-
1
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
-
Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR 2001 Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303-1310
-
(2001)
Crit Care Med
, vol.29
, pp. 1303-1310
-
-
Angus, D.C.1
Linde-Zwirble, W.T.2
Lidicker, J.3
Clermont, G.4
Carcillo, J.5
Pinsky, M.R.6
-
2
-
-
0037151571
-
Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
-
Annane D, Sebille V, Charpentier C et al 2002 Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288: 862-871
-
(2002)
JAMA
, vol.288
, pp. 862-871
-
-
Annane, D.1
Sebille, V.2
Charpentier, C.3
-
3
-
-
0036900535
-
Shock induced neutrophil mediated priming for acute lung injury in mice: Divergent effects of TLR-4 and TLR-4/FasL deficiency
-
Ayala A, Chung CS, Lomas JL et al 2002 Shock induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency. Amer J Pathol 161:2283-2294
-
(2002)
Amer J Pathol
, vol.161
, pp. 2283-2294
-
-
Ayala, A.1
Chung, C.S.2
Lomas, J.L.3
-
5
-
-
0032575687
-
Is apoptosis key in Alzheimer's disease?
-
Barinaga M 1998 Is apoptosis key in Alzheimer's disease? Science 281:1303-1304
-
(1998)
Science
, vol.281
, pp. 1303-1304
-
-
Barinaga, M.1
-
6
-
-
0028212937
-
Apoptosis and its role in human disease
-
Barr PJ, Tomei LD 1994 Apoptosis and its role in human disease. Bio/Technology 12: 487-493
-
(1994)
Bio/Technology
, vol.12
, pp. 487-493
-
-
Barr, P.J.1
Tomei, L.D.2
-
7
-
-
2942527148
-
Akt decreases lymphocyte apoptosis and improves survival in sepsis
-
Bommhardt U, Chang KC, Swanson PE et al 2004 Akt decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol 172:7583-7591
-
(2004)
J Immunol
, vol.172
, pp. 7583-7591
-
-
Bommhardt, U.1
Chang, K.C.2
Swanson, P.E.3
-
8
-
-
0038419800
-
Induction of an interferon response by RNAi vectors in mammalian cells
-
Bridge AJ, Pebernard S, Ducraux A, Nicovlaz AL, Iggo R 2004 Induction of an interferon response by RNAi vectors in mammalian cells. Nature Genet 34:263-264
-
(2004)
Nature Genet
, vol.34
, pp. 263-264
-
-
Bridge, A.J.1
Pebernard, S.2
Ducraux, A.3
Nicovlaz, A.L.4
Iggo, R.5
-
9
-
-
0041666539
-
Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties
-
Caserta TM, Smith AN, Gultice AD, Reedy MA, Brown TL 2003 Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis 8:345-352
-
(2003)
Apoptosis
, vol.8
, pp. 345-352
-
-
Caserta, T.M.1
Smith, A.N.2
Gultice, A.D.3
Reedy, M.A.4
Brown, T.L.5
-
10
-
-
3643052918
-
Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis?
-
Chung CS, Xu YX, Wang W, Chaudry IH, Ayala A 1998 Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis? Arch Surg 133:1213-1220
-
(1998)
Arch Surg
, vol.133
, pp. 1213-1220
-
-
Chung, C.S.1
Xu, Y.X.2
Wang, W.3
Chaudry, I.H.4
Ayala, A.5
-
11
-
-
0034908235
-
Inhibition of Fas signaling prevents hepatic injury and improves organ blood flow during sepsis
-
Chung CS, Yang SL, Song GY et al 2001 Inhibition of Fas signaling prevents hepatic injury and improves organ blood flow during sepsis. Surgery 130:339-345
-
(2001)
Surgery
, vol.130
, pp. 339-345
-
-
Chung, C.S.1
Yang, S.L.2
Song, G.Y.3
-
12
-
-
0142093069
-
Inhibition of Fas/Fas ligand signaling improves septic survival: Differential effects on macrophage apoptotic and functional capacity
-
Chung CS, Song GY, Lomas J, Simms HH, Chaudry IH, Ayala A 2003 Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity. J Leukoc Biol 74:344-351
-
(2003)
J Leukoc Biol
, vol.74
, pp. 344-351
-
-
Chung, C.S.1
Song, G.Y.2
Lomas, J.3
Simms, H.H.4
Chaudry, I.H.5
Ayala, A.6
-
13
-
-
0037012470
-
Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis
-
Coopersmith CM, Stromberg PE, Dunne WM et al 2002 Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA 287:1716-1721
-
(2002)
JAMA
, vol.287
, pp. 1716-1721
-
-
Coopersmith, C.M.1
Stromberg, P.E.2
Dunne, W.M.3
-
15
-
-
0030917203
-
Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment
-
Docke WD, Randow F, Syrbe U et al 1997 Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 3:678-681
-
(1997)
Nat Med
, vol.3
, pp. 678-681
-
-
Docke, W.D.1
Randow, F.2
Syrbe, U.3
-
16
-
-
0033692759
-
Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis
-
Guo R-F, Huber-Lang M, Wang X et al 2000 Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis. J Clin Invest 106:1271-1280
-
(2000)
J Clin Invest
, vol.106
, pp. 1271-1280
-
-
Guo, R.-F.1
Huber-Lang, M.2
Wang, X.3
-
18
-
-
17044413706
-
Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathway
-
Hotchkiss RS, Osmon SB, Chang KC, Wagner TH, Coopersmith CM, Karl IE 2005 Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathway. J Immunol 174:5110-5118
-
(2005)
J Immunol
, vol.174
, pp. 5110-5118
-
-
Hotchkiss, R.S.1
Osmon, S.B.2
Chang, K.C.3
Wagner, T.H.4
Coopersmith, C.M.5
Karl, I.E.6
-
19
-
-
0036793526
-
Protection of innate immunity by C5aR antagonist in septic mice
-
Huber-Lang MS, Riedemann NC, Sarma JV et al 2002 Protection of innate immunity by C5aR antagonist in septic mice. FASEB J 16:1567-1574
-
(2002)
FASEB J
, vol.16
, pp. 1567-1574
-
-
Huber-Lang, M.S.1
Riedemann, N.C.2
Sarma, J.V.3
-
20
-
-
0042333417
-
Over-expression of Bcl-2 provides protection in septic mice by a trans effect
-
Iwata A, Stevenson VM, Minard A et al 2003 Over-expression of Bcl-2 provides protection in septic mice by a trans effect. J Immunol 171:3136-3141
-
(2003)
J Immunol
, vol.171
, pp. 3136-3141
-
-
Iwata, A.1
Stevenson, V.M.2
Minard, A.3
-
21
-
-
2642603194
-
Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome
-
Jimenez MF, Watson WG, Parodo J et al 1997 Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome. Arch Surg 132:1263-1270
-
(1997)
Arch Surg
, vol.132
, pp. 1263-1270
-
-
Jimenez, M.F.1
Watson, W.G.2
Parodo, J.3
-
22
-
-
0033797774
-
Nitric oxide prevents tumor necrosis factor ?-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8
-
Kim Y-M, Kim T-H, Chung H-T, Talanian RV, Yin X-M, Billiar TR 2000 Nitric oxide prevents tumor necrosis factor ?-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8. Hepatology 32: 770-778
-
(2000)
Hepatology
, vol.32
, pp. 770-778
-
-
Kim, Y.-M.1
Kim, T.-H.2
Chung, H.-T.3
Talanian, R.V.4
Yin, X.-M.5
Billiar, T.R.6
-
23
-
-
0033533669
-
Virus treatment questioned after gene therapy death
-
Lehrman S 1999 Virus treatment questioned after gene therapy death. Nature 401:517-518
-
(1999)
Nature
, vol.401
, pp. 517-518
-
-
Lehrman, S.1
-
24
-
-
0029062573
-
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein
-
Li CJ, Friedman DJ, Wang C, Metelev V, Pardee AB 1995 Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science 268:429-431
-
(1995)
Science
, vol.268
, pp. 429-431
-
-
Li, C.J.1
Friedman, D.J.2
Wang, C.3
Metelev, V.4
Pardee, A.B.5
-
25
-
-
4444243683
-
A small molecule smac mimic potentiates TRAIL- and TNF-alpha-mediated cell death
-
Li L, Thomas RM, Suzuki H, DeBrabander JK, Wang X, Harran PG 2004 A small molecule smac mimic potentiates TRAIL- and TNF-alpha-mediated cell death. Science 305:1471-1474
-
(2004)
Science
, vol.305
, pp. 1471-1474
-
-
Li, L.1
Thomas, R.M.2
Suzuki, H.3
DeBrabander, J.K.4
Wang, X.5
Harran, P.G.6
-
26
-
-
0030927115
-
Apoptosis-role in infection and inflammation
-
Liles WC 1997 Apoptosis-role in infection and inflammation. Curr Opin Infect Dis 10: 165-170
-
(1997)
Curr Opin Infect Dis
, vol.10
, pp. 165-170
-
-
Liles, W.C.1
-
27
-
-
0035148874
-
Circulating endothelial cells in patients with septic shock
-
Mutunga M, Fulton B, Bullock R et al 2001 Circulating endothelial cells in patients with septic shock. Am J Respir Crit Care Med 163:195-200
-
(2001)
Am J Respir Crit Care Med
, vol.163
, pp. 195-200
-
-
Mutunga, M.1
Fulton, B.2
Bullock, R.3
-
28
-
-
28244480458
-
Silencing of Fas- but not caspase-8 in lung epithelial cells ameliorates experimental acute lung injury
-
Perl M, Chung CS, Lomas-Neira J et al 2005 Silencing of Fas- but not caspase-8 in lung epithelial cells ameliorates experimental acute lung injury. Am J Pathol 167:1545-1559
-
(2005)
Am J Pathol
, vol.167
, pp. 1545-1559
-
-
Perl, M.1
Chung, C.S.2
Lomas-Neira, J.3
-
29
-
-
0025244009
-
Decreased Fc receptor expression on macrophages following simple hemorrhage as observed by scanning immuno electron microscopy
-
Rana MW, Ayala A, Dean RE, Chaudry IH 1990 Decreased Fc receptor expression on macrophages following simple hemorrhage as observed by scanning immuno electron microscopy. J Leukocyte Biol 48:512-518
-
(1990)
J Leukocyte Biol
, vol.48
, pp. 512-518
-
-
Rana, M.W.1
Ayala, A.2
Dean, R.E.3
Chaudry, I.H.4
-
30
-
-
14544299688
-
Therapeutic interventions and targets for sepsis
-
Rice TW, Bernard GR 2005 Therapeutic interventions and targets for sepsis. Annual Review Medicine 56:225-248
-
(2005)
Annual Review Medicine
, vol.56
, pp. 225-248
-
-
Rice, T.W.1
Bernard, G.R.2
-
31
-
-
0030250572
-
ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis
-
Rouquet N, Pages JC, Molina T, Briand J, Joulin V 1996 ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis. Curr Biol 6:1192-1195
-
(1996)
Curr Biol
, vol.6
, pp. 1192-1195
-
-
Rouquet, N.1
Pages, J.C.2
Molina, T.3
Briand, J.4
Joulin, V.5
-
32
-
-
23844498727
-
CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis
-
Scumpia PO, McAuliffe PF, O'Malley KA et al 2005 CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis. J Immunol 175:3282-3286
-
(2005)
J Immunol
, vol.175
, pp. 3282-3286
-
-
Scumpia, P.O.1
McAuliffe, P.F.2
O'Malley, K.A.3
-
33
-
-
0037869222
-
B2 microglobulin knockout mice are resistant to lethal intra-abdominal sepsis
-
Sherwood ER, Lin CY, Tao W et al 2003 B2 microglobulin knockout mice are resistant to lethal intra-abdominal sepsis. Am J Respir Crit Care Med 167:1641-1649
-
(2003)
Am J Respir Crit Care Med
, vol.167
, pp. 1641-1649
-
-
Sherwood, E.R.1
Lin, C.Y.2
Tao, W.3
-
34
-
-
0037348329
-
RNA interference targeting Fas protects mice from fulminant hepatitis
-
Song E, Lee-S-K, Wang J et al 2003 RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 9:347-351
-
(2003)
Nat Med
, vol.9
, pp. 347-351
-
-
Song, E.1
S-K, L.2
Wang, J.3
-
35
-
-
0141552295
-
Gene silencing by systemic delivery of synthetic siRNAs in adult mice
-
Sorenson DR, Leirdal M, Sioud M 2003 Gene silencing by systemic delivery of synthetic siRNAs in adult mice. J Mol Biol 327:761-766
-
(2003)
J Mol Biol
, vol.327
, pp. 761-766
-
-
Sorenson, D.R.1
Leirdal, M.2
Sioud, M.3
-
36
-
-
3142704153
-
Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity
-
Taneja R, Parodo J, Jia SH, Kapus A, Rotstein OD 2004 Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity. Crit Care Med 32:1460-1469
-
(2004)
Crit Care Med
, vol.32
, pp. 1460-1469
-
-
Taneja, R.1
Parodo, J.2
Jia, S.H.3
Kapus, A.4
Rotstein, O.D.5
-
37
-
-
0035829852
-
Intensive insulin therapy in critically ill patients
-
van den Berghe G, Wouters P, Weekers F et al 2001 Intensive insulin therapy in critically ill patients. N Engl J Med 345:1359-1367
-
(2001)
N Engl J Med
, vol.345
, pp. 1359-1367
-
-
van den Berghe, G.1
Wouters, P.2
Weekers, F.3
-
38
-
-
0036195343
-
Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis
-
Vandivier RW, Fadok VA, Hoffmann PR et al 2002 Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest 109:661-670
-
(2002)
J Clin Invest
, vol.109
, pp. 661-670
-
-
Vandivier, R.W.1
Fadok, V.A.2
Hoffmann, P.R.3
-
39
-
-
4444291734
-
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
-
Walensky LD, Kung AL, Escher I et al 2004 Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science 305:1466-1470
-
(2004)
Science
, vol.305
, pp. 1466-1470
-
-
Walensky, L.D.1
Kung, A.L.2
Escher, I.3
-
40
-
-
0036184191
-
A mechanism of cell survival: Sequestration of Fas by the HGF receptor Met
-
Wang X, DeFrances MC, Dai Y et al 2002 A mechanism of cell survival: sequestration of Fas by the HGF receptor Met. Mol Cell 9:411-421
-
(2002)
Mol Cell
, vol.9
, pp. 411-421
-
-
Wang, X.1
DeFrances, M.C.2
Dai, Y.3
-
41
-
-
27144512743
-
In vivo delivery of caspase 8 or Fas siRNA improves the survival of septic mice
-
Wesche-Soldato DE, Chung CS, Lomas-Neira J, Doughty LA, Gregory SH, Ayala A 2005 In vivo delivery of caspase 8 or Fas siRNA improves the survival of septic mice. Blood 106:2295-2301
-
(2005)
Blood
, vol.106
, pp. 2295-2301
-
-
Wesche-Soldato, D.E.1
Chung, C.S.2
Lomas-Neira, J.3
Doughty, L.A.4
Gregory, S.H.5
Ayala, A.6
-
42
-
-
23044477087
-
Leukocyte apoptosis and its significance in sepsis and shock
-
Wesche DE, Lomas-Neira JL, Perl M, Chung CS, Ayala A 2005 Leukocyte apoptosis and its significance in sepsis and shock. J Leukocyte Biol 25:325-337
-
(2005)
J Leukocyte Biol
, vol.25
, pp. 325-337
-
-
Wesche, D.E.1
Lomas-Neira, J.L.2
Perl, M.3
Chung, C.S.4
Ayala, A.5
-
43
-
-
0031755096
-
Monocyte anergy in septic shock is associated with a prediliction to apoptosis and is reversed by granulocyte-macrophage colony stimulating factor ex vivo
-
Williams MA, Withington S, Newland AC, Kelsey SM 1998 Monocyte anergy in septic shock is associated with a prediliction to apoptosis and is reversed by granulocyte-macrophage colony stimulating factor ex vivo. J Infect Dis 178:1421-1433
-
(1998)
J Infect Dis
, vol.178
, pp. 1421-1433
-
-
Williams, M.A.1
Withington, S.2
Newland, A.C.3
Kelsey, S.M.4
-
44
-
-
3242664327
-
Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial cell apoptosis in sepsis
-
Zhou M, Simms HH, Wang P 2004 Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial cell apoptosis in sepsis. Ann Surgery 240:321-330
-
(2004)
Ann Surgery
, vol.240
, pp. 321-330
-
-
Zhou, M.1
Simms, H.H.2
Wang, P.3
|