Pretreatment with recombinant human vascular endothelial growth factor reduces virus replication and inflammation in a perinatal lamb model of respiratory syncytial virus infection

Viral Immunology

Volumn 20, Issue 1, 2007, Pages 188-196

  Meyerholz, David K ^a   Gallup, Jack M ^a   Lazic, Tatjana ^a   De Macedo, Marcia M A ^a   Lehmkuhl, Howard D ^b   Ackermann, Mark R ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b NATIONAL ANIMAL DISEASE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN; BETAMETHASONE; CEFTIOFUR; MESSENGER RNA; RECOMBINANT VASCULOTROPIN; SHEEP BETA DEFENSIN 1; SODIUM CHLORIDE; SURFACTANT PROTEIN A; SURFACTANT PROTEIN D; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; EXUDATE; FEVER; INNATE IMMUNITY; LAMB; NEUTROPHIL; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; VIRUS INFECTION; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANIMALS, NEWBORN; BETA-DEFENSINS; DISEASE MODELS, ANIMAL; IMMUNITY, NATURAL; PULMONARY SURFACTANT-ASSOCIATED PROTEIN D; RECOMBINANT PROTEINS; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RNA, MESSENGER; SHEEP; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VIRUS REPLICATION;

BOVINE RESPIRATORY SYNCYTIAL VIRUS; OVIS ARIES; RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

EID: 34247184226     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.2006.0089     Document Type: Article

References (43)

1. Ackermann MR, Gallup JM, Zabner J, et al.: Differential expression of sheep β-defensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumonia. Microb Pathog 2004;37:21-27.
2. Alix C, Martin JP, and Braunwald J: Temperature sensitivity of two different steps in the viral life cycle of feline immunodeficiency virus. Virology 1999;253:309-318.
3. Barleon B, Sozzani S, Zhou D, et al.: Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor Flt-1. Blood 1996;87:3336-3343.
4. Bataki EL, Evans GS, and Everard ML: Respiratory syncytial virus and neutrophil activation. Clin Exp Immunol 2005;140:470-477.
5. Bolt RJ, van Weissenbach MM, Lafeber HN, and Delemarre-van de Waal HA: Glucocorticoids and lung development in the fetus and preterm infant. Pediatr Pulmonol 2001;32:76-91.
6. Brown KR, England KM, Goss KL, et al.: VEGF induces airway epithelial cell proliferation in human fetal lung in vitro. Am J Physiol Lung Cell Mol Physiol 2001;281:L1001-L1010.
7. Wright PF, Karron RA, Belshe RB, et al.: Evaluation of a live, cold-passaged, temperature-sensitive, respiratory syncytial virus vaccine candidate in infancy. J Infect Dis 2000;182:1331-1342.
8. Compernolle V, Brusselmans K, Acker T, et al.: Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 2002;8:702-710.
9. Conejo-Garcia JR, Benencia F, Courreges MC, et al.: Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A. Nat Med 2004;10:950-958.
10. Conti B, Tabarean I, Andrei C, and Bartfai T: Cytokines and fever. Front Biosci 2004;9:1433-1449.
11. Dvorak HF: How tumors make bad blood vessels and stroma. Am J Pathol 2003;162:1747-1757.
12. Ferrara N, Gerber HP, and LeCouter J: The biology of VEGF and its receptors. Nat Med 2003;9:669-676.
13. Gabrilovich D, Ishida T, Oyama T, Ran S, Kravtsov V, Nadaf S, and Carbone DP: Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 1998;92:4150-4166.
14. Gallup JM, Kawashima K, Lucero G, and Ackermann MR: New quick method for isolating RNA from laser captured cells stained by immunofluorescent immunohistochemistry; RNA suitable for direct use in fluorogenic TaqMan one-step real-time RT-PCR. Biol Proced Online 2005;7:70-92.
15. Griese M: Respiratory syncytial virus and pulmonary surfactant. Viral Immunol 2002;15:357-363.
16. Grubor B, Gallup JM, Meyerholz DK, et al.: Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs. Clin Diagn Lab Immunol 2004;11:599-607.
17. Grubor B, Meyerholz DK, and Ackermann MR: Collectins and cationic antimicrobial peptides of the respiratory epithelia. Vet Pathol 2006;43:595-612.
18. Hall CB: Respiratory syncytial virus and parainfluenza virus. N Engl J Med 2001;344:1917-1928.
19. Kato N: Pyrogenicity of human adenoviruses. J Gen Virol 2000;81:2611-2616.
20. Kawashima K, Meyerholz DK, Gallup JM, et al.: Differential expression of ovine innate immune genes by preterm and neonatal lung epithelia infected with respiratory syncytial virus. Viral Immunol 2006;19:316-323.
21. Kutschera J, Tomaselli J, Maurer U, et al.: Minor neurological dysfunction, cognitive development, and somatic development at the age of 3 to 7 years after dexamethasone treatment in very-low birth-weight infants. Early Hum Dev 2005;81:281-287.
22. Le Cras TD, Spitzmiller RE, Albertine KH, et al.: VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice. Am J Physiol Lung Cell Mol Physiol 2004;287:L134-L142.
23. Lehmkuhl HD, and Cutlip RC: Experimentally induced respiratory syncytial viral infection in lambs. Am J Vet Res 1979;40:512-544.
24. McNamara PS, and Smyth RL: The pathogenesis of respiratory syncytial virus disease in childhood. Br Med Bull 2002;61:13-28.
25. Meyerholz DK, Grubor B, Fach SJ, et al.: Reduced clearance of respiratory syncytial virus infection in a preterm lamb model. Microbes Infect 2004;6:1312-1319.
26. Meyerholz DK, Grubor B, Gallup JM, et al.: Adenovirus-mediated gene therapy enhances parainfluenza virus 3 infection in neonatal lambs. J Clin Microbiol 2004;42:4780-4787.
27. Meyerholz DK, Grubor B, Lazic T, et al.: Monocytic/macrophagic pneumonitis following intrabronchial deposition of vascular endothelial growth factor in neonatal lambs. Vet Pathol 2006;43:689-694.
28. Neuzil KM, Tang YW, and Graham BS: Protective role of TNF-α in respiratory syncytial virus infection in vitro and in vivo. Am J Med Sci 1996;311:201-204.
29. Panitch HB: Bronchiolitis in infants. Curr Opin Pediatr 2001;13:256-260.
30. Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:2002-2007.
31. Platzker AC, Kitterman JA, Mescher EJ, et al.: Surfactant in the lung and tracheal fluid of the fetal lamb and acceleration of its appearance by dexamethasone. Pediatrics 1975;56:554-561.
32. Resch B, Pasnocht A, Gusenleitner W, and Muller W: Rehospitalisations for respiratory disease and respiratory syncytial virus infection in preterm infants of 29-36 weeks gestational age. J Infect 2005;50:397-403.
33. Rodriguez RJ: Management of respiratory distress syndrome: An update. Respir Care 2003;48:279-286.
34. Sakaguchi A, Hirayama E, Hiraki A, et al.: Nuclear export of influenza viral ribonucleoprotein is temperature-dependently inhibited by dissociation of viral matrix protein. Virology 2003;306:244-253.
35. Shay DK, Holman RC, Newman RD, et al.: Bronchiolitis-associated hospitalizations among US children, 1980-1996. J Am Med Assoc 1999;282:1440-1446.
36. Shay DK, Holman RC, Roosevelt GE, et al.: Bronchiolitis-associated mortality and estimates of respiratory syncytial virus-associated deaths among US children, 1979-1997. J Infect Dis 2001;183:16-22.
37. Smith PK, Wang SZ, Dowling KD, and Forsyth KD: Leucocyte populations in respiratory syncytial virus-induced bronchiolitis. J Paediatr Child Health 2001;37:146-151.
38. Soukup JM, and Becker S: Role of monocytes and eosinophils in human respiratory syncytial virus infection in vitro. Clin Immunol 2003;107:178-185.
39. Tan RC, Ikegami M, Jobe AH, et al.: Developmental and glucocorticoid regulation of surfactant protein mRNAs in preterm lambs. Am J Physiol 1999;277:L1142-L1148.
40. Tripp RA: Pathogenesis of respiratory syncytial virus infection. Viral Immunol 2004;17:165-181.
41. Viuff, Tjornehoj BK, Larsen LE, et al.: Replication and clearance of respiratory syncytial virus: apoptosis is an important pathway of virus clearance after experimental infection with bovine respiratory syncytial virus. Am J Pathol 2002;161:2195-2207.
42. Wang SZ, Xu H, Wraith A, et al.: Neutrophils induce damage to respiratory epithelial cells infected with respiratory syncytial virus. Eur Respir J 1998;12:612-618.
43. Zhang H, and Issekutz AC: Growth factor regulation of neutrophil-endothelial cell interactions. Leukoc Biol 2001;70:225-232.