Factors associated with diabetes onset during metformin versus placebo therapy in the diabetes prevention program

Diabetes

Volumn 56, Issue 4, 2007, Pages 1153-1159

  Lachin, John M ^a   Christophi, Costas A ^a   Edelstein, Sharon L ^a   Ehrmann, David A ^b   Hamman, Richard F ^c   Kahn, Steven E ^d   Knowler, William C ^e   Nathan, David M ^f  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^e NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; METFORMIN; PROINSULIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DRUG EFFECT; DRUG MECHANISM; FEMALE; GLUCOSE BLOOD LEVEL; HEALTH PROGRAM; HIGH RISK PATIENT; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; WEIGHT CHANGE; WEIGHT REDUCTION;

BLOOD GLUCOSE; BODY SIZE; DIABETES MELLITUS; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; LIFE STYLE; METFORMIN; MULTIVARIATE ANALYSIS; PLACEBOS; PROPORTIONAL HAZARDS MODELS;

EID: 34047131663     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-0918     Document Type: Article

References (24)

1. The Diabetes Prevention Program Research Group: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403, 2002
2. The Diabetes Prevention Program Research Group: Effect of weight loss with lifestyle intervention on risk of diabetes. Diabetes Care 29:2102-2107, 2006
3. The Diabetes Prevention Program Research Group: Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the Diabetes Prevention Program: effects of lifestyle intervention and metformin. Diabetes 54:2404-2414, 2005
4. The Diabetes Prevention Program Research Group. The Diabetes Prevention Program: design and methods for a clinical trial in the prevention of type 2 diabetes. Diabetes Care 22:623-634, 1999
5. American Diabetes Association: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20:1183-1197, 1997
6. World Health Organization: Diabetes Mellitus: Report of a WHO Study Group. Geneva, World Health Org., 1985 (Tech. Rep. Ser., no. 727)
7. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP, Porte D Jr: Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function. Diabetes 42:1663-1672, 1993
8. Hanson RL, Pratley RE, Bogardus C, Narayan KM, Roumain JM, Imperatore G, Fagot-Campagna A, Pettitt DJ, Bennett PH, Knowler WC: Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies. Am J Epidemiol 151:190-198, 2000
9. Phillips DI, Clark PM, Hales CN, Osmond C: Understanding oral glucose tolerance: comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion. Diabet Med 11:286-292, 1994
10. Mayer-Davis EJ, Vitolins MZ, Carmichael SL, Hemphill S, Tsaroucha G, Rushing J, Levin S: Validity and reproducibility of a food frequency interview in a Multi-Cultural Epidemiology Study. Ann Epidemiol 9:314-324, 1999
11. Mayer-Davis EJ, Sparks KC, Hirst K, Costacou T, Lovejoy JC, Regensteiner JG, Hoskin MA, Kriska AM, Bray GA: Dietary intake in the diabetes prevention program cohort: baseline and 1-year post randomization. Ann Epidemiol 14:763-772, 2004
12. Kriska AM, Caspersen CJ: Introduction to the collection of physical activity questionnaires. In A Collection of Physical Activity Questionnaires for Health-Related Research. Atlanta, GA, Centers For Disease Control and Prevention, 1997
13. Regensteiner JG, Steiner JF, Hiatt WR: Exercise training improves functional status in patients with peripheral arterial disease. J Vasc Surg 23:104-115, 1996
14. Snedecor GW, Cochran WG. Statistical Methods. 7th ed. Ames, IA, Iowa State University Press, 1980
15. Diggle PJ, Liang K-Y, Zeger SL: Analysis of Longitudinal Data. New York, Oxford University Press, 1994
16. Cox DR: Regression models and life-tables. JRSS (B) 34:187-220, 1972
17. Lachin JM. Biostatistical Methods: The Assessment of Relative Risks. New York, John Wiley and Sons, 2000
18. Cusi K, Consoli A, DeFronzo RA: Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 81:4059-4067, 1996
19. DeFronzo RA: Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med 131:281-303, 1999
20. Hundal RS, Krssak M, DuFour S, Laurent D, Lebon V, Chandramouli V, Inzucchi SE, Schumann WC, Petersen KF, Landau BR, Shulman GI: Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 49:2063-2069, 2000
21. The Diabetes Prevention Program Research Group: Effects of withdrawal from metformin on the development of diabetes in the diabetes prevention program. Diabetes Care 26:977-980, 2003
22. Halban PA: Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic beta cell. Diabetologia 34:767-778, 1991
23. Kahn SE, Halban PA: Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM. Diabetes 46:1725-1732, 1997
24. Jensen CC, Cnop M, Hull RL, Fujimoto WY, Kahn SE, American Diabetes Association GENNID Study Group: β-Cell function is the major determinant of oral glucose tolerance in four ethnic groups in the U.S. Diabetes 51:2170-2178, 2002