-
1
-
-
0033614446
-
Chronic myeloid leukemia
-
Apr 29
-
Sawyers CL. Chronic myeloid leukemia. N Engl J Med 1999 Apr 29; 340: 1330-40
-
(1999)
N Engl J Med
, vol.340
, pp. 1330-1340
-
-
Sawyers, C.L.1
-
2
-
-
0035207448
-
The biology of signal transduction inhibition: Basic science to novel therapies
-
Oct
-
Griffin J. The biology of signal transduction inhibition: basic science to novel therapies. Semin Oncol 2001 Oct; 28 (5 Suppl. 17): 3-8
-
(2001)
Semin Oncol
, vol.28
, Issue.5 SUPPL. 17
, pp. 3-8
-
-
Griffin, J.1
-
3
-
-
0035934067
-
Chronic myelogenous leukemia
-
Aug 22
-
Kalidas M, Kantarjian H, Talpaz M. Chronic myelogenous leukemia. JAMA 2001 Aug 22; 286: 895-8
-
(2001)
JAMA
, vol.286
, pp. 895-898
-
-
Kalidas, M.1
Kantarjian, H.2
Talpaz, M.3
-
4
-
-
0037186924
-
Imatinib mesylate: A new oral targeted therapy
-
Feb 28
-
Savage DG, Antman KH. Imatinib mesylate: a new oral targeted therapy. N Engl J Med 2002 Feb 28; 346 (9): 683-93
-
(2002)
N Engl J Med
, vol.346
, Issue.9
, pp. 683-693
-
-
Savage, D.G.1
Antman, K.H.2
-
5
-
-
0034670036
-
The molecular biology of chronic myeloid leukemia
-
Nov 15
-
Deininger MW, Goldman JM, Melo JV. The molecular biology of chronic myeloid leukemia. Blood 2000 Nov 15; 96 (10): 3343-56
-
(2000)
Blood
, vol.96
, Issue.10
, pp. 3343-3356
-
-
Deininger, M.W.1
Goldman, J.M.2
Melo, J.V.3
-
6
-
-
0037255947
-
Advanced-phase chronic myeloid leukemia
-
Jan
-
Cortes J, Kantarjian H. Advanced-phase chronic myeloid leukemia. Semin Hematol 2003 Jan; 40 (1): 79-86
-
(2003)
Semin Hematol
, vol.40
, Issue.1
, pp. 79-86
-
-
Cortes, J.1
Kantarjian, H.2
-
7
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
May
-
Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996 May; 2: 561-6
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
8
-
-
0033816156
-
Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
-
Oct
-
Buchdunger E, Cioffi CL, Law N, et al. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 2000 Oct; 295 (1): 139-45
-
(2000)
J Pharmacol Exp Ther
, vol.295
, Issue.1
, pp. 139-14
-
-
Buchdunger, E.1
Cioffi, C.L.2
Law, N.3
-
9
-
-
0035871874
-
ARG tyrosine kinase activity is inhibited by ST1571
-
Okuda K, Weisberg E, Gilliland DG, et al. ARG tyrosine kinase activity is inhibited by ST1571. Blood 2001; 97 (8): 2440-8
-
(2001)
Blood
, vol.97
, Issue.8
, pp. 2440-2448
-
-
Okuda, K.1
Weisberg, E.2
Gilliland, D.G.3
-
11
-
-
0037225829
-
Imatinib mesylate: In the treatment of gastrointestinal stromal tumours
-
Croom KF, Perry CM. Imatinib mesylate: in the treatment of gastrointestinal stromal tumours. Drugs 2003; 63 (5): 513-22
-
(2003)
Drugs
, vol.63
, Issue.5
, pp. 513-522
-
-
Croom, K.F.1
Perry, C.M.2
-
12
-
-
0031454003
-
CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
-
Dec 15
-
Carroll M, Ohno-Jones S, Tamura S, et al. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins. Blood 1997 Dec 15; 90: 4947-52
-
(1997)
Blood
, vol.90
, pp. 4947-4952
-
-
Carroll, M.1
Ohno-Jones, S.2
Tamura, S.3
-
13
-
-
0030031766
-
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
-
Buchdunger E, Zimmerman J, Mett H, et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res 1996; 56: 100-4
-
(1996)
Cancer Res
, vol.56
, pp. 100-104
-
-
Buchdunger, E.1
Zimmerman, J.2
Mett, H.3
-
14
-
-
0031409736
-
Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis
-
Gambacorti-Passerini C, le Coutre P, Mologni L, et al. Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis. Blood Cells Mol Dis 1997; 23 (19): 380-94
-
(1997)
Blood Cells Mol Dis
, vol.23
, Issue.19
, pp. 380-394
-
-
Gambacorti-Passerini, C.1
Le Coutre, P.2
Mologni, L.3
-
15
-
-
0030853063
-
The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells
-
Nov 1
-
Deininger MW, Goldman JM, Lydon N, et al. The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells. Blood 1997 Nov 1; 90 (9): 3691-8
-
(1997)
Blood
, vol.90
, Issue.9
, pp. 3691-3698
-
-
Deininger, M.W.1
Goldman, J.M.2
Lydon, N.3
-
16
-
-
0742309580
-
Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing 190-KD BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148)
-
Nov 15
-
Beran M, Cao X, Estrov Z, et al. Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing 190-KD BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148) [abstract]. Blood 1997 Nov 15; 90 (Suppl. 1, Pt 1): 248a
-
(1997)
Blood
, vol.90
, Issue.SUPPL. 1 AND PART 1
-
-
Beran, M.1
Cao, X.2
Estrov, Z.3
-
17
-
-
0033585504
-
In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor
-
Jan 20
-
le Coutre P, Mologni L, Cleris L, et al. In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor. J Natl Cancer Inst 1999 Jan 20; 91 (2): 163-8
-
(1999)
J Natl Cancer Inst
, vol.91
, Issue.2
, pp. 163-168
-
-
Le Coutre, P.1
Mologni, L.2
Cleris, L.3
-
18
-
-
0035073392
-
Effect of a selective Abl tyrosine kinase inhibitor, STI571, on in vitro growth of BCR-ABL-positive acute lymphoblastic leukemia cells
-
Apr
-
Kawaguchi Y, Jinnai I, Nagai K, et al. Effect of a selective Abl tyrosine kinase inhibitor, STI571, on in vitro growth of BCR-ABL-positive acute lymphoblastic leukemia cells. Leukemia 2001 Apr; 15: 590-4
-
(2001)
Leukemia
, vol.15
, pp. 590-594
-
-
Kawaguchi, Y.1
Jinnai, I.2
Nagai, K.3
-
19
-
-
18344383326
-
ST1571 (imatinib mesylate) reduces bone marrow cellularity and normalizes morphologic features irrespective of cytogenetic response
-
Mar
-
Hasserjian RP, Boecklin F, Parker S, et al. ST1571 (imatinib mesylate) reduces bone marrow cellularity and normalizes morphologic features irrespective of cytogenetic response. Am J Clin Pathol 2002 Mar; 117 (3): 360-7
-
(2002)
Am J Clin Pathol
, vol.117
, Issue.3
, pp. 360-367
-
-
Hasserjian, R.P.1
Boecklin, F.2
Parker, S.3
-
20
-
-
0037100308
-
Hematopathologic and cytogenetic findings in imatinib mesylate-treated chronic myelogenous leukemia patients: 14 Months' experience
-
Jul 15
-
Braziel RM, Launder TM, Druker BJ, et al. Hematopathologic and cytogenetic findings in imatinib mesylate-treated chronic myelogenous leukemia patients: 14 months' experience. Blood 2002 Jul 15; 100 (2): 435-41
-
(2002)
Blood
, vol.100
, Issue.2
, pp. 435-441
-
-
Braziel, R.M.1
Launder, T.M.2
Druker, B.J.3
-
21
-
-
0036399997
-
Combination therapy with imatinib mesylate (STI571): Synopsis of in vitro studies
-
Oct
-
Topaly J, Zeller WJ, Fruehauf S. Combination therapy with imatinib mesylate (STI571): synopsis of in vitro studies. Br J Haematol 2002 Oct; 119 (1): 3-14
-
(2002)
Br J Haematol
, vol.119
, Issue.1
, pp. 3-14
-
-
Topaly, J.1
Zeller, W.J.2
Fruehauf, S.3
-
22
-
-
0037315281
-
Molecular mechanisms of resistance to imatinib in Philadelphia-chromosome-positive leukaemias
-
Gambacorti-Passerini CB, Gunby RH, Piazza R, et al. Molecular mechanisms of resistance to imatinib in Philadelphia-chromosome-positive leukaemias. Lancet Oncol 2003; 4: 75-85
-
(2003)
Lancet Oncol
, vol.4
, pp. 75-85
-
-
Gambacorti-Passerini, C.B.1
Gunby, R.H.2
Piazza, R.3
-
23
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Aug 3
-
Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001 Aug 3; 293 (5531): 876-80
-
(2001)
Science
, vol.293
, Issue.5531
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
24
-
-
0034161460
-
Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification
-
Mar 1
-
le Coutre P, Tassi E, Varella-Garcia M, et al. Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification. Blood 2000 Mar 1; 95: 1758-66
-
(2000)
Blood
, vol.95
, pp. 1758-1766
-
-
Le Coutre, P.1
Tassi, E.2
Varella-Garcia, M.3
-
25
-
-
0036566540
-
High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
-
May 1
-
Branford S, Rudzki Z, Walsh S, et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 2002 May 1; 99 (9): 3472-5
-
(2002)
Blood
, vol.99
, Issue.9
, pp. 3472-3475
-
-
Branford, S.1
Rudzki, Z.2
Walsh, S.3
-
26
-
-
0037045583
-
BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: A prospective study
-
Feb 9
-
von Bubnoff N, Schneller F, Peschel C, et al. BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study. Lancet 2002 Feb 9; 359: 487-91
-
(2002)
Lancet
, vol.359
, pp. 487-491
-
-
Von Bubnoff, N.1
Schneller, F.2
Peschel, C.3
-
27
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Aug
-
Shah NP, Nicoll JM, Nagar B, et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2002 Aug; 2 (2): 117-25
-
(2002)
Cancer Cell
, vol.2
, Issue.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
-
28
-
-
0036850514
-
Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
-
Hochhaus A, Kreil S, Corbin AS, et al. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 2002; 16: 2190-6
-
(2002)
Leukemia
, vol.16
, pp. 2190-2196
-
-
Hochhaus, A.1
Kreil, S.2
Corbin, A.S.3
-
29
-
-
0037093082
-
Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation
-
May 15
-
Holtz MS, Slovak ML, Zhang F, et al. Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation. Blood 2002 May 15; 99 (10): 3792-800
-
(2002)
Blood
, vol.99
, Issue.10
, pp. 3792-3800
-
-
Holtz, M.S.1
Slovak, M.L.2
Zhang, F.3
-
30
-
-
0034018326
-
The tyrosine kinase inhibitor STI571, like interferon-alpha, preferentially reduces the capacity for amplification of granolocyte-macrophage progenitors from patients with chronic myeloid leukemia
-
May
-
Marley SB, Deininger MWN, Davidson RJ, et al. The tyrosine kinase inhibitor STI571, like interferon-alpha, preferentially reduces the capacity for amplification of granolocyte-macrophage progenitors from patients with chronic myeloid leukemia. Exp Hematol 2000 May; 28: 551-7
-
(2000)
Exp Hematol
, vol.28
, pp. 551-557
-
-
Marley, S.B.1
Deininger, M.W.N.2
Davidson, R.J.3
-
31
-
-
0034796301
-
Progenitor cells from patients with advanced phase chronic myeloid leukaemia respond to STI571 in vitro and in vivo
-
Nov
-
Marley SB, Davidson RJ, Lewis JL, et al. Progenitor cells from patients with advanced phase chronic myeloid leukaemia respond to STI571 in vitro and in vivo. Leuk Res 2001 Nov; 25 (11): 997-1002
-
(2001)
Leuk Res
, vol.25
, Issue.11
, pp. 997-1002
-
-
Marley, S.B.1
Davidson, R.J.2
Lewis, J.L.3
-
33
-
-
0038518619
-
Practical management of patients with chronic myeloid leukemia receiving imatinib
-
Deininger MW, O'Brien SG, Ford JM, et al. Practical management of patients with chronic myeloid leukemia receiving imatinib. J Clin Oncol 2003; 21 (8): 1637-47
-
(2003)
J Clin Oncol
, vol.21
, Issue.8
, pp. 1637-1647
-
-
Deininger, M.W.1
O'Brien, S.G.2
Ford, J.M.3
-
34
-
-
0034254368
-
Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor ST1571: Diverse mechanisms of resistance
-
Mahon FX, Deininger MWN, Schultheis B. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor ST1571: diverse mechanisms of resistance. Blood 2000; 96 (3): 1070-9
-
(2000)
Blood
, vol.96
, Issue.3
, pp. 1070-1079
-
-
Mahon, F.X.1
Deininger, M.W.N.2
Schultheis, B.3
-
36
-
-
0042305479
-
α1 Acid glycoprotein binds to imatinib (ST1571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients
-
Feb
-
Gambacorti-Passerini C, Zucchetti M, Russo D, et al. α1 Acid glycoprotein binds to imatinib (ST1571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients. Clin Cancer Res 2003 Feb; 9 (2): 625-32
-
(2003)
Clin Cancer Res
, vol.9
, Issue.2
, pp. 625-632
-
-
Gambacorti-Passerini, C.1
Zucchetti, M.2
Russo, D.3
-
38
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Apr 5
-
Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001 Apr 5; 344 (14): 1031-7
-
(2001)
N Engl J Med
, vol.344
, Issue.14
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
39
-
-
0000324194
-
Effect of food on STI571 Glivec pharmacokinetics and bioavailability
-
May 12-15; San Francisco, CA
-
Reckmann AH, Fischer T, Peng B, et al. Effect of food on STI571 Glivec pharmacokinetics and bioavailability [abstract 1223]. Proceedings of the 37th Annual Meeting of the American Society of Clinical Oncology; 2001 May 12-15; San Francisco, CA; 20 (Pt 1): 307a
-
(2001)
Proceedings of the 37th Annual Meeting of the American Society of Clinical Oncology
, vol.20
, Issue.PART 1
-
-
Reckmann, A.H.1
Fischer, T.2
Peng, B.3
-
40
-
-
79960971419
-
Low penetration of imatinib (STI571) into the CSF indicates the need for standard CNS prophylaxis in patients with CML lymphoid blast crisis and Philadelphia chromosome positive ALL
-
Leis JF, Stepan DE, Curtin PT, et al. Low penetration of imatinib (STI571) into the CSF indicates the need for standard CNS prophylaxis in patients with CML lymphoid blast crisis and Philadelphia chromosome positive ALL [abstract no. 590]. Blood 2001; 98 (11 Pt 1): 140a
-
(2001)
Blood
, vol.98
, Issue.11 PART 1
-
-
Leis, J.F.1
Stepan, D.E.2
Curtin, P.T.3
-
41
-
-
79960970861
-
A pharmacokinetic interaction of Glivec® and simvastatin, a cytochrome 3A4 substrate, in patients with chronic myeloid leukemia
-
O'Brien SG, Peng B. Dutreix C, et al. A pharmacokinetic interaction of Glivec® and simvastatin, a cytochrome 3A4 substrate, in patients with chronic myeloid leukemia [abstract no. 593]. Blood 2001; 98 (11 Pt 1): 141a
-
(2001)
Blood
, vol.98
, Issue.11 PART 1
-
-
O'Brien, S.G.1
Peng, B.2
Dutreix, C.3
-
42
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348 (11): 994-1004
-
(2003)
N Engl J Med
, vol.348
, Issue.11
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
43
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
-
May 15
-
Sawyers CL, Hochhaus A, Feldman E, et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood 2002 May 15; 99: 3530-9
-
(2002)
Blood
, vol.99
, pp. 3530-3539
-
-
Sawyers, C.L.1
Hochhaus, A.2
Feldman, E.3
-
44
-
-
0037085785
-
Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
-
Mar 15
-
Talpaz M, Silver RT, Druker BJ, et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood 2002 Mar 15; 99 (6): 1928-37
-
(2002)
Blood
, vol.99
, Issue.6
, pp. 1928-1937
-
-
Talpaz, M.1
Silver, R.T.2
Druker, B.J.3
-
45
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Feb 28
-
Kantarjian H, Sawyers C, Hochhaus A, et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 2002 Feb 28; 346 (9): 645-52
-
(2002)
N Engl J Med
, vol.346
, Issue.9
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
-
46
-
-
23544481546
-
Imatinib (Glivec®) in patients with Ph+ chronic myeloid leukemia in chronic phase after interferon failure: Results of a phase II trial of the Italian Cooperative Study Group on CML
-
Bassi S, Trabacchi E, Bonifazi F, et al. Imatinib (Glivec®) in patients with Ph+ chronic myeloid leukemia in chronic phase after interferon failure: results of a phase II trial of the Italian Cooperative Study Group on CML [abstract no. 3096]. Blood 2002; 100 (Pt 1): 783a
-
(2002)
Blood
, vol.100
, Issue.PART 1
-
-
Bassi, S.1
Trabacchi, E.2
Bonifazi, F.3
-
47
-
-
0037731068
-
High rates of major cytogenetic response in patients with newly diagnosed chronic myeloid leukemia (CML) in early chronic phase treated with imatinib at 400 mg or 800 mg daily
-
Nov 16
-
Cortes JE, Talpaz M, O'Brien S, et al. High rates of major cytogenetic response in patients with newly diagnosed chronic myeloid leukemia (CML) in early chronic phase treated with imatinib at 400 mg or 800 mg daily [abstract no. 350]. Blood 2002 Nov 16; 100 (11 Pt 1): 95a
-
(2002)
Blood
, vol.100
, Issue.11 PART 1
-
-
Cortes, J.E.1
Talpaz, M.2
O'Brien, S.3
-
48
-
-
0038304378
-
Imatinib (Glivec®) in patients with Ph+ chronic myeloid leukemia in accelerated/blastic phase (AP/B): Results of a phase II trial of the Italian Cooperative Study Group on CML (ICSG on CML)
-
Trabacchi E, Bonifazi F, Bassi S, et al. Imatinib (Glivec®) in patients with Ph+ chronic myeloid leukemia in accelerated/blastic phase (AP/B): results of a phase II trial of the Italian Cooperative Study Group on CML (ICSG on CML) [abstract no. 2295]. Blood 2002; 100 (Pt 1): 584a
-
(2002)
Blood
, vol.100
, Issue.PART 1
-
-
Trabacchi, E.1
Bonifazi, F.2
Bassi, S.3
-
49
-
-
0037092980
-
Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase
-
May 15
-
Kantarjian HM, Cortes J, O'Brien S, et al. Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase. Blood 2002 May 15; 99 (10): 3547-53
-
(2002)
Blood
, vol.99
, Issue.10
, pp. 3547-3553
-
-
Kantarjian, H.M.1
Cortes, J.2
O'Brien, S.3
-
50
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Apr 5
-
Druker BJ, Sawyers CL, Kantarjian H, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001 Apr 5; 344 (14): 1038-42
-
(2001)
N Engl J Med
, vol.344
, Issue.14
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
-
51
-
-
23544479004
-
Imatinib treatment for advanced CML improves patients' quality of life
-
Nov 16
-
Arthur C, Fay K, Grigg A. et al. Imatinib treatment for advanced CML improves patients' quality of life [abstract no. 4859]. Blood 2002 Nov 16; 100 (Pt 2): 327b
-
(2002)
Blood
, vol.100
, Issue.PART 2
-
-
Arthur, C.1
Fay, K.2
Grigg, A.3
-
52
-
-
0037568145
-
Molecular responses to imatinib (ST1571) or interferon + Ara-C as initial therapy for CML; results in the IRIS Study
-
Nov 16
-
Hughes T, Kaeda J, Branford S, et al. Molecular responses to imatinib (ST1571) or interferon + Ara-C as initial therapy for CML; results in the IRIS Study [abstract no. 345]. Blood 2002 Nov 16; 100 (Pt 1): 93a-4a
-
(2002)
Blood
, vol.100
, Issue.PART 1
-
-
Hughes, T.1
Kaeda, J.2
Branford, S.3
-
53
-
-
0141863481
-
Residual disease in chronic myeloid leukemia after induction of molecular remission
-
Lange T, Niederwieser DW. Residual disease in chronic myeloid leukemia after induction of molecular remission. N Eng J Med 2003; 349 (15): 1483-4
-
(2003)
N Eng J Med
, vol.349
, Issue.15
, pp. 1483-1484
-
-
Lange, T.1
Niederwieser, D.W.2
-
54
-
-
0742309583
-
Quality of life of patients with chronic phase chronic myeloid leukemia in the IRIS Study of interferon-alpha plus Ara-C vs imatinib (STI571, Glivec®, Gleevec™)
-
Nov 16
-
Hahn EA, Sorensen MV, Hudgens SA, et al. Quality of life of patients with chronic phase chronic myeloid leukemia in the IRIS Study of interferon-alpha plus Ara-C vs imatinib (STI571, Glivec®, Gleevec™) [abstract no. 346]. Blood 2002 Nov 16; 100 (Pt 1): 94a
-
(2002)
Blood
, vol.100
, Issue.PART 1
-
-
Hahn, E.A.1
Sorensen, M.V.2
Hudgens, S.A.3
-
55
-
-
0742309579
-
Within-trial resource utilization and costs of patients randomized to treatment with imatinib (STI571) versus interferon-alpha (IFN-α) combined with cytarabine (Ara-C) in newly diagnosed patients with chronic myeloid leukemia in chronic phase
-
Nov 16
-
Reed SD, Radeva JI, Glendenning A, et al. Within-trial resource utilization and costs of patients randomized to treatment with imatinib (STI571) versus interferon-alpha (IFN-α) combined with cytarabine (Ara-C) in newly diagnosed patients with chronic myeloid leukemia in chronic phase [abstract no. 698]. Blood 2002 Nov 16; 100 (Pt 1): 187a
-
(2002)
Blood
, vol.100
, Issue.PART 1
-
-
Reed, S.D.1
Radeva, J.I.2
Glendenning, A.3
-
56
-
-
0742327254
-
Imatinib in chronic myeloid leukemia (CML): Outcomes in >7000 patients treated on expanded access program (EAP)
-
May 31-Jun 3; Chicago
-
Hensley ML, Van Hoomissen IC, Krahnke T, et al. Imatinib in chronic myeloid leukemia (CML): outcomes in >7000 patients treated on expanded access program (EAP) [abstract no. 2328]. 39th Annual Meeting of the American Society of Clinical Oncology; 2003 May 31-Jun 3; Chicago, 579
-
(2003)
39th Annual Meeting of the American Society of Clinical Oncology
, pp. 579
-
-
Hensley, M.L.1
Van Hoomissen, I.C.2
Krahnke, T.3
-
57
-
-
0032999728
-
Chronic myelogenous leukemia: Update on biology and treatment
-
Feb; discussion 181, 184
-
Faderl S, Kantarjian HM, Talpaz M. Chronic myelogenous leukemia: update on biology and treatment. Oncology (Huntingt) 1999 Feb; 13 (2): 169-80; discussion 181, 184
-
(1999)
Oncology (Huntingt)
, vol.13
, Issue.2
, pp. 169-180
-
-
Faderl, S.1
Kantarjian, H.M.2
Talpaz, M.3
-
58
-
-
0003406214
-
-
Jun 1 [online]
-
National Cancer Institute. Common Toxicity Criteria, Version 2.0 1999 Jun 1 [online]. Available from URL: http://ctep.cancer.gov [Accessed 2003 Mar 30]
-
(1999)
Common Toxicity Criteria, Version 2.0
-
-
-
61
-
-
0037346335
-
Current use of imatinib in the treatment of chronic myeloid leukemia
-
Mar
-
O'Dwyer M. Current use of imatinib in the treatment of chronic myeloid leukemia. Haematologica 2003 Mar; 88 (3): 241-4
-
(2003)
Haematologica
, vol.88
, Issue.3
, pp. 241-244
-
-
O'Dwyer, M.1
-
62
-
-
0037434853
-
Imatinib mesylate-the new gold standard for treatment of chronic myeloid leukemia
-
Peggs K, Mackinnon S. Imatinib mesylate-the new gold standard for treatment of chronic myeloid leukemia. N Engl J Med 2003; 348 (11): 1048-50
-
(2003)
N Engl J Med
, vol.348
, Issue.11
, pp. 1048-1050
-
-
Peggs, K.1
Mackinnon, S.2
-
63
-
-
0035496899
-
Chronic myeloid leukemia: Current treatment options
-
Oct 1
-
Goldman JM, Druker BJ. Chronic myeloid leukemia: current treatment options. Blood 2001 Oct 1; 98 (7): 2039-42
-
(2001)
Blood
, vol.98
, Issue.7
, pp. 2039-2042
-
-
Goldman, J.M.1
Druker, B.J.2
-
64
-
-
13044294682
-
An evidence-based analysis of the effect of busulfan, hydroxyurea, interferon, and allogeneic bone marrow transplantation in treating the chronic phase of chronic myeloid leukemia: Developed for the American Society of Hematology
-
Sep 1
-
Silver RT, Woolf SH, Hehlmann R, et al. An evidence-based analysis of the effect of busulfan, hydroxyurea, interferon, and allogeneic bone marrow transplantation in treating the chronic phase of chronic myeloid leukemia: developed for the American Society of Hematology. Blood 1999 Sep 1; 94 (5): 1517-36
-
(1999)
Blood
, vol.94
, Issue.5
, pp. 1517-1536
-
-
Silver, R.T.1
Woolf, S.H.2
Hehlmann, R.3
-
65
-
-
23444462074
-
Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia
-
Mar 24
-
Italian Cooperative Study Group on Chronic Myeloid Leukemia. Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. N Engl J Med 1994 Mar 24; 330 (12): 820-5
-
(1994)
N Engl J Med
, vol.330
, Issue.12
, pp. 820-825
-
-
-
66
-
-
0029041749
-
UK Medical Research Council randomised, multicentre trial of interferon-α n1 for chronic myeloid leukaemia: Improved survival irrespective of cytogenetic response
-
UK Medical Research Council's Working Parties for Therapeutic Trials in Adult Leukaemia. Jun 3
-
Allan NC, Richards SM, Shepherd PCA. UK Medical Research Council randomised, multicentre trial of interferon-α n1 for chronic myeloid leukaemia: improved survival irrespective of cytogenetic response. UK Medical Research Council's Working Parties for Therapeutic Trials in Adult Leukaemia. Lancet 1995 Jun 3; 345 (8962): 1392-7
-
(1995)
Lancet
, vol.345
, Issue.8962
, pp. 1392-1397
-
-
Allan, N.C.1
Richards, S.M.2
Shepherd, P.C.A.3
-
67
-
-
0030715606
-
Interferon alfa versus chemotherapy for chronic myeloid leukemia: A meta-analysis of seven randomized trials
-
Nov 5
-
Chronic Myeloid Leukemia Trialists' Collaborative Group. Interferon alfa versus chemotherapy for chronic myeloid leukemia: a meta-analysis of seven randomized trials: J Natl Cancer Inst 1997 Nov 5; 89 (21): 1616-20
-
(1997)
J Natl Cancer Inst
, vol.89
, Issue.21
, pp. 1616-1620
-
-
-
68
-
-
0032522945
-
Randomized study on hydroxyurea alone versus hydroxyurea combined with low-dose interferon-α 2b for chronic myeloid leukemia
-
Apr 15
-
Benelux CML Study Group. Randomized study on hydroxyurea alone versus hydroxyurea combined with low-dose interferon-α 2b for chronic myeloid leukemia. Blood 1998 Apr 15; 91 (8): 2713-21
-
(1998)
Blood
, vol.91
, Issue.8
, pp. 2713-2721
-
-
-
69
-
-
0345696854
-
Interferon alfa-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia
-
French Chronic Myeloid Leukemia Study Group. Jul 24
-
Guilhot F, Chastang C, Michallet M. et al. Interferon alfa-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia. French Chronic Myeloid Leukemia Study Group. N Engl J Med 1997 Jul 24; 337 (4): 223-9
-
(1997)
N Engl J Med
, vol.337
, Issue.4
, pp. 223-229
-
-
Guilhot, F.1
Chastang, C.2
Michallet, M.3
-
70
-
-
0033572876
-
Chronic myelogenous leukemia in nonlymphoid blastic phase: Analysis of the results of first salvage therapy with three different treatment approaches for 162 patients
-
Dec 15
-
Sacchi S, Kantarjian HM, O'Brien S, et al. Chronic myelogenous leukemia in nonlymphoid blastic phase: analysis of the results of first salvage therapy with three different treatment approaches for 162 patients. Cancer 1999 Dec 15; 86 (12): 2632-41
-
(1999)
Cancer
, vol.86
, Issue.12
, pp. 2632-2641
-
-
Sacchi, S.1
Kantarjian, H.M.2
O'Brien, S.3
-
71
-
-
79960971752
-
Myeloid growth factors for neutropenia during imatinib mesylate (STI571) therapy for CML: Preliminary evidence of safety and efficacy
-
Mauro MJ, Kurilik G, Balleisen S, et al. Myeloid growth factors for neutropenia during imatinib mesylate (STI571) therapy for CML: preliminary evidence of safety and efficacy [abstract no. 584]. Blood 2001; 98: 139a
-
(2001)
Blood
, vol.98
-
-
Mauro, M.J.1
Kurilik, G.2
Balleisen, S.3
-
72
-
-
0034873546
-
Implications of imatinib mesylate for hematopoietic stem cell transplantation
-
Jul
-
Goldman J. Implications of imatinib mesylate for hematopoietic stem cell transplantation. Semin Hematol 2001 Jul; 38 (3 Suppl. 8): 28-34
-
(2001)
Semin Hematol
, vol.38
, Issue.3 SUPPL. 8
, pp. 28-34
-
-
Goldman, J.1
-
73
-
-
0037467490
-
Imatinib for chronic myelogenous leukaemia: A 9 or 24 carat gold standard?
-
Sausville EA. Imatinib for chronic myelogenous leukaemia: a 9 or 24 carat gold standard? Lancet 2003; 361: 1400-1
-
(2003)
Lancet
, vol.361
, pp. 1400-1401
-
-
Sausville, E.A.1
-
74
-
-
19244365299
-
Imatinib mesylate (STI571) treatment in patients with chronic-phase chronic myelogenous leukaemia previously submitted to autologous stem cell transplantation
-
Feb
-
Cervantes F, Hernández-Boluda J-C, Odriozola J. et al. Imatinib mesylate (STI571) treatment in patients with chronic-phase chronic myelogenous leukaemia previously submitted to autologous stem cell transplantation. Br J Haematol 2003 Feb; 120 (3): 500-4
-
(2003)
Br J Haematol
, vol.120
, Issue.3
, pp. 500-504
-
-
Cervantes, F.1
Hernández-Boluda, J.-C.2
Odriozola, J.3
-
75
-
-
23544436467
-
A phase II open-label study to investigate the safety profile and potential of imatinib mesylate (Gleevec, STI-571) to restore molecular remissions and chimerism in patients with BCR-ABL-positive CML with minimal residual disease (MRD) post allogeneic BMT/SCT
-
Nov 16
-
Hess G, Siegert W, Kolb HJ, et al. A phase II open-label study to investigate the safety profile and potential of imatinib mesylate (Gleevec, STI-571) to restore molecular remissions and chimerism in patients with BCR-ABL-positive CML with minimal residual disease (MRD) post allogeneic BMT/ SCT [abstract no. 665]. Blood 2002 Nov 16; 100 (Pt 1): 177a-8a
-
(2002)
Blood
, vol.100
, Issue.PART 1
-
-
Hess, G.1
Siegert, W.2
Kolb, H.J.3
-
76
-
-
0037093061
-
Imatinib mesylate (STI571) in the treatment of relapse of chronic myeloid leukemia after allogeneic stem cell transplantation
-
May 15
-
Olavarria E, Craddock C, Dazzi F, et al. Imatinib mesylate (STI571) in the treatment of relapse of chronic myeloid leukemia after allogeneic stem cell transplantation. Blood 2002 May 15; 99 (10): 3861-2
-
(2002)
Blood
, vol.99
, Issue.10
, pp. 3861-3862
-
-
Olavarria, E.1
Craddock, C.2
Dazzi, F.3
-
77
-
-
79960970573
-
Clinical and laboratory evaluation of patients treated with STI-571 (Gleevec™) after allogeneic and syngeneic stem cell transplantation with relapsed Philadelphia chromosome-positive leukemia
-
Nov 16
-
Ullmann AJ, Beck J, Kolbe K, et al. Clinical and laboratory evaluation of patients treated with STI-571 (Gleevec™) after allogeneic and syngeneic stem cell transplantation with relapsed Philadelphia chromosome-positive leukemia [abstract no. 1685]. Blood 2001 Nov 16; 98 (Pt 1): 401a
-
(2001)
Blood
, vol.98
, Issue.PART 1
-
-
Ullmann, A.J.1
Beck, J.2
Kolbe, K.3
-
78
-
-
79960970521
-
Imatinib mesylate (Gleevec) for disease relapse following allogeneic bone marrow transplantation
-
Nov 16
-
Soiffer RJ, Galinsky I, DeAngelo D, et al. Imatinib mesylate (Gleevec) for disease relapse following allogeneic bone marrow transplantation [abstract no. 1682]. Blood 2001 Nov 16; 98 (Pt 1): 400a
-
(2001)
Blood
, vol.98
, Issue.PART 1
-
-
Soiffer, R.J.1
Galinsky, I.2
DeAngelo, D.3
-
79
-
-
0141763983
-
ST1571 (Glivec) in the treatment of patients with chronic myeloid leukemia (CML) relapsing after allogeneic stem cell transplantation
-
Mar
-
Pfeifer H, Wassmann B, Scheuring U. et al. ST1571 (Glivec) in the treatment of patients with chronic myeloid leukemia (CML) relapsing after allogeneic stem cell transplantation [abstract no. 0240]. Bone Marrow Transplant 2002 Mar; 29 Suppl. 2: S34
-
(2002)
Bone Marrow Transplant
, vol.29
, Issue.SUPPL. 2
-
-
Pfeifer, H.1
Wassmann, B.2
Scheuring, U.3
-
80
-
-
0742309585
-
Imatinib (STI-571) for treatment of relapse after stem cell transplantation (SCT)
-
Nov 16
-
Miller CB, Smith BD, Gore SD, et al. Imatinib (STI-571) for treatment of relapse after stem cell transplantation (SCT) [abstract no. 1683]. Blood 2001 Nov 16; 98 (Pt 1): 400a-1a
-
(2001)
Blood
, vol.98
, Issue.PART 1
-
-
Miller, C.B.1
Smith, B.D.2
Gore, S.D.3
-
81
-
-
23544440959
-
Use of imatinib mesylate in CML patients autografted in the pre-imatinib mesylate era: A single center experience
-
Nov 16
-
Liesveld JL, Nichols D, Ifthikharuddin JJ, et al. Use of imatinib mesylate in CML patients autografted in the pre-imatinib mesylate era: a single center experience [abstract no. 5471]. Blood 2002 Nov 16; 100 (Pt 2): 473b
-
(2002)
Blood
, vol.100
, Issue.PART 2
-
-
Liesveld, J.L.1
Nichols, D.2
Ifthikharuddin, J.J.3
-
82
-
-
0042027061
-
Allografting after imatinib therapy. No evidence for increased transplant-related mortality and favorable result in patients transplanted in remission. A retrospective study by the EBMT
-
Deininger MWN, Schleuning M, Sayer H-G, et al. Allografting after imatinib therapy. No evidence for increased transplant-related mortality and favorable result in patients transplanted in remission. A retrospective study by the EBMT. [abstract no. 3097] Blood 2003; 100 (Pt 1): 783a
-
(2003)
Blood
, vol.100
, Issue.PART 1
-
-
Deininger, M.W.N.1
Schleuning, M.2
Sayer, H.-G.3
-
83
-
-
20844461361
-
Risk and early cytogenetic response to imatinib and interferon in chronic myeloid leukemia
-
Mar
-
Rosti G, Trabacchi E, Bassi S, et al. Risk and early cytogenetic response to imatinib and interferon in chronic myeloid leukemia. Haematologica 2003 Mar; 88 (3): 256-9
-
(2003)
Haematologica
, vol.88
, Issue.3
, pp. 256-259
-
-
Rosti, G.1
Trabacchi, E.2
Bassi, S.3
-
84
-
-
79960970988
-
Preliminary evaluation of the combination f imatinib mesylate (Gleevec) in combination with low dose interferon-alpha for the treatment of chronic phase CML [abstract no
-
Nov 16
-
O'Dwyer ME, Mauro MJ, Kuyl JM, et al. Preliminary evaluation of the combination f imatinib mesylate (Gleevec) in combination with low dose interferon-alpha for the treatment of chronic phase CML [abstract no. 3513]. Blood 2001 Nov 16; 98: 846a
-
(2001)
Blood
, vol.98
-
-
O'Dwyer, M.E.1
Mauro, M.J.2
Kuyl, J.M.3
-
85
-
-
79960970508
-
PEGIntron and ST1571 combination evaluation study (PISCES) in chronic phase chronic myeloid leukaemia
-
Nov 16
-
O'Brien S, Vallance SE, Craddock C, et al. PEGIntron and ST1571 combination evaluation study (PISCES) in chronic phase chronic myeloid leukaemia [abstract no. 3512]. Blood 2001 Nov 16; 98: 846a
-
(2001)
Blood
, vol.98
-
-
O'Brien, S.1
Vallance, S.E.2
Craddock, C.3
-
86
-
-
79960971561
-
A phase I study of Gleevec (imatinib mesylate) administered concomitantly with cytosine arabinoside (Ara-C) in patients with Philadelphia positive chronic myeloid leukemia (CML)
-
Nov 16
-
Druker BJ, Kantarjian HM, Talpaz M, et al. A phase I study of Gleevec (imatinib mesylate) administered concomitantly with cytosine arabinoside (Ara-C) in patients with Philadelphia positive chronic myeloid leukemia (CML) [abstract no. 3511]. Blood 2001 Nov 16; 98: 845a-6a
-
(2001)
Blood
, vol.98
-
-
Druker, B.J.1
Kantarjian, H.M.2
Talpaz, M.3
-
87
-
-
0038769442
-
A dose-escalating phase I/II study of imatinib (Glivec) and cytarabin in first chronic phase chronic myeloid leukemia
-
Nov 16
-
Cornelissen JJ, Verhoef GEG, Straetmans N, et al. A dose-escalating phase I/II study of imatinib (Glivec) and cytarabin in first chronic phase chronic myeloid leukemia. Blood 2002 Nov 16; 100 (Pt 1): 95a
-
(2002)
Blood
, vol.100
, Issue.PART 1
-
-
Cornelissen, J.J.1
Verhoef, G.E.G.2
Straetmans, N.3
-
88
-
-
0742327258
-
Imatiuib (Glivec®) and pegylated interferon α2a (Pegasys®) I/II combination study in chronic phase chronic myelogenous leukemia (CML)
-
Hocchaus A, Fischer T, Brummendorf TH. Imatiuib (Glivec®) and pegylated interferon α2a (Pegasys®) I/II combination study in chronic phase chronic myelogenous leukemia (CML) [abstract no. 616]. Blood 2002; 100 (Pt 1): 164a-5a
-
(2002)
Blood
, vol.100
, Issue.PART 1
-
-
Hocchaus, A.1
Fischer, T.2
Brummendorf, T.H.3
-
89
-
-
4243233494
-
Imatinib (Gleevec®) and cytarabine (ARA-C) C) is an effective regimen in Philadephia (Ph)-positive chronic myelogenous leukaemia (CML) chronic phase (CP) patients (pts)
-
Martine G, Philippe R, Michel T, et al. Imatinib (Gleevec®) and cytarabine (ARA-C) C) is an effective regimen in Philadephia (Ph)-positive chronic myelogenous leukaemia (CML) chronic phase (CP) patients (pts) [abstract no. 351]. Blood 2002; 100 (Pt 1): 95a
-
(2002)
Blood
, vol.100
, Issue.PART 1
-
-
Martine, G.1
Philippe, R.2
Michel, T.3
-
90
-
-
0012566091
-
Preliminary evaluation of the combination of imatinib mesylate (Gleevec) with low dose Ara-C as initial therapy for newly diagnosed chronic phase CML
-
Mauro MJ, O'Dwyer ME, Stone RM, et al. Preliminary evaluation of the combination of imatinib mesylate (Gleevec) with low dose Ara-C as initial therapy for newly diagnosed chronic phase CML [abstract no. 617]. Blood 2002; 100 (Pt 1): 165a
-
(2002)
Blood
, vol.100
, Issue.PART 1
-
-
Mauro, M.J.1
O'Dwyer, M.E.2
Stone, R.M.3
|