Effect of CCK-1 receptor blockade on ghrelin and PYY secretion in men

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 292, Issue 4, 2007, Pages

  Degen, Lukas ^a   Drewe, Juergen ^a   Piccoli, Franziska ^a   Gräni, Karin ^a   Oesch, Sibylle ^a   Bunea, Raluca ^a   D'Amato, Massimo ^b   Beglinger, Christoph ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b Rotta Pharma Spa   (Italy)

Author keywords

Cholecystokinin; Peptide YY

Indexed keywords

CHOLECYSTOKININ A RECEPTOR; DEXLOX; DEXLOXIGLUMIDE; GHRELIN; LONG CHAIN FATTY ACID; MEDIUM CHAIN FATTY ACID; PEPTIDE YY; TETRAHYDROLIPSTATIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; FAT INTAKE; HORMONE BLOOD LEVEL; HORMONE INHIBITION; HORMONE RELEASE; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; CHOLECYSTOKININ; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENZYME INHIBITORS; FATTY ACIDS; HUMANS; INFUSIONS, INTRAVENOUS; LACTONES; LIPASE; MALE; OCTANOIC ACIDS; OLEIC ACID; PENTANOIC ACIDS; PEPTIDE HORMONES; PEPTIDE YY; PLANT OILS; RECEPTORS, CHOLECYSTOKININ; TIME FACTORS;

EID: 34147178061     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00734.2006     Document Type: Article

References (37)

1. Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 89: 1070-1077, 1985.
2. Aponte GW, Fink AS, Meyer JH, Tatemoto K, Taylor IL. Regional distribution and release of peptide YY with fatty acids of different chain length. Am J Physiol Gastrointest Liver Physiol 249: G745-G750, 1985.
3. Aponte GW, Park K, Hess R, Garcia R, Taylor IL. Meal-induced peptide tyrosine inhibition of pancreatic secretion in the rat. FASEB J 3: 1949-1955, 1989.
4. Batterham RL, Cohen MA, Ellis SM, La Roux CW, Withers DJ, Frost GS, Ghatei MA, Bloom SR. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 349: 941-948, 2003.
5. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Bloom SR. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418: 650-654, 2002.
6. Cantor P, Mortensen PE, Myhre J, Gjorup I, Worning H, Stahl E, Survill TT. The effect of the cholecystokinin receptor antagonist MK-329 on meal-stimulated pancreaticobiliary output in humans. Gastroenterology 102: 1742-1751, 1992.
7. Cox JE, Kelm GR, Meller ST, Randich A. Suppression of food intake by GI fatty acid infusions: roles of celiac vagal afferents and cholecystokinin. Physiol Behav 82: 27-33, 2004.
8. Cuche G, Blat S, Malbert CH. Desensitization of ileal vagal receptors by short-chain fatty acids in pigs. Am J Physiol Gastrointest Liver Physiol 280: G1013-G1021, 2001.
9. Cummings DE, Frayo RS, Marmonier C, Aubert R, Chapelot D. Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am J Physiol Endocrinol Metab 287: E297-E304, 2004.
10. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50: 1714-1719, 2001.
11. Cummings DE, Shannon MH. Roles for ghrelin in the regulation of appetite and body weight. Arch Surg 138: 389-396, 2003.
12. Erdmann J, Lippl F, Schusdziarra V. Differential effect of protein and fat on plasma ghrelin levels in man. Regul Pept 116: 101-107, 2003.
13. Feinle-Bisset C, O'Donovan D, Doran S, Andrews JM, Wishart J, Chapman I, Horowitz M. Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans. Am J Physiol Gastrointest Liver Physiol 284: G798-G807, 2003.
14. Feinle-Bisset C, Patterson M, Ghatei MA, Bloom SR, Horowitz M. Fat digestion is required for suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide secretion by intraduodenal lipid. Am J Physiol Endocrinol Metab 289: E948-E953, 2005.
15. Feltrin KL, Patterson M, Ghatei MA, Bloom SR, Meyer JH, Horowitz M, Feinle-Bisset C. Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men. Peptides 27: 1638-1643, 2006.
16. Guimbaud R, Moreau JA, Bouisson M, Durand S, Escourrou J, Vaysse N, Frexinos J. Intraduodenal free fatty acids rather than triglycerides are responsible for the release of CCK in humans. Pancreas 14: 76-82, 1997.
17. Gutzwiller JP, Degen L, Matzinger D, Prestin S, Beglinger C. Interaction between GLP-1 and CCK-33 in inhibiting food intake and appetite in men. Am J Physiol Regul Integr Comp Physiol 287: R562-R567, 2004.
18. Gutzwiller JP, Drewe J, Goke B, Schmidt H, Rohrer B, Lareida J, Beglinger C. Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2. Am J Physiol Regul Integr Comp Physiol 276: R1541-R1544, 1999.
19. Gutzwiller JP, Drewe J, Ketterer S, Hildebrand P, Krautheim A, Beglinger C. Interaction between CCK and a preload on reduction of food intake is mediated by CCK-A receptors in humans. Am J Physiol Regul Integr Comp Physiol 279: R189-R195, 2000.
20. Hildebrand P, Beglinger C, Gyr K, Jansen JB, Rovati LC, Zuercher M, Lamers CB, Setnikar I, Stalder GA. Effects of a cholecystokinin receptor antagonist on intestinal phase of pancreatic and biliary responses in man. J Clin Invest 85: 640-646, 1990.
21. Hildebrand P, Petrig C, Burckhardt B, Ketterer S, Lengsfeld H, Fleury A, Hadvary P, Beglinger C. Hydrolysis of dietary fat by pancreatic lipase stimulates cholecystokinin release. Gastroenterology 114: 123-129, 1998.
22. Kissileff HR, Pi-Sunyer FX, Thornton J, Smith GP. C-terminal octapeptide of cholecystokinin decreases food intake in man. Am J Clin Nutr 34: 154-160, 1981.
23. Lal S, Kirkup AJ, Brunsden AM, Thompson DG, Grundy D. Vagal afferent responses to fatty acids of different chain length in the rat. Am J Physiol Gastrointest Liver Physiol 281: G907-G915, 2001.
24. Layer P, Holst JJ, Grandt D, Goebell H. Ileal release of glucagon-like peptide-1 (GLP-1). Association with inhibition of gastric acid secretion in humans. Dig Dis Sci 40: 1074-1082, 1995.
25. Leonhardt M, Hrupka BJ, Langhans W. Subdiaphragmatic vagal deaf-ferentation fails to block the anorectic effect of hydroxycitrate. Physiol Behav 82: 263-268, 2004.
26. Liddle RA, Gertz BJ, Kanayama S, Beccaria L, Coker LD, Turnbull TA, Morita ET. Effects of a novel cholecystokinin (CCK) receptor antagonist, MK-329, on gallbladder contraction and gastric emptying in humans. Implications for the physiology of CCK. J Clin Invest 84: 1220-1225, 1989.
27. Lin HC, Chey WY. Cholecystokinin and peptide YY are released by fat in either the proximal or distal small intestine in dogs. Regul Pept 114: 131-135, 2003.
28. Lin HC, Zhao XT, Wang L, Wong H. Fat-induced ileal brake in the dog depends on peptide YY. Gastroenterology 110: 1491-1495, 1996.
29. Matzinger D, Degen L, Drewe J, Meuli J, Duebendorfer R, Ruckstuhl N, D'Amato M, Rovati L, Beglinger C. The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans. Gut 46: 688-693, 2000.
30. Matzinger D, Gutzwiller JP, Drewe J, Orban A, Engel R, D'Amato M, Rovati L, Beglinger C. Inhibition of food intake in response to intestinal lipid is mediated by cholecystokinin in humans. Am J Physiol Regul Integr Comp Physiol 277: R1718-R1724, 1999.
31. McLaughlin J, Grazia Lucà M, Jones MN, D'Amato M, Dockray GJ, Thompson DG. Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility. Gastroenterology 116: 46-53, 1999.
32. Peter SA, D'Amato M, Beglinger C. CCK1 antagonists: are they ready for clinical use? Dig Dis 24: 70-82, 2006.
33. Randich A, Tyler WJ, Cox JE, Meller ST, Kelm GR, Bharaj SS. Responses of celiac and cervical vagal afferents to infusions of lipids in the jejunum or ileum of the rat. Am J Physiol Regul Integr Comp Physiol 278: R34-R43, 2000.
34. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 404: 661-671, 2000.
35. Strader AD, Woods SC. Gastrointestinal hormones and food intake. Gastroenterology 128: 175-191, 2005.
36. Woods SC, Seeley RJ, Porte D Jr, Schwartz MW. Signals that regulate food intake and energy homeostasis. Science 280: 1378-1383, 1998.
37. Zhao XT, Walsh JH, Wong H, Wang L, Lin HC. Intestinal fat-induced inhibition of meal-stimulated gastric acid secretion depends on CCK but not peptide YY. Am J Physiol Gastrointest Liver Physiol 276: G550-G555, 1999.