Tryptase- and leptin-positive mast cells correlate with vascular density in uterine leiomyomas

American Journal of Obstetrics and Gynecology

Volumn 196, Issue 5, 2007, Pages 470.e1-470.e7

  Ribatti, Domenico ^a   Belloni, Anna S ^b   Nico, Beatrice ^a   Salà, Giorgia ^b   Longo, Vito ^a   Mangieri, Domenica ^a   Crivellato, Enrico ^c   Nussdorfer, Gastone G ^b  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^b UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^c UNIVERSITY OF UDINE   (Italy)

Author keywords

angiogenesis; leptin; leyomiomas; mast cells; tryptase

Indexed keywords

CD31 ANTIGEN; LEPTIN; MONOCLONAL ANTIBODY; TRYPTASE;

ANGIOGENESIS; ARTICLE; CELL DENSITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MAST CELL; MICROVASCULATURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECRETORY GRANULE; UTERUS MYOMA;

EID: 34247220976     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2006.12.039     Document Type: Article

References (48)

1. Stewart E.A. Uterine fibroids. Lancet 357 (2001) 293-298
2. Reynolds L.P., Killilea S.D., and Redmer D.A. Angiogenesis in the female reproductive system. FASEB J 6 (1992) 886-892
3. Kurjak A., Salihagic A., Kupesic-Urek S., and Predanic A. Clinical value of the assessment of gynaecological tumour angiogenesis by transvaginal colour doppler. Ann Intern Med 24 (1992) 97-103
4. Stafl A., and Mattingly R.F. Angiogenesis of cervical neoplasia. Am J Obstet Gynecol 121 (1975) 845-852
5. Sillman F., Boyce J., and Fruchter R. The significance of atypical vessels and neovascularization in cervical neoplasia. Am J Obstet Gynecol 139 (1981) 154-159
6. Wells M., et al. Female genital tract. In: Underwood J.C. (Ed). General and systemic pathology (1996), Churchill Livingstone, Edinburgh 551-584
7. Hague S., Zhang L., Oehler M.K., Manek S., Mackenzie I.Z., Bicknell R., et al. Expression of hypoxically regulated angiogenic factor adrenomedullin correlates with uterine leiomyoma vascular density. Clin Cancer Res 6 (2000) 2808-2814
8. Andersen J. Growth factors and cytokines in uterine leiomyomas. Semin Reprod Endocrinol 14 (1996) 268-282
9. Senturk L.M., Sozen J., Gutierrez L., and Arici A. Interleukin-8 production and intereleukin-8 receptor expression in human myometrium and leiomyomas. Am J Obstet Gynecol 184 (2001) 559-566
10. Walocha J.A., Litwin J.A., and Miodonski J. Vascular system of intratumoral leiomyomata revealed by corrosion casting and scanning electron microscopy. Hum Reprod 18 (2003) 1088-1093
11. Folkman J. What is the evidence that tumors are angiogenesis dependent?. J Natl Cancer Inst 82 (1990) 4-6
12. Ribatti D., Vacca A., and Dammacco F. The role of the vascular phase in solid tumor growth: a historical review. Neoplasia 1 (1999) 293-302
13. Park C.C., Bissell M.J., and Barcellos-Hoff M.H. The influence of the microenvironment on the malignant phenotype. Mol Medicine Today 6 (2000) 324-329
14. Ribatti D., Crivellato E., Roccaro A.M., Ria R., and Vacca A. Mast cell contribution to angiogenesis related to tumor progression. Clin Exp Allergy 34 (2004) 1660-1664
15. Irani A.M.A., Bradford T.R., Kepley C.L., Schechter N.M., and Schwartz L.B. Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monclonal antitryptase and antichymase antibodies. J Histochem Cytochem 37 (1989) 1509-1515
16. Blair R.J., Meng H., Marchese M.J., Ren S., Schwartz L.B., Tonnesen M.G., et al. Human mast cells stimulate vascular tube formation. Tryptase is a novel, potent angiogenic factor. J Clin Invest 99 (1997) 2691-2700
17. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432
18. Ahima R.S., and Flier J.S. Leptin. Ann Rev Physiol 62 (2000) 417-437
19. Sierra-Honigmann M.R., Nath A.K., Murakami C., Garcia-Cardena G., Papapetropoulos A., Sessa W.C., et al. Biological action of leptin as an angiogenic factor. Science 281 (1998) 1683-1686
20. Ribatti D., Nico B., Belloni A.S., Vacca A., Roncali L., and Nussdorfer G.G. Angiogenic activity of leptin in the chick embryo chorioallantoic membrane is in part mediated by endogenous fibroblast growth factor-2. Int J Mol Med 8 (2001) 265-268
21. Vacca A., Ribatti D., Roncali L., Lospalluti M., Serio G., Carrel S., et al. Melanocyte tumour progression is associated with changes in angiogenesis and expression of the 67-kilodalton laminin receptor. Cancer 72 (1993) 455-461
22. Ribatti D., Nico B., Vacca A., Marzullo A., Calvi N., Roncali L., et al. Do mast cells help to induce angiogenesis in B-cell non-Hodgkin's lymphomas?. Br J Cancer 77 (1998) 1900-1906
23. Harrison-Woolrych M.L., Charnock-Jones D.S., and Smith S.K. Quantification of messanger ribonucleic acid for epidermal growth factor in human myometrium and leiomyomata. J Clin Endocrinol Metab 78 (1994) 1179-1184
24. Harrison-Woolrych M.L., Sharkey A.M., Charnock-Jones D.S., and Smith S.K. Localization and quantifaction of vascular endothelial growth factor messanger ribonucleic acid in human myometrium and leiomyomata. J Clin Endocrinol Metab 80 (1995) 1853-1858
25. Mangrulkar R.S., Ono M., Ishikawa M., Takashima S., Klabrun M., and Nowark R.A. Isolation and characterization of heparin-binding growth factors in human leiomyomas and normal myometrium. Biol Repr 53 (1995) 636-646
26. Vollenhoven B.J., Pearce P., Herington A.C., and Healy D.L. Messenger ribonucleic acid expression of the insuline-like growth factors and their binding protein in uterine fibroids and myometrium. J Clin Endocrinol Metab 76 (1993) 1106-1110
27. Arici A., and Sozen I. Transforming growth factor-beta3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation. Fertil Steril 73 (1995) 1106-1110
28. Hong T., Shimada Y., Uchida S., Itami A., Li Z., Ding Y., et al. Expression of angiogenic factors and apoptotic factors in leiomyosarcoma and leiomyoma. Int J Mol Med 8 (2001) 141-148
29. Crow J., Wilkins M., Howe S., More L., and Helliwell P. Mast cells in the female genital tract. Int J Gynecol Pathol 10 (1991) 230-237
30. Mori A., Zhai Y.L., Toki T., Nikaido T., and Fuji S. Distribution and heterogeneity of mast cells in the human uterus. Human Reprod 12 (1997) 368-372
31. Maluf H.M., and Gersell D.J. Uterine leiomyomas with high content of mast cells. Arch Pathol Lab Med 118 (1994) 712-714
32. Orii A., Mori A., Zhai Y.L., Toki T., Nikaido T., and Fujii S. Mast cells in smooth muscle tumors of the uterus. Int J Gynecol Pathol 17 (1998) 336-342
33. McKay D.G. Metachromasia in the endometrium. Am J Obstet Gynecol 59 (1950) 875-882
34. Gupta R.K., and Schueller E.S. Acid mucopolysaccharide and mast cells variations in human endometrium and some uterine tumors. Obstet Gynecol 30 (1976) 510-517
35. Drudy L., Sheppard D.B.L., and Bonnar J. Mast cells in the normal uterus and dysfunctional uterine bleeding. Eur J Obstet Gynecol Reprod Biol 39 (1991) 193-201
36. Starkey J.R., Crowle P.K., and Taubenberger S. Mast cell-deficiency W/Wv mice exhibit a decreased rate of tumor angiogenesis. Int J Cancer 42 (1998) 48-52
37. Norrby K. Oral administration of a nitric oxide synthase inhibitor enhances de novo mammalian angiogenesis mediated by TNF-alpha, saline and mast cell secretion. APMIS 108 (2000) 496-502
38. Grutzkau A., Kruger-Krasagakes S., Kogel H., Moller A., Lippert U., and Henz B.M. Detection of intracellular interleukin-8 in human mast cells: flow cytometry as a guide for immunoelectron microscopy. J Histochem Cytochem 45 (1997) 935-945
39. Qu Z., Liebler J.M., Powers M.R., Galey T., Ahmadi P., Huang X.N., et al. Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma. Am J Pathol 147 (1995) 564-573
40. Grutzkau A., Kruger-Krasagakes S., Baumeister H., Schwarz C., Kogel H., Welker P., et al. Synthesis, storage, and release of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) by human mast cells: implications for the biological significance of VEGF 206. Mol Biol Cell 9 (1998) 875-884
41. Ribatti D., Vacca A., Nico B., Quondamatteo F., Ria R., Minischetti M., et al. Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma. Brit J Cancer 79 (1999) 451-455
42. Ribatti D., Vacca A., Marzullo A., Nico B., Ria R., Roncali L., et al. Angiogenesis and mast cell density with tryptase activity increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas. Int J Cancer 85 (2000) 171-175
43. Ribatti D., Polimeno G., Vacca A., Marzullo A., Crivellato E., Nico B., et al. Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes. Leukemia 16 (2002) 1680-1684
44. Ribatti D., Molica S., Vacca A., Nico B., Crivellato E., Roccaro A.M., et al. Tryptase-positive mast cells correlate positively with bone marrow angiogenesis in B-cell chronic lymphocytic leukemia. Leukemia 17 (2003) 1428-1430
45. Ribatti D., Vacca A., Ria R., Marzullo A., Nico B., Filotico R., et al. Neovascularization, expression of fibroblast growth factor-2, and mast cells with tryptase activity increase simultaneously with pathological progression in human malignant melanoma. Eur J Cancer 39 (2003) 666-674
46. Ribatti D., Finato N., Crivellato E., Marzullo A., Mangieri D., Nico B., et al. Neovascularization and mast cells with tryptase activity increase simultaneously with pathologic progression in human endometrial cancer. Am J Obstet Gynecol 193 (2005) 1961-1965
47. Ribatti D., Ennas M.G., Vacca A., Ferreli F., Nico B., Orru S., et al. Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma. Eur J Clin Invest 33 (2003) 420-425
48. Markowska A., Belloni A.S., Rucinski M., Parenti A.R., Nardelli G.B., Drews K., et al. Leptin and leptin receptor expression in the myometrium and uterine myomas: is leptic involved in tumor development?. Int J Oncol 27 (2005) 1505-1509