메뉴 건너뛰기




Volumn 9, Issue 2, 2007, Pages 285-291

High-throughput microwave-assisted organic synthesis: Moving from automated sequential to parallel library-generation formats in silicon carbide microtiter plates

Author keywords

[No Author keywords available]

Indexed keywords

INORGANIC COMPOUND; SILICON CARBIDE; SILICON DERIVATIVE;

EID: 34047205297     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc060138z     Document Type: Article
Times cited : (57)

References (43)
  • 3
    • 0011932271 scopus 로고    scopus 로고
    • Loupy, A, Ed, Wiley-VCH: Weinheim, Germany
    • (a) Microwaves in Organic Synthesis; Loupy, A., Ed.; Wiley-VCH: Weinheim, Germany, 2002.
    • (2002) Microwaves in Organic Synthesis
  • 5
    • 0141878086 scopus 로고    scopus 로고
    • Lidström, P, Tierney, J. P, Eds, Blackwell Publishing: Oxford, U.K
    • (c) Microwave-Assisted Organic Synthesis; Lidström, P., Tierney, J. P., Eds.; Blackwell Publishing: Oxford, U.K., 2005.
    • (2005) Microwave-Assisted Organic Synthesis
  • 7
    • 0011932271 scopus 로고    scopus 로고
    • 2nd ed, Loupy, A, Ed, Wiley-VCH: Weinheim, Germany
    • (e) Microwaves in Organic Synthesis, 2nd ed.; Loupy, A., Ed.; Wiley-VCH: Weinheim, Germany, 2006.
    • (2006) Microwaves in Organic Synthesis
  • 8
    • 34047199638 scopus 로고    scopus 로고
    • Larhed, M, Olofsson, K, Ed, Springer: Berlin
    • (f) Microwave Methods in Organic Synthesis; Larhed, M., Olofsson, K., Ed.; Springer: Berlin, 2006.
    • (2006) Microwave Methods in Organic Synthesis
  • 20
    • 0001260317 scopus 로고    scopus 로고
    • Kappe, C. O.; Stadler, A. J. Comb. Chem. 2001, 3, 624. An Emrys Synthesizer (Biotage AB) was used in this work. Other automated microwave systems for sequential processing include the CEM Navigator (www.cem.com) and the Chemspeed SWAVE (www.chemspeed.com).
    • Kappe, C. O.; Stadler, A. J. Comb. Chem. 2001, 3, 624. An Emrys Synthesizer (Biotage AB) was used in this work. Other automated microwave systems for sequential processing include the CEM Navigator (www.cem.com) and the Chemspeed SWAVE (www.chemspeed.com).
  • 23
    • 0141878086 scopus 로고    scopus 로고
    • Lidström, P, Tierney, J. P, Ed, Blackwell Publishing: Oxford, U.K
    • Sarko, C. R. In Microwave-Assisted Organic Synthesis; Lidström, P., Tierney, J. P., Ed.; Blackwell Publishing: Oxford, U.K., 2005; pp 222-236.
    • (2005) Microwave-Assisted Organic Synthesis , pp. 222-236
    • Sarko, C.R.1
  • 25
  • 26
    • 34047207929 scopus 로고    scopus 로고
    • CombiCHEM module/MicroSYNTH Labstation (Milestone srl., www.milestonesci.com). Other, open vessel microtiter plate systems for multimode microwave reactors are available from CEM Corp. (www.cem.com).
    • CombiCHEM module/MicroSYNTH Labstation (Milestone srl., www.milestonesci.com). Other, open vessel microtiter plate systems for multimode microwave reactors are available from CEM Corp. (www.cem.com).
  • 35
    • 0003597031 scopus 로고
    • Harris, G. L, Ed, Institute of Electrical Engineers: London
    • (a) Properties of Silicon Carbide; Harris, G. L., Ed.; Institute of Electrical Engineers: London, 1995.
    • (1995) Properties of Silicon Carbide
  • 36
    • 18844459488 scopus 로고    scopus 로고
    • Choyke, W. J, Matsunami, H, Pensl, G, Ed, Springer: Berlin
    • (b) Silicon Carbide: Recent Major Advances; Choyke, W. J., Matsunami, H., Pensl, G., Ed.; Springer: Berlin, 2004.
    • (2004) Silicon Carbide: Recent Major Advances
  • 38
    • 34047210761 scopus 로고    scopus 로고
    • Employing metal components in the microwave field without any arcing is possible, as long as all parts are in perfect electrical contact to each other. Sparks and arcing are only caused if a difference of the electrical potential between two individual metal parts occurs. Fixing the top plate with the steel bolts builds up the electrical contact to the base and the entire assembly is equipotential. Thus, no arcing will occur, and the assembly can safely be used in the microwave cavity
    • Employing metal components in the microwave field without any arcing is possible, as long as all parts are in perfect electrical contact to each other. Sparks and arcing are only caused if a difference of the electrical potential between two individual metal parts occurs. Fixing the top plate with the steel bolts builds up the electrical contact to the base and the entire assembly is equipotential. Thus, no arcing will occur, and the assembly can safely be used in the microwave cavity.
  • 40
    • 34047208315 scopus 로고    scopus 로고
    • This is also true for microtiter plates designed for microwave synthesis that are made out of strongly microwave-absorbing polymeric materials such as carbon-doped Teflon see refs 12 and 13
    • This is also true for microtiter plates designed for microwave synthesis that are made out of strongly microwave-absorbing polymeric materials such as carbon-doped Teflon (see refs 12 and 13).
  • 41
    • 34047199099 scopus 로고    scopus 로고
    • The ability of a specific solvent to convert microwave energy into heat at a given frequency and temperature is determined by the so-called loss tangent (tan δ, expressed as the quotient tan δ= ε″/ ε′. A reaction medium with a high tan δ at the standard operating frequency of a microwave synthesis reactor (2.45 GHz) is required for good absorption and, consequently, for efficient heating. Solvents used for microwave synthesis can be classified as high (tan δ > 0.5, medium (tan δ 0.1-0.5, and low microwave absorbing tan δ < 0.1, Microwave synthesis in low-absorbing solvents is often not feasible, unless either the substrates or some of the reagents/catalysts are strongly polar and therefore microwave absorbing
    • The ability of a specific solvent to convert microwave energy into heat at a given frequency and temperature is determined by the so-called loss tangent (tan δ), expressed as the quotient tan δ= ε″/ ε′. A reaction medium with a high tan δ at the standard operating frequency of a microwave synthesis reactor (2.45 GHz) is required for good absorption and, consequently, for efficient heating. Solvents used for microwave synthesis can be classified as high (tan δ > 0.5), medium (tan δ 0.1-0.5), and low microwave absorbing (tan δ < 0.1). Microwave synthesis in low-absorbing solvents is often not feasible, unless either the substrates or some of the reagents/catalysts are strongly polar and therefore microwave absorbing.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.