Nitric oxide synthase inhibition speeds oxygen uptake kinetics in horses during moderate domain running

Respiratory Physiology and Neurobiology

Volumn 132, Issue 2, 2002, Pages 169-178

  Kindig, Casey A ^a,b   McDonough, Paul ^a   Erickson, Howard H ^a   Poole, David C ^a  

^a KANSAS STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Exercise, O2 uptake kinetics; Gas exchange, pulmonary exercise; Mammals, horse; Oxygen, uptake kinetics, oxidative machinery; Pharmacological agents, L NAME

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; ENZYME INHIBITOR; LACTIC ACID; N(G) NITROARGININE METHYL ESTER; OXYGEN;

ARTICLE; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME INHIBITION; EXERCISE; HORSE; HYPOTHESIS; KINETICS; METABOLIC RATE; MOLECULAR DYNAMICS; NONHUMAN; ONSET AGE; OXIDATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REDUCTION; RUNNING; VELOCITY; ANALYSIS OF VARIANCE; ANIMAL; BLOOD; BREATHING; DRUG ANTAGONISM; DRUG EFFECT; EXERCISE TEST; MALE; PHYSIOLOGY; STATISTICAL ANALYSIS;

ANALYSIS OF VARIANCE; ANIMALS; ENZYME INHIBITORS; EXERCISE TEST; HORSES; LACTIC ACID; MALE; MATCHED-PAIR ANALYSIS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; OXYGEN; OXYGEN CONSUMPTION; RESPIRATION; RUNNING;

EID: 0036024153     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1569-9048(02)00068-X     Document Type: Article

References (49)

1. O2max and oxidative capacity in muscles of Standardbred horses
2. 2 uptake at onset of intense exercise in humans
3. Linear and nonlinear characteristics of oxygen uptake kinetics during heavy exercise
4. Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide
5. Nanomolar concentrations of NO reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
6. Effects of prior heavy exercise on phase II pulmonary oxygen uptake kinetics during heavy exercise
7. O2 during heavy exercise
8. Reversible inhibition of cytochrome oxidase, the terminal enzyme of the mitochondrial respiratory chain, by NO
9. Cardiac output, oxygen consumption and arteriovenous oxygen difference following sudden rise in exercise level in humans
10. Control of skeletal muscle perfusion at the onset of dynamic exercise
11. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
12. The slow component of oxygen uptake kinetics in humans
13. Effects of prior exercise on pulmonary gas-exchange kinetics during high-intensity exercise in humans
14. 2 utilization? New insights into an old issue
15. 2 uptake kinetics in humans: Implications for metabolic control
16. O2 on-kinetics in isolated in situ canine muscle
17. 2 on-kinetics in isolated in situ canine muscle
18. Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate
19. 2 inhalation
20. Effects of NO synthase inhibition on the muscular blood flow response to treadmill exercise in rats
21. Relating maximal oxygen consumption to skeletal muscle mitochondria in horses
22. Effects of dichloroacetate infusion on human skeletal muscle metabolism at the onset of exercise
23. Faster oxygen uptake kinetics at onset of supine exercise with lower body negative pressure
24. O2 on blood flow dynamics at onset of forearm exercise
25. Nitric oxide and vasodilation in human limbs
26. Cardiorespiratory impact of the nitric oxide synthase inhibitor L-NAME in the exercising horse
27. Effect of L-NAME on oxygen uptake kinetics during heavy-intensity exercise in the horse
28. Effects of increased muscle temperature on oxygen uptake kinetics during exercise
29. Effect of interbreath fluctuations on characeterizing exercise gas exchange kinetics
30. O2 kinetics in the horse during moderate and heavy exercise
31. O2 kinetics in heavy submaximal exercise by hyperoxia and prior high-intensity exercise
32. Effects of hyperthyroidism on vascular contractile and relaxation responses
33. Nitric oxide and thermoregulation during exercise in the horse
34. Metabolic effects of nitric oxide synthase inhibition during exercise in the horse
35. Multiple dilator pathways in skeletal muscle contraction-induced arteriolar dilations
36. O2 kinetics during exercise in obstructive pulmonary disease
37. Asymmetries of oxygen uptake transients at the on- and offset of heavy exercise in humans
38. Contribution of exercising legs to the slow component of oxygen uptake kinetics in humans
39. Nitric oxide in the regulation of vasomotor tone in human skeletal muscle
40. CO2 in the horse and comparison of five methods for determination of maximum oxygen uptake
41. Skeletal muscle adaptability: Significance for metabolism and performance
42. Role of nitric oxide in the regulation of oxygen consumption in conscious dogs
43. Is rapid rise in vascular conductance at onset of dynamic exercise due to muscle pump
44. Muscle fiber composition of a number of limb muscles in different types of horses
45. Interaction of factors determining oxygen uptake at the onset of exercise
46. Dynamics of pulmonary gas exchange during exercise
47. Inhibition of creatine kinase by S-nitrosoglutathione
48. Are oxygen uptake kinetics at the onset of exercise speeded up by local metabolic status in active muscles
49. Nitric oxide and the nervous system