Delay or inhibition of rat lens opacification using pantethine and WR-77913

Experimental Eye Research

Volumn 62, Issue 1, 1996, Pages 75-84

  Clark, John I ^a,b   Livesey, John C ^b,c   Steele, Jeannette E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF THE PACIFIC   (United States)

Author keywords

amino phosphorothioate anti cataract agents; cataract; lens; pantethine; transparency; WR 77913

Indexed keywords

PANTETHINE; PHOSPHOROTHIOIC ACID S (3 AMINO 2 HYDROXYPROPYL) ESTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATARACT; CATARACTOGENESIS; CONTROLLED STUDY; DRUG THERAPY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PREVENTION; PRIORITY JOURNAL; RAT;

EID: 0029918607     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.1996.0009     Document Type: Article

References (74)

1. Benedek, G. B. (1971). Theory of transparency of the eye. Appl. Ophth. 10, 459-73.
2. Bettelheim, F. A. (1985). Physical basis of lens transparency. In: The Ocular Lens: Structure, Function, and Pathology (Ed. Maisel, H.). Pp. 265-300. Marcel Dekker: New York, U.S.A.
3. Blakytny, R. and Harding, J. J. (1992). Prevention of cataract in diabetic rats by aspirin, paracetamol (acetaminophen) and Ibuprofen, Exp. Eye Res. 54, 509-18.
4. Bunce, G. E., Hess, J. L., Batra, R. (1984). Lens calcium and selenite-induced cataract. Curr. Eye Res. 3, 315-20.
5. Chen, T. T., Hockwin, O., Dobbs, R., Knowles, W. and Eckerskorn, U. (1988). Cataract and health status: a case-control study. Ophthalmol. Res. 20, 1-9.
6. Chylack, L. T., Jr. (1994). Aging changes in the crystalline lens and zonules. In Principles and Practice of Ophthalmology (Eds Albert, D. M. and Jakobiec, F. A.). Pp. 702-10. W. B. Saunders Co.: Philadelphia, U.S.A.
7. Clark, J. I. (1990). Phase separation and hydrogen bonding in cells of the ocular lens. Biopolymers 30, 995-9.
8. Clark, J. I. (1994a) Lens cytoplasmic protein solutions: analysis of a biologically occurring aqueous phase separation. Methods Enzymol. 228, 525-37.
9. Clark, J. I. (1994b). Development and maintenance of lens transparency. In Principles and Practice of Ophthalmology (Eds Albert, D. M. and Jakobiec, F. A.). Pp. 114-23. W. B. Saunders Co.: Philadelphia, U.S.A.
10. Clark, J. I. and Benedek, G. B. (1980a). Phase diagram for cell cytoplasm from the calf lens. Biochem. Biophys. Res. Comm. 95, 482-9.
11. Clark, J. I. and Benedek, G. B. (1980b). The effects of glycols, aldehydes, and acrylamide on phase separation and opacification in the calf lens. Invest. Ophthalmol. Vis. Sci. 19, 771-6.
12. Clark, J. I. and Carper, D. (1987). Phase separation in lens cytoplasm is genetically linked to cataract formation in the Philly mouse. Proc. Natl. Acad. Sci., USA 84, 122-5.
13. Clark, J. I., Danford-Kaplan, M. E. and Delaye, M. (1988). Calcium decreases transparency of homogenate from lens cortex and has no effect on nucleus. Exp. Eye Res. 47, 447-55.
14. Clark, J. I., Giblin, F. J., Reddy, V. N. and Benedek, G. B. (1982). Phase separation in x-irradiated lenses of rabbit. Invest Ophthalmol. Vis. Sci. 22, 186-90.
15. Clark, J. I., Mengel, M., Bagg, A. and Benedek, H. G. (1980). Cortical opacity, calcium concentration and fiber membrane structure in the calf lens. Exp. Eye Res. 31, 399-410.
16. Clark, J. I., Osgood, T. B. and Trask, S. J. (1987). Inhibition of phase separation by reagents that prevent x-irradiation cataract in vivo. Exp Eye Res 45, 961-7.
17. Clark, J. I. and Steele, J. E. (1992). Phase-separation inhibitors and prevention of selenite cataract. Proc Natl. Acad Sci., USA 89, 1720-4.
18. Datiles, M. B. and Kinoshita, J. H. (1994). Pathogenesis of Cataracts. In Duane's Clinical Ophthalmology, Vol. 1. (Eds Tasman, W. and Jaeger, E. A.) J. B. Lippincott: Philadelphia, 72B.
19. DeDuve, C. (1991). Blueprint for a Cell. Neil Patterson Publications: Burlington, N.C.
20. Delaye, M. and Tardieu, A. (1983). Short-range order of crystallin proteins accounts for eye lens transparency. Nature 302, 415-17.
21. Delaye, M., Clark, J. I. and Benedek, G. B. (1981). Co-existence curve for phase separation in the calf lens cytoplasm. Biochem. Biophys. Res. Comm. 100, 908-14.
22. Dvornik, D. (1987). Aldose Reductase Inhibition. (Ed. Porte, D.). McGraw-Hill: New York, U.S.A.
23. Faktorovich, E. G., Steinberg, R. H., Yasumura, D., Matthes, M. T. and LaVail, M. M. (1990). Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature 347, 83-6.
24. Hankinson, S. E. (1994). The epidemiology of age-related cataract. In Principles and Practice of Ophthalmology. (Eds Albert, D. M. and Jakobiec, F. A.) pp. 1255-66. W. B. Saunders Co.: Philadelphia.
25. Harding, J. (1991). Cataract: Biochemistry, Epidemiology and Pharmacology. Chapman & Hall: London.
26. Harding, J. J. and Rixon, K. C. (1980). Carbamylation of lens proteins: a possible factor in cataractogenesis in some tropical countries. Exp. Eye Res. 31: 567-71.
27. Hess, H. H., Newsome, D. A., Knapka, J. J. and Westney, G. E. (1982/1983). Slitlamp assessment of age of onset and incidence of cataracts in pink-eyed, tan-hooded retinal dystrophic rats. Curr. Eye Res. 2, 265-9.
28. Hess, H. H., Newsome, D. A., Knapka, J. J. and Westney, G. E. (1983). Slit-lamp assessment of onset of cataracts in black-eyed, black-hooded retinal dystrophic rats. Invest. Ophthalmol. Vis. Sci. 24, 654-7.
29. Hightower K. R., McReady, J. P. and Goudsmit, E. M. (1987). Calcium-induced opacification is dependent upon lens pH. Curr. Eye Res. 6, 1415-20.
30. Hiraoka, T., Clark, J. I. (1995). Inhibition of lens opacification during the early stages of cataract formation. Invest. Ophthalmol. Vis. Sci. 36, 2550-5.
31. Hiraoka, T., Clark, J. I., Li, X. Y. and Thurston, G. M. (1996). Effect of selected anti-cataract agents on opacification in the selenite cataract model. Exp. Eye Res. 62, 11-20
32. Ishimoto, I., Goalwin, P. W., Sun, S. T., Nishio, I. & Tanaka, T. (1979). Cytoplasmic phase separation in formation of galactosemic cataract in lenses of young rats. Proc. Natl. Acad. Sci., USA 76, 4414-16.
33. Kador, P. F. (1983). Overview of the current attempts toward the medical treatment of cataract. Ophthalmology 90, 352-64.
34. Kador, P. F., Zigler, J. S. and Kinoshita, J. H. (1979). Alteration of lens protein synethesis in galactosemic rats. Invest. Ophthalmol. Vis. Sci. 18, 696-702.
35. Kador, P. F., Akagi, Y. and Kinoshita, J. H. (1986). The effect of aldose reductase and its inhibition on sugar cataract formation. Metabolism 35, 15-29.
36. Kupfer, C. (1983). Worldwide prevention of blindness. Am. J. Ophthalmol. 96, 543-5.
37. Kupfer, C. (1984). The conquest of cataract: a global challenge. Trans. Ophthal. Soc. U.K. 104, 1-10.
38. Kuriyama, H., Sasaki, K. and Fukuda, M. (1983). Studies on diabetic rats induced by streptozotocin II. Ophthalmic Res. 15, 191-7.
39. Kuwabara, T., Gorn, R. A. (1968). Retinal damage by visible light. Arch. Ophthalmol. 79, 69-78.
40. LaVail, M. M., Sidman, R. L. and Gerhardt, C. O. (1975). Congenic strains of RCS rats with inherited retinal dystrophy. J. Heredity 66, 242-4.
41. Leske, C., Chylack, L. T., Jr., Wu, S.-Y. (1991). The lens opacities cast-control study. Arch. Ophthalmol. 109, 244-51.
42. Lewis, B. S. and Harding, J. (1990). The effects of amino-guanidine on the glycation (non-enzymic glycosylation) of lens protein. Exp. Eye Res. 50, 463-7.
43. Lipmann, F. (1971). Attempts to map a process evolution to peptide biosynthesis. Science 173, 875-84.
44. Liu, C.-W., Lomakin, A., Thurston, G. M., Hayen, D. L., Pande, A., Pande, J., Ogun, O., Asherie, N. and Benedek, G. B. (1995). Phase separation in multicomponent aqueous-protein solutions. J. Phys. Chem. 99, 454-61.
45. Livesey, J. C., Wiens, L. W., Von Seggern, D. J., Barlow, W. E. and Arnold, A. M. (1995). Inhibition of radiation cataractogenesis by WR-77913. Radiat. Res. 141, 99-104.
46. Livesey, J. C. and Reed, D. J. (1987). Chemical protection against ionizing radiation. Adv. Radiat. Biol. 13, 285-353.
47. Menard, T. W., Osgood, T. B., Clark, J. I., Spence, A. M., Steele, J. E., Krohn, K. A. and Livesey, J. C. (1986). Radioprotection against cataract formation by WR-77913 in gamma-irradiated rats. Int. J. Radiat. Oncol. Biol Phys. 12, 1483-6.
48. Meydani, M., Martin, A., Sastre, J., Smith, D., Dallal, G., Taylor, A. and Blumberg, J. (1994). Dose-response characteristics of galactose-induced cataract in the rat. Ophthalmic Res. 26, 368-74.
49. Osgood, T. B., Menard, T. W., Clark, J. I. and Krohn, K. A. (1986). Inhibition of lens opacification in x-irradiated rats treated with WR-77913. Invest. Ophthalmol. Vis. Sci. 27, 1780-4.
50. Pande, J., Berland, C., Broide, M., Ogun, O., Melhuish, J. and Benedek, G. B. (1991). Suppression of phase separation in solutions of bovine γIV-crystallin by polar modification of the sulfur-containing amino acids. Proc Natl Acad. Sci., USA 88, 4916-20.
51. Pande, J., Ogun, O., Nath, C. and Benedek, G. (1993). Suppression of phase separation in bovine γIV crystallin solutions: effect of modification by charged versus uncharged polar groups. Exp. Eye Res. 57, 257-64.
52. Perry, J., Du, J., Kjeldbye, H. and Gouras, P. (1995). The effects of bFGF on RCS rat eyes. Curr. Eye Res. 14, 585-92.
53. Rakoczy, P. E., Humphrey, M. F., Cavaney, D. M., Chu, Y. and Constable, I. J. (1993). Expression of basic fibroblast growth factor and its receptor in the retina of Royal College of Surgeons rats. Invest. Ophthamol. Vis. Sci. 34, 1845-52.
54. 35S-labeled 3-amino-2-hydroxypropyl phosphorothioate (WR77913). Radiat. Res. 102, 130-7.
55. Reddy, V. N., Ikebe, H., Giblin, F. J., Clark, J. I. and Livesey, J. C. (1989). Effect of radioprotective agents on x-ray cataracts. Lens Eye Toxicity Res. 6, 573-88.
56. Sakamoto, N., Kinoshita, J. H., Kador, P. F. and Hotta, N. (eds) (1988). Polyol Pathway and Its Role in Diabetic Complications. Excepta Medica: Amsterdam.
57. Sasaki, K., Kuriyama, H., Yeh, L. I. and Fukuda, M. (1983). Studies on diabetic cataract in rats induced by streptozotocin. Opthalmic. Res. 15, 185-90.
58. Sasaki, K., Hockwin, O., Leske, M. C. (eds) (1987). Cataract Epidemiology. Karger: Basel.
59. Shearer, T. R., David, L. L. and Anderson, R. S. (1987). Selenite cataract: a review. Curr. Eye Res. 6, 289-300.
60. Shearer, T. R., David, L. L., Anderson, R. S. and Azuma, M. (1992). Review of selenite cataract. Curr. Eye Res. 11, 357-69.
61. Swamy, M. S. and Abraham, E. C. (1991). Differential glycation of rat crystallins. Exp. Eye Res., 52, 439-44.
62. Tanaka, T. and Benedek, G. B. (1975). Observation of protein diffusivity in intact human and bovine lenses with application to cataract. Invest. Ophthalmol. 14, 449-501.
63. Tanaka, T., Ishimoto, C. and Chylack, L. T. (1977). Phase separation of a protein-water mixture in cold cataract in the young rat lens. Science 197, 1010-12.
64. Tripathi, R. C. and Tripathi, B. J. (1983). Morphology of the normal, aging and cataractous human lens. Lens Res. 1, 1-42.
65. Tripathi, B. J., Tripathi, R. C., Borisuth, N. S. C., Dhaliwal, R. and Dhaliwal, D. (1991). Rodent models of congenital and hereditary cataract in man. Lens Eye Toxicity Res. 8, 373-413.
66. Trokel, S. (1962). The physical basis for transparency of the crystalline lens. Invest. Ophthalmol. 1, 493-501.
67. Vaezy, S., Clark, J. and Clark, J. (1995). Quantitative analysis of the lens cell microstructure in selenite cataract using a two-dimensional fourier analysis. Exp. Eye Res. 60, 245-55.
68. Von Sallmann, L. (1952). Further efforts to influence x-ray cataract by chemical agents. Arch. Ophthalmol. 48, 276-91.
69. Von Sallmann, L. (1957). The lens epithelium in the pathogenesis of cataract. Am. J. Ophthalmol. 44, 159-69.
70. Worgul, B. V., Merriam, G. R., Jr and Medvedovsky, C. (1986). Accelerated heavy particles and the lens II. Invest. Ophthalmol. Vis. Sci. 27, 108-14.
71. Yamaguchi, K., Yamaguchi, K., Sheedlo, H. J. and Turner, J. E. (1991). Ciliary body degeneration in the Royal College of Surgeons dystrophic rat. Exp. Eye Res. 52, 539-48.
72. Young, R. W. (1991). Age-Related Cataract. Oxford University Press: New York, U.S.A.
73. Zigler, J. S. and Hess, H. H. (1985). Cataract in the Royal College of Surgeons rat: evidence for initiation by lipid peroxidation products. Exp. Eye Res. 41, 67-76.
74. Zigler, J. S. (1990). Animal models for the study of maturity-onset and hereditary cataract. Exp. Eye Res. 50, 651-7.