The neural crest: Understanding stem cell function in development and disease

Neurodegenerative Diseases

Volumn 4, Issue 1, 2007, Pages 6-12

  Fuchs, Sebastian ^a   Sommer, Lukas ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Cancer stem cells; Neural crest; Signaling; Stem cells

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; CD133 ANTIGEN; MYC PROTEIN; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; STEM CELL FACTOR; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SOX10; TRANSCRIPTION FACTOR SOX8; TRANSCRIPTION FACTOR SOX9; WNT PROTEIN;

CANCER CELL; CANCER GROWTH; CANCER STEM CELL; CELL DIFFERENTIATION; CELL LINEAGE; CELL MIGRATION; CELL POPULATION; CLINICAL RESEARCH; ECTODERM; ENDODERM; HEMATOPOIETIC STEM CELL; HIRSCHSPRUNG DISEASE; HUMAN; INTESTINE INNERVATION; MEDULLOBLASTOMA; MESODERM; MULTIPOTENT STEM CELL; NERVE CELL CULTURE; NEURAL CREST; NEURAL CREST CELL; NEURAL STEM CELL; NEURAL TUBE; NEUROBLASTOMA; PARASYMPATHETIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SPINAL GANGLION; SYMPATHETIC NERVE;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; HUMANS; MODELS, BIOLOGICAL; NERVOUS SYSTEM MALFORMATIONS; NEURAL CREST; STEM CELLS;

EID: 34247113673     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000100354     Document Type: Review

References (43)

1. Pardal R, Clarke MF, Morrison SJ: Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 2003;3:895-902.
2. Le Douarin NM, Dupin E: Multipotentiality of the neural crest. Curr Opin Genet Dev 2003;13:529-536.
3. Hall BK: The neural crest as a fourth germ layer and vertebrates as quadroblastic not triploblastic. Evol Dev 2000;2:3-5.
4. Aybar MJ, Mayor R: Early induction of neural crest cells: lessons learned from frog, fish and chick. Curr Opin Genet Dev 2002;12:452-458.
5. Le Douarin NM, Ziller C, Couly GF: Patterning of neural crest derivatives in the avian embryo: in vivo and in vitro studies. Dev Biol 1993;159:24-49.
6. Trainor PA: Specification of neural crest cell formation and migration in mouse embryos. Semin Cell Dev Biol 2005;16:683-693.
7. Stemple DL, Anderson DJ: Isolation of a stem cell for neurons and glia from the mammalian neural crest. Cell 1992;71:973-985.
8. Barembaum M, Bronner-Fraser M: Early steps in neural crest specification. Semin Cell Dev Biol 2005;16:642-646.
9. Morales AV, Barbas JA, Nieto MA: How to become neural crest: from segregation to delamination. Semin Cell Dev Biol 2005;16:655-662.
10. Steventon B, Carmona-Fontaine C, Mayor R: Genetic network during neural crest induction: from cell specification to cell survival. Semin Cell Dev Biol 2005;16:647-654.
11. Garcia-Castro MI, Marcelle C, Bronner-Fraser M: Ectodermal Wnt function as a neural crest inducer. Science 2002;297:848-851.
12. Deardorff MA, Tan C, Saint-Jeannet JP, Klein PS: A role for frizzled 3 in neural crest development. Development 2001;128:3655-3663.
13. Saint-Jeannet JP, He X, Varmus HE, Dawid IB: Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a. Proc Natl Acad Sci USA 1997;94:13713-13718.
14. Spokony RF, Aoki Y, Saint-Germain N, Magner-Fink E, Saint-Jeannet JP: The transcription factor Sox9 is required for cranial neural crest development in Xenopus. Development 2002;129:421-432.
15. Cheung M, Briscoe J: Neural crest development is regulated by the transcription factor Sox9. Development 2003;130:5681-5693.
16. Shah NM, Groves AK, Anderson DJ: Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell 1996;85:331-343.
17. Lee HY, Kleber M, Hari L, Brault V, Suter U, Taketo MM, Kemler R, Sommer L: Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells. Science 2004;303:1020-1023.
18. Hari L, Brault V, Kleber M, Lee HY, Ille F, Leimeroth R, Paratore C, Suter U, Kemler R, Sommer L: Lineage-specific requirements of beta-catenin in neural crest development. J Cell Biol 2002;159:867-880.
19. Kleber M, Sommer L: Wnt signaling and the regulation of stem cell function. Curr Opin Cell Biol 2004;16:681-687.
20. Kleber M, Lee HY, Wurdak H, Buchstaller J, Riccomagno MM, Ittner LM, Suter U, Epstein DJ, Sommer L: Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling. J Cell Biol 2005;169:309-320.
21. Britsch S, Goerich DE, Riethmacher D, Peirano RI, Rossner M, Nave KA, Birchmeier C, Wegner M: The transcription factor Sox10 is a key regulator of peripheral glial development. Genes Dev 2001;15:66-78.
22. Paratore C, Goerich DE, Suter U, Wegner M, Sommer L: Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling. Development 2001;128:3949-3961.
23. Kim J, Lo L, Dormand E, Anderson DJ: SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells. Neuron 2003;38:17-31.
24. Paratore C, Eichenberger C, Suter U, Sommer L: Sox10 haploinsufficiency affects maintenance of progenitor cells in a mouse model of Hirschsprung disease. Hum Mol Genet 2002;11:3075-3085.
25. Kruger GM, Mosher JT, Bixby S, Joseph N, Iwashita T, Morrison SJ: Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness. Neuron 2002;35:657-669.
26. Bixby S, Kruger GM, Mosher JT, Joseph NM, Morrison SJ: Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity. Neuron 2002;35:643-656.
27. Taraviras S, Marcos-Gutierrez CV, Durbec P, Jani H, Grigoriou M, Sukumaran M, Wang LC, Hynes M, Raisman G, Pachnis V: Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system. Development 1999;126:2785-2797.
28. Heuckeroth RO, Lampe PA, Johnson EM, Milbrandt J: Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro. Dev Biol 1998;200: 116-129.
29. Iwashita T, Kruger GM, Pardal R, Kiel MJ, Morrison SJ: Hirschsprung disease is linked to defects in neural crest stem cell function. Science 2003;301:972-976.
30. Bondurand N, Natarajan D, Barlow A, Thapar N, Pachnis V: Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling. Development 2006;133:2075-2086.
31. Puffenberger EG, Hosoda K, Washington SS, Nakao K, deWit D, Yanagisawa M, Chakravarti A: A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell 1994;79:1257-1266.
32. Baynash AG, Hosoda K, Giaid A, Richardson JA, Emoto N, Hammer RE, Yanagisawa M: Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell 1994;79:1277-1285.
33. Wurdak H, Ittner LM, Lang KS, Leveen P, Suter U, Fischer JA, Karlsson S, Born W, Sommer L: Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes Dev 2005;19:530-535.
34. Ittner LM, Wurdak H, Schwerdtfeger K, Kunz T, Ille F, Leveen P, Hjalt TA, Suter U, Karlsson S, Hafezi F, Born W, Sommer L: Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells. J Biol 2005;4:11.
35. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003;100:3983-3988.
36. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD, Dirks PB: Identification of human brain tumour initiating cells. Nature 2004;432:396-401.
37. Bonnet D, Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730-737.
38. Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri MA, Dick JE: A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994;367:645-648.
39. Bjerkvig R, Tysnes BB, Aboody KS, Najbauer J, Terzis AJ: Opinion: the origin of the cancer stem cell: current controversies and new insights. Nat Rev Cancer 2005;5:899-904.
40. Fang D, Nguyen TK, Leishear K, Finko R, Kulp AN, Hotz S, Van Belle PA, Xu X, Elder DE, Herlyn M: A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res 2005;65:9328-9337.
41. Kulesa PM, Kasemeier-Kulesa JC, Teddy JM, Margaryan NV, Seftor EA, Seftor RE, Hendrix MJ: Reprogramming metastatic melanoma cells to assume a neural crest cell-like phenotype in an embryonic microenvironment. Proc Natl Acad Sci USA 2006;103:3752-3757.
42. Walton JD, Kattan DR, Thomas SK, Spengler BA, Guo HF, Biedler JL, Cheung NK, Ross RA: Characteristics of stem cells from human neuroblastoma cell lines and in tumors. Neoplasia 2004;6:838-845.
43. Hirschmann-Jax C, Foster AE, Wulf GG, Nuchtern JG, Jax TW, Gobel U, Goodell MA, Brenner MK: A distinct 'side population' of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci USA 2004;101:14228-14233.