y.C., Hung P.T., and Hou P.K. Changes in ocular refraction and its components among medical students-a 5-year longitudinal study. Optom. Vis. Sci. 73 (1996) 495-498
4. Javitt J.C., and Chiang Y.P. The socioeconomic aspects of laser refractive surgery. Arch. Ophthalmol. 112 (1994) 1526-1530
5. H.E. Mahlman, Handbook of Federal Vision Requirements and Information, Professional Press, Chicago, IL, 1982, pp. 8-18.
6. T. Grosvenor, D.A. Goss, Clinical Management of Myopia, Butterworth-Heinemann, Boston, MA, 1999, pp. 49-62.
7. Scammon R.E., and Armstrong E.L. On the growth of the human eyeball and optic nerve. J. Comp. Neurol. 38 (1925) 165-219
8. A.G. Bennett, R.B. Rabbetts, R.B., Clinical Visual Optics, Butterworth-Heinemann, Woburn, MA, 1989, p. 75.
9. Yackle K., and Fitzgerald D.E. Emmetropization: an overview. J. Behav. Optom. 10 (1999) 38-43
10. McBrien N.A., and Millodot M. The effect of refractive error on the accommodative response gradient. Ophthal. Physiol. Opt. 6 (1986) 145-149
11. E. Ong, K.J. Ciuffreda, Accommodation, Nearwork, Myopia, Optometric Extension Program Foundation, Inc., Santa Ana, CA, 1997, pp. 76-96, 177-201.
12. Wallman J. Can myopia be prevented?. 14th Biennial Research to Prevent Blindness Science Writers Seminar in Ophthalmology (1997), Research to Prevent Blindness, New York 50-52
13. Wallman J., and Winawer J. Homeostasis of eye growth and the question of myopia. Neuron 43 (2004) 447-468
14. Sorsby A., Sheridan M., and Leary G.A. Refraction and Its Components in Twins (1962), Her Majesty's Stationery Office, London
15. Goss D.A., and Erickson P. Meridional corneal components of myopia progression in young adults and children. Am. J. Optom. Physiol. Opt. 64 (1987) 475-481
16. Goss D.A., and Jackson T.W. Cross-sectional study of changes in the ocular components in school children. Appl. Opt. 32 (1993) 4169-4173
17. Fledelius H.C., and Stubgaard M. Changes in refraction and corneal curvature during growth and adult life. A cross-sectional study, Acta Ophthalmol. 64 (1986) 487-491
18. Smith E.L., and Hung L.F. Form deprivation myopia in monkeys is a graded phenomenon. Vis. Res. 40 (2000) 371-381
19. Tigges M., Tigges J., Fernendes A., Effers H.M., and Gammon J.A. Postnatal axial eye elongation in normal and visually deprived rhesus monkeys. Invest. Ophthal. Vis. Sci. 31 (1990) 1035-1046
20. Iuvone P.M., Tigges M., Stone R.A., Lambert A., and Laties A.M. Effect of apomorphine, a dopamine receptor agonist, on ocular refraction and axial elongation in primate model of myopia. Invest. Ophthal. Vis. Sci. 32 (1991) 1674-1677
21. D.J. O'Leary, K.M. Chung, N. Mohikin, Undercorrection causes more rapid progression of myopia in children, Am. Acad. Optom. (Abstract) (2000) p. 24.
22. Chung K., Mohidin N., and O'Leary D.J. Undercorrection of myopia enhances rather than inhibits myopia progression. Vis. Res. 42 (2002) 2555-2559
23. Goss D.A., and Wickham M.G. Retinal-image mediated ocular growth as a mechanism for juvenile onset myopia and for emmetropization. Doc. Ophthalmol. 90 (1995) 341-375
24. O'Leary D.J., Chung K.M., and Othman S. Contrast reduction without myopia induction in monkey. Invest. Ophthal. Vis. Sci. 33 (1992) S712
25. Bradley D.V., Fernandes A., Tigges M., and Boothe R.G. Diffuser contact lenses retard axial elongation in infant rhesus monkeys. Vis. Res. 36 (1996) 509-514
26. Wilson J.R., Fernandes A., Chankler C.V., Tigges M., Boothe R.G., Gammon J.A., and 1987. Abnormal development of the axial length of aphakic monkey eyes. Invest. Ophthal. Vis. Sci. 28 (1987) 2096-2099
27. Lauber J.K., Schutze J.V., and McGinnis J. Effect of exposure to continuous light on the eye of the growing chick. Proc. Soc. Exptal. Biol. Med. 106 (1961) 871-872
28. Kinnear A., and Lauber J.K. TAS Boyd. Genesis of light-induced avian glaucoma. Invest. Ophthal. Vis. Sci. 13 (1974) 872-875
29. Li T., Troilo D., Glasser A., and Howland H. Constant light produces severe corneal flattening and hyperopia in chickens. Vis. Res. 35 (1995) 1203-1209
30. Li T., and Howland H. Modulation of constant light effects on the eye by ciliary ganglionectomy and optic nerve section. Vis. Res. 40 (2000) 2249-2256
31. Schaeffel F., Troilo D., Wallman J., and Howland H.C. Developing eyes that lack accommodation grow to compensate for imposed defocus. Vis. Neurosci. 4 (1990) 177-183
32. Norton T.T. Animal models of myopia: learning how vision controls the size of the eye. Inst. Lab. Animal Res. J. 40 (1999) 59-77
33. Siegwart Jr. J.T., and Norton T.T. Regulation of the mechanical properties of tree shrew sclera by the visual environment. Vis. Res. 39 (1999) 387-407
34. Smith E.L., and Hung L.F. The role of optical defocus in regulating refractive development in infant monkeys. Vis. Res. 39 (1999) 1415-1435
35. Troilo D., Gottlieb M.D., and Wallman J. Visual deprivation causes myopia in chicks with optic nerve section. Curr. Eye Res. 6 (1987) 993-999
36. Wildsoet C.F., and Pettigrew J.D. Experimental myopia and anomalous eye growth patterns unaffected by optic nerve section in chickens: evidence for local control of eye growth. Clin. Vis. Sci. 3 (1988) 99-107
37. D. Troilo, The visual control of eye growth in chicks, Ph.D. Dissertation, Faculty of Biology, City University of New York, New York, NY, 1989.
38. L. Stark, Neurological Control Systems, Studies in Bioengineering, Plenum Press, New York, 1968, pp. 205-219.
39. K.J. Ciuffreda, Accommodation and its anomalies, in W.N. Charman (Ed.), Vision and Visual Dysfunction: Visual Optics and Instrumentation, vol. 1, Macmillan, London, 1991, pp. 231-279.
40. K.J. Ciuffreda, Accommodation, pupil, and presbyopia, in: W.J. Benjamin (Ed.), Borish's Clinical Refraction, W. B. Saunders Co., Philadelphia, PA, 1998, pp. 77-120.
41. Diether S., Gekeler F., and Schaeffel F. Changes in contrast sensitivity induced by defocus and their possible relations to emmetropization in the chicken. Invest. Ophthal. Vis. Sci. 42 (2001) 3072-3079
42. Baccus S.A., and Meister M. Fast and slow contrast adaptation in retinal circuitry. Neuron 36 (2002) 909-919
43. Heinrich T.S., and Bach M. Contrast adaptation in retinal and cortical evoked potentials: no adaptation to low spatial frequencies. Vis. Neurosci. 19 (2002) 645-650
44. Troilo D., Nickla D.L., and Wildsoet C.F. Choroidal thickness changes during altered eye growth and refractive state in a primate. Invest. Ophthal. Vis. Sci. 41 (2000) 1249-1258
45. Hung L.F., Wallman J., and Smith E.L. Vision-dependent changes in the choroidal thickness of macaque monkeys. Invest. Ophthal. Vis. Sci. 41 (2000) 1259-1269
46. Crewther D.P. The role of photoreceptors in the control of refractive state. Prog. Retinal Eye Res. 19 (2000) 421-457
47. Kolb H. How the retina works. Am. Sci. 91 (2003) 28-35
48. Bjelke B., et al. Dopaminergic transmission in the rat retina: evidence for volume transmission. Chem. Neuroanat. 12 (1996) 37-50
49. McFadden S.A., Howlett M.H., and Mertz J.R. Retinoic acid signals the direction of ocular elongation in the guinea pig eye. Vis. Res. 44 (2004) 643-653
50. Wildsoet C.F., and Wallman J. Choroidal and scleral mechanisms of compensation for spectacle lenses in chicks. Vis. Res. 35 (1995) 1175-1194
51. Hung G.K., and Ciuffreda K.J. Model of refractive error development. Curr. Eye Res. 19 (1999) 41-52
52. Hung G.K., and Ciuffreda K.J. Differential retinal-defocus magnitude during eye growth provides the appropriate direction signal. Med. Sci. Monitor. 6 (2000) 791-795
53. Hung G.K., and Ciuffreda K.J. Quantitative analysis of the effect of near lens addition on accommodation and myopigenesis. Curr. Eye Res. 20 (2000) 293-312
54. Hung G.K., and Ciuffreda K.J. A unifying theory of refractive error development. Bull. Math. Biol. 62 (2000) 1087-1108
55. Hung G.K., and Ciuffreda K.J. Models of refractive error development. In: Hung G.K., and Ciuffreda K.J. (Eds). Models of the Visual System (2002), Kluwer Academic/Plenum Publishers, Dordrecht, New York 643-677
56. Hung G.K., and Ciuffreda K.J. An incremental retinal-defocus theory of the development of myopia. Comments Theor. Biol. 8 (2003) 511-538
57. Hung G.K., and Ciuffreda K.J. Incremental retinal-defocus theory predicts experimental effect of under-correction on myopic progression. J. Behav. Optom. 15 (2004) 59-63
58. Hung G.K., and Ciuffreda K.J. Incremental retinal-defocus theory predicts experimental effect of constant light on myopic progression. J. Behav. Optom. 16 (2005) 31-36
59. Goss D.A., and Winkler R.L. Progression of myopia in youth: age of cessation. Am. J. Optom. Physiol. Opt. 60 (1983) 651-658
60. Adams D.W., and McBrien N.A. Prevalence of myopia and myopic progression in a population of clinical microscopists. Optom. Vis. Sci. 69 (1992) 467-473
61. Sorsby A., Sheridan M., and Leary G.A. Refraction and Its Components during the Growth of the Eye from Age Three (1961), Her Majesty's Stationary Office, London
62. Weiss L. Ueber das Wachstum des menschlichen Auges und über die Veranderung der Muskelinsertionen am wachsenden Auge. Arb. Anat. Inst. Wiesbaden 8 (1897) 191
63. Werblin F. Control of sensitivity of the retina. Sci. Am. 228 (1973) 71-79
64. Wildsoet C.F. Structural correlates of myopia. In: Rosenfield M., and Gilmartin B. (Eds). Myopia and Nearwork (1998), Butterworth-Heinemann, Oxford 32-51
65. Goettlieb M.D., Joshi H.B., and Nikla D.L. Scleral changes in chicks with form-deprivation myopia. Curr. Eye Res. 9 (1990) 1157-1165
66. Marzani D., and Wallman J. Growth of the two layers of the chick sclera is modulated reciprocally by visual conditions. Invest. Ophthal. Vis. Sci. 38 (1997) 1726-1739
67. Thibos L.N., Hong X., Bradley A., and Cheng X. Statistical variation of aberration structure and image quality in a normal population of healthy eyes. J. Opt. Soc. Am. A 12 (2002) 2329-2348
68. R.C. Gonzalez, P. Wintz, Digital Image Processing, second ed., Addison-Wesley, Reading, MA, 1987, pp. 81-90.
69. Schmid K.L., and Wildsoet C.F. Contrast and spatial-frequency requirements for emmetropization in chicks. Vis. Res. 37 (1997) 2011-2021
70. Diether S., and Schaeffel R. Long-term changes in retinal contrast sensitivity in chicks from frosted occluders and drugs: relations to myopia?. Vis. Res. 39 (1999) 2499-2510
71. Ciuffreda K.C. The Glenn A. Fry invited lecture. Accommodation to gratings and more naturalistic stimuli. Optom. Vis. Sci. 68 (1990) 243-260
72. Zhu X.-Y., Winawer J., and Wallman J. Potency of myopic defocus in spectacle lens compensation. Invest. Ophthal. Vis. Sci. 44 (2003) 2818-2827
73. Zhu X.-Y., Park T.W., Winawer J., and Wallman J. In a matter of minutes, the eye can know which way to grow. Invest. Ophthal. Vis. Sci. 46 (2005) 2238-2241
74. Smith E.L., Hung L.-F., Kee C.S., and Qiao Y. Effect of brief periods of unrestricted vision on the development of form-deprivation myopia in monkeys. Invest. Ophthal. Vis. Sci. 43 (2002) 291-299
75. Dowling J.E. Retinal processing of vision. In: Greger R., and Windhorst U. (Eds). Comprehensive Human Physiology vol. 1 (1996), Springer, Berlin 773-778
76. Stone R.A., Lin T., and Laties A.M. Retinal dopamine and form-deprivation myopia. Proc. Natl. Acad. Sci. 86 (1989) 704-706
77. Windhorst U. Specific networks of the cerebral cortex: functional organization and plasticity. In: Greger R., and Windhorst U. (Eds). Comprehensive Human Physiology: From Cellular Mechanisms to Integration vol. 1 (1996), Springer, Berlin 1105-1136
78. Schmid K.L., Strang N.C., and Wildsoet C.F. Imposed retinal image size changes, do they provide a cue to the sign of lens-induced defocus in chick?. Optom. Vis. Sci. 76 (1999) 320-325
79. Gilmartin B., Bullimore M.A., Rosenfield M., Winn B., and Owens H. Pharmacological effects on accommodative adaptation. Optom. Vis. Sci. 69 (1992) 276-282
80. Webster M.A., Georgeson M.A., and Webster S.M. Neural adjustment to image blur. Nat. Neurosci. 5 (2002) 839-840
81. J. Rada, Choroidal regulation of scleral extracellular matrix remodelling, Assoc. Res. Vis. Ophthal. Ann. Conf. (2006) 4.
82. Norton T.T., and Rada J.A. Reduced extracellular matrix in mammalian sclera with induced myopia. Vis. Res. 35 (1995) 1271-1281
83. Jiang B.C., and Woessner W.M. Increase in axial length is responsible for late-onset myopia. Optom. Vis. Sci. 73 (1996) 231-234
84. Heath G.G. The influence of visual acuity on accommodative responses of the eye. Am. J. Optom. Arch. Am. Acad. Optom. 33 (1956) 513-524
85. Morgan M.J. Accommodation and its relation to convergence. Am. J. Optom. Arch. Am. Acad. Optom. 21 (1944) 183-195
86. Charman W.N., and Tucker J. Accommodation as a function of object form. Am. J. Optom. Physiol. Opt. 55 (1978) 84-92
87. Hung G.K., and Semmlow J.L. Static behavior of accommodation and vergence: computer simulation of an interactive dual-feedback system. IEEE. Trans. Biomed. Eng. 27 (1980) 439-447
88. Ciuffreda K.J., and Kenyon R.V. Accommodative vergence and accommodation in normals, amblyopes, and strabismics. In: Schor M.C., and Ciuffreda K.J. (Eds). Vergence Eye Movements: Basic and Clinical Aspects (1983), Butterworths, Boston, MA 101-173
89. Miege C., and Denieul P. Mean response and oscillations of accommodation for various stimulus vergences in relation to accommodation feedback control. Ophthal. Physiol. Opt. 8 (1988) 165-171
90. Ciuffreda K.J., Hokoda S.C., Hung G.K., Semmlow J.L., and Selenow A. Accommodative stimulus/response function in human amblyopia. Doc. Ophthalmol. 56 (1984) 303-326
91. Hung G.K. Sensitivity analysis of the stimulus-response function of a static nonlinear accommodation model. IEEE Trans. Biomed. Eng. 45 (1998) 335-341
92. Gwiazda J., Hyman L., Hussein M., Everett D., Norton T.T., Kurtz D., Leske M.C., Manny R., Marsh-Tootle W., and Scheiman M. the COMET Group, A randomized clinical trial of progressive addition lenses versus single vision lenses on the progression of myopia in children. Invest. Ophthalmol. Vis. Sci. 44 (2003) 1492-1500
93. Gwiazda J., Hyman L., Norton T.T., Hussein M.E.M., Marsh-Tootle W., Manny R., Wang Y., and Everett D. the COMET Group, Accommodation and related risk factors associated with myopia progression and their interaction with treatment in COMET children. Invest. Ophthal. Vis. Sci. 45 (2004) 2143-2151
94. B.-C. Jiang, Changes in vergence responses when viewing through near addition lenses is related to the subject's AC/A, Ann. Conf. Assoc. Res. Vis. Ophthal. (2006) 3674.
95. Zadnik K., Jones L.A., Irvin B.C., Kleinstein R.N., Manny R.E., Shin J.A., and Mutti D.O. Myopia and ambient night-time lighting. Nature 404 (2000) 143-144
96. Yinon U., and Koslowe K.C. Eyelid closure effects on the refractive error of the eye in dark and in light reared kittens. Am. J. Optom. Physiol. Opt. 61 (1984) 271-273
97. Gottlieb M.D., Fugate-Wentzek L.A., and Wallman J. Different visual deprivations produce different ametropias and different eye shapes. Invest. Ophthal. Vis. Sci. 28 (1987) 1225-1235
98. Rehurek J., Spicarova R., and Vancurova J. Normal values of intraocular pressure in children. Cesk. Slov. Oftalmol. 56 (2000) 361-365
99. Grosvenor T., and Goss D.A. Role of the cornea in emmetropia and myopia. Optom. Vis. Sci. 75 (1998) 132-145
100. Gloster J., Perkins E.S., and Pommier M.-L. Extensibility of strips of sclera and cornea. Brit. J. Ophthal. 41 (1957) 103-110
101. R.A. Moses (Ed.), Adler's Physiology of the Eye, Clinical Applications, seventh ed., C. V. Mosby and Co., 1981, p. 241.
102. Hung G.K., and Stark L. Dynamics of the human eyeblink. Am. J. Optom. Physiol. Opt. 54 (1977) 678-690
103. Yinon U., Rose L., and Shapiro A. Myopia in the eye of developing chicks following monocular and binocular lid closure. Vis. Res. 20 (1980) 137-141
104. Ong E., and Ciuffreda K.J. Nearwork-induced transient myopia-a critical review. Doc. Ophthalmol. 91 (1995) 57-85
105. Ong E., Ciuffreda K.J., and Tannen B. Static accommodation in congenital nystagmus. Invest. Ophthal. Vis. Sci. 34 (1993) 194-204
106. Wolffsohn J.S., Gilmartin B., Li R.W.H., Edwards M.H., Chat S.W.-S., Lew J.K.-F., and Yu B.S.-Y. Near work-induced transient myopia in preadolescent Hong Kong Chinese. Invest. Ophthal. Vis. Sci. 44 (2003) 2284-2289
107. Ciuffreda K.J., and Wallis D.M. Myopes show increased susceptibility to nearwork aftereffects. Invest. Ophthal. Vis. Sci. 39 (1998) 1797-1803
108. Ciuffreda K.J., and Ordoñez X. Abnormal transient myopia in symptomatic individuals after sustained nearwork. Optom. Vis. Sci. 72 (1995) 506-610
109. Ciuffreda K.J., and Ordo nez X. Vision therapy to reduce abnormal nearwork-induced transient myopia. Opt. Vis. Sci. 75 (1998) 311-315
110. Ciuffreda K.J., and Thunyalukull V. Myopic nearwork aftereffects in children. Invest. Ophthal. Vis. Sci. 40 (1999) S448
111. Gilmartin B., Mallen E.A.H., and Wolffsohn J.S. Sympathetic control of accommodation: evidence for inter-subject variation. Ophthal. Physiol. Opt. 22 (2002) 366-371
112. Wolffsohn J.S., Gilmartin B., Thomas R., and Mallen E.A.H. Refractive error, cognitive demand and nearwork-induced transient myopia. Curr. Eye Res. 27 (2003) 363-370
113. Hung G.K., and Ciuffreda K.J. Adaptation model of nearwork-induced transient myopia. Physiol. Opt. 19 (1999) 151-158
114. Ciuffreda K.J., and Lee M. Differential refractive susceptibility to sustained nearwork. Ophthal. Physiol. Opt. 22 (2002) 372-379
115. Rosenfield M., Ciuffreda K.J., Novogrodsky L., Yu A., and Gillard M. Sustained near-vision does indeed induce myopia!. Invest. Ophthal. Vis. Sci. 33 (1992) S710
116. Normann R.A., and Guillory K.S. Anatomy and physiology of the retina. In: Hung G.K., and Ciuffreda K.J. (Eds). Models of the Visual System (2002), Kluwer Academic/Plenum Publishers, New York, NY 109-145
117. Rada J.A., McFarland A.L., Cornuet P.K., and Hassell J.R. Proteoglycan synthesis by scleral chondrocytes is modulated by a vision dependent mechanism. Curr. Eye Res. 11 (1992) 767-782
118. McBrien N.A., Gentle A., and Cottriall C. Optical correction of induced axial myopia in the tree shrew: implications for emmetropization. Optom. Vis. Sci. 76 (1999) 419-427
119. Troilo D., Nickla D.L., and Wildsoet C.F. Form deprivation myopia in mature common Marmoset (Callitbrix jaccbus). Invest. Ophthal. Vis. Sci. 41 (2000) 2043-2049