Prevention of experimental colitis by parenteral administration of a pathogen-derived immunomodulatory molecule

Gut

Volumn 56, Issue 3, 2007, Pages 351-357

  Braat, Henri ^b   McGuirk, Peter ^a   Ten Kate, Fiebo J W ^b   Huibregtse, Inge ^b   Dunne, Padraic J ^a   Hommes, Daan W ^b   Van Deventer, Sander J H ^b   Mills, Kingston H G ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FILAMENTOUS HEMAGGLUTININ; HEMAGGLUTININ; INTERLEUKIN 10; PHOSPHATE BUFFERED SALINE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ADHESIN; BORDETELLA VIRULENCE FACTOR; CD45 ANTIGEN; CYTOKINE; FILAMENTOUS HEMAGGLUTININ ADHESIN, BORDETELLA PERTUSSIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; IN VIVO STUDY; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN SYNTHESIS; REGULATORY T LYMPHOCYTE; SCID MOUSE; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; WEIGHT REDUCTION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; BORDETELLA PERTUSSIS; DISEASE MODEL; IMMUNOLOGY; LYMPH NODE; LYMPHOCYTE TRANSFUSION; MOUSE MUTANT; PATHOLOGY;

ADHESINS, BACTERIAL; ANIMALS; ANTIGENS, CD45; BORDETELLA PERTUSSIS; COLITIS; CYTOKINES; DISEASE MODELS, ANIMAL; INTERLEUKIN-10; LYMPH NODES; LYMPHOCYTE TRANSFUSION; MICE; MICE, INBRED BALB C; MICE, SCID; PEYER'S PATCHES; TH1 CELLS; TH2 CELLS; TRANSFORMING GROWTH FACTOR BETA; VIRULENCE FACTORS, BORDETELLA;

EID: 34047123052     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2006.099861     Document Type: Article

References (28)

1. Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 2003;3:521-33.
2. Watanabe T, Kitani A, Murray PJ, et al. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 2004;5:800-8.
3. Netea MG, Kullberg BJ, de Jong DJ, et al. NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease. Eur J Immunol 2004;34:2052-9.
4. Mills KH, McGuirk P. Antigen-specific regulatory T cells - their induction and role in infection. Semin Immunol 2004;16:107-17.
5. Asseman C, Mauze S, Leach MW, et al. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999;190:995-1004.
6. Mills KH. Immunity to Bordetella pertussis. Microbes Infect 2001;3:655-77.
7. Ryan M, Murphy G, Gothefors L, et al. Bordetella pertussis respiratory infection in children is associated with preferential activation of type 1 T helper cells. J Infect Dis 1997;175:1246-50.
8. McGuirk P, Johnson PA, Ryan EJ, et al. Filamentous hemagglutinin and pertussis toxin from Bordetella pertussis modulate immune responses to unrelated antigens. J Infect Dis 2000;182:1286-9.
9. McGuirk P, McCann C, Mills KH. Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J Exp Med 2002;195:221-31.
10. Higgins SC, Lovelle EC, McCann C, et al. Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology. J Immunol 2003;171:3119-27.
11. Van Montfrans C, Rodriguez Pena MS, Prank I, et al. Prevention of colitis by interleukin 10-transduced T lymphocytes in the SCID mice transfer model. Gastroenterology 2002;123:1865-76.
12. Asseman C, Read S, Powrie F. Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10. J Immunol 2003;171:971-8.
13. Powrie F, Carlino J, Leach MW, et al. A critical role for transforming growth factor-beta but not inteHeukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med 1996;183:2669-74.
14. Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol 2002;20:495-549.
15. te VeMe AA, van Kooyk Y, Braat H, et al. Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease. Eur J Immunol 2003;33:143-51.
16. Van den Brande JM, Braat H, van den Brink GR, et al. Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease. Gastroenterology 2003;124: 1774-85.
17. Tiede I, Fritz G, Strand S, et al. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. J Clin Invest 2003;111:1133-45.
18. van Deventer SJ, Elson CO, Fedorak RN. Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's Disease Study Group. Gastroenterology 1997;113:383-9.
19. Steidler L, Hans W, Schotte L, et al. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 2000;289:1352-5.
20. Braat H, Rottiers P, Hommes DW, et al. A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease. Clin Gastroenterol Hepatol 2006;6:754-9.
21. Stagg AJ, Hart AL, Knight SC, et al. The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria. Gut 2003;52:1522-9.
22. Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-64.
23. Yazdanbakhsh M, Kremsner PG, van Ree R. Allergy, parasites, and the hygiene hypothesis. Science 2002;296:490-4.
24. Elliott DE, Setiawan T, Metwali A, et al. Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice. Eur J Immunol 2004;34:2690.
25. McGuirk P, Mills KH. Direct anti-inflammatory effect of a bacterial virulence factor: IL-10-dependent suppression of IL-12 production by filamentous hemagglutinin from Bordetella pertussis. Eur J Immunol 2000;30:415-22.
26. Read S, Malmstrom V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 2000;192:295-302.
27. Simondon F, Preziosi MP, Yam A, et al. A randomized double-blind trial comparing a two-component acellular to a whole-cell pertussis vaccine in Senegal. Vaccine 1997;15:1606-12.
28. Greco D, Salmaso S, Mastrantonio P, et al. A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. Progetto Pertosse Working Group. N Engl J Med 1996;334:341-8.