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Volumn 16, Issue 7, 2006, Pages 1784-1787

How cyclodextrins can mask their toxic effect on the blood-brain barrier

Author keywords

Blood brain barrier; Cyclodextrins; Endothelial cells; In vitro model; Permeability; Toxicity

Indexed keywords

BETA CYCLODEXTRIN DERIVATIVE; CYCLODEXTRIN DERIVATIVE;

EID: 33144457514     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.031     Document Type: Article
Times cited : (12)

References (15)
  • 13
    • 33144483764 scopus 로고    scopus 로고
    • note
    • 10 by dividing the amount of compound in the receiver compartment by the drug concentration in the donor compartment at each time point. The average cumulative volume cleared was plotted versus time, and the slope was estimated by linear regression analysis to give the mean and standard deviation of the estimate. The slope of the clearance curve with inserts alone and inserts with BCEC monolayer is equal to PSf and PSt, respectively, where PS = the permeability surface area product. The units of PS and S are microlitres per minute and square centimetres, respectively. The PS value for endothelial monolayer (PSe) was obtained as follows: 1/PSe = 1/PSt - 1/PSf. To generate the endothelial permeability coefficient Pe (centimetres per minute), the PSe value was divided by the surface area of the insert. For the CDs, results were expressed as a percentage of transport across the BCEC monolayer alone and were obtained from the transport across the inserts coated with collagen and seeded with BCECs and the transport across the inserts coated only with collagen.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.