C5aR-mediated myocardial ischemia/reperfusion injury

Biochemical and Biophysical Research Communications

Volumn 357, Issue 2, 2007, Pages 446-452

  Zhang, Haimou ^a   Qin, Gangjian ^b   Liang, Gang ^c   Li, Jinan ^d   Barrington, Robert A ^d   Liu, Dong xu ^a  

^a HUBEI UNIVERSITY   (China)

^b NORTHWESTERN UNIVERSITY   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

C5aR; Complement; Ischemia reperfusion; Myocardial cell; Signaling

Indexed keywords

COMPLEMENT COMPONENT C5A RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; PROTEIN; PROTEIN KINASE C DELTA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; ENDOTHELIUM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; HEART INFARCTION SIZE; HEART MUSCLE; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; IN VIVO STUDY; LEUKOCYTE ADHERENCE; MALE; MICROVASCULARIZATION; MOUSE; NONHUMAN; PATHOGENESIS; PERMEABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; RECEPTOR UPREGULATION;

ANIMALS; CAPILLARY PERMEABILITY; CELLS, CULTURED; DISEASE MODELS, ANIMAL; INFLAMMATION MEDIATORS; MALE; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MYOCYTES, CARDIAC; RECEPTORS, COMPLEMENT; REPERFUSION INJURY;

MUS;

EID: 34247097120     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.03.152     Document Type: Article

References (34)

1. Entman M.L., Michael L., Rossen R.D., Dreyer W.J., Anderson D.C., Taylor A.A., and Smith C.W. Inflammation in the course of early myocardial ischemia. FASEB J. 5 (1991) 2529-2537
2. Maroko P.R., Carpenter C.B., Chiariello M., Fishbein M.C., Radvany P., Knostman J.D., and Hale S.L. Reduction by cobra venom factor of myocardial necrosis after coronary artery occlusion. J. Clin. Invest. 61 (1978) 661-670
3. Weiser M.R., Williams J.P., Moore Jr. F.D., Kobzik L., Ma M., Hechtman H.B., and Carroll M.C. Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement. J. Exp. Med. 183 (1996) 2343-2348
4. Amsterdam E.A., Stahl G.L., Pan H.L., Rendig S.V., Fletcher M.P., and Longhurst J.C. Limitation of reperfusion injury by a monoclonal antibody to C5a during myocardial infarction in pigs. Am. J. Physiol. 268 (1995) H448-H457
5. Gerard N.P., and Gerard C. The chemotactic receptor for human C5a anaphylatoxin. Nature 349 (1991) 614-617
6. Buhl A.M., Avdi N., Worthen G.S., and Johnson G.L. Mapping of the C5a receptor signal transduction network in human neutrophils. Proc. Natl. Acad. Sci. USA 91 (1994) 9190-9194
7. Buhl A.M., Osawa S., and Johnson G.L. Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor. J. Biol. Chem. 270 (1995) 19828-19832
8. Czermak B.J., Sarma V., Pierson C.L., Warner R.L., Huber-Lang M., Bless N.M., Schmal H., Friedl H.P., and Ward P.A. Protective effects of C5a blockade in sepsis. Nat. Med. 5 (1999) 788-792
9. De Vries B., Matthijsen R.A., Wolfs T.G., Van Bijnen A.A., Heeringa P., and Buurman W.A. Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury: inhibition of late apoptosis and inflammation. Transplantation 75 (2003) 375-382
10. Heller T., Hennecke M., Baumann U., Gessner J.E., zu Vilsendorf A.M., Baensch M., Boulay F., Kola A., Klos A., Bautsch W., and Kohl J. Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury. J. Immunol. 163 (1999) 985-994
11. Huber-Lang M.S., Riedeman N.C., Sarma J.V., Younkin E.M., McGuire S.R., Laudes I.J., Lu K.T., Guo R.F., Neff T.A., Padgaonkar V.A., Lambris J.D., Spruce L., Mastellos D., Zetoune F.S., and Ward P.A. Protection of innate immunity by C5aR antagonist in septic mice. FASEB J. 16 (2002) 1567-1574
12. Short A., Wong A.K., Finch A.M., Haaima G., Shiels I.A., Fairlie D.P., and Taylor S.M. Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat. Br. J. Pharmacol. 126 (1999) 551-554
13. Amsterdam E.A., Rendig S.V., and Longhurst J.C. Contractile actions of C5a on isolated porcine myocardium. Am. J. Physiol. 263 (1992) H740-H745
14. Vakeva A.P., Agah A., Rollins S.A., Matis L.A., Li L., and Stahl G.L. Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy. Circulation 97 (1998) 2259-2267
15. Gerard C., and Gerard N.P. C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 12 (1994) 775-808
16. Morgan E.L., Ember J.A., Sanderson S.D., Scholz W., Buchner R., Ye R.D., and Hugli T.E. Anti-C5a receptor antibodies. Characterization of neutralizing antibodies specific for a peptide, C5aR-(9-29), derived from the predicted amino-terminal sequence of the human C5a receptor. J. Immunol. 151 (1993) 377-388
17. Hutchison A.J., and Krause J.E. The discovery of small molecule C5a antagonists. Annu. Rep. Med. Chem. 39 (2004) 139-147
18. Sumichika H., Sakata K., Sato N., Takeshita S., Ishibuchi S., Nakamura M., Kamahori T., Ehara S., Itoh K., Ohtsuka T., Ohbora T., Mishina T., Komatsu H., and Naka Y. Identification of a potent and orally active non-peptide C5a receptor antagonist. J. Biol. Chem. 277 (2002) 49403-49407
19. Wong A.K., Finch A.M., Pierens G.K., Craik D.J., Taylor S.M., and Fairlie D.P. Small molecular probes for G-protein-coupled C5a receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a. J. Med. Chem. 41 (1998) 3417-3425
20. Arumugam T.V., Shiels I.A., Woodruff T.M., Reid R.C., Fairlie D.P., and Taylor S.M. Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine. J. Surg. Res. 103 (2002) 260-267
21. Arumugam T.V., Woodruff T.M., Stocks S.Z., Proctor L.M., Pollitt S., Shiels I.A., Reid R.C., Fairlie D.P., and Taylor S.M. Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. J. Hepatol. 40 (2004) 934-941
22. Woodruff T.M., Arumugam T.V., Shiels I.A., Reid R.C., Fairlie D.P., and Taylor S.M. Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats. J. Surg. Res. 116 (2004) 81-90
23. Riley R.D., Sato H., Zhao Z.Q., Thourani V.H., Jordan J.E., Fernandez A.X., Ma X.L., Hite D.R., Rigel D.F., Pellas T.C., Peppard J., Bill K.A., Lappe R.W., and Vinten-Johansen J. Recombinant human complement C5a receptor antagonist reduces infarct size after surgical revascularization. J. Thorac. Cardiovasc. Surg. 120 (2000) 350-358
24. Laudes I.J., Chu J.C., Huber-Lang M., Guo R.F., Riedemann N.C., Sarma J.V., Mahdi F., Murphy H.S., Speyer C., Lu K.T., Lambris J.D., Zetoune F.S., and Ward P.A. Expression and function of C5a receptor in mouse microvascular endothelial cells. J. Immunol. 169 (2002) 5962-5970
25. Albrecht E.A., Chinnaiyan A.M., Varambally S., Kumar-Sinha C., Barrette T.R., Sarma J.V., and Ward P.A. C5a-induced gene expression in human umbilical vein endothelial cells. Am. J. Pathol. 164 (2004) 849-859
26. Granger D.N., Benoit J.N., Suzuki M., and Grisham M.B. Leukocyte adherence to venular endothelium during ischemia-reperfusion. Am. J. Physiol. 257 (1989) G683-G688
27. Tofukuji M., Stahl G.L., Agah A., Metais C., Simons M., and Sellke F.W. Anti-C5a monoclonal antibody reduces cardiopulmonary bypass and cardioplegia-induced coronary endothelial dysfunction. J. Thorac. Cardiovasc. Surg. 116 (1998) 1060-1068
28. Engler R.L., Roth D.M., del Balzo U., and Ito B.R. Intracoronary C5a induces myocardial ischemia by mechanisms independent of the neutrophil: leukocyte filters desensitize the myocardium to C5a. FASEB J. 5 (1991) 2983-2991
29. Jordan J.E., Zhao Z.Q., and Vinten-Johansen J. The role of neutrophils in myocardial ischemia-reperfusion injury. Cardiovasc. Res. 43 (1999) 860-878
30. Pellas T.C., Boyar W., van Oostrum J., Wasvary J., Fryer L.R., Pastor G., Sills M., Braunwalder A., Yarwood D.R., Kramer R., Kimble E., Hadala J., Haston W., Moreira-Ludewig R., Uziel-Fusi S., Peters P., Bill K., and Wennogle L.P. Novel C5a receptor antagonists regulate neutrophil functions in vitro and in vivo. J. Immunol. 160 (1998) 5616-5621
31. Norgauer J., Dobos G., Kownatzki E., Dahinden C., Burger R., Kupper R., and Gierschik P. Complement fragment C3a stimulates Ca2+ influx in neutrophils via a pertussis-toxin-sensitive G protein. Eur. J. Biochem. 217 (1993) 289-294
32. Rollins T.E., Siciliano S., Kobayashi S., Cianciarulo D.N., Bonilla-Argudo V., Collier K., and Springer M.S. Purification of the active C5a receptor from human polymorphonuclear leukocytes as a receptor-Gi complex. Proc. Natl. Acad. Sci. USA 88 (1991) 971-975
33. Ping P., Zhang J., Cao X., Li R.C., Kong D., Tang X.L., Qiu Y., Manchikalapudi S., Auchampach J.A., Black R.G., and Bolli R. PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits. Am. J. Physiol. 276 (1999) H1468-H1481
34. Simon H.U. Neutrophil apoptosis pathways and their modifications in inflammation. Immunol. Rev. 193 (2003) 101-1010