Rabies review: Immunopathology, clinical aspects and treatment

Journal of Venomous Animals and Toxins Including Tropical Diseases

Volumn 13, Issue 1, 2007, Pages 5-38

  Consales, Cleide Aschenbrenner ^a   Bolzan, V L ^a  

^a Instituto Pasteur de Sao Paulo   (Brazil)

Author keywords

Clinical aspects; Immunopathology; Rabies; Treatment

Indexed keywords

ANIMALIA; RABIES VIRUS;

EID: 34047209089     PISSN: 16789199     EISSN: 16789199     Source Type: Journal    
DOI: 10.1590/S1678-91992007000100002     Document Type: Review

References (104)

1. ALVAREZ L., FARJADO R., LOPEZ E. Partial recovery from rabies in a nine-year-old boy. Pediat. Infect. Dis. J., 1994, 13, 1154-55.
2. BAER GM., BELLINI WJ., FISHBEIN DB. Rhabdoviruses. In: FIELDS BN., KNIPE DM. Eds. Virology. 2.ed. New York: Raven Press, 1990: 883-930.
3. BALOUL L., LAFON M. Apoptosis and rabies virus neuroinvasion. Biochem., 2003, 85, 777-88.
4. BASGOZ N., FROSCH MP. Case 21-1998. A 32-year-old woman with pharyngeal spasms and paresthesias after a dog bite. N. Eng. J. Med., 1998, 339, 105-12.
5. BENMCHAMED L., WECHSLER S L., NESBUM A B. Lipopeptide vaccines - yesterday, today, and tomorrow. Lancet Infect. Dis., 2002, 2, 425-31.
6. BENVENISTE EN. Inflammatory cytokines within the central nervous system: sources, function and mechanism of action. Am. J. Physiol., 1992, 263, C1-C16.
7. BINGHEM J., VAN DER MERWE M. Distribution of rabies antigen in infected material: determining the reliability of different regions of the brain for the rabies fluorescent antibody test. J. Virol. Methods, 2002, 101, 85-94.
8. BOLZAN VL., CUNHA RS. Reações adversas ao soro anti-rábico no ambulatório do Instituto Pasteur de São Paulo, de 1999 a 2005. Braz. J. Infect. Dis., 2005, 9, Suppl 1, S260.
9. BORDIGNON J., BRASIL-DOS-ANJOS G., BUENO C., SALVATIERA-OPORTO J., DÁVILA AMR., GRISARD EC., ZANETTI CR. Detection and characterization of rabies virus in Southern Brazil by PCR amplification and sequencing of the nucleoprotein gene. Arch. Virol., 2005, 15, 695-708.
10. BOTVINKIN DA., POLESCHUK EM., KUZMIN VI., BORISOVA TI., GAZARYAN SV., RUPPRECHT CE. Novel lyssaviruses isolated from bats in Russia. Emerg. Infect. Dis., 2003, 9, 1623-25.
11. BRADAME H., TORDO N. Host switching in Lyssavirus history from the chiroptera to the carnivora orders. J. Virol., 2001, 75, 8096-104.
12. BRASIL. Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Resolução RDC no 153, de 14 de junho de 2004. Regulamento Técnico para Procedimentos Hemoterápicos. Poder Executivo: Diário Oficial da União.
13. BRASIL. Ministério da Saúde. Secretaria de Vigilância à Saúde. Guia de Vigilância Epidemiológica. 6.ed. Brasília: Ministério da Saúde, 2005, 816p. (Série A: Normas e Manuais Técnicos).
14. CECCALDI PE., FILLION MP., ERMINE A., TSIANG H., FILLION G. Rabies virus selectively alters 5-ht1 receptor subtypes in rat brain. Euro. J. Pharmacol., 1993, 245, 129-38.
15. CENTERS FOR DISEASE CONTROL. Investigation of rabies infections in organ donor and transplant recipients - Alabama, Arkansas, Oklahoma, and Texas, 2004. Morb. Mort. Wkly. Rep., 2004, 53, 1-3.
16. CENTERS FOR DISEASE CONTROL. Mass treatment of humans who drank unpasteurized milk from rabid cows. Morb. Mort. Wkly. Rep., 1999, 48, 228-30.
17. CENTERS FOR DISEASE CONTROL. Rabies in laboratory workers. Morb. Mort. Wkly. Rep., 1977, 26, 183-84.
18. CENTERS FOR DISEASE CONTROL. Travelers' Health. Rabies. The Yellow Book. Nat. Center Infect. Dis., 2001-2003.
19. CONSTANTINE DG. Rabies transmission by non-bite route. Public Health Rep., 1962, 77, 287-95.
20. COSTA WA., ÁVILA CA., VALENTINE EJG., REICHMANN MLAB., CUNHA RS., GUIDOLIN R., PANACHÃO RI., OMOTO T., BOLZAN VL. Profilaxia da Raiva Humana. São Paulo: Instituto Pasteur, 1999 (Manuais 4). 33p.
21. CREPIN P., AUNDRY L., ROTIVEL Y., GACOIN A., CAROFF C., BOURHY H. Intravitam diagnosis of human rabies by PCR using saliva and cerebrospinal fluid. J. Clin. Microbiol., 1998, 36, 1177-81.
22. DAHER EF., SILVA JÚNIOR GB., FERREIRA MT., BARROS FAS., GURGEL TM., PATROCÍNIO RMSV. Renal involvement in human rabies: clinical manifestations and autopsy findings of nine cases from northeast of Brazil. Rev. Inst. Med. Trop. S. Paulo, 2005, 47, 315-20.
23. DIETZSCHOLD B., MORIMOTO K., HOOPER DC., SMITH JS., RUPPRECHET CE., KOPROWSKI H. Genotypic and phenotypic diversity of rabies virus variants involved in human rabies: implications for postexposure prophylaxis. J. Hum. Virol., 2000, 3, 50-7.
24. DIETZSCHOLD B., KOPROWSKI H. Screening of organ and tissue donors for rabies. Lancet, 2005, 365, 1305.
25. DUMRONGPHOL H., SRIKIATKIATKHACHORN A., HEMACHUDHA T., KOTCHABHAKDI N., GOVITRAPONG P. Alteration of muscarinic acetylcholine receptors in rabies viral-infected dog brains. J. Neurol. Sci., 1996, 137, 1-6.
26. EMMONS RW., LEONARD LI., DEGENARO FJR. A case of human rabies with prolonged survival. Intervirology, 1973, 1, 60-3.
27. ENRIGHT JB., FRANTI CE., FRYE FL., BEHYMER DE. The effects of corticosteroids on rabies in mice. Can. J. Microbiol., 1970, 16, 667-75.
28. FABET M., PULMANAUSAHAKUL R., HODAWADEKAR SS., SPITSIN S., MCGETTIGAN JP., SCHNELL MJ., DIETZSCHOLD B. Overexpression of the rabies virus glycoprotein results in enhancement of apoptosis and antiviral immune response. J. Virol., 2002, 76, 3374-81.
29. FAZAKERLEY JK., ALLSOPP TE. Programmed cell death in virus infections of the nervous system. Curr. Trop. Microbiol. Immunol., 2001, 253, 95-119.
30. FEKADU M., ENDESHAW T., WONDIMAGEGNEHU A., TESHAGER T., OLSON JG. Possible human-to-human transmission of rabies in Ethiopia. Ethiop. Med. J., 1992, 34, 123-7.
31. FISHBEIN DB., BERNARD KW. Rabies Virus. In: MANDELL GL., BENNETT JE., DOLIN R. Eds. Principles and practice of infectious diseases. New York: Churchill Livingstone, 1995: 1527-43.
32. FISHBEIN DB., ROBINSON LE. Rabies. Brit. Med. J., 1994, 330, 1088-9.
33. FOOKS AR., BROOKES SM., JOHNSON N., MCELHINNEY LM., HUTSON AM. European bat lyssaviruses: an emerging zoonosis. Epidemiol. Infect., 2003, 131, 1029-39.
34. FRAZATTI-GALLINA NM., MOURÃO-FUCHER RM., PAOLI RL., SILVA MLN., MIYAKI C., VALENTIN EJG., RAW I., HIGASHI HG. Vero cell rabies vaccine produced using serum-free medium. Vaccine, 2004, 20, 511-17.
35. FU ZF., WINE E., ZENG YM., SHAFER MH., SHENG H., CORISDE OS., RAUSCHER FJ., KOPROWSKI H., DIETZSCHOLD B. Differential effects of rabies and Borna disease viruses on immediate-early- and late-response gene expression in brain tissues. J. Virol., 1993, 67, 6674-81.
36. GIBBONS RV. Cryptogenic rabies, bats, and the question of aerosol transmission. Ann. Emerg. Med., 2002, 39, 528-36.
37. GLENN GM., KENNEY RT., ELLINGSWORTH LR., FRECH SA., HAMMOND SA., ZOETEWEIJ JP. Transcutaneous immunization and immunostimulant strategies: capitalizing on the immunocompetence of the skin. Expert. Rev. Vaccines, 2003, 2, 253-67.
38. GODE GA., RAJU AV., JAYALAKSHMI TS., KAUL HI., BIDE NK. Intensive care in rabies therapy: clinical observation. Lancet, 1976, 2, 6-8.
39. GODE GA., SAKSENA R., BATRA RK., KALIA PK., BHIDE NK. Treatment of 54 clinically diagnosed rabies patients with two survivals. Indian J. Med. Res., 1998, 88, 564-6.
40. GRIFFIN DE., HARDWICK JM. Perspective: virus infections and the death of neurons. Trends Microbiol., 1999, 7,155-60.
41. HAMMOND AS., WELWENDER D., ALVING CR., BLEEN GM. Transcutaneous immunization: T cell response and boosting of existing immunity. Vaccine, 2001, 19, 2701-7.
42. HATTWICK MA., WEISS TT., STECHSCHULTE CJ., BAER GM., GREGG MB. Recovery from rabies: a case report. Ann. Intern. Med., 1972, 76, 931-42.
43. HELLENBRAND W., MEYER C., RASCH G., STEFFENS I., AMMON A. Cases of rabies in Germany following organ transplantation. Eurosurveillance Weekly Release: E-alert 18 February, 2005, 10, 050217.
44. HELMICK CG., TAUXE RV., VERNON AA. Is there a risk to contacts of patients with rabies? Rev. Infect. Dis., 1987, 9, 511-18.
45. HEMACHUDHA T., LAOTHAMATAS J., RUPPRECHT CE. Human rabies: a disease of complex neuropathogenic mechanism and diagnostic challenges. Lancet Neurol., 2002, 1, 101-9.
46. HEMACHUDHA T., PHANUPHAK P., SRIWANTHANA B. Immunologic study of human encephalitic and paralytic rabies: preliminary report of 16 patients. Am. J. Med., 1988, 84, 673-7.
47. HEMACHUDHA T., WACHARAPLUERSADEE S. Antemortem diagnosis of human rabies. Clin. Infect. Dis., 2004, 39, 1085-6.
48. HOOPER DC., MORIMOTO K., BETTE M., WEIHE M., KOPROWSKI H., DIETSHCHOLD B. Collaboration of antibody and inflammation in the clearance of rabies virus from the CNS. J. Virol., 1998, 72, 3711-19.
49. IWASAKI Y., GERHAD W., CLARK HF. Role of host immune response in the development of either encephalitic or paralytic disease after experimental rabies infection in mice. Infect. Immun., 1997, 18, 220-5.
50. JACKSON AC. Cholinergic system in experimental rabies in mice. Acta Virol., 1993, 37, 502-8.
51. JACKSON AC. Rabies virus infection: an update. J. Neurovirol., 2003, 9, 253-8.
52. JACKSON AC., WARRELL MJ., RUPPRECHT CE., ERTL HCJ., O'REILLY M., DIETZSCHOLD B., LEACH RP., FU ZF., WUNNER WH., BLECK TP., WILDE H. Management of rabies in humans. Clin. Infect. Dis., 2003, 36, 60-3.
53. JADAVI M., FAYAZ A., MIRDEHGHAN SA., AINOLLAHI B. Transmission of rabies by corneal graft. Cornea., 1996, 15, 431-3.
54. JOINT OF UNITED KINGDON BLOOD TRANSFUSION AND TISSUE TRANSPLANTATION SERVICES. Rabies and blood transfusion/tissue transplantation. Guidelines for the appropriate selection of blood donors in the UK, [serial online], 2005. Position Statement 08. Available from: (http://transfusionguidelines.org.uk/ index.asp?Publication=DL&Section=12&pageid=808)
55. KAPLAN MM., WIKTOR TJ., KOPROWSKI H. Pathogenesis of rabies in immunodeficient mice. J. Immunol., 1975, 114, 1761-5.
56. KARLINER JS., BELAVAL GS. Incidence of reactions following administration of anti-rabies serum. Study of 526 cases. J. Am. Med. Assoc., 1965, 5, 109-12.
57. KLINMAN DM. Immunotherapeutic uses of CgG oligonucleotides. Nat. Rev. Immunol., 2004, 4, 249-58.
58. KOCH KJ., SAGARTZ JW., DAVIDSON D., LAWHASWAHS K. Diagnosis of human rabies by cornea test. Am. J. Clin. Pathol., 1975, 63, 509-15.
59. KOPROWSKI H., ZENG YM., HEBES-KATES E., FRASER N., RORKE L., FU ZF., HANLON C., DIETZSCHOLD B. In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic disease. Proc. Natl. Acad. Sci. USA, 1993, 90, 3024-32.
60. KUZMIN VI., ORICIARI LA., ARAI YT., SMITH JS., HANLON CA., RUPPRECTH CE. Bat lyssaviruses (Aravan and Khujand) from Central Asia: phylogenetic relationships according to N, P and G genes sequences. Virus Res., 2003, 97, 65-79.
61. LIMA ER., RIET-CORREA F., CASTRO RS., GOMES AAB., LIMA FS. Sinais clínicos, distribuição das lesões no sistema nervoso e epidemiologia da raiva em herbívoros na região Nordeste do Brasil. Braz. J. Vet. Res., 2005, 25, 250-64.
62. LOCKHART BP., TORDO N., TSIANG H. Inhibition of rabies virus transcription in rat cortical neurons with the dissociative anesthetic ketamine. Antimicrobiol. Agents Chemother., 1992, 36, 1750-5.
63. MADHUSUDANA SN., NAGARAJ D., UDAY N., RATNAVALLI E., KUMAR MV. Partial recovery from rabies in a six-year-old girl. Int. J. Infect. Dis., 2002, 6, 85-6.
64. MAZARAKIS ND., AZZOUZ M., ROHELL JB. Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery. Hum. Mol. Genet., 2001, 10, 2109-21.
65. MESSENGER SL., SMITS JS., RUPPRECHT CE. Emerging Epidemiology of Batassociated cryptic cases of rabies in humans in the United States. Clin. Infect. Dis., 2002, 35, 738-47.
66. MIKSZTA JA., ALARCON JB., BRITTINGHAM JM., SUTTER DE., PETTIS RJ., HARVEY NG. Improved genetic immunization via micro-mechanical disruption of skin-barrier function and target epidermal delivery. Nat. Med., 2002, 8, 415-19.
67. MODELSKA A., DIETZSCHOLD B., SLPYSH N., FU ZF., STEPLEWSKI K., HOOPER DC., KOPROWISKI H., YUSIBOV V. Immunization against rabies with plant-derived antigen. Proc. Natl. Acad. Sci. USA, 1998, 95, 2481-85.
68. MOINGEON L., HAENSLER J., LINDENBERG A. Towards the rational dosing of Th1 adjuvants. Vaccine, 2001, 19, 4363-72.
69. MONTAGNON B., FANGET B. Purified Vero cell vaccine for humans. In: MESLIN FX., KAPLAN MM. Laboratory Techniques in Rabies. Koprowski. 4.ed. WHO Library Cataloguing in Publication Data: 1996, p.285-91.
70. MORTIERE MD., FALCONE AL. An acute neurologic syndrome temporally associated with postexposure treatment of rabies. Pediatrics, 1997, 100, 720-1.
71. MULLER EE., NISTIC OE. Brain messengers and the pituitary. New York: Academic Press, 1988.
72. NATIONAL ADVISORY COMMITTEE ON IMMUNIZATION. Update on Rabies Vaccine. Can. Commun. Dis. Rep., 2005, 1, 1-8.
73. NICHOLSON KG., FARROW PR., BIJOUK V. Pre-exposure studies with purified chick embryo cell culture rabies vaccine and human diploid cell vaccine. Serological and clinical response in man. Vaccine, 1997, 5, 208-10.
74. NICHOLSON KG. Cell-culture vaccines for human use: general considerations. In: MESLIN FX., KAPLAN MM., KOPROWSKI H. Eds. Laboratory Techniques in Rabies. 4.ed. Geneva: World Health Organization, 1996: 272-9.
75. O'GARRA A., VIEIRA P. Regulatory T cells and mechanisms of immune system control. Nat. Med., 2004, 10, 801-5.
76. PORRAS C., BARBOZA JJ., FUENZALIDA E., ADAROS HL., OVIEDO AM., FURST J. Recovery from rabies in man. Ann. Intern. Med., 1976, 85, 44-8.
77. PORTER RH., GREENAMYRE JI. Regional variations in the pharmacology of NMDA receptor channel blockers: implications for therapeutic potential. J. Neurochem., 1995, 64, 614-23.
78. PRABHAKAR BS., NATHANSON N. Acute rabies death mediated by antibody. Nature, 1981, 290, 590-1.
79. PRÉHAUD C., LAY S., DIETZSCHOLD B., LAFON M. Glycoprotein of nonpathogenic rabies viruses is a key determinant of human cell apoptosis. J. Virol. 2003, 77, 10537-47.
80. PRESSUTI RJ. Treatment and prophylaxis against infectious complications. Postgrad. Med. J., 1997, 101, 243-52.
81. RUPPRECHT CE., HANLON CA., HEMACHUDHA T. Rabies re-examined. Lancet Infect. Dis., 2002, 2, 327-43.
82. SMITH JS., McCELLAND CL., REID FL., BAER GM. Dual role of the immune response in street rabies virus infection of mice. Infect. Immun., 1982, 35, 213-21.
83. SRINIVASON A., BURTON EC., KUEHNERT MJ., RUPPRECHT CE., SUTKER WL., KSIAZEK TG., PADDOCK CD., GUARNER J., SHIEH WJ., GOLDSMITH C., HANLON N., ZORETIC J., FISCHBACH B., NIEZGODA M., EL-FEKY WH., ORCIARI L., SANCHEZ EQ., LIKOS A., KLINTMALM G.B., CARDO, D., LEDUC J., CHAMBERLAND ME., JERNIGAN DB., ZAKI SR. Transmission of rabies virus from an organ donor to four transplant recipients. N. Eng. J. Med., 2005, 352, 1103-11.
84. SUGAMATA M., MIYAZAWA M., MOR S., SPANGRUDE GJ., EWALT LC., LODMELL DL. Paralysis of street rabies virus-infected mice is dependent on T lymphocytes. J. Virol., 1992, 66, 1252-60.
85. TACKED CO. Garden-variety vaccines: antigens derived from transgenic plants. Exp. Rev. Vaccine, 2004, 3, 529-31.
86. TALAN DA., CITRON DM., ABRAHAMIAN FM., MORAN GJ., GOLDSTEIN EJC. Bacteriologic analysis of infected dog and cat bites. New Eng. J. Med., 1999, 340, 85-92.
87. TAM RC., LAU JY., HONG Z. Mechanisms of action of ribavirin in antiviral therapies. Antivirol. Chem. Chemother., 2001, 12, 261-72.
88. TANTAWICHIESN T., BENJAVONGKULCHAI M., WILDE H., JAIJAROENSUP W., SIAKASEM A., CHAREONWAI S., YOUNTONG C. Value of skin testing for predicting reactions to equine rabies immune globulin. Clin. Infect. Dis., 1995, 21, 660-2.
89. TEPSUMETHANON V., LUMERTDACHA B., MIMOONPITAK C., WILDE H. Clinical diagnosis for rabies in live dogs. In: WORLD CONGRESS OF THE WORLD ANIMALS VETERINARIAN ASSOCIATION, 28, Bangkok, 2003. Proceedings... Bangkok, 2003.
90. THOULOUZE MI., LFAGE M., MONTANO-HIROSE JA., LAFON M. Rabies virus infects mouse and human lymphocytes and induces apoptosis. J. Virol., 1997, 71, 7372-80.
91. TINLINE RR. Persistence of rabies in wildlife. In: CAMPBELL JB., CHARLTON JM. Eds. Rabies. London: Kluwer Academic Publ., 1985: 301-22.
92. TSIANG H. Neuronal function impairment in rabies-infected rat brain. J. Gen. Virol., 1982, 61, 277-81.
93. UBOL S., SUKWATTANAPAN C., MANEERAT Y. Inducible nitric oxicide synthase inhibition delays death of rabies virus-infected mice. J. Med. Microbiol., 2001, 50, 238-42.
94. WARRELL MJ., WARRELL DA. Rabies and other lyssaviruses disease. Lancet, 2004, 363, 959-69.
95. WORLD HEALTH ORGANIZATION. Current WHO GUIDE for rabies pre and post-exposure treatment in humans. WHO Department of Communicable Surveillance and Response, 2002. 23p.
96. WORLD HEALTH ORGANIZATION. Expert Committee on Rabies. 8. Report. Geneva: WHO Tech. Rep. Series, 1992, 824. 87p.
97. WORLD HEALTH ORGANIZATION. Expert Consultation on Rabies. 1. Report. Geneva: WHO Tech. Rep. Series, 2004, 931. 121p.
98. WIKTOR TJ., FERNANDES MV., KOPROWSKI H. Cultivation of rabies virus in human diploid cell strain WI38. J. Immunol., 1964, 93, 353-66.
99. WILDE H., CHUTIVONGSE S. Equine rabies immunoglobulin: a product with an underserved poor reputation. Am. J. Trop. Med. Hyg., 1990, 42, 175-8.
100. WILDE H., THIPKONG P., SITPRIJA V., CHAIYABUTR N. Heterologous antisera and antivenins are essential biological: perspectives on worldwide crises. Ann. Intern. Med., 1996, 125, 233-6.
101. WILLOUGHBY RE., TIEVES KS., HOFFMAN GM., GHANAYEM NS., AMLIELEFOND CA., SCHWABE MJ., CHUSID MJ., RUPPRECHET CE. Survival after treatment of rabies with induction of coma. New Eng. J. Med., 2005, 352, 2508-14.
102. WINKLER WG., FASHINELL TR., LEFFINGWELL L., HOWARD P., CONOMY JP. Airborne rabies transmission in a laboratory worker. J. Am. Med. Assoc., 1973, 226, 1219-21.
103. XIANG ZQ., KNOWLESS BB., MCCARICK JW., ERTH HC. Immune effectors mechanisms required for protection to rabies virus. Virology, 1995, 214, 398-404.
104. YUSIBOV V., HOOPER DC., STITSIN SV., FLEYSH N., KEAN RB., MIKHEEVA T., DEKA D., KARASEV A., COX S., RANDALL J., KOPROWSKI H. Expression in plants and immunogenicity of plant virusbased experimental rabies vaccine. Vaccine, 2002, 20, 3155-64.