Effects of hypoxic hypoxia on O2 uptake and heart rate kinetics during heavy exercise

Journal of Applied Physiology

Volumn 81, Issue 6, 1996, Pages 2500-2508

  Engelen, Marielle ^a   Porszasz, Janos ^a   Riley, Marshall ^a   Wasserman, Karlman ^a   Maehara, Kazuhira ^a   Barstow, Thomas J ^a,b  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

Author keywords

curve fitting; oxygen uptake kinetics

Indexed keywords

LACTIC ACID;

ADULT; ARTICLE; BICYCLE ERGOMETRY; BREATH ANALYSIS; EXERCISE; EXERCISE TEST; FEMALE; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS; LUNG GAS EXCHANGE; MALE; MATHEMATICAL MODEL; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; WORK;

EID: 0030481157     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.81.6.2500     Document Type: Article

References (35)

1. Aaron, E. A., B. D. Johnson, C. K. Seow, and J. A. Dempsey. Oxygen cost of exercise hyperpnea: measurement. J. Appl. Physiol. 72: 1810-1817, 1992.
2. Barstow, T. J., S. Buchthal, S. Zanconato, and D. M. Cooper. Changes in potential controllers of human skeletal muscle respiration during incremental calf exercise. J. Appl. Physiol. 77: 2169-2176, 1994.
3. Barstow, T. J., S. Buchthal, S. Zanconato, and D. M. Cooper. Muscle energetics and pulmonary oxygen uptake kinetics during moderate exercise. J. Appl. Physiol. 77: 1742-1749, 1994.
4. 2 deficit as related to exercise intensity and blood lactate. J. Appl. Physiol. 75: 755-762, 1993.
5. Barstow, T. J. and P. A. Molé. Linear and nonlinear characteristics of oxygen uptake kinetics during heavy exercise. J. Appl. Physiol. 71: 2099-2106, 1991.
6. Beaver, W. L., N. LaMarra, and K. Wasserman. Breath-by-breath measurement of true alveolar gas exchange. J. Appl. Physiol. 51: 1662-1675, 1981.
7. Beaver, W. L., K. Wasserman, and B. J. Whipp. A new method for detecting anaerobic threshold by gas exchange. J. Appl. Physiol. 60: 2020-2027, 1986.
8. Belardinelli, R., T. J. Barstow, J. Porszasz, and K. Wasserman. Skeletal muscle oxygenation during constant work rate exercise. Med. Sci. Sports Exercise 27: 512-519, 1995.
9. Casaburi, R., T. J. Barstow, T. Robinson, and K. Wasserman. Influence of work rate on ventilatory and gas exchange kinetics. J. Appl. Physiol. 67: 547-555, 1989.
10. Escourrou, P., D. G. Johnson, and L. B. Rowell. Hypoxemia increases plasma catecholamine concentrations in exercising humans. J. Appl. Physiol. 57: 1507-1511, 1984.
11. Fagraeus, L., and D. Linnarsson. Autonomic origin of heart rate fluctuations at the onset of muscular exercise. J. Appl. Physiol. 40: 679-682, 1976.
12. 2 uptake kinetics in humans: implications for metabolic control. J. Appl. Physiol. 80: 988-998, 1996.
13. 2 in regulating tissue respiration in dog muscle working in situ. J. Appl. Physiol. 73: 728-736, 1992.
14. a delivery in canine gastrocnemius in situ. J. Appl. Physiol. 66: 1219-1226, 1989.
15. Huszczuk, A., B. J. Whipp, and K. Wasserman. A respiratory gas exchange simulator for routine calibration in metabolic studies. Eur. Respir. J. 3: 465-468, 1990.
16. Ibanez, J., R. Rama, M. Riera, M. T. Prats, and L. Palacios. Severe hypoxia decreases oxygen uptake relative to intensity during submaximal graded exercise. Eur. J. Appl. Physiol. Occup. Physiol. 67: 7-13, 1993.
17. 2 uptake kinetics during exercise in man. J. Clin. Invent. 86: 1698-1706, 1990.
18. Linnarsson, D. Dynamics of pulmonary gas exchange and heart rate changes at start and end of exercise. Acta Physiol. Scand. 415, Suppl: S1-S68, 1974.
19. Linnarsson, D., J. Karlsson, L. Fagraeus, and B. Saltin. Muscle metabolites and oxygen deficit with exercise in hypoxia and hyperoxia. J. Appl. Physiol. 36: 399-402, 1974.
20. Marsh, G. D., D. H. Paterson, R. T. Thompson, and A. A. Driedger. Coincident thresholds in intracellular phosphorylation potential and pH during progressive exercise. J. Appl. Physiol. 71: 1076-1081, 1991.
21. McCann, D. J., P. A. Mole, and J. R. Caton. Phosphocreatine kinetics in humans during exercise and recovery. J. Appl. Physiol. 27: 378-387, 1995.
22. Murphy, P. C., L. A. Cuervo, and R. L. Hughson. A study of cardiorespiratory dynamics with step and ramp exercise tests in normoxia and hypoxia. Cardiovasc. Res. 23: 825-832, 1989.
23. Paterson, D. H., and B. J. Whipp. Asymmetries of oxygen uptake transients at the on- and offset of heavy exercise in humans. J. Physiol. Lond. 443: 575-586, 1991.
24. Petersen, E. S., B. J. Whipp, J. A. Davis, D. J. Huntsman, H. V. Brown, and K. Wasserman. Effects of β-adrenergic blockade on ventilation and gas exchange during exercise in humans. J. Appl. Physiol. 54: 1306-1313, 1983.
25. 2 slow component: physiological and functional significance. Med. Sci. Sports Exercise 26: 1354-1358, 1994.
26. 2 slow component. J. Appl. Physiol. 76: 787-792, 1994.
27. Poole, D. C., W. Schaffartzik, D. R. Knight, T. Derion, B. Kennedy, H. J. Guy, R. Prediletto, and P. D. Wagner. Contribution of exercising legs to the slow component of oxygen uptake kinetics in humans. J. Appl. Physiol. 71: 1245-1253, 1991.
28. Ren, J. M., S. Broberg, and K. Sahlin. Oxygen deficit is not affected by the rate of transition from rest to submaximal exercise. J. Physiol. Lond. 135: 545-548, 1989.
29. Robinson, B. F., S. E. Epstein, G. D. Beiser, and E. Braunwald. Control of heart rate by the autonomic nervous system. Circ. Res. 19: 400-411, 1966.
30. Roston, W. L., B. J. Whipp, J. A. Davis, D. A. Cunningham, R. M. Effros, and K. Wasserman. Oxygen uptake kinetics and lactate concentration during exercise in humans. Am. Rev. Respir. Dis. 135: 1080-1084, 1987.
31. Springer, C. S., T. J. Barstow, K. Wasserman, and D. M. Cooper. Oxygen uptake and heart rate responses during hypoxic exercise in children and adults. Med. Sci. Sports Exercise 23: 71-79, 1991.
32. Stringer, W. S., K. Wasserman, R. Casaburi, J. Porszasz, K. Maehara, and W. French. Lactic acidosis as a facilitator of oxyhemoglobin dissociation during exercise. J. Appl. Physiol. 76: 1462-1467, 1994.
33. Wasserman, K. Facilitation of oxygen consumption by lactic acidosis during exercise. News Physiol. Sci. 6: 29-34, 1991.
34. Wolfel, E. E., B. M. Groves, G. A. Brooks, G. E. Butterfield, R. S. Mazzeo, L. G. Moore, J. R. Sutton, P. R. Bender, T. E. Dahms, R. E. McCullough, R. G. McCullough, S.-Y. Huang, S.-F. Sun, R. F. Grover, H. N. Hultgren, and J. T. Reeves. Oxygen transport during steady-state submaximal exercise in chronic hypoxia. J. Appl. Physiol. 70: 1129-1136, 1991.
35. Xing, H. C., J. E. Cochrane, Y. Yamamoto, and R. L. Hughson. Frequency domain analysis of ventilation and gas exchange kinetics in hypoxic exercise. J. Appl. Physiol. 71: 2394-2401, 1991.