Capsaicin causes protein synthesis inhibition and microtubule disassembly through TRPV1 activities both on the plasma membrane and intracellular membranes

Biochemical Pharmacology

Volumn 73, Issue 10, 2007, Pages 1635-1645

  Han, Ping ^a   McDonald, Heath A ^a   Bianchi, Bruce R ^a   Kouhen, Rachid El ^a   Vos, Melissa H ^a   Jarvis, Michael F ^a   Faltynek, Connie R ^a   Moreland, Robert B ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Calcium; Capsaicin; Microtubule; Protein synthesis; TRPV1; VR1

Indexed keywords

A 425619; CAPSAICIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ANALYTIC METHOD; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE; CELL STRUCTURE; CELL SURFACE; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY; DEPOLYMERIZATION; EMBRYO; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR MEMBRANE; MICROTUBULE ASSEMBLY; NEUROTRANSMISSION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; CALCIUM; CAPSAICIN; CELL MEMBRANE; CELLS, CULTURED; CYTOSOL; EUKARYOTIC INITIATION FACTOR-2; HUMANS; INTRACELLULAR MEMBRANES; MICROTUBULES; PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITORS; RATS; TRPV CATION CHANNELS;

EID: 34047104415     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.12.035     Document Type: Article

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