Control of the pacemaker activity of the sinoatrial node by intracellular Ca2+. Experiments and modelling

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

Volumn 359, Issue 1783, 2001, Pages 1091-1110

  Boyett, M R ^a   Zhang, H ^a   Garny, A ^a   Holden, A V ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Action potential; Ca2+ dependent ionic currents; Computer modelling; Intracellular Ca2+ handling; Pacemaker activity; Sinoatrial node

Indexed keywords

EID: 34047167724     PISSN: 1364503X     EISSN: None     Source Type: Journal    
DOI: 10.1098/rsta.2001.0818     Document Type: Review

References (33)

1. Rapid regulation of the 'second inward current' by intracellular calcium in isolated rat and ferret ventricular myocytes
2. The role of intracellular calcium, sodium and pH in rate-dependent changes of cardiac contractile force
3. The sinoatrial node, a heterogeneous pacemaker structure
4. si, in the rabbit sino-atrial node investigated by voltage clamp and computer simulation
5. A mathematical model of a rabbit sinoatrial node cell
6. Ion currents underlying sinoatrial node pacemaker activity: A new single cell mathematical model
7. Modification of DiFrancesco - Noble equations to simulate the effects of vagal stimulation on in vivo mammalian sinoatrial node electrical activity
8. A sustained inward current activated at the diastolic potential range in rabbit sino-atrial node cells
9. 2+-mediated and voltage-dependent inactivation in the rabbit sinoatrial node
10. 2+ of the hyperpolarization-activated inward current in rabbit single sino-atrial node cells
11. The relationship between contraction and intracellular sodium in rat and guinea-pig ventricular myocytes
12. Kr, through a reduction in C-type inactivation in guinea-pig ventricular myocytes
13. Correlation between electrical activity and the size of rabbit sinoatrial node cells
14. 2+ release contributes to automaticity in cat atrial pacemaker cells
15. Pacemaker mechanisms of mammalian sinoatrial node cells
16. The role of Na-Ca exchange current in the cardiac action potential
17. 2+ exchange current in isolated toad pacemaker cells
18. 2+ release in amphibian pacemaker cells
19. 2+ handling proteins in sinoatrial node
20. Ionic basis of ryanodine's negative chronotropic effect on pacemaker cells isolated from the sinoatrial node
21. Ryanodine prolongs Ca-currents while suppressing contraction in rat ventricular muscle cells
22. Heterogeneous expression of the ryanodine receptor in the rabbit sinoatrial node
23. Ionic mechanisms in normal and abnormal cardiac pacemaker activity
24. 2+ channels
25. Calcium transients in pacemaker cells isolated from the rabbit sinoatrial node
26. Calcium transients in guinea-pig sino-atrial node cells imaged by confocal microscopy
27. Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea-pig sino-atrial node
28. Electrophysiological actions of ryanodine on single rabbit sinoatrial nodal cells
29. + current in pacemaker cells dissociated from rat sinoatrial node
30. Calcium-sensitive delayed rectifier potassium current in guinea-pig ventricular cells
31. K by protein kinases A and C
32. Pacemaker activity of the rabbit sinoatrial node. A comparison of mathematical models
33. Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node