Spinal prostaglandins facilitate exaggerated A- and C-fiber-mediated reflex responses and are critical to the development of allodynia early after L5-L6 spinal nerve ligation

Anesthesiology

Volumn 106, Issue 4, 2007, Pages 795-805

  O'Rielly, Darren D ^b   Loomis, Christopher W ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; PROSTAGLANDIN; PROSTAGLANDIN E RECEPTOR;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BICEPS BRACHII MUSCLE; CATHETER; CONTROLLED STUDY; ELECTROMYOGRAPHY; EVOKED MUSCLE RESPONSE; FIBER; FLEXOR REFLEX; IMMUNOBLOTTING; LUMBAR SPINAL CORD; MALE; NERVE LIGATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD DORSAL HORN; SPINAL NERVE; WITHDRAWAL REFLEX;

ANIMALS; CYCLOOXYGENASE 1; INJECTIONS, SPINAL; LIGATION; MALE; NERVE FIBERS, MYELINATED; NERVE FIBERS, UNMYELINATED; PAIN; PROSTAGLANDINS; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROSTAGLANDIN E; REFLEX; SPINAL NERVES; SULFONAMIDES;

EID: 34147119037     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/01.anes.0000264777.94662.d6     Document Type: Article

References (43)

1. Beydoun A, Backonja MM: Mechanistic stratification of antineuralgic agents. J Pain Symptom Manage 2003; 25:S18-30
2. Dworkin RH, Backonja M, Rowbotham MC, Allen RR, Argoff CR, Bennett GJ, Bushnell MC, Farrar JT, Galer BS, Haythornthwaite JA, Hewitt DJ, Loeser JD, Max MB, Saltarelli M, Schmader KE, Stein C, Thompson D, Turk DC, Wallace MS, Watkins LR, Weinstein SM: Advances in neuropathic pain: Diagnosis, mechanisms, and treatment recommendations. Arch Neurol 2003; 60:1524-34
3. Takeda K, Sawamura S, Tamai H, Sekiyama H, Hanaoka K: Role for cyclooxygenase 2 in the development and maintenance of neuropathic pain and spinal glial activation. ANESTHESIOLOGY 2005; 103:837-44
4. O'Rielly DD, Loomis CW: Increased expression of cyclooxygenase and nitric oxide isoforms, and exaggerated sensitivity to prostaglandin E2, in the rat lumbar spinal cord 3 days after L5-L6 spinal nerve ligation. ANESTHESIOLOGY 2006; 104:328-37
5. Tonai T, Taketani Y, Ueda N, Nishisho T, Ohmoto Y, Sakata Y, Muraguchi M, Wada K, Yamamoto S: Possible involvement of interleukin-1 in cyclooxygenase-2 induction after spinal cord injury in rats. J Neurochem 1999; 72:302-9
6. Ma W, Eisenach JC: Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain. Eur J Neurosci 2002; 15:1037-47
7. Ma W, Eisenach JC: Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury. Neuroscience 2003; 121:691-704
8. Zhu X, Eisenach JC: Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury. ANESTHESIOLOGY 2003; 99:1175-9
9. Hefferan MP, Carter P, Haley M, Loomis CW: Spinal nerve injury activates prostaglandin synthesis in the spinal cord that contributes to early maintenance of tactile allodynia. Pain 2003; 101:139-47
10. Baba H, Kohno T, Moore KA, Woolf CJ: Direct activation of rat spinal dorsal horn neurons by prostaglandin E2. J Neurosci 2001; 21:1750-6
11. Willingale HL, Gardiner NJ, McLymont N, Giblett S, Grubb BD: Prostanoids synthesized by cyclo-oxygenase isoforms in the rat spinal cord and their contribution to the development of neuronal hyperexcitability. Br J Pharmacol 1997; 122:1593-604
12. Ferreira SH, Lorenzetti BB: Intrathecal administration of prostaglandin E2 causes sensitization of the primary afferent neuron via the spinal release of glutamate. Inflamm Res 1996; 45:499-502
13. Hingtgen CM, Waite KJ, Vasko MR: Prostaglandins facilitate peptide release from rat sensory neurons by activating the adenosine 3′,5′-cyclic monophosphate transduction cascade. J Neurosci 1995; 15:5411-9
14. Ahmadi S, Lippross S, Neuhuber WL, Zeilhofer HU: PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Nat Neurosci 2002; 5:34-40
15. Gao X, Kim HK, Chung JM, Chung K: Enhancement of NMDA receptor phosphorylation of the spinal dorsal horn and nucleus gracilis neurons in neuropathic rats. Pain 2005; 116:62-72
16. Li CY, Song YH, Higuera ES, Luo ZD: Spinal dorsal horn calcium channel alpha2delta-1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia. J Neurosci 2004; 24:8494-9
17. Zhuang ZY, Gerner P, Woolf CJ, Ji RR: ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 2005; 114:149-59
18. Hefferan MP, O'Rielly DD, Loomis CW: Inhibition of spinal prostaglandin synthesis early after L5/L6 nerve ligation prevents the development of prostaglandin-dependent and prostaglandin-independent allodynia in the rat. ANESTHESIOLOGY 2003; 99:1180-8
19. Ma W, Eisenach JC: Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation. Exp Neurol 2003; 183:581-92
20. Yaksh TL, Rudy TA: Chronic catheterization of the spinal subarachnoid space. Physiol Behav 1976; 17:1031-6
21. Marsala M, Malmberg AB, Yaksh TL: The spinal loop dialysis catheter: Characterization of use in the unanesthetized rat. J Neurosci Methods 1995; 62:43-53
22. Kim SH, Chung JM: An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992; 50:355-63
23. Wiesenfeld-Hallin Z: Partially overlapping territories of nerves to hindlimb foot skin demonstrated by plasma extravasation to antidromic C-fiber stimulation in the rat. Neurosci Lett 1988; 84:261-5
24. Lynn B, Carpenter SE: Primary afferent units from the hairy skin of the rat hind limb. Brain Res 1982; 238:29-43
25. Herrero JF, Cervero F: Changes in nociceptive reflex facilitation during carrageenan-induced arthritis. Brain Res 1996; 717:62-8
26. Herrero JF, Cervero F: Supraspinal influences on the facilitation of rat nociceptive reflexes induced by carrageenan monoarthritis. Neurosci Lett 1996; 209:21-4
27. de Sousa BM, Horrocks LA: Development of rat spinal cord. Dev Neurosci 1979; 2:115-21
28. Tallarida RJ, Murray RB: Manual of Pharmacologic Calculations with Computer Programs, 2nd edition. New York, Springer-Verlag, 1987
29. Millan MJ: The induction of pain: An integrative review. Prog Neurobiol 1999; 57:1-164
30. Vanegas H, Schaible HG: Prostaglandins and cyclooxygenases in the spinal cord. Prog Neurobiol 2001; 64:327-63
31. Hartell NA, Headley PM: The effect of naloxone on spinal reflexes to electrical and mechanical stimuli in the anaesthetized, spinalized rat. Physiol 1991; 442:513-26
32. Laird JM, Bennett GJ: An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy. J Neurophysiol 1993; 69:2072-85
33. Okamoto M, Baba H, Goldstein PA, Higashi H, Shimoji K, Yoshimura M: Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injury. J Physiol 2001; 532:241-50
34. Kohno T, Moore KA, Baba H, Woolf CJ: Peripheral nerve injury alters excitatory synaptic transmission in lamina II of the rat dorsal horn. J Physiol 2003; 548:131-8
35. Colvin LA, Mark MA, Duggan AW: Bilaterally enhanced dorsal horn postsynaptic currents in a rat model of peripheral mononeuropathy. Neurosci Lett 1996; 207:29-32
36. Meyerson BA, Ren B, Herregodts P, Linderoth B: Spinal cord stimulation in animal models of mononeuropathy: Effects on the withdrawal response and the flexor reflex. Pain 1995; 61:229-43
37. Bennett DJ, Sanelli L, Cooke CL, Harvey PJ, Gorassini MA: Spastic longlasting reflexes in the awake rat after sacral spinal cord injury. J Neurophysiol 2004; 91:2247-58
38. Chapman V, Suzuki R, Dickenson AH: Electrophysiological characterization of spinal neuronal response properties in anaesthetized rats after ligation of spinal nerves L5-L6. J Physiol 1998; 507:881-94
39. Yaksh TL: Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: Effects of modulatory receptor systems and excitatory amino acid antagonists. Pain 1989; 37:111-23
40. Matsumura S, Abe T, Mabuchi T, Katano T, Takagi K, Okuda-Ashitaka E, Tatsumi S, Nakai Y, Hidaka H, Suzuki M, Sasaki Y, Minami T, Ito S: Rho-kinase mediates spinal nitric oxide formation by prostaglandin E2 via EP3 subtype. Biochem Biophys Res Commun 2005; 338:550-7
41. Bredt DS, Snyder SH: Nitric oxide, a novel neuronal messenger. Neuron 1992; 8:3-11
42. Mollace V, Colasanti M, Rodino P, Lauro GM, Rotiroti D, Nistico G: NMDA-dependent prostaglandin E2 release by human cultured astroglial cells is driven by nitric oxide. Biochem Biophys Res Commun 1995; 215:793-9
43. Hefferan MP, Loomis CW: Interaction of spinal nitric oxide and prostaglandins after L5-L6 spinal nerve ligation in the rat: An isobolographic analysis. ANESTHESIOLOGY 2004; 100:1611-4