메뉴 건너뛰기




Volumn 280, Issue , 2007, Pages 37-49

Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; APOPTOSIS; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVIEW; SEPSIS; SIGNAL TRANSDUCTION;

EID: 34247159956     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper
Times cited : (21)

References (44)
  • 1
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR 2001 Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303-1310
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 2
    • 0037151571 scopus 로고    scopus 로고
    • Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
    • Annane D, Sebille V, Charpentier C et al 2002 Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288: 862-871
    • (2002) JAMA , vol.288 , pp. 862-871
    • Annane, D.1    Sebille, V.2    Charpentier, C.3
  • 3
    • 0036900535 scopus 로고    scopus 로고
    • Shock induced neutrophil mediated priming for acute lung injury in mice: Divergent effects of TLR-4 and TLR-4/FasL deficiency
    • Ayala A, Chung CS, Lomas JL et al 2002 Shock induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency. Amer J Pathol 161:2283-2294
    • (2002) Amer J Pathol , vol.161 , pp. 2283-2294
    • Ayala, A.1    Chung, C.S.2    Lomas, J.L.3
  • 5
    • 0032575687 scopus 로고    scopus 로고
    • Is apoptosis key in Alzheimer's disease?
    • Barinaga M 1998 Is apoptosis key in Alzheimer's disease? Science 281:1303-1304
    • (1998) Science , vol.281 , pp. 1303-1304
    • Barinaga, M.1
  • 6
    • 0028212937 scopus 로고
    • Apoptosis and its role in human disease
    • Barr PJ, Tomei LD 1994 Apoptosis and its role in human disease. Bio/Technology 12: 487-493
    • (1994) Bio/Technology , vol.12 , pp. 487-493
    • Barr, P.J.1    Tomei, L.D.2
  • 7
    • 2942527148 scopus 로고    scopus 로고
    • Akt decreases lymphocyte apoptosis and improves survival in sepsis
    • Bommhardt U, Chang KC, Swanson PE et al 2004 Akt decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol 172:7583-7591
    • (2004) J Immunol , vol.172 , pp. 7583-7591
    • Bommhardt, U.1    Chang, K.C.2    Swanson, P.E.3
  • 9
    • 0041666539 scopus 로고    scopus 로고
    • Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties
    • Caserta TM, Smith AN, Gultice AD, Reedy MA, Brown TL 2003 Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis 8:345-352
    • (2003) Apoptosis , vol.8 , pp. 345-352
    • Caserta, T.M.1    Smith, A.N.2    Gultice, A.D.3    Reedy, M.A.4    Brown, T.L.5
  • 10
    • 3643052918 scopus 로고    scopus 로고
    • Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis?
    • Chung CS, Xu YX, Wang W, Chaudry IH, Ayala A 1998 Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis? Arch Surg 133:1213-1220
    • (1998) Arch Surg , vol.133 , pp. 1213-1220
    • Chung, C.S.1    Xu, Y.X.2    Wang, W.3    Chaudry, I.H.4    Ayala, A.5
  • 11
    • 0034908235 scopus 로고    scopus 로고
    • Inhibition of Fas signaling prevents hepatic injury and improves organ blood flow during sepsis
    • Chung CS, Yang SL, Song GY et al 2001 Inhibition of Fas signaling prevents hepatic injury and improves organ blood flow during sepsis. Surgery 130:339-345
    • (2001) Surgery , vol.130 , pp. 339-345
    • Chung, C.S.1    Yang, S.L.2    Song, G.Y.3
  • 12
    • 0142093069 scopus 로고    scopus 로고
    • Inhibition of Fas/Fas ligand signaling improves septic survival: Differential effects on macrophage apoptotic and functional capacity
    • Chung CS, Song GY, Lomas J, Simms HH, Chaudry IH, Ayala A 2003 Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity. J Leukoc Biol 74:344-351
    • (2003) J Leukoc Biol , vol.74 , pp. 344-351
    • Chung, C.S.1    Song, G.Y.2    Lomas, J.3    Simms, H.H.4    Chaudry, I.H.5    Ayala, A.6
  • 13
    • 0037012470 scopus 로고    scopus 로고
    • Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis
    • Coopersmith CM, Stromberg PE, Dunne WM et al 2002 Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA 287:1716-1721
    • (2002) JAMA , vol.287 , pp. 1716-1721
    • Coopersmith, C.M.1    Stromberg, P.E.2    Dunne, W.M.3
  • 15
    • 0030917203 scopus 로고    scopus 로고
    • Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment
    • Docke WD, Randow F, Syrbe U et al 1997 Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 3:678-681
    • (1997) Nat Med , vol.3 , pp. 678-681
    • Docke, W.D.1    Randow, F.2    Syrbe, U.3
  • 16
    • 0033692759 scopus 로고    scopus 로고
    • Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis
    • Guo R-F, Huber-Lang M, Wang X et al 2000 Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis. J Clin Invest 106:1271-1280
    • (2000) J Clin Invest , vol.106 , pp. 1271-1280
    • Guo, R.-F.1    Huber-Lang, M.2    Wang, X.3
  • 18
    • 17044413706 scopus 로고    scopus 로고
    • Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathway
    • Hotchkiss RS, Osmon SB, Chang KC, Wagner TH, Coopersmith CM, Karl IE 2005 Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathway. J Immunol 174:5110-5118
    • (2005) J Immunol , vol.174 , pp. 5110-5118
    • Hotchkiss, R.S.1    Osmon, S.B.2    Chang, K.C.3    Wagner, T.H.4    Coopersmith, C.M.5    Karl, I.E.6
  • 19
    • 0036793526 scopus 로고    scopus 로고
    • Protection of innate immunity by C5aR antagonist in septic mice
    • Huber-Lang MS, Riedemann NC, Sarma JV et al 2002 Protection of innate immunity by C5aR antagonist in septic mice. FASEB J 16:1567-1574
    • (2002) FASEB J , vol.16 , pp. 1567-1574
    • Huber-Lang, M.S.1    Riedemann, N.C.2    Sarma, J.V.3
  • 20
    • 0042333417 scopus 로고    scopus 로고
    • Over-expression of Bcl-2 provides protection in septic mice by a trans effect
    • Iwata A, Stevenson VM, Minard A et al 2003 Over-expression of Bcl-2 provides protection in septic mice by a trans effect. J Immunol 171:3136-3141
    • (2003) J Immunol , vol.171 , pp. 3136-3141
    • Iwata, A.1    Stevenson, V.M.2    Minard, A.3
  • 21
    • 2642603194 scopus 로고    scopus 로고
    • Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome
    • Jimenez MF, Watson WG, Parodo J et al 1997 Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome. Arch Surg 132:1263-1270
    • (1997) Arch Surg , vol.132 , pp. 1263-1270
    • Jimenez, M.F.1    Watson, W.G.2    Parodo, J.3
  • 22
    • 0033797774 scopus 로고    scopus 로고
    • Nitric oxide prevents tumor necrosis factor ?-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8
    • Kim Y-M, Kim T-H, Chung H-T, Talanian RV, Yin X-M, Billiar TR 2000 Nitric oxide prevents tumor necrosis factor ?-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8. Hepatology 32: 770-778
    • (2000) Hepatology , vol.32 , pp. 770-778
    • Kim, Y.-M.1    Kim, T.-H.2    Chung, H.-T.3    Talanian, R.V.4    Yin, X.-M.5    Billiar, T.R.6
  • 23
    • 0033533669 scopus 로고    scopus 로고
    • Virus treatment questioned after gene therapy death
    • Lehrman S 1999 Virus treatment questioned after gene therapy death. Nature 401:517-518
    • (1999) Nature , vol.401 , pp. 517-518
    • Lehrman, S.1
  • 24
    • 0029062573 scopus 로고
    • Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein
    • Li CJ, Friedman DJ, Wang C, Metelev V, Pardee AB 1995 Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science 268:429-431
    • (1995) Science , vol.268 , pp. 429-431
    • Li, C.J.1    Friedman, D.J.2    Wang, C.3    Metelev, V.4    Pardee, A.B.5
  • 25
    • 4444243683 scopus 로고    scopus 로고
    • A small molecule smac mimic potentiates TRAIL- and TNF-alpha-mediated cell death
    • Li L, Thomas RM, Suzuki H, DeBrabander JK, Wang X, Harran PG 2004 A small molecule smac mimic potentiates TRAIL- and TNF-alpha-mediated cell death. Science 305:1471-1474
    • (2004) Science , vol.305 , pp. 1471-1474
    • Li, L.1    Thomas, R.M.2    Suzuki, H.3    DeBrabander, J.K.4    Wang, X.5    Harran, P.G.6
  • 26
    • 0030927115 scopus 로고    scopus 로고
    • Apoptosis-role in infection and inflammation
    • Liles WC 1997 Apoptosis-role in infection and inflammation. Curr Opin Infect Dis 10: 165-170
    • (1997) Curr Opin Infect Dis , vol.10 , pp. 165-170
    • Liles, W.C.1
  • 27
    • 0035148874 scopus 로고    scopus 로고
    • Circulating endothelial cells in patients with septic shock
    • Mutunga M, Fulton B, Bullock R et al 2001 Circulating endothelial cells in patients with septic shock. Am J Respir Crit Care Med 163:195-200
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 195-200
    • Mutunga, M.1    Fulton, B.2    Bullock, R.3
  • 28
    • 28244480458 scopus 로고    scopus 로고
    • Silencing of Fas- but not caspase-8 in lung epithelial cells ameliorates experimental acute lung injury
    • Perl M, Chung CS, Lomas-Neira J et al 2005 Silencing of Fas- but not caspase-8 in lung epithelial cells ameliorates experimental acute lung injury. Am J Pathol 167:1545-1559
    • (2005) Am J Pathol , vol.167 , pp. 1545-1559
    • Perl, M.1    Chung, C.S.2    Lomas-Neira, J.3
  • 29
    • 0025244009 scopus 로고
    • Decreased Fc receptor expression on macrophages following simple hemorrhage as observed by scanning immuno electron microscopy
    • Rana MW, Ayala A, Dean RE, Chaudry IH 1990 Decreased Fc receptor expression on macrophages following simple hemorrhage as observed by scanning immuno electron microscopy. J Leukocyte Biol 48:512-518
    • (1990) J Leukocyte Biol , vol.48 , pp. 512-518
    • Rana, M.W.1    Ayala, A.2    Dean, R.E.3    Chaudry, I.H.4
  • 30
    • 14544299688 scopus 로고    scopus 로고
    • Therapeutic interventions and targets for sepsis
    • Rice TW, Bernard GR 2005 Therapeutic interventions and targets for sepsis. Annual Review Medicine 56:225-248
    • (2005) Annual Review Medicine , vol.56 , pp. 225-248
    • Rice, T.W.1    Bernard, G.R.2
  • 31
    • 0030250572 scopus 로고    scopus 로고
    • ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis
    • Rouquet N, Pages JC, Molina T, Briand J, Joulin V 1996 ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis. Curr Biol 6:1192-1195
    • (1996) Curr Biol , vol.6 , pp. 1192-1195
    • Rouquet, N.1    Pages, J.C.2    Molina, T.3    Briand, J.4    Joulin, V.5
  • 32
    • 23844498727 scopus 로고    scopus 로고
    • CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis
    • Scumpia PO, McAuliffe PF, O'Malley KA et al 2005 CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis. J Immunol 175:3282-3286
    • (2005) J Immunol , vol.175 , pp. 3282-3286
    • Scumpia, P.O.1    McAuliffe, P.F.2    O'Malley, K.A.3
  • 33
    • 0037869222 scopus 로고    scopus 로고
    • B2 microglobulin knockout mice are resistant to lethal intra-abdominal sepsis
    • Sherwood ER, Lin CY, Tao W et al 2003 B2 microglobulin knockout mice are resistant to lethal intra-abdominal sepsis. Am J Respir Crit Care Med 167:1641-1649
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1641-1649
    • Sherwood, E.R.1    Lin, C.Y.2    Tao, W.3
  • 34
    • 0037348329 scopus 로고    scopus 로고
    • RNA interference targeting Fas protects mice from fulminant hepatitis
    • Song E, Lee-S-K, Wang J et al 2003 RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 9:347-351
    • (2003) Nat Med , vol.9 , pp. 347-351
    • Song, E.1    S-K, L.2    Wang, J.3
  • 35
    • 0141552295 scopus 로고    scopus 로고
    • Gene silencing by systemic delivery of synthetic siRNAs in adult mice
    • Sorenson DR, Leirdal M, Sioud M 2003 Gene silencing by systemic delivery of synthetic siRNAs in adult mice. J Mol Biol 327:761-766
    • (2003) J Mol Biol , vol.327 , pp. 761-766
    • Sorenson, D.R.1    Leirdal, M.2    Sioud, M.3
  • 36
    • 3142704153 scopus 로고    scopus 로고
    • Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity
    • Taneja R, Parodo J, Jia SH, Kapus A, Rotstein OD 2004 Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity. Crit Care Med 32:1460-1469
    • (2004) Crit Care Med , vol.32 , pp. 1460-1469
    • Taneja, R.1    Parodo, J.2    Jia, S.H.3    Kapus, A.4    Rotstein, O.D.5
  • 37
    • 0035829852 scopus 로고    scopus 로고
    • Intensive insulin therapy in critically ill patients
    • van den Berghe G, Wouters P, Weekers F et al 2001 Intensive insulin therapy in critically ill patients. N Engl J Med 345:1359-1367
    • (2001) N Engl J Med , vol.345 , pp. 1359-1367
    • van den Berghe, G.1    Wouters, P.2    Weekers, F.3
  • 38
    • 0036195343 scopus 로고    scopus 로고
    • Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis
    • Vandivier RW, Fadok VA, Hoffmann PR et al 2002 Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest 109:661-670
    • (2002) J Clin Invest , vol.109 , pp. 661-670
    • Vandivier, R.W.1    Fadok, V.A.2    Hoffmann, P.R.3
  • 39
    • 4444291734 scopus 로고    scopus 로고
    • Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
    • Walensky LD, Kung AL, Escher I et al 2004 Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science 305:1466-1470
    • (2004) Science , vol.305 , pp. 1466-1470
    • Walensky, L.D.1    Kung, A.L.2    Escher, I.3
  • 40
    • 0036184191 scopus 로고    scopus 로고
    • A mechanism of cell survival: Sequestration of Fas by the HGF receptor Met
    • Wang X, DeFrances MC, Dai Y et al 2002 A mechanism of cell survival: sequestration of Fas by the HGF receptor Met. Mol Cell 9:411-421
    • (2002) Mol Cell , vol.9 , pp. 411-421
    • Wang, X.1    DeFrances, M.C.2    Dai, Y.3
  • 43
    • 0031755096 scopus 로고    scopus 로고
    • Monocyte anergy in septic shock is associated with a prediliction to apoptosis and is reversed by granulocyte-macrophage colony stimulating factor ex vivo
    • Williams MA, Withington S, Newland AC, Kelsey SM 1998 Monocyte anergy in septic shock is associated with a prediliction to apoptosis and is reversed by granulocyte-macrophage colony stimulating factor ex vivo. J Infect Dis 178:1421-1433
    • (1998) J Infect Dis , vol.178 , pp. 1421-1433
    • Williams, M.A.1    Withington, S.2    Newland, A.C.3    Kelsey, S.M.4
  • 44
    • 3242664327 scopus 로고    scopus 로고
    • Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial cell apoptosis in sepsis
    • Zhou M, Simms HH, Wang P 2004 Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial cell apoptosis in sepsis. Ann Surgery 240:321-330
    • (2004) Ann Surgery , vol.240 , pp. 321-330
    • Zhou, M.1    Simms, H.H.2    Wang, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.