A versatile liposome/cyclodextrin supramolecular carrier for drug delivery through the blood-brain barrier

Journal of Inclusion Phenomena and Macrocyclic Chemistry

Volumn 57, Issue 1-4, 2007, Pages 567-572

  Machut Binkowski, Cécile ^a   Hapiot, Frédéric ^a   Cecchelli, Roméo ^a   Martin, Patrick ^a   Monflier, Eric ^a  

^a UNIVERSITÉ D'ARTOIS   (France)

Author keywords

Blood brain barrier; Cyclodextrin; Drug delivery; In vitro model; Liposome; Saccharide; Supramolecular chemistry

Indexed keywords

EID: 34047173452     PISSN: 09230750     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10847-006-9250-7     Document Type: Conference Paper

References (17)

1. Pardridge, W. J.: Drug and gene targeting to the brain with molecular trojan horses. Nature Rev.: Drug Discovery 1, 131-139 (2002)
2. Cordon-Cardo, C., O'Brien, J. P., Casals, D., Rittman-Grauer, L., Biedler, J. L., Melamed, M. R., Bertino, J. R.: Multidrug resistance gene P-glycoprotein is expressed by endothelial cells at blood-brain barrier sites. Proc. Natl. Acad. Sci. USA. 816, 695-698 (1989)
3. Wang, G., Pincheira, R., Zhang, J. T.: Dissection of drug binding induced conformational changes of P-glycoprotein. Eur. J. Biochem. 255, 383-390 (1998)
4. Cornford, E. M., Hyman, S.: Blood-brain barrier permeability to small and large molecules. Adv. Drug Deliv. Rev. 36, 145-163 (1999)
5. Gulyaev, A. E., Gelperina, S. E., Skidan, I. N., Antropov, A. S., Kivman, G. Y., Kreuter, J.: Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles. Pharm. Res. 16, 1564-1569 (1999)
6. Saito, R., Bringas, J. R., McKnight, T. R., Wendland, M. F., Mamot, C., Drummond, D. C., Kirpotin, D. B., Park, J. W., Berger, M. S., Bankiewicz, K. S.: Distribution of liposomes into brain and rat brain-tumor models by convection-enhanced delivery monitored with magnetic resonance imaging. Cancer Res. 64, 2572-2579 (2004)
7. Barenholz, Y.: Liposome application: problems and prospects. Curr. Opin. Colloid Interface Sci. 6, 66-77 (2001)
8. Binkowski, C., Lequart, V., Hapiot, F., Tilloy, S., Cecchelli, R., Monflier, E., Martin, P.: Adamantoylated monosaccharides: new compounds for modification of cyclodextrin containing material properties. Carbohy. Res. 340, 1461-1468 (2005)
9. Binkowski, C., Hapiot, F., Lequart, V., Martin, P., Monflier, E.: Evidence of Self-inclusion Phenomenon for a New Class of Mono-substituted β-Alkylammonium-Cyclodextrins. Org. Biomol. Chem. 3, 1129-1133 (2005)
10. Binkowski-Machut, C., Hapiot, F., Martin, P., Cecchelli, R., Monflier, E.: How cyclodextrins can mask their toxic effect on the blood-brain barrier. Bioorg. Med. Chem. Lett. 16, 1784-1787 (2006)
11. Bangham, A. D., Standish, M. N., Watkins, J. C.: Diffusion of univalent ions across the lamellae of swollen phospholipids. J. Mol. Biol. 13, 238-252 (1965)
12. Monnaert, V., Tilloy, S., Bricout, H., Fenart, L., Cecchelli, R., Monflier, E.: Behavior of α-, β-, γ-cyclodextrins and their derivatives on an in vitro model of blood brain barrier. J. Pharmacol. Exp. Ther. 310, 745-751 (2004)
13. Monnaert, V., Betbeder, D., Fenart, L., Bricout, H., Lenfant, A. M., Landry, C., Cecchelli, R., Monflier, E., Tilloy, S.: Effects of g- and hydroxypropyl-g-cyclodextrins on the transport of doxorubicin across an in vitro model of blood-brain barrier. J. Pharmacol. Exp. Ther. 311, 1115-1120 (2004)
14. Sahoo, S. K., Labhasetwar, V.: Nanotech approaches to drug delivery and imaging. Drug Disc. Today 8, 1112-1120 (2003)
15. Claassen, E.: Post-formation fluorescent labelling of liposomal membranes. In vivo detection, localisation and kinetics. J. Immuno. Methods 147, 231-240 (1992)
16. Dehouck, M. P., Jolliet-Riant, P., Bree, F., Fruchart, J. C., Cecchelli, R., Tillement, J. P.: Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo models. J. Neurochem. 58, 1790-1797 (1992)
17. Huwyler, J., Wu, D., Pardridge, W. M.: Brain drug delivery of small molecules using immunoliposomes. Proc. Natl. Acad. Sci. 93, 14164-14169 (1996)