Haplotype-based analysis of common variation in the acetyl-CoA carboxylase α gene and breast cancer risk: A case-control study nested within the European Prospective Investigation into Cancer and Nutrition

Cancer Epidemiology Biomarkers and Prevention

Volumn 16, Issue 3, 2007, Pages 409-415

  Sinilnikova, Olga M ^a,b   McKay, James D ^a   Tavtigian, Sean V ^a   Canzian, Federico ^a   DeSilva, Deepika ^a   Biessy, Carine ^a   Monnier, Stéphanie ^a   Dossus, Laure ^a   Boillot, Catherine ^a   Gioia, Lydie ^a   Hughes, David J ^a   Jensen, Majken K ^c   Overvad, Kim ^c   Tjonneland, Anne ^d   Olsen, Anja ^d   Clavel Chapelon, Françoise ^e   Chajès, Véronique ^f   Joulin, Virginie ^f   Linseisen, Jakob ^g   Chang Claude, Jenny ^g   Boeing, Heiner ^h   Dahm, Stephan ^h   Trichopoulou, Antonia ⁱ   Trichopoulos, Dimitrios ⁱ   Koliva, Maria ⁱ   Khaw, Kay Tee ^j   Bingham, Sheila ^k   Allen, Naomi E ^l   Key, Timothy ^l   Palli, Domenico ^m   Panico, Salvatore ⁿ   Berrino, Franco ^o   Tumino, Rosario ^p   Vineis, Paolo ^q   Bueno de Mesquita, H Bas ^r   Peeters, Petra H ^s   Van Gils, Carla H ^s   Lund, Eiliv ^t   Pera, Guillem ^u   Quirós, José Ramón ^v   Dorronsoro, Miren ^w   García, Carmen Martínez ^x   Tormo, María José ^y   Ardanaz, Eva ^z   Hallmans, Goran ^aa   Lenner, Per ^ab   Berglund, Göran ^ac   Manjer, Jonas ^ac   Riboli, Elio ^ad   Lenoir, Gilbert M ^f   Kaaks, Rudolf ^a,g   more..

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^b HOSPICES CIVILS DE LYON   (France)

^c AALBORG UNIVERSITY HOSPITAL   (Denmark)

^d INSTITUTE OF CANCER EPIDEMIOLOGY   (Denmark)

^e INSTITUT GUSTAVE ROUSSY   (France)

^f CNRS   (France)

^g GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^h GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

ⁱ UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^j UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^k UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^l UNIVERSITY OF OXFORD   (United Kingdom)

^m CANCER RESEARCH AND PREVENTION INSTITUTE ISPO   (Italy)

ⁿ UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^o NATIONAL CANCER INSTITUTE   (Italy)

^p CIVILE M P AREZZO HOSPITAL   (Italy)

^q National Institute of Public Health and the Environment ^*  (Italy)

^r NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^s UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^t UNIVERSITY OF TROMSØ   (Norway)

^u CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^v Public Health and Health Planning Directorate   (Spain)

^w Basque Government   (Spain)

^x ANDALUSIAN SCHOOL OF PUBLIC HEALTH   (Spain)

^y Public Health Institute of Navarra ^*  (Spain)

^z INSTITUTO DE SALUD PÚBLICA DE NAVARRA   (Spain)

^aa UMEÅ UNIVERSITY   (Sweden)

^ab UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^ac LUND UNIVERSITY HOSPITAL   (Sweden)

^ad IMPERIAL COLLEGE LONDON   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE ALPHA; BRCA1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; HAPLOTYPE; HOMOZYGOSITY; HUMAN; MALE; MENOPAUSE; NUTRITION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ACETYL-COA CARBOXYLASE; ADULT; AGED; ALLELES; BREAST NEOPLASMS; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; EUROPE; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; LOGISTIC MODELS; MIDDLE AGED; RISK FACTORS; VARIATION (GENETICS);

EID: 34047273734     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-06-0617     Document Type: Article

References (43)

1. Kaaks R. Nutrition, hormones, and breast cancer: is insulin the missing link? Cancer Causes Control 1996;7:605-25.
2. Augustin LS, Dal ML, La Vecchia C, et al. Dietary glycemic index and glycemic load, and breast cancer risk: a case-control study. Ann Oncol 2001; 12:1533-8.
3. Kaaks R, Lukanova A. Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Proc Nutr Soc 2001;60:91-106.
4. Bianchini F, Kaaks R, Vainio H. Overweight, obesity, and cancer risk. Lancet Oncol 2002;3:565-74.
5. Kaaks R, Lukanova A. Effects of weight control and physical activity in cancer prevention: role of endogenous hormone metabolism. Ann N Y Acad Sci 2002;963:268-81.
6. Kaaks R, Lundin E, Rinaldi S, et al. Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in northern and southern Sweden. Cancer Causes Control 2002;13:307-16.
7. Key T, Appleby P, Barnes I, Reeves G. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 2002;94:606-16.
8. Muti P, Quattrin T, Grant BJ, et al. Fasting glucose is a risk factor for breast cancer: a prospective studv. Cancer Epidemiol Biomarkers Prev 2002;11: 1361-8.
9. Lahmann PH, Schulz M, Hoffmann K, et al. Long-term weight change and breast cancer risk: the European prospective investigation into cancer and nutrition (EPIC). Br J Cancer 2005;93:582-9.
10. Kuhajda FP. Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition 2000;16:202-8.
11. Milgraum LZ, Witters LA, Pasternack GR, Kuhajda FP. Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin Cancer Res 1997;3:2115-20.
12. Alo PL, Visca P, Botti C, et al. Immunohistochemical expression of human erythrocyte glucose transporter and fatty acid synthase in infiltrating breast carcinomas and adjacent typical/atypical hyperplastic or normal breast tissue. Am J Clin Pathol 2001;116:129-34.
13. Swinnen JV, Roskams T, Joniau S, et al. Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer. Int J Cancer 2002;98:19-22.
14. Rossi S, Graner E, Febbo P, et al. Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. Mol Cancer Res 2003;1: 707-15.
15. Sebastiani V, Visca P, Botti C, et al. Fatty acid synthase is a marker of increased risk of recurrence in endometrial carcinoma. Gynecol Oncol 2004; 92:101-5.
16. Visca P, Sebastiani V, Botti C, et al. Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma. Anticancer Res 2004;24: 4169-73.
17. Kuhajda FP, Jenner K, Wood FD, et al. Fatty acid synthesis: a potential selective target for antineoplastic therapy. Proc Natl Acad Sci U S A 1994;91: 6379-83.
18. Pizer ES, Jackisch C, Wood FD, Pasternack GR, Davidson NE, Kuhajda FP. Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells. Cancer Res 1996;56:2745-7.
19. Thupari JN, Pinn ML, Kuhajda FP. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun 2001;285: 217-23.
20. Zhou W, Simpson PJ, McFadden JM, et al. Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res 2003;63: 7330-7.
21. Menendez JA, Mehmi I, Verma VA, Teng PK, Lupu R. Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation. Mol Carcinog 2004;41: 164-78.
22. Brasselmans K, De SE, Verhoeven G, Swinnen JV. RNA interference-mediated silencing of the acetyl-CoA-carboxylase-α gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Res 2005;65: 6719-25.
23. Lu S, Archer MC. Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer. Carcinogenesis 2005;26:153-7.
24. Chajes V, Cambot M, Moreau K, Lenoir GM, Joulin V. Acetyl-CoA carboxylase a is essential to breast cancer cell survival. Cancer Res 2006; 66:5287-94.
25. Magnard C, Bachelier R, Vincent A, et al. BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains. Oncogene 2002;21: 6729-39.
26. Moreau K, Dizin E, Ray H, et al. BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase. J Biol Chem 2006;281:3172-81.
27. Mao J, Chirala SS, Wakil SJ. Human acetyl-CoA carboxylase 1 gene: presence of three promoters and heterogeneity at the 5′-untranslated mRNA region. Proc Natl Acad Sci U S A 2003;100:7515-20.
28. Barber MC, Price NT, Travers MT. Structure and regulation of acetyl-CoA carboxylase genes of metazoa. Biochim Biophys Acta 2005;1733:1-28.
29. Sinilnikova OM, Ginolhac SM, Magnard C, et al. Acetyl-CoA carboxylase a gene and breast cancer susceptibility. Carcinogenesis 2004;25: 2417-24.
30. Riboli E, Hunt KJ, Slimani N, et al. European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Public Health Nutr 2002;5:1113-24.
31. Bingham S, Riboli E. Diet and cancer - the European Prospective Investigation into Cancer and Nutrition. Nat Rev Cancer 2004;4:206-15.
32. Gabriel SB, Schaffner SF, Nguyen H, et al. The structure of haplotype blocks in the human genome. Science 2002;296:2225-9.
33. Barrett JC, Fry B, Mailer J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-5.
34. Stram DO. Tag SNP selection for association studies. Genet Epidemiol 2004; 27:365-74.
35. Canzian F, McKay JD, Cleveland RJ, et al. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. Cancer Epidemiol Biomarkers Prev 2005;14: 2316-25.
36. Cheng I, Stram DO, Penney KL, et al. Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort. J Natl Cancer Inst 2006;98: 123-34.
37. Wacholder S, Chanock S, Garcia-Closas M, El GL, Rothman N. Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst 2004;96:434-42.
38. Risch N, Burchard E, Ziv E, Tang H. Categorization of humans in biomedical research: genes, race and disease. Genome Biol 2002;3:comment 2007.
39. Mueller JC, Lohmussaar E, Magi R, et al. Linkage disequilibrium patterns and tagSNP transferability among European populations. Am J Hum Genet 2005;76:387-98.
40. Travers MT, Cambot M, Kennedy HT, Lenoir GM, Barber MC, Joulin V. Asymmetric expression of transcripts derived from the shared promoter between the divergently oriented ACACA and TADA2L genes. Genomics 2005;85:71-84.
41. Weiderpass E, Braaten T, Magnusson C, et al. A prospective study of body size in different periods of life and risk of premenopausal breast cancer. Cancer Epidemiol Biomarkers Prev 2004;13:1121-7.
42. Lahmann PH, Hoffmann K, Allen N, et al. Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer 2004;111:762-71.
43. Silvera SA, Jain M, Howe GR, Miller AB, Rohan TE. Energy balance and breast cancer risk: a prospective cohort study. Breast Cancer Res Treat 2006; 97:97-106.