Breast cancer risk associated with AURKA 91T → A polymorphism in relation to BRCA mutations

Cancer Letters

Volumn 250, Issue 2, 2007, Pages 206-212

  Vidarsdottir, Linda ^a,b   Bodvarsdottir, Sigridur K ^a,b   Hilmarsdottir, Holmfridur ^a,b   Tryggvadottir, Laufey ^a   Eyfjord, Jorunn E ^a,b  

^a ICELANDIC CANCER SOCIETY   (Iceland)

^b UNIVERSITY OF ICELAND   (Iceland)

Author keywords

Allele specific amplification; Aurora kinase A polymorphism; BRCA; Breast cancer risk; Hormone receptor status

Indexed keywords

AURORA A KINASE; PROTEIN SERINE THREONINE KINASE;

ADULT; AGED; ALLELE; ARTICLE; BREAST CANCER; CANCER RISK; CONFIDENCE INTERVAL; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE DETECTION; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; ONCOGENE; PRIORITY JOURNAL; RISK ASSESSMENT; STATISTICAL SIGNIFICANCE;

ADENINE; ALLELES; CASE-CONTROL STUDIES; FEMALE; GENES, BRCA1; GENES, BRCA2; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MUTATION; POLYMORPHISM, GENETIC; PROTEIN-SERINE-THREONINE KINASES; THYMINE;

EID: 34047109151     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2006.10.003     Document Type: Article

References (29)

1. Bischoff J.R., and Plowman G.D. The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis. Trends Cell. Biol. 9 (1999) 454-459
2. Dutertre S., Descamps S., and Prigent C. On the role of aurora-A in centrosome function. Oncogene 21 (2002) 6175-6183
3. Sen S., Zhou H., and White R.A. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene 14 (1997) 2195-2200
4. Zhou H., Kuang J., Zhong L., et al. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet. 20 (1998) 189-193
5. Ewart-Toland A., Briassouli P., de Koning J.P., et al. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat. Genet. 34 (2003) 403-412
6. Sun T., Miao X., Wang J., et al. Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma. Carcinogenesis 25 (2004) 2225-2230
7. Cox D.G., Hankinson S.E., and Hunter D.J. Polymorphisms of the AURKA (STK15/aurora kinase) gene and breast cancer risk (United States). Cancer Causes Control 17 (2006) 81-83
8. Ewart-Toland A., Dai Q., Gao Y.T., et al. Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis 26 (2005) 1368-1373
9. Dicioccio R.A., Song H., Waterfall C., et al. STK15 polymorphisms and association with risk of invasive ovarian cancer. Cancer Epidemiol. Biomarkers Prev. 13 (2004) 1589-1594
10. Miao X., Sun T., Wang Y., et al. Functional STK15 Phe31Ile polymorphism is associated with the occurrence and advanced disease status of esophageal squamous cell carcinoma. Cancer Res. 64 (2004) 2680-2683
11. Dai Q., Cai Q.Y., Shu X.O., et al. Synergistic effects of STK15 gene polymorphisms and endogenous estrogen exposure in the risk of breast cancer. Cancer Epidemiol. Biomarkers Prev. 13 (2004) 2065-2070
12. Hienonen T., Salovaara R., Mecklin J.P., et al. Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers. Int. J. Cancer 118 (2006) 505-508
13. Miki Y., Swensen J., Shattuck-Eidens D., et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266 (1994) 66-71
14. Tavtigian S.V., Simard J., Rommens J., et al. The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nat. Genet. 12 (1996) 333-337
15. Wooster R., Bignell G., Lancaster J., et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 378 (1995) 789-792
16. Venkitaraman A.R. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108 (2002) 171-182
17. Bergthorsson J.T., Jonasdottir A., Johannesdottir G., et al. Identification of a novel splice-site mutation of the BRCA1 gene in two breast cancer families: screening reveals low frequency in Icelandic breast cancer patients. Hum. Mutat. Suppl. 1 (1998) S195-S197
18. Thorlacius S., Olafsdottir G., Tryggvadottir L., et al. A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes. Nat. Genet. 13 (1996) 117-119
19. Thorlacius S., Sigurdsson S., Bjarnadottir H., Olafsdottir G., Jonasson J.G., Tryggvadottir L., Tulinius H., and Eyfjord J.E. Study of a single BRCA2 mutation with high carrier frequency in a small population. Am. J. Hum. Genet. 60 (1997) 1079-1084
20. Tulinius H., Olafsdottir G.H., Sigvaldason H., et al. The effect of a single BRCA2 mutation on cancer in Iceland. J. Med. Genet. 39 (2002) 457-462
21. Mikaelsdottir E.K., Valgeirsdottir S., Eyfjord J.E., and Rafnar T. The Icelandic founder mutation BRCA2 999del5: analysis of expression. Breast Cancer Res. 6 (2004) R284-R290
22. Bodvarsdottir S.K., Hilmarsdottir H., Birgisdottir V., et al. Aurora-A amplification associated with BRCA2 mutation in breast tumours. Cancer Lett. (2006) 10.1016/j.canlet.2006.06.003
23. Krystyniak A., Garcia-Echeverria C., Prigent C., et al. Inhibition of Aurora A in response to DNA damage. Oncogene 25 (2006) 338-348
24. Anand S., Penrhyn-Lowe S., and Venkitaraman A.R. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 3 (2003) 51-62
25. Daniels M.J., Wang Y., Lee M., and Venkitaraman A.R. Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. Science 306 (2004) 876-879
26. Rafnar T., Benediktsdottir K.R., Eldon B.J., et al. BRCA2, but not BRCA1, mutations account for familial ovarian cancer in Iceland: a population-based study. Eur. J. Cancer 40 (2004) 2788-2793
27. Gudmundsdottir K., Thorlacius S., Jonasson J.G., et al. CYP17 promoter polymorphism and breast cancer risk in males and females in relation to BRCA2 status. Br. J. Cancer 88 (2003) 933-936
28. Fletcher O., Johnson N., Palles C., et al. Inconsistent association between the STK15 F31I genetic polymorphism and breast cancer risk. J. Natl. Cancer Inst. 98 (2006) 1014-1018
29. Tchatchou S., Wirtenberger M., Hemminki K., et al. Aurora kinases A and B and familial breast cancer risk. Cancer Lett. (2006) 10.1016/j.canlet.2006.05.002