Combined stimulation with the T helper cell type 2 cytokines interleukin (IL)-4 and IL-10 induces mouse mast cell apoptosis

Journal of Experimental Medicine

Volumn 192, Issue 8, 2000, Pages 1093-1103

  Yeatman II, C Fitzhugh ^a   Jacobs Helber, Sarah M ^a   Mirmonsef, Paria ^a   Gillespie, Sheila R ^a   Bouton, Lawrence Andrew ^a   Collins, Henrietta A ^a   Sawyer, Stephen T ^a   Shelburne, Christopher P ^a   Ryan, John J ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Allergy; Apoptosis; Interleukin 10; Interleukin 4; Mast cells

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN E ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 3; INTERLEUKIN 4; PROTEIN BCL 2; PROTEIN BCL X; STAT6 PROTEIN; STEM CELL FACTOR;

ALLERGY; ANIMAL CELL; ANTIGEN ANTIBODY REACTION; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CROSS LINKING; DNA CONTENT; HELPER CELL; HOMEOSTASIS; MAST CELL; MAST CELL DEGRANULATION; MASTOCYTOMA; MOUSE; NONHUMAN; PERITONEUM MAST CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANNEXIN A5; APOPTOSIS; BONE MARROW CELLS; CELLS, CULTURED; FLOW CYTOMETRY; INTERLEUKIN-10; INTERLEUKIN-3; INTERLEUKIN-4; KINETICS; MAST CELLS; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; RECOMBINANT PROTEINS; STEM CELL FACTOR; TH2 CELLS;

EID: 0034676086     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.8.1093     Document Type: Article

References (36)

1. Biology of mast cells and basophils
2. The human IgE network
3. Interleukin-4: A prototypic immunoregulatory lymphokine
4. T-cell and mast cell lines respond to B-cell stimulatory factor 1
5. Interleukin-4 is an essential factor for in vitro clonal growth of murine connective tissue mast cells
6. Interleukin 10: A novel stimulatory factor for mast cells and their progenitors
7. Cofactors are essential for stem cell factor-dependent growth and maturation of mast cell progenitors: Comparative effects of interleukin-3 (IL-3), IL-4, IL-10, and fibroblasts
8. IL-4 inhibits mouse mast cell FcεRI expression through a STAT6-dependent mechanism
9. Inhibition of Kit expression by IL-4 and IL-10 in murine mast cells: Role of STAT6 and phosphatidylinositol 3'-kinase
10. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
11. Fas (CD95 APO-1) antigen expression and function in murine mast cells
12. Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis
13. Fas ligand (FasL, CD95L, APO-1L) expression in murine mast cells
14. The Bcl-2 protein family: Arbiters of cell survival
15. The IL-4 receptor: Signaling mechanisms and biological functions
16. IL-4 enhances programmed cell death in stimulated human monocytes
17. Interleukin-4 induces programmed cell death (apoptosis) in cases of high-risk acute lymphoblastic leukemia
18. Absence of exogenous interleukin-4-induced apoptosis of gingival macrophages may contribute to chronic inflammation in periodontal diseases
19. Interleukin-4 inhibits growth and induces apoptosis in human breast cancer cells
20. IL-4-induced apoptosis in peripheral blood eosinophils
21. IL-10 enhances resolution of pulmonary inflammation in vivo by promoting apoptosis of neutrophils
22. The role of IL-10 in human B cell activation, proliferation, and differentiation
23. Cytometry in cell necrobiology: Analysis of apoptosis and accidental cell death (necrosis)
24. Recombinant human (rh)IL-4-mediated apoptosis and rhIL-6-mediated protection of rh-stem cell factor-dependent human mast cells derived from cord blood mononuclear cell progenitors
25. Bcl-x protects primary B cells against Fas-mediated apoptosis
26. Effect of bcl-2 on Fas antigen-mediated cell death
27. Immunologically-mediated intestinal mastocytosis in Nippopstrongylus brasiliensis-infected rats
28. Eosinophilia in antigen-induced airways inflammation
29. Effects of the T-helper 2-type cytokines, interleukin-3 (IL-3), IL-4, IL-5, and IL-6 on the survival of cultured human mast cells
30. IL-13, IL-4Rα, and STAT6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
31. Surface and gene expression of immunoglobulin E receptors on mast cells and mast cell numbers in interleukin-4-gene knockout mice
32. A survey of the number and distribution of mast cells in the skin of patients with mast cell disorders
33. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with associated hematologic disorder
34. Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P815 generated by a point mutation
35. Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1
36. Activated mast cells produce interleukin 13