CEBPβ, JunD and c-Jun contribute to the transcriptional activation of the metastasis-associated C4.4A gene

International Journal of Cancer

Volumn 120, Issue 10, 2007, Pages 2135-2147

  Fries, Frank ^a   Nazarenko, Irina ^a   Hess, Jochen ^a   Claas, Andreas ^a,c   Angel, Peter ^a   Zöller, Margot ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF KARLSRUHE   (Germany)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

ChIP assay; Gene expression; Promoter analysis; Tumor progression

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; MESSENGER RNA; TRANSCRIPTION FACTOR JUND; TRANSCRIPTION FACTOR SP3; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY C4.4A; PROTEIN C JUN; SP3 PROTEIN, RAT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; C4.4A GENE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GC RICH SEQUENCE; GENE CONSTRUCT; GENE DELETION; GENE MUTATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; METASTASIS; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE C JUN; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; RAT; TRANSCRIPTION INITIATION; UPREGULATION; WOUND HEALING; ANIMAL; BIOSYNTHESIS; EXPERIMENTAL NEOPLASM; GENETICS; METABOLISM; MOLECULAR GENETICS; ONCOGENE; PATHOLOGY; TRANSACTIVATION; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL LINE, TUMOR; GENES, JUN; MOLECULAR SEQUENCE DATA; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-JUN; RATS; SP3 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 34147176985     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.22447     Document Type: Article

References (65)

1. Rösel M, Claas C, Seiter S, Herlevsen M, Zöller M. Cloning and functional characterization of a new phosphatidyl-inositol anchored molecule of a metastasizing rat pancreatic tumor. Oncogene 1998;17: 1989-2002.
2. Friedman S, Palfree RG, Sirlin S, Hammerling U. Analysis of three distinct Ly6-A-related cDNA sequences isolated from rat kidney. Immunogenetics 1990;31:104-11.
3. Ploug M, Ellis V. Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom α-neurotoxins. FEBS Lett 1994; 349:163-8.
4. Spivak JL, Barosi G, Tognoni G, Barbui T, Finazzi G, Marchioli R, Marchetti M. Chronic myeloproliferative disorders. Hematology 2003;200-4.
5. Behrendt N, Ronne E, Dano K. The structure and function of the urokinase receptor a membrane protein governing plasminogen activation on the cell surface. Biol Chem Hoppe Seyler 1995;376:269-79.
6. Behrendt N. The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling. Biol Chem 2004;385:103-36.
7. Mondino A, Resnati M, Blasi F. Structure and function of the urokinase receptor. Thromb Haemost 1999;82:19-22.
8. Seiter S, Stassar M, Rappl G, Reinhold U, Tilgen W, Zöller M. Upregulation of C4.4A expression during progression of melanoma. J Invest Dermatol 2001;116:344-7.
9. Smith BA, Kennedy WJ, Harnden P, Selby PJ, Trejdosiewicz LK, Southgate J. Identification of genes involved in human urothelial cell-matrix interactions: implications for the progression pathways of malignant urothelium. Cancer Res 2001;61:1678-85.
10. Würfel J, Rösel M, Seiter S, Claas C, Herlevsen M, Weth R, Zöller M. Cloning of the human homologue of the metastasis-associated rat C4.4A. Gene 2001;262:35-41.
11. Fletcher GC, Patel S, Tyson K, Adam PJ, Schenker M, Loader JA, Daviet L, Legrain P, Parekh R, Harris AL, Terrett JA. hAG-2 and hAG-3 human homologues of genes involved in differentiation are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. Br J Cancer 2003; 88:579-85.
12. Hansen LV, Gardsvoll H, Nielsen BS, Lund LR, Dano K, Jensen ON, Ploug M. Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor. Biochem J 2004;380: 845-57.
13. Claas C, Herrmann K, Matzku S, Möller P, Zöller M. Developmentally regulated expression of metastasis-associated antigens in the rat. Cell Growth Differ 1996;7:663-78.
14. Paret C, Bourouba M, Beer A, Miyazaki K, Schnölzer M, Fiedler S, Zoller M. Ly6 family member C4.4A binds laminins 1 and 5 associates with galectin-3 and supports cell migration. Int J Cancer 2005; 115:724-33.
15. Opdenakker G, Van Damme J. Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer. Cytokine 1992;4:251-8.
16. Curran S, Murray GI. Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis. Eur J Cancer 2000;36: 1621-30.
17. Stamenkovic I. Extracellular matrix remodelling: the role of matrix metalloproteinases. J Pathol 2003;200:448-64.
18. Lund LR, Ellis V, Ronne E, Pyke C, Dano K. Transcriptional and post-transcriptional regulation of the receptor for urokinase-type plasminogen activator by cytokines and tumour promoters in the human lung carcinoma cell line A549. Biochem J 1995;310:345-52.
19. Soravia E, Grebe A, De Luca P, Helin K, Suh TT, Degen JL, Blasi F. A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene. Blood 1995;86:624-35.
20. Dang J, Boyd D, Wang H, Allgayer H, Doe WF, Wang Y. A region between -141 and -61 bp containing a proximal AP-1 is essential for constitutive expression of urokinase-type plasminogen activator receptor. Eur J Biochem 1999;264:92-9.
21. Park IK, Lyu MA, Yeo SJ, Han TH, Kook YH. Sp1 mediates constitutive and transforming growth factor β-inducible expression of urokinase type plasminogen activator receptor gene in human monocyte-like U937 cells. Biochim Biophys Acta 2000;1490:302-10.
22. Okan E, Drewett V, Shaw PE, Jones P. The small-GTPase RalA activates transcription of the urokinase plasminogen activator receptor (uPAR) gene via an AP1-dependent mechanism. Oncogene 2001;20: 1816-24.
23. Milde-Langosch K, Roder H, Andritzky B, Asian B, Hemminger G, Brinkmann A, Bamberger CM, Loning T, Bamberger AM. The role of the AP-1 transcription factors c-Fos, FosB, Fra-1 and Fra-2 in the invasion process of mammary carcinomas. Breast Cancer Res Treat 2004;86:139-52.
24. Trisciuoglio D, Iervolino A, Candiloro A, Fibbi G, Fanciulli M, Zangemeister-Wittke U, Zupi G, Del Bufalo D. bcl-2 Induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: involvement of ERK1/ERK2 activity. J Biol Chem 2004;279:6737-45.
25. Matzku S, Komitowski D, Mildenberger M, Zöller M. Characterization of BSp73 a spontaneous rat tumor and its in vivo selected variants showing different metastasizing capacities. Invasion Metastasis 1983; 3:109-23.
26. Martin F, Caignard A, Jeannin JF, Leclerc A, Martin M. Selection by trypsin of two sublines of rat colon cancer cells forming progressive or regressive tumors. Int J Cancer 1983;32:623-7.
27. Matzku S, Wenzel A, Liu S, Zöller M. Antigenic differences between metastatic and nonmetastatic BSp73 rat tumor variants characterized by monoclonal antibodies. Cancer Res 1989;49:1294-9.
28. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
29. Woon PY, Osoegawa K, Kaisaki PJ, Zhao B, Catanese JJ, Gauguier D, Cox R, Levy ER, Lathrop GM, Monaco AP, de Jong PJ. Construction and characterization of a 10-fold genome equivalent rat P1-derived artificial chromosome library. Genomics 1998;50: 306-16.
30. Amoureux MC, Wurch T, Pauwels PJ. Expression of human metallothionein-III confers protection against serum-free exposure of stably transfected Chinese hamster ovary CHO-K1. cells. Neurosci Lett 1995; 201:61-4.
31. Robbins M, McKinney M. Transcriptional regulation of neuromodulin (GAP-43) in mouse neuroblastoma clone N1E-115 as evaluated by the RT/PCR method. Mol Brain Res 1992;13:83-92.
32. Luckow B, Schütz G. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res 1987;15:5490.
33. Burger HJ, Schuetz JD, Schuetz EG, Guzelian PS. Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 α-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. Proc Natl Acad Sci USA 1992;89:2145-9.
34. Chiu R, Angel P, Karin M. Jun-B differs in its biological properties from and is a negative regulator of c-Jun. Cell 1989;59:979-86.
35. Kovary K, Bravo R. The jun and fos protein families are both required for cell cycle progression in fibroblasts. Mol Cell Biol 1991;11: 2451-9.
36. Akira S, Isshiki H, Sugita T, Tanabe O, Kinoshita S, Nishio Y, Nakajima T, Hirano T, Kishimoto T. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J 1990;9:1897-1906.
37. Li-Weber M, Giaisi M, Krammer PH. Roles of CCAAT/enhancer-binding protein in transcriptional regulation of the human IL-5 gene. Eur J Immunol 2001;31:3694-703.
38. Majello B, De Luca P, Hagen G, Suske G, Lania L. Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1. Nucleic Acids Res 1994; 22:4914-21.
39. Kingsley C, Winoto A. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol Cell Biol 1992;12:4251-61.
40. Hagen G, Mullet S, Beato M, Suske G. Sp1-mediated transcriptional activation is repressed by Sp3. EMBO J 1994;13:3843-51.
41. Gorman CM, Moffat LF, Howard BH. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol 1982;2:1044-51.
42. Larson DE, Zahradka P, Stein G, Stein J, Sells BH. Down-regulation of histone H3 and H4 gene transcription in differentiated L6 myotubes. Biochim Biophys Acta 1989;1009:177-83.
43. Porte D, Tuckermann J, Becker M, Baumann B, Teurich S, Higgins T, Owen MJ, Schorpp-Kistner M, Angel P. Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone. Oncogene 1999;18:667-78.
44. Kroft TL, Jethanandani P, McLean DJ, Goldberg E. Methylation of CpG dinucleotides alters binding and silences testis-specific transcription directed by the mouse lactate dehydrogenase C promoter. Biol Reprod 2001;65:1522-7.
45. Rickert AM, Ballvora A, Matzner U, Klemm M, Gebhardt C. Quantitative genotyping of single-nucleotide polymorphisms by allele-specific oligonucleotide hybridization on DNA microarrays. Biotechnol Appl Biochem 2005;42:93-6.
46. Nepveu A. Role of the multifunctional CDP/Cut/Cux homeodomain transcription factor in regulating differentiation cell growth and development. Gene 2001;270:1-15.
47. Stallcup MR, Kim JH, Teyssier C, Lee YH, Ma H, Chen D. The roles of protein-protein interactions and protein methylation in transcriptional activation by nuclear receptors and their coactivators. J Steroid Biochem Mol Biol 2003;85:139-45.
48. Huang JH, Liao WS. Induction of the mouse serum amyloid A3 gene by cytokines requires both C/EBP family proteins and a novel constitutive nuclear factor. Mol Cell Biol 1994;14:4475-84.
49. Chun KS, Surh YJ. Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. Biochem Pharmacol 2004;68:1089-100.
50. Shen CN, Slack JM, Tosh D. Molecular basis of transdifferentiation of pancreas to liver. Nat Cell Biol 2000;2:879-87.
51. Jin L, Yang GY, Auborn K. Differences in C/EBPs in normal tissue and papillomas of the larynx. Cell Prolif 1998;31:127-38.
52. Oh HS, Smart RC. On the effect of estrogen receptor agonists and antagonists on the mouse hair follicle cycle. J Invest Dermatol 1998;110:939-45.
53. Maytin EV, Lin JC, Krishnamurthy R, Batchvarova N, Ron D, Mitchell PJ, Habener JF. Keratin 10 gene expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2. Dev Biol 1999;216:164-81.
54. Ondrey FG, Dong G, Sunwoo J, Chen Z, Wolf JS, Crowl-Bancroft CV, Mukaida N, Van Waes C. Constitutive activation of transcription factors NF-(κ)B AP-1 and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines. Mol Carcinog 1999;26:119-29.
55. Zhu S, Oh HS, Shim M, Sterneck E, Johnson PF, Smart RC. C/EBPβ modulates the early events of keratinocyte differentiation involving growth arrest and keratin 1 and keratin 10 expression. Mol Cell Biol 1999;19:7181-90.
56. Hsu W, Kerppola TK, Chen PL, Curran T, Chen-Kiang S. Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region. Mol Cell Biol 1994;14:268-76.
57. Komine M, Rao LS, Kaneko T, Tomic-Canic M, Tamaki K, Freedberg IM, Blumenberg M. Inflammatory versus proliferative processes in epidermis. Tumor necrosis factor α induces K6b keratin synthesis through a transcriptional complex containing NFκ B and C/EBPβ. J Biol Chem 2000;275:32077-88.
58. Li-Weber M, Salgame P, Hu C, Davydov IV, Krammer PH. Differential interaction of nuclear factors with the PRE-I enhancer element of the human IL-4 promoter in different T cell subsets. J Immunol 1997; 158:1194-200.
59. Lopez-Rodriguez C, Botella L, Corbi AL. CCAAT-enhancer-binding proteins (C/EBP) regulate the tissue specific activity of the CD11c integrin gene promoter through functional interactions with Sp1 proteins. J Biol Chem 1997;272:29120-6.
60. Zagariya A, Mungre S, Lovis R, Birrer M, Ness S, Thimmapaya B, Pope R. Tumor necrosis factor a gene regulation: enhancement of C/ EBPβ-induced activation by c-Jun. Mol Cell Biol 1998;18:2815-24.
61. Suske G. The Sp-family of transcription factors. Gene 1999;238:291-300.
62. Hughes TR, Tengku-Muhammad TS, Irvine SA, Ramji DP. A novel role of Sp1 and Sp3 in the interferon-γ-mediated suppression of macrophage lipoprotein lipase gene transcription. J Biol Chem 2002;277: 11097-106.
63. Le Mee S, Fromigue O, Marie PJ. Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts. Exp Cell Res 2005;302:129-42.
64. Liu S, Shapiro RA, Nie S, Zhu D, Vodovotz Y, Billiar TR. Characterization of rat CD 14 promoter and its regulation by transcription factors AP1 and Sp family proteins in hepatocytes. Gene 2000;250:137-47.
65. 2 cells. Oncogene 2004;23:2454-64.