-
1
-
-
0035934067
-
Chronic myelogenous leukemia
-
Aug;
-
Kalidas M, Kantarjian H, Talpaz M. Chronic myelogenous leukemia. JAMA 2001 Aug; 286: 895-8
-
(2001)
JAMA
, vol.286
, pp. 895-898
-
-
Kalidas, M.1
Kantarjian, H.2
Talpaz, M.3
-
2
-
-
0034670036
-
The molecular biology of chronic myeloid leukemia
-
Nov 15;
-
Deininger MW, Goldman JM, Melo JV. The molecular biology of chronic myeloid leukemia. Blood 2000 Nov 15; 96 (10): 3343-56
-
(2000)
Blood
, vol.96
, Issue.10
, pp. 3343-3356
-
-
Deininger, M.W.1
Goldman, J.M.2
Melo, J.V.3
-
3
-
-
3042747704
-
Use and limitations of imatinib mesylate (Glivec), a selective inhibitor of the tyrosine kinase Abl transcript in the treatment of chronic myeloid leukaemia
-
Knight GW, McLellan D. Use and limitations of imatinib mesylate (Glivec), a selective inhibitor of the tyrosine kinase Abl transcript in the treatment of chronic myeloid leukaemia. Br J Biomed Sci 2004; 61 (2): 103-11
-
(2004)
Br J Biomed Sci
, vol.61
, Issue.2
, pp. 103-111
-
-
Knight, G.W.1
McLellan, D.2
-
4
-
-
1642447079
-
Treatment options for chronic myeloid leukemia: Imatinib versus interferon versus allogeneic transplant
-
Mar;
-
Angstreich GR, Smith BD, Jones RJ. Treatment options for chronic myeloid leukemia: imatinib versus interferon versus allogeneic transplant. Curr Opin Oncol 2004 Mar; 16 (2): 95-9
-
(2004)
Curr Opin Oncol
, vol.16
, Issue.2
, pp. 95-99
-
-
Angstreich, G.R.1
Smith, B.D.2
Jones, R.J.3
-
5
-
-
0742320300
-
Imatinib mesylate: A review of its use in chronic myeloid leukemia
-
Curran MP, Croom KF, Goa KL. Imatinib mesylate: a review of its use in chronic myeloid leukemia. Am J Cancer 2003; 2 (6): 439-54
-
(2003)
Am J Cancer
, vol.2
, Issue.6
, pp. 439-454
-
-
Curran, M.P.1
Croom, K.F.2
Goa, K.L.3
-
6
-
-
0037225829
-
Imatinib mesylate: In the treatment of gastrointestinal stromal tumours
-
Croom KF, Perry CM. Imatinib mesylate: in the treatment of gastrointestinal stromal tumours. Drugs 2003; 63 (5): 513-22
-
(2003)
Drugs
, vol.63
, Issue.5
, pp. 513-522
-
-
Croom, K.F.1
Perry, C.M.2
-
8
-
-
15944404601
-
The development of imatinib as a therapeutic agent for chronic myeloid leukemia
-
Apr 1;
-
Deininger M, Buchdunger E, Druker BJ. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 2005 Apr 1; 105 (7): 2640-53
-
(2005)
Blood
, vol.105
, Issue.7
, pp. 2640-2653
-
-
Deininger, M.1
Buchdunger, E.2
Druker, B.J.3
-
9
-
-
0030031766
-
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
-
Buchdunger E, Zimmermann J, Mett H, et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res 1996; 56: 100-4
-
(1996)
Cancer Res
, vol.56
, pp. 100-104
-
-
Buchdunger, E.1
Zimmermann, J.2
Mett, H.3
-
10
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
May;
-
Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996 May; 2 (5): 561-6
-
(1996)
Nat Med
, vol.2
, Issue.5
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
11
-
-
0031454003
-
CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
-
Dec 15;
-
Carroll M, Ohno-Jones S, Tamura S, et al. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins. Blood 1997 Dec 15; 90: 4947-52
-
(1997)
Blood
, vol.90
, pp. 4947-4952
-
-
Carroll, M.1
Ohno-Jones, S.2
Tamura, S.3
-
12
-
-
25144442282
-
Differential tyrosine phosphorylation of leukemic cells during apoptosis as a result of treatment with imatinib mesylate
-
Oct 28;
-
Park J, Kim S, Oh C, et al. Differential tyrosine phosphorylation of leukemic cells during apoptosis as a result of treatment with imatinib mesylate. Biochem Biophys Res Commun 2005 Oct 28; 336 (3): 942-51
-
(2005)
Biochem Biophys Res Commun
, vol.336
, Issue.3
, pp. 942-951
-
-
Park, J.1
Kim, S.2
Oh, C.3
-
13
-
-
0033585504
-
In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor
-
Jan 20;
-
le Coutre P, Mologni L, Cleris L, et al. In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor. J Natl Cancer Inst 1999 Jan 20; 91 (2): 163-8
-
(1999)
J Natl Cancer Inst
, vol.91
, Issue.2
, pp. 163-168
-
-
le Coutre, P.1
Mologni, L.2
Cleris, L.3
-
14
-
-
0033816156
-
Abl protein-tyrosine kinase inhibitor ST1571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
-
Buchdunger E, Cioffi CL, Law N, et al. Abl protein-tyrosine kinase inhibitor ST1571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 2000; 295 (1): 139-45
-
(2000)
J Pharmacol Exp Ther
, vol.295
, Issue.1
, pp. 139-145
-
-
Buchdunger, E.1
Cioffi, C.L.2
Law, N.3
-
15
-
-
20344374146
-
-
Uziel O, Fenig E, Nordenberg J, et al. Imatinib mesylate (Gleevec) downregulates telomerase activity and inhibits proliferation in telomerase-expressing cell lines. Br J Cancer 2005 May 23; 92 (10): 1881-91
-
Uziel O, Fenig E, Nordenberg J, et al. Imatinib mesylate (Gleevec) downregulates telomerase activity and inhibits proliferation in telomerase-expressing cell lines. Br J Cancer 2005 May 23; 92 (10): 1881-91
-
-
-
-
16
-
-
3142583182
-
Imatinib mesylate (STI571) decreases the vascular endothelial growth factor plasma concentration in patients with chronic myeloid leukemia
-
Jul 15;
-
Legros L, Bourcier C, Jacquel A, et al. Imatinib mesylate (STI571) decreases the vascular endothelial growth factor plasma concentration in patients with chronic myeloid leukemia. Blood 2004 Jul 15; 104 (2): 495-501
-
(2004)
Blood
, vol.104
, Issue.2
, pp. 495-501
-
-
Legros, L.1
Bourcier, C.2
Jacquel, A.3
-
17
-
-
5144225468
-
Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells
-
Oct 1;
-
Gottschalk S, Anderson N, Hainz C, et al. Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells. Clin Cancer Res 2004 Oct 1; 10 (19): 6661-8
-
(2004)
Clin Cancer Res
, vol.10
, Issue.19
, pp. 6661-6668
-
-
Gottschalk, S.1
Anderson, N.2
Hainz, C.3
-
18
-
-
20944448212
-
Bone marrow changes in chronic myelogenous leukaemia after long-term treatment with the tyrosine kinase inhibitor STI571: An immunohistochemical study on 75 patients
-
May;
-
Thiele J, Kvasnicka HM, Schmitt-Graeff A, et al. Bone marrow changes in chronic myelogenous leukaemia after long-term treatment with the tyrosine kinase inhibitor STI571: an immunohistochemical study on 75 patients. Histopathology 2005 May; 46 (5): 540-50
-
(2005)
Histopathology
, vol.46
, Issue.5
, pp. 540-550
-
-
Thiele, J.1
Kvasnicka, H.M.2
Schmitt-Graeff, A.3
-
19
-
-
1942425070
-
Reversal of bone marrow angiogenesis in chronic myeloid leukemia following imatinib mesylate (STI571) therapy
-
May 1;
-
Kvasnicka HM, Thiele J, Staib P, et al. Reversal of bone marrow angiogenesis in chronic myeloid leukemia following imatinib mesylate (STI571) therapy. Blood 2004 May 1; 103 (9): 3549-51
-
(2004)
Blood
, vol.103
, Issue.9
, pp. 3549-3551
-
-
Kvasnicka, H.M.1
Thiele, J.2
Staib, P.3
-
20
-
-
3042785719
-
Imatinib mesylate therapy reduces bone marrow fibrosis in patients with chronic myelogenous leukemia
-
Jul 15;
-
Bueso-Ramos CE, Cortes J, Talpaz M, et al. Imatinib mesylate therapy reduces bone marrow fibrosis in patients with chronic myelogenous leukemia. Cancer 2004 Jul 15; 101 (2): 332-6
-
(2004)
Cancer
, vol.101
, Issue.2
, pp. 332-336
-
-
Bueso-Ramos, C.E.1
Cortes, J.2
Talpaz, M.3
-
21
-
-
0037315281
-
Molecular mechanisms of resistance to imatinib in Philadelphia-chromosome-positive leukaemias
-
Gambacorti-Passerini CB, Gunby RH, Piazza R, et al. Molecular mechanisms of resistance to imatinib in Philadelphia-chromosome-positive leukaemias. Lancet Oncol 2003; 4: 75-85
-
(2003)
Lancet Oncol
, vol.4
, pp. 75-85
-
-
Gambacorti-Passerini, C.B.1
Gunby, R.H.2
Piazza, R.3
-
22
-
-
0037100308
-
Hematopathologic and cytogenetic findings in imatinib mesylate-treated chronic myelogenous leukemia patients: 14 months' experience
-
Jul 15;
-
Braziel RM, Launder TM, Druker BJ, et al. Hematopathologic and cytogenetic findings in imatinib mesylate-treated chronic myelogenous leukemia patients: 14 months' experience. Blood 2002 Jul 15; 100 (2): 435-41
-
(2002)
Blood
, vol.100
, Issue.2
, pp. 435-441
-
-
Braziel, R.M.1
Launder, T.M.2
Druker, B.J.3
-
23
-
-
18344383326
-
ST1571 (imatinib mesylate) reduces bone marrow cellularity and normalizes morphologic features irrespective of cytogenetic response
-
Mar;
-
Hasserjian RP, Boecklin F, Parker S, et al. ST1571 (imatinib mesylate) reduces bone marrow cellularity and normalizes morphologic features irrespective of cytogenetic response. Am J Clin Pathol 2002 Mar; 117 (3): 360-7
-
(2002)
Am J Clin Pathol
, vol.117
, Issue.3
, pp. 360-367
-
-
Hasserjian, R.P.1
Boecklin, F.2
Parker, S.3
-
24
-
-
0036399997
-
Combination therapy with imatinib mesylate (STI571): Synopsis of in vitro studies
-
Oct;
-
Topaly J, Zeller WJ, Fruehauf S. Combination therapy with imatinib mesylate (STI571): synopsis of in vitro studies. Br J Haematol 2002 Oct; 119 (1): 3-14
-
(2002)
Br J Haematol
, vol.119
, Issue.1
, pp. 3-14
-
-
Topaly, J.1
Zeller, W.J.2
Fruehauf, S.3
-
25
-
-
33646806516
-
Overcoming drug resistance in chronic myeloid leukemia
-
Mar;
-
Cortes J. Overcoming drug resistance in chronic myeloid leukemia. Curr Opin Hematol 2006 Mar; 13 (2): 79-86
-
(2006)
Curr Opin Hematol
, vol.13
, Issue.2
, pp. 79-86
-
-
Cortes, J.1
-
26
-
-
10344225622
-
4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein
-
Dec 15;
-
4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein. Blood 2004 Dec 15; 104 (13): 4219-25
-
(2004)
Blood
, vol.104
, Issue.13
, pp. 4219-4225
-
-
Yin, T.1
Wu, Y.L.2
Sun, H.P.3
-
27
-
-
32644449422
-
Coordination of intrinsic, extrinsic and endoplasmic reticulum-mediated apoptosis by imatinib mesylate combined with arsenic trioxide in chronic myeloid leukemia
-
Feb 15;
-
Du Y, Wang K, Fang H, et al. Coordination of intrinsic, extrinsic and endoplasmic reticulum-mediated apoptosis by imatinib mesylate combined with arsenic trioxide in chronic myeloid leukemia. Blood 2006 Feb 15; 107 (4): 1582-90
-
(2006)
Blood
, vol.107
, Issue.4
, pp. 1582-1590
-
-
Du, Y.1
Wang, K.2
Fang, H.3
-
28
-
-
31544451592
-
Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate
-
Jan 15;
-
Jorgensen HG, Copland M, Allan EK, et al. Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate. Clin Cancer Res 2006 Jan 15; 12 (2): 626-33
-
(2006)
Clin Cancer Res
, vol.12
, Issue.2
, pp. 626-633
-
-
Jorgensen, H.G.1
Copland, M.2
Allan, E.K.3
-
29
-
-
32644438345
-
BCR-ABL nuclear entrapment kills human CML cells: Ex vivo study on 35 patients with the combination of imatinib mesylate and leptomycin B
-
Feb 15;
-
Aloisi A, Di Gregorio S, Stagno F, et al. BCR-ABL nuclear entrapment kills human CML cells: ex vivo study on 35 patients with the combination of imatinib mesylate and leptomycin B. Blood 2006 Feb 15; 107 (4): 1591-8
-
(2006)
Blood
, vol.107
, Issue.4
, pp. 1591-1598
-
-
Aloisi, A.1
Di Gregorio, S.2
Stagno, F.3
-
30
-
-
33644826711
-
Resistance to imatinib: Mechanisms and management
-
Nov;
-
Deininger M. Resistance to imatinib: mechanisms and management. J Natl Compr Canc Netw 2005 Nov; 3 (6): 757-68
-
(2005)
J Natl Compr Canc Netw
, vol.3
, Issue.6
, pp. 757-768
-
-
Deininger, M.1
-
31
-
-
33645464074
-
Detection of BCR-ABL mutations and resistance to imatinib mesylate
-
Branford S, Hughes T. Detection of BCR-ABL mutations and resistance to imatinib mesylate. Methods Mol Med 2006; 125: 93-106
-
(2006)
Methods Mol Med
, vol.125
, pp. 93-106
-
-
Branford, S.1
Hughes, T.2
-
32
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Aug 3;
-
Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001 Aug 3; 293 (5531): 876-80
-
(2001)
Science
, vol.293
, Issue.5531
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
33
-
-
0034161460
-
Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification
-
Mar 1;
-
le Coutre P, Tassi E, Varella-Garcia M, et al. Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification. Blood 2000 Mar 1; 95: 1758-66
-
(2000)
Blood
, vol.95
, pp. 1758-1766
-
-
le Coutre, P.1
Tassi, E.2
Varella-Garcia, M.3
-
34
-
-
1342287959
-
High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib
-
Al-Ali HK, Heinrich MC, Lange T, et al. High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib. Hematol J 2004; 5 (1): 55-60
-
(2004)
Hematol J
, vol.5
, Issue.1
, pp. 55-60
-
-
Al-Ali, H.K.1
Heinrich, M.C.2
Lange, T.3
-
35
-
-
10744232038
-
-
Larghero J, Leguay T, Mourah S, et al. Relationship between elevated levels of the alpha 1 acid glycoprotein in chronic myelogenous leukemia in blast crisis and pharmacological resistance to imatinib (Gleevec®) in vitro and in vivo. Biochem Pharmacol 2003 Nov 15; 66 (10): 1907-13
-
Larghero J, Leguay T, Mourah S, et al. Relationship between elevated levels of the alpha 1 acid glycoprotein in chronic myelogenous leukemia in blast crisis and pharmacological resistance to imatinib (Gleevec®) in vitro and in vivo. Biochem Pharmacol 2003 Nov 15; 66 (10): 1907-13
-
-
-
-
36
-
-
0042305479
-
α1 Acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients
-
Feb;
-
Gambacorti-Passerini C, Zucchetti M, Russo D, et al. α1 Acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients. Clin Cancer Res 2003 Feb; 9 (2): 625-32
-
(2003)
Clin Cancer Res
, vol.9
, Issue.2
, pp. 625-632
-
-
Gambacorti-Passerini, C.1
Zucchetti, M.2
Russo, D.3
-
37
-
-
13244262939
-
Monitoring minimal residual disease in BCR-ABL-positive chronic myeloid leukemia in the imatinib era
-
Jan;
-
Goldman J. Monitoring minimal residual disease in BCR-ABL-positive chronic myeloid leukemia in the imatinib era. Curr Opin Hematol 2005 Jan; 12 (1): 33-9
-
(2005)
Curr Opin Hematol
, vol.12
, Issue.1
, pp. 33-39
-
-
Goldman, J.1
-
38
-
-
33644516935
-
The role of serial BCR-ABL transcript monitoring in predicting the emergence of BCR-ABL kinase mutations in imatinib-treated patients with chronic myeloid leukemia
-
Feb;
-
Wang L, Knight K, Lucas C, et al. The role of serial BCR-ABL transcript monitoring in predicting the emergence of BCR-ABL kinase mutations in imatinib-treated patients with chronic myeloid leukemia. Haematologica 2006 Feb; 91 (2): 235-9
-
(2006)
Haematologica
, vol.91
, Issue.2
, pp. 235-239
-
-
Wang, L.1
Knight, K.2
Lucas, C.3
-
39
-
-
20844447330
-
Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have BCR-ABL kinase domain mutations
-
Nov 1;
-
Branford S, Rudzki Z, Parkinson I, et al. Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have BCR-ABL kinase domain mutations. Blood 2004 Nov 1; 104 (9): 2926-32
-
(2004)
Blood
, vol.104
, Issue.9
, pp. 2926-2932
-
-
Branford, S.1
Rudzki, Z.2
Parkinson, I.3
-
40
-
-
0036038791
-
Serial monitoring of BCR-ABL by peripheral blood real time polymerase chain reaction predicts the marrow cytogenic response to imatinib mesylate in chronic myeloid leukaemia
-
Wang L, Pearson K, Pillitteri L, et al. Serial monitoring of BCR-ABL by peripheral blood real time polymerase chain reaction predicts the marrow cytogenic response to imatinib mesylate in chronic myeloid leukaemia. Br J Haematol 2002; 118: 771-7
-
(2002)
Br J Haematol
, vol.118
, pp. 771-777
-
-
Wang, L.1
Pearson, K.2
Pillitteri, L.3
-
41
-
-
33644668707
-
Prediction of response to imatinib by prospective quantitation of BCR-ABL transcript in late chronic phase chronic myeloid leukemia patients
-
Mar;
-
Martinelli G, Iacobucci I, Rosti G, et al. Prediction of response to imatinib by prospective quantitation of BCR-ABL transcript in late chronic phase chronic myeloid leukemia patients. Ann Oncol 2006 Mar; 17 (3): 495-502
-
(2006)
Ann Oncol
, vol.17
, Issue.3
, pp. 495-502
-
-
Martinelli, G.1
Iacobucci, I.2
Rosti, G.3
-
42
-
-
33744463354
-
-
Press RD, Love Z, Tronnes AA, et al. BCR-ABL mRNA levels at and after the time of a complete cytogenetic response (CCR) predict the duration of CCR in imatinib-treated patients with CML. Blood 2006 Jun 1; 107 (11): 4250-6. Epub 2006 Feb 7
-
Press RD, Love Z, Tronnes AA, et al. BCR-ABL mRNA levels at and after the time of a complete cytogenetic response (CCR) predict the duration of CCR in imatinib-treated patients with CML. Blood 2006 Jun 1; 107 (11): 4250-6. Epub 2006 Feb 7
-
-
-
-
43
-
-
33744798191
-
Achieving a major molecular response at the time of a complete cytogenetic response (CCgR) predicts a better duration of CCgR in imatinib-treated chronic myeloid leukemia patients
-
May 15;
-
Iacobucci I, Saglio G, Rosti G, et al. Achieving a major molecular response at the time of a complete cytogenetic response (CCgR) predicts a better duration of CCgR in imatinib-treated chronic myeloid leukemia patients. Clin Cancer Res 2006 May 15; 12 (10): 3037-42
-
(2006)
Clin Cancer Res
, vol.12
, Issue.10
, pp. 3037-3042
-
-
Iacobucci, I.1
Saglio, G.2
Rosti, G.3
-
44
-
-
23044458596
-
ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: A study by the GIMEMA Working Party on Chronic Myeloid Leukemia
-
Jun 20;
-
Soverini S, Martinelli G, Rosti G, et al. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol 2005 Jun 20; 23 (18): 4100-9
-
(2005)
J Clin Oncol
, vol.23
, Issue.18
, pp. 4100-4109
-
-
Soverini, S.1
Martinelli, G.2
Rosti, G.3
-
46
-
-
24344482346
-
Clinical pharmacokinetics of imatinib
-
Peng B, Lloyd P, Schran H. Clinical pharmacokinetics of imatinib. Clin Pharmacokinet 2005; 44 (9): 879-94
-
(2005)
Clin Pharmacokinet
, vol.44
, Issue.9
, pp. 879-894
-
-
Peng, B.1
Lloyd, P.2
Schran, H.3
-
47
-
-
16244385619
-
Clinical pharmacokinetics of imatinib mesylate
-
Leveque D, Maloisel F. Clinical pharmacokinetics of imatinib mesylate. In Vivo 2005; 19 (1): 77-84
-
(2005)
In Vivo
, vol.19
, Issue.1
, pp. 77-84
-
-
Leveque, D.1
Maloisel, F.2
-
48
-
-
24944581623
-
Metabolism and disposition of imatinib mesylate in healthy volunteers
-
Oct;
-
Gschwind HP, Pfaar U, Waldmeier F, et al. Metabolism and disposition of imatinib mesylate in healthy volunteers. Drug Metab Dispos 2005 Oct; 33 (10): 1503-12
-
(2005)
Drug Metab Dispos
, vol.33
, Issue.10
, pp. 1503-1512
-
-
Gschwind, H.P.1
Pfaar, U.2
Waldmeier, F.3
-
49
-
-
33847038935
-
-
Novartis Pharmaceuticals Corporation, online, Available from URL:, Accessed Jan 16
-
Novartis Pharmaceuticals Corporation. Prescribing information (US): Gleevec® (imatinib mesylate) tablets [online]. Available from URL: http://www.fda.gov/cder [Accessed 2007 Jan 16]
-
(2007)
Prescribing information (US): Gleevec® (imatinib mesylate) tablets
-
-
-
50
-
-
33847013130
-
-
Novartis Europharm Limited. Prescribing information (EU): Glivec® (imatinib mesylate) tablets [online]. Available from URL: http://www.emea. europa.eu/humandocs/Humans/EPAR/glivec/glivec.htm [Accessed 2007 Jan 17]
-
Novartis Europharm Limited. Prescribing information (EU): Glivec® (imatinib mesylate) tablets [online]. Available from URL: http://www.emea. europa.eu/humandocs/Humans/EPAR/glivec/glivec.htm [Accessed 2007 Jan 17]
-
-
-
-
51
-
-
1542608328
-
Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients
-
Mar 1;
-
Peng B, Hayes M, Resta D, et al. Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients. J Clin Oncol 2004 Mar 1; 22 (5): 935-42
-
(2004)
J Clin Oncol
, vol.22
, Issue.5
, pp. 935-942
-
-
Peng, B.1
Hayes, M.2
Resta, D.3
-
52
-
-
10744231436
-
-
O'Brien SG, Meinhardt P, Bond E, et al. Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome P450 3A4 substrate, in patients with chronic myeloid leukaemia. Br J Cancer 2003 Nov 17; 89 (10): 1855-9
-
O'Brien SG, Meinhardt P, Bond E, et al. Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome P450 3A4 substrate, in patients with chronic myeloid leukaemia. Br J Cancer 2003 Nov 17; 89 (10): 1855-9
-
-
-
-
53
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
Mar 13;
-
O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003 Mar 13; 348 (11): 994-1004
-
(2003)
N Engl J Med
, vol.348
, Issue.11
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
54
-
-
33845444046
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
Druker BJ, Guilhot F, O'Brien SG, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Eng J Med 2006; 355 (23): 2408-17
-
(2006)
N Eng J Med
, vol.355
, Issue.23
, pp. 2408-2417
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
-
55
-
-
0037085785
-
-
Talpaz M, Silver RT, Druker BJ, et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood 2002 Mar 15; 99 (6): 1928-37
-
Talpaz M, Silver RT, Druker BJ, et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood 2002 Mar 15; 99 (6): 1928-37
-
-
-
-
56
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
-
May 15;
-
Sawyers CL, Hochhaus A, Feldman E, et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood 2002 May 15; 99 (10): 3530-9
-
(2002)
Blood
, vol.99
, Issue.10
, pp. 3530-3539
-
-
Sawyers, C.L.1
Hochhaus, A.2
Feldman, E.3
-
57
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Feb 28;
-
Kantarjian H, Sawyers C, Hochhaus A, et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 2002 Feb 28; 346 (9): 645-52
-
(2002)
N Engl J Med
, vol.346
, Issue.9
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
-
58
-
-
20844452050
-
Imatinib mesylate (STI571) for treatment of children with Philadelphia chromosome-positive leukemia: Results from a Children's Oncology Group phase 1 study
-
Nov 1;
-
Champagne MA, Capdeville R, Krailo M, et al. Imatinib mesylate (STI571) for treatment of children with Philadelphia chromosome-positive leukemia: results from a Children's Oncology Group phase 1 study. Blood 2004 Nov 1; 104 (9): 2655-60
-
(2004)
Blood
, vol.104
, Issue.9
, pp. 2655-2660
-
-
Champagne, M.A.1
Capdeville, R.2
Krailo, M.3
-
59
-
-
31444450642
-
Imatinib mesylate is effective in children with chronic myelogenous leukemia in late chronic and advanced phase and in relapse after stem cell transplantation
-
Feb;
-
Millot F, Guilhot J, Nelken B, et al. Imatinib mesylate is effective in children with chronic myelogenous leukemia in late chronic and advanced phase and in relapse after stem cell transplantation. Leukemia 2006 Feb; 20 (2): 187-92
-
(2006)
Leukemia
, vol.20
, Issue.2
, pp. 187-192
-
-
Millot, F.1
Guilhot, J.2
Nelken, B.3
-
60
-
-
11144354274
-
High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia
-
Apr 15;
-
Kantarjian H, Talpaz M, O'Brien S, et al. High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia. Blood 2004 Apr 15; 103 (8): 2873-8
-
(2004)
Blood
, vol.103
, Issue.8
, pp. 2873-2878
-
-
Kantarjian, H.1
Talpaz, M.2
O'Brien, S.3
-
61
-
-
10744231480
-
Result of high-dose imatinib mesylate in patients with Philadelphia chromosome-postive chronic myeloid leukemia after failure of interferon-α
-
Jul 1;
-
Cortes J, Giles F, O'Brien S, et al. Result of high-dose imatinib mesylate in patients with Philadelphia chromosome-postive chronic myeloid leukemia after failure of interferon-α. Blood 2003 Jul 1; 102 (1): 83-6
-
(2003)
Blood
, vol.102
, Issue.1
, pp. 83-86
-
-
Cortes, J.1
Giles, F.2
O'Brien, S.3
-
62
-
-
0038205817
-
Quality of life in patients with newly diagnosed chronic phase chronic myecoloid leukemia on imatinib versus interferon alfa plus low-dose cytarabine: Results from the IRIS study
-
Jun 1;
-
Hahn EA, Glendenning GA, Sorensen MV, et al. Quality of life in patients with newly diagnosed chronic phase chronic myecoloid leukemia on imatinib versus interferon alfa plus low-dose cytarabine: results from the IRIS study. J Clin Oncol 2003 Jun 1; 21 (11): 2138-46
-
(2003)
J Clin Oncol
, vol.21
, Issue.11
, pp. 2138-2146
-
-
Hahn, E.A.1
Glendenning, G.A.2
Sorensen, M.V.3
-
63
-
-
33644535340
-
Continuing reduction in level of residual disease after 4 years in patients with CML in chronic phase responding to first-line imatinib (IM) in the IRIS study [abstract no. 163]
-
Nov 16;
-
Goldman JM, Hughes T, Radich J, et al. Continuing reduction in level of residual disease after 4 years in patients with CML in chronic phase responding to first-line imatinib (IM) in the IRIS study [abstract no. 163]. Blood 2005 Nov 16; 106 (11): 51a
-
(2005)
Blood
, vol.106
, Issue.11
-
-
Goldman, J.M.1
Hughes, T.2
Radich, J.3
-
64
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Apr 5;
-
Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001 Apr 5; 344 (14): 1031-7
-
(2001)
N Engl J Med
, vol.344
, Issue.14
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
65
-
-
33847075984
-
-
Silver RT, Talpaz M, Sawyers CL, et al. Four years of follow-up of 1027 patients with late chronic phase (L-CP), accelerated phase (AP), or blast crisis (BC) chronic myeloid leukemia (CML) treated with imatinib in three large phase II trials [abstract no. 23]. Blood 2004 Nov 16; 104 (11 Pt 1): 11a. Plus oral presentation presented at the 46th Annual Meeting and Exposition of the American Society of Hematology; 2004 Dec 3-7; San Diego (CA)
-
Silver RT, Talpaz M, Sawyers CL, et al. Four years of follow-up of 1027 patients with late chronic phase (L-CP), accelerated phase (AP), or blast crisis (BC) chronic myeloid leukemia (CML) treated with imatinib in three large phase II trials [abstract no. 23]. Blood 2004 Nov 16; 104 (11 Pt 1): 11a. Plus oral presentation presented at the 46th Annual Meeting and Exposition of the American Society of Hematology; 2004 Dec 3-7; San Diego (CA)
-
-
-
-
66
-
-
33847046536
-
Six year follow-up results of a phase II study of imatinib in late chronic phase (L-CP) Chronic Myeloid Leukemia (CML) post interferon-alpha (IFN) [abstract no. 428]
-
Nov;
-
Kantarjian HM, Sawyers C, Hocchaus A, et al. Six year follow-up results of a phase II study of imatinib in late chronic phase (L-CP) Chronic Myeloid Leukemia (CML) post interferon-alpha (IFN) [abstract no. 428]. Blood 2006 Nov; 108 (11): 130-1
-
(2006)
Blood
, vol.108
, Issue.11
, pp. 130-131
-
-
Kantarjian, H.M.1
Sawyers, C.2
Hocchaus, A.3
-
67
-
-
16844369751
-
Imatinib expanded access program (EAP): Results of treatment in >7000 patients with chronic myeloid leukemia (CML) [abstract no. 3370]
-
Nov 16;
-
Van Hoomissen IC, Hensley ML, Krahnke T, et al. Imatinib expanded access program (EAP): results of treatment in >7000 patients with chronic myeloid leukemia (CML) [abstract no. 3370]. Blood 2003 Nov 16; 102 (11 Pt 1): 906a
-
(2003)
Blood
, vol.102
, Issue.11 PART 1
-
-
Van Hoomissen, I.C.1
Hensley, M.L.2
Krahnke, T.3
-
68
-
-
0035992318
-
Treatment of Philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate
-
Jul;
-
Kantarjian HM, O'Brien S, Cortes JE, et al. Treatment of Philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate. Clin Cancer Res 2002 Jul; 8 (7): 2167-76
-
(2002)
Clin Cancer Res
, vol.8
, Issue.7
, pp. 2167-2176
-
-
Kantarjian, H.M.1
O'Brien, S.2
Cortes, J.E.3
-
69
-
-
33748133844
-
Survival advantage from imatinib compared with the combination interferon-α plus cytarabine in chronic-phase chronic myelogenous leukemia: Historical comparison between two phase 3 trials
-
Sep 1;
-
Roy L, Guilhot J, Krahnke T, et al. Survival advantage from imatinib compared with the combination interferon-α plus cytarabine in chronic-phase chronic myelogenous leukemia: historical comparison between two phase 3 trials. Blood 2006 Sep 1; 108 (5): 1478-84
-
(2006)
Blood
, vol.108
, Issue.5
, pp. 1478-1484
-
-
Roy, L.1
Guilhot, J.2
Krahnke, T.3
-
70
-
-
0345696854
-
Interferon alfa-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia. French Chronic Myeloid Leukemia Study Group
-
Jul 24;
-
Guilhot F, Chastang C, Michallet M, et al. Interferon alfa-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia. French Chronic Myeloid Leukemia Study Group. N Engl J Med 1997 Jul 24; 337 (4): 223-9
-
(1997)
N Engl J Med
, vol.337
, Issue.4
, pp. 223-229
-
-
Guilhot, F.1
Chastang, C.2
Michallet, M.3
-
71
-
-
18044371828
-
-
Kantarjian H, Talpaz M, O'Brien S, et al. Survival benefit with imatinib mesylate therapy in patients with accelerated-phase chronic myelogenous leukemia-comparison with historic experience. Cancer 2005 May 15; 103 (10): 2099-108
-
Kantarjian H, Talpaz M, O'Brien S, et al. Survival benefit with imatinib mesylate therapy in patients with accelerated-phase chronic myelogenous leukemia-comparison with historic experience. Cancer 2005 May 15; 103 (10): 2099-108
-
-
-
-
72
-
-
0037092980
-
Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase
-
May 15;
-
Kantarjian HM, Cortes J, O'Brien S, et al. Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase. Blood 2002 May 15; 99 (10): 3547-53
-
(2002)
Blood
, vol.99
, Issue.10
, pp. 3547-3553
-
-
Kantarjian, H.M.1
Cortes, J.2
O'Brien, S.3
-
73
-
-
33746845181
-
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate
-
Aug;
-
Kerkel̈a R, Grazette L, Yacobi R, et al. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med 2006 Aug; 12 (8): 908-16
-
(2006)
Nat Med
, vol.12
, Issue.8
, pp. 908-916
-
-
Kerkel̈a, R.1
Grazette, L.2
Yacobi, R.3
-
74
-
-
33846091260
-
In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' [letter]
-
Jan;
-
Hatfield A, Owen S, Pilot PR. In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' [letter]. Nat Med 2007 Jan; 13 (1): 13
-
(2007)
Nat Med
, vol.13
, Issue.1
, pp. 13
-
-
Hatfield, A.1
Owen, S.2
Pilot, P.R.3
-
75
-
-
33846059080
-
In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' [letter]
-
Jan;
-
Force T. In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' [letter]. Nat Med 2007 Jan; 13 (1): 15-6
-
(2007)
Nat Med
, vol.13
, Issue.1
, pp. 15-16
-
-
Force, T.1
-
76
-
-
33646482407
-
-
Berman E, Nicolaides M, Maki RG, et al. Altered bone and mineral metabolism in patients receiving imatinib mesylate. N Engl J Med 2006 May 11; 354 (19): 2006-13
-
Berman E, Nicolaides M, Maki RG, et al. Altered bone and mineral metabolism in patients receiving imatinib mesylate. N Engl J Med 2006 May 11; 354 (19): 2006-13
-
-
-
-
77
-
-
22244468056
-
Cost effectiveness of imatinib compared with interferon-α or hydroxycarbamide for first-line treatment of chronic myeloid leukaemia
-
Dalziel K, Round A, Garside R, et al. Cost effectiveness of imatinib compared with interferon-α or hydroxycarbamide for first-line treatment of chronic myeloid leukaemia. Pharmacoeconomics 2005; 23 (5): 515-26
-
(2005)
Pharmacoeconomics
, vol.23
, Issue.5
, pp. 515-526
-
-
Dalziel, K.1
Round, A.2
Garside, R.3
-
78
-
-
11844278529
-
Cost-utility analysis of imatinib mesylate for the treatment of chronic myelogenous leukemia in the chronic phase
-
Nov;
-
Warren E, Ward S, Gordois A, et al. Cost-utility analysis of imatinib mesylate for the treatment of chronic myelogenous leukemia in the chronic phase. Clin Ther 2004 Nov; 26 (11): 1924-33
-
(2004)
Clin Ther
, vol.26
, Issue.11
, pp. 1924-1933
-
-
Warren, E.1
Ward, S.2
Gordois, A.3
-
79
-
-
0041733714
-
Cost-utility analysis of imatinib mesilate for the treatment of advanced stage chronic myeloid leukaemia
-
Aug 18;
-
Gordois A, Scuffham P, Warren E, et al. Cost-utility analysis of imatinib mesilate for the treatment of advanced stage chronic myeloid leukaemia. Br J Cancer 2003 Aug 18; 89 (4): 634-40
-
(2003)
Br J Cancer
, vol.89
, Issue.4
, pp. 634-640
-
-
Gordois, A.1
Scuffham, P.2
Warren, E.3
-
80
-
-
8844262900
-
Cost-effectiveness of imatinib versus interferon-α plus low-dose cytarabine for patients with newly diagnosed chronic-phase chronic myeloid leukemia
-
Dec 1;
-
Reed SD, Anstrom KJ, Ludmer JA, et al. Cost-effectiveness of imatinib versus interferon-α plus low-dose cytarabine for patients with newly diagnosed chronic-phase chronic myeloid leukemia. Cancer 2004 Dec 1; 101 (11): 2574-83
-
(2004)
Cancer
, vol.101
, Issue.11
, pp. 2574-2583
-
-
Reed, S.D.1
Anstrom, K.J.2
Ludmer, J.A.3
-
81
-
-
14544299196
-
Cost-efficacy of imatinib versus allogeneic bone marrow transplantation with a matched unrelated donor in the treatment of chronic myelogenous leukemia: A decision-analytic approach
-
Mar;
-
Skrepnek GH, Ballard EE. Cost-efficacy of imatinib versus allogeneic bone marrow transplantation with a matched unrelated donor in the treatment of chronic myelogenous leukemia: a decision-analytic approach. Pharmacotherapy 2005 Mar; 25 (3): 325-34
-
(2005)
Pharmacotherapy
, vol.25
, Issue.3
, pp. 325-334
-
-
Skrepnek, G.H.1
Ballard, E.E.2
-
83
-
-
21044454073
-
ESMO minimum clinical recommendations for the diagnosis, treatment and follow-up of chronic myelogenous leukemia (CML). ESMO Guidelines Task Force
-
Simonsson B, Kloke O, Stahel RA. ESMO minimum clinical recommendations for the diagnosis, treatment and follow-up of chronic myelogenous leukemia (CML). ESMO Guidelines Task Force. Ann Oncol 2005; 16 Suppl. 1: i52-3
-
(2005)
Ann Oncol
, vol.16
, Issue.SUPPL. 1
-
-
Simonsson, B.1
Kloke, O.2
Stahel, R.A.3
-
84
-
-
33847025817
-
-
National Comprehensive Cancer Network (NCCN). NCCN clinical practice guidelines in oncology: chronic myelogenous leukemia v.2.2007 [online]. Available from URL: http://www.nccn.org [Accessed 2007 Jan 17]
-
National Comprehensive Cancer Network (NCCN). NCCN clinical practice guidelines in oncology: chronic myelogenous leukemia v.2.2007 [online]. Available from URL: http://www.nccn.org [Accessed 2007 Jan 17]
-
-
-
-
85
-
-
33747154547
-
-
Baccarani M, Saglio G, Goldman J, et al. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 2006 Sep 15; 108 (6): 1809-20
-
Baccarani M, Saglio G, Goldman J, et al. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 2006 Sep 15; 108 (6): 1809-20
-
-
-
-
86
-
-
2942716849
-
Imatinib mesylate (Gleevec/Glivec) a molecular-targeted therapy for chronic myeloid leukaemia and other malignancies
-
May;
-
Nadal E, Olavarria E. Imatinib mesylate (Gleevec/Glivec) a molecular-targeted therapy for chronic myeloid leukaemia and other malignancies. Int J Clin Pract 2004 May; 58 (5): 511-6
-
(2004)
Int J Clin Pract
, vol.58
, Issue.5
, pp. 511-516
-
-
Nadal, E.1
Olavarria, E.2
-
87
-
-
2942619994
-
Indications for imatinib mesylate therapy and clinical management
-
Guilhot F. Indications for imatinib mesylate therapy and clinical management. Oncologist 2004; 9 (3): 271-81
-
(2004)
Oncologist
, vol.9
, Issue.3
, pp. 271-281
-
-
Guilhot, F.1
-
88
-
-
33847023682
-
-
Bristol-Myers Squibb Company. Prescribing information (US): Sprycel. (dasatinib) tablets [online]. Available from URL: https://www.sprycel.com/ [Accessed 2006 Nov 23]
-
Bristol-Myers Squibb Company. Prescribing information (US): Sprycel. (dasatinib) tablets [online]. Available from URL: https://www.sprycel.com/ [Accessed 2006 Nov 23]
-
-
-
-
89
-
-
79959308232
-
Loss of response to imatinib: Mechanisms and management
-
Shah NP. Loss of response to imatinib: mechanisms and management. Hematology (Am Soc Hematol Educ Program) 2005, 83-7
-
(2005)
Hematology (Am Soc Hematol Educ Program)
, pp. 83-87
-
-
Shah, N.P.1
-
90
-
-
33745086350
-
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
-
Jun 15;
-
Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006 Jun 15; 354 (24): 2542-51
-
(2006)
N Engl J Med
, vol.354
, Issue.24
, pp. 2542-2551
-
-
Kantarjian, H.1
Giles, F.2
Wunderle, L.3
|