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Volumn 8, Issue 1, 2007, Pages 30-39

Other mucoactive agents for cystic fibrosis

Author keywords

agonist; cystic fibrosis; denufosol; hypertonic saline; mannitol

Indexed keywords

ANTIBIOTIC AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CORTICOSTEROID; DENUFOSOL; DORNASE ALFA; EXPECTORANT AGENT; HISTAMINE; ION TRANSPORT AFFECTING AGENT; ISOTONIC SOLUTION; MANNITOL; METHACHOLINE; MUCIN; MUCOKINETIC AGENT; PLACEBO; PURINE P2Y2 RECEPTOR STIMULATING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; RESPIRATORY TRACT AGENT; SALBUTAMOL; SODIUM CHLORIDE; TERBUTALINE; UNCLASSIFIED DRUG; WATER;

EID: 34047099736     PISSN: 15260542     EISSN: 15260550     Source Type: Journal    
DOI: 10.1016/j.prrv.2007.02.008     Document Type: Review
Times cited : (27)

References (100)
  • 1
    • 34047144270 scopus 로고    scopus 로고
    • Taxonomy of mucoactive medications
    • Rubin B.K., and van der Schans C.P. (Eds), Marcel Dekker, New York
    • Rubin B.K. Taxonomy of mucoactive medications. In: Rubin B.K., and van der Schans C.P. (Eds). Therapy for mucus-clearance disorders. Lung biology in health and disease vol 188 (2004), Marcel Dekker, New York 129-145
    • (2004) Therapy for mucus-clearance disorders. Lung biology in health and disease , vol.188 , pp. 129-145
    • Rubin, B.K.1
  • 2
    • 0034885192 scopus 로고    scopus 로고
    • The relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition
    • Tarran R., Grubb B.R., Gatzy J.T., Davis C.W., and Boucher R.C. The relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition. J Gen Physiol 118 (2001) 223-236
    • (2001) J Gen Physiol , vol.118 , pp. 223-236
    • Tarran, R.1    Grubb, B.R.2    Gatzy, J.T.3    Davis, C.W.4    Boucher, R.C.5
  • 3
    • 23244461620 scopus 로고    scopus 로고
    • Reduced three-dimensional motility in dehydrated airway mucus prevents neutrophil capture and killing bacteria on airway epithelial surfaces
    • Matsui H., Verghese M.W., Kesimer M., et al. Reduced three-dimensional motility in dehydrated airway mucus prevents neutrophil capture and killing bacteria on airway epithelial surfaces. J Immunol 175 (2005) 1090-1099
    • (2005) J Immunol , vol.175 , pp. 1090-1099
    • Matsui, H.1    Verghese, M.W.2    Kesimer, M.3
  • 4
    • 34047170671 scopus 로고
    • The high molecular weight components of sputum
    • Brogen T.D. The high molecular weight components of sputum. Br J Exp Pathol 41 (1960) 288-297
    • (1960) Br J Exp Pathol , vol.41 , pp. 288-297
    • Brogen, T.D.1
  • 5
    • 0025181636 scopus 로고
    • The origin of DNA associated with mucus glycoproteins in cystic fibrosis sputum
    • Lethem M.I., James S.L., Marriott C., and Burke J.F. The origin of DNA associated with mucus glycoproteins in cystic fibrosis sputum. Eur Respir J 3 (1990) 19-23
    • (1990) Eur Respir J , vol.3 , pp. 19-23
    • Lethem, M.I.1    James, S.L.2    Marriott, C.3    Burke, J.F.4
  • 7
    • 0023912397 scopus 로고
    • Sputum changes associated with therapy for endobronchial exacerbation in cystic fibrosis
    • Smith A.L., Redding G., Doershuk C., et al. Sputum changes associated with therapy for endobronchial exacerbation in cystic fibrosis. J Pediatr 112 (1988) 547-554
    • (1988) J Pediatr , vol.112 , pp. 547-554
    • Smith, A.L.1    Redding, G.2    Doershuk, C.3
  • 8
    • 0037027912 scopus 로고    scopus 로고
    • An overview of the pathogenesis of cystic fibrosis lung disease
    • Boucher R.C. An overview of the pathogenesis of cystic fibrosis lung disease. Adv Drug Del Rev 54 (2002) 1359-1371
    • (2002) Adv Drug Del Rev , vol.54 , pp. 1359-1371
    • Boucher, R.C.1
  • 9
    • 0142010657 scopus 로고    scopus 로고
    • Update on pathogenesis of cystic fibrosis lung disease
    • Donaldson S.H., and Boucher R.C. Update on pathogenesis of cystic fibrosis lung disease. Curr Opin Pulm Med 9 (2003) 486-491
    • (2003) Curr Opin Pulm Med , vol.9 , pp. 486-491
    • Donaldson, S.H.1    Boucher, R.C.2
  • 10
    • 0028982894 scopus 로고
    • CFTR as a cAMP-dependent regulator of sodium channels
    • Stutts M.J., Canessa C.M., Olsen J.C., et al. CFTR as a cAMP-dependent regulator of sodium channels. Science 269 (1995) 847-850
    • (1995) Science , vol.269 , pp. 847-850
    • Stutts, M.J.1    Canessa, C.M.2    Olsen, J.C.3
  • 11
    • 4244174566 scopus 로고    scopus 로고
    • Inhibition of airway liquid secretion and its effect on the physical properties of airway mucus
    • Trout L., King M., Feng W., Inglis S.K., and Ballard S.T. Inhibition of airway liquid secretion and its effect on the physical properties of airway mucus. Am J Physiol 272 (1997) L372-L377
    • (1997) Am J Physiol , vol.272
    • Trout, L.1    King, M.2    Feng, W.3    Inglis, S.K.4    Ballard, S.T.5
  • 12
    • 0032433707 scopus 로고    scopus 로고
    • Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    • Matsui H., Grubb B.R., Tarran R., et al. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95 (1998) 1005-1015
    • (1998) Cell , vol.95 , pp. 1005-1015
    • Matsui, H.1    Grubb, B.R.2    Tarran, R.3
  • 14
    • 0027141851 scopus 로고
    • Elemental composition of human airway surface fluid in healthy and diseased airways
    • Joris L., Dab I., and Quinton P.M. Elemental composition of human airway surface fluid in healthy and diseased airways. Am Rev Respir Dis 148 (1993) 1633-1637
    • (1993) Am Rev Respir Dis , vol.148 , pp. 1633-1637
    • Joris, L.1    Dab, I.2    Quinton, P.M.3
  • 15
    • 0029870085 scopus 로고    scopus 로고
    • Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid
    • Smith J., Travis S., Greenberg E., and Welsh M. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 85 (1996) 229-236
    • (1996) Cell , vol.85 , pp. 229-236
    • Smith, J.1    Travis, S.2    Greenberg, E.3    Welsh, M.4
  • 16
    • 0030949875 scopus 로고    scopus 로고
    • Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis
    • Goldman M.J., Anderson G.M., Stolzenberg E.D., Kari U.P., Zasloff M., and Wilson J.M. Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88 (1997) 553-560
    • (1997) Cell , vol.88 , pp. 553-560
    • Goldman, M.J.1    Anderson, G.M.2    Stolzenberg, E.D.3    Kari, U.P.4    Zasloff, M.5    Wilson, J.M.6
  • 17
    • 0032160101 scopus 로고    scopus 로고
    • Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro
    • Zabner J., Smith J.J., Karp P.H., Widdicombe J.H., and Welsh M.J. Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro. Mol Cell 2 (1998) 397-403
    • (1998) Mol Cell , vol.2 , pp. 397-403
    • Zabner, J.1    Smith, J.J.2    Karp, P.H.3    Widdicombe, J.H.4    Welsh, M.J.5
  • 18
    • 0032169557 scopus 로고    scopus 로고
    • Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung
    • Bals R., Wang X., Wu Z., et al. Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest 102 (1998) 874-880
    • (1998) J Clin Invest , vol.102 , pp. 874-880
    • Bals, R.1    Wang, X.2    Wu, Z.3
  • 19
    • 0034885663 scopus 로고    scopus 로고
    • The CF salt controversy: In vivo observations and therapeutic approaches
    • Tarran R., Grubb B.R., Parsons D., et al. The CF salt controversy: In vivo observations and therapeutic approaches. Mol Cell 8 (2001) 149-158
    • (2001) Mol Cell , vol.8 , pp. 149-158
    • Tarran, R.1    Grubb, B.R.2    Parsons, D.3
  • 20
    • 0032987476 scopus 로고    scopus 로고
    • Airway surface fluid volume and Cl content in cystic fibrosis and normal bronchial xenografts
    • Zhang Y., and Engelhardt J.F. Airway surface fluid volume and Cl content in cystic fibrosis and normal bronchial xenografts. Am J Physiol Cell Physiol 276 (1999) C469-C476
    • (1999) Am J Physiol Cell Physiol , vol.276
    • Zhang, Y.1    Engelhardt, J.F.2
  • 21
    • 0030814886 scopus 로고    scopus 로고
    • Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects
    • Knowles M.R., Robinson J.M., Wood R.E., et al. Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects. J Clin Invest 100 (1997) 2588-2595
    • (1997) J Clin Invest , vol.100 , pp. 2588-2595
    • Knowles, M.R.1    Robinson, J.M.2    Wood, R.E.3
  • 22
    • 0027141851 scopus 로고
    • Elemental composition of human airway surface fluid in health and diseased airways
    • Joris L., Dab I., and Quinton P.M. Elemental composition of human airway surface fluid in health and diseased airways. Am Rev Respir Dis 148 (1993) 1633-1637
    • (1993) Am Rev Respir Dis , vol.148 , pp. 1633-1637
    • Joris, L.1    Dab, I.2    Quinton, P.M.3
  • 23
    • 0031918382 scopus 로고    scopus 로고
    • Elemental content of airway surface liquid from infants with cystic fibrosis
    • Hull J., Skinner W., Robertson C., and Phelan P. Elemental content of airway surface liquid from infants with cystic fibrosis. Am J Respir Crit Care Med 157 (1998) 10-14
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 10-14
    • Hull, J.1    Skinner, W.2    Robertson, C.3    Phelan, P.4
  • 24
    • 0035132659 scopus 로고    scopus 로고
    • Noninvasive in vivo fluorescence measurement of airway-surface liquid depth, salt concentration, and pH
    • Jayaraman S., Song Y., Vetrivel L., Shankar L., and Verkman A.S. Noninvasive in vivo fluorescence measurement of airway-surface liquid depth, salt concentration, and pH. J Clin Invest 107 (2001) 317-324
    • (2001) J Clin Invest , vol.107 , pp. 317-324
    • Jayaraman, S.1    Song, Y.2    Vetrivel, L.3    Shankar, L.4    Verkman, A.S.5
  • 25
    • 24644474439 scopus 로고    scopus 로고
    • Epithelial lining fluid solute concentrations in chronic obstructive lung disease patients and normal subjects
    • Effros R.M., Peterson B., Casaburi R., et al. Epithelial lining fluid solute concentrations in chronic obstructive lung disease patients and normal subjects. J Appl Physiol 99 (2005) 1286-1292
    • (2005) J Appl Physiol , vol.99 , pp. 1286-1292
    • Effros, R.M.1    Peterson, B.2    Casaburi, R.3
  • 26
    • 0035036947 scopus 로고    scopus 로고
    • Airway surface liquid osmolality measured using fluorophore-encapsulated liposomes
    • Jayaraman S., Song Y., and Verkman A.S. Airway surface liquid osmolality measured using fluorophore-encapsulated liposomes. J Gen Physiol 117 (2001) 423-430
    • (2001) J Gen Physiol , vol.117 , pp. 423-430
    • Jayaraman, S.1    Song, Y.2    Verkman, A.S.3
  • 27
    • 0028912457 scopus 로고
    • Effects of guaifenesin on nasal mucociliary clearance and ciliary beat frequency in healthy volunteers
    • Sisson J.H., Yonkers A.J., and Waldman R.H. Effects of guaifenesin on nasal mucociliary clearance and ciliary beat frequency in healthy volunteers. Chest 107 (1995) 747-751
    • (1995) Chest , vol.107 , pp. 747-751
    • Sisson, J.H.1    Yonkers, A.J.2    Waldman, R.H.3
  • 28
    • 0015757462 scopus 로고
    • A preliminary study of the effect of guaifenesin on mucociliary clearance from the human lung
    • Thomson M.L., Pavia D., and McNicol M.W. A preliminary study of the effect of guaifenesin on mucociliary clearance from the human lung. Thorax 28 (1973) 742-747
    • (1973) Thorax , vol.28 , pp. 742-747
    • Thomson, M.L.1    Pavia, D.2    McNicol, M.W.3
  • 29
    • 0030024302 scopus 로고    scopus 로고
    • Iodinated glycerol has no effect on pulmonary function, symptom score, or sputum properties in patients with stable bronchitis
    • Rubin B.K., Ramirez O., and Ohar J.A. Iodinated glycerol has no effect on pulmonary function, symptom score, or sputum properties in patients with stable bronchitis. Chest 109 (1996) 348-352
    • (1996) Chest , vol.109 , pp. 348-352
    • Rubin, B.K.1    Ramirez, O.2    Ohar, J.A.3
  • 30
    • 0022023019 scopus 로고
    • The effect of systemic hydration on normal and impaired mucociliary function
    • Marchette L.C., Marchette B.E., Abraham W.M., and Wanner A. The effect of systemic hydration on normal and impaired mucociliary function. Pediatr Pulmonol 1 (1985) 107-111
    • (1985) Pediatr Pulmonol , vol.1 , pp. 107-111
    • Marchette, L.C.1    Marchette, B.E.2    Abraham, W.M.3    Wanner, A.4
  • 31
    • 0019128894 scopus 로고
    • Clinical indications for and effects of bland, mucolytic and antimicrobial aerosols
    • Wanner A., and Rao A. Clinical indications for and effects of bland, mucolytic and antimicrobial aerosols. Am Rev Respir Dis 122 (1980) 79-87
    • (1980) Am Rev Respir Dis , vol.122 , pp. 79-87
    • Wanner, A.1    Rao, A.2
  • 32
    • 0017517706 scopus 로고
    • Clinical aspects of mucociliary transport
    • Wanner A. Clinical aspects of mucociliary transport. Am Rev Respir Dis 116 (1977) 73-125
    • (1977) Am Rev Respir Dis , vol.116 , pp. 73-125
    • Wanner, A.1
  • 33
    • 0023819109 scopus 로고
    • Bronchodilator responsiveness in infants and young children with cystic fibrosis
    • Hiatt P., Eigen H., Yu P., and Tepper R.S. Bronchodilator responsiveness in infants and young children with cystic fibrosis. Am Rev Respir Dis 137 (1988) 119-122
    • (1988) Am Rev Respir Dis , vol.137 , pp. 119-122
    • Hiatt, P.1    Eigen, H.2    Yu, P.3    Tepper, R.S.4
  • 34
    • 0025614795 scopus 로고
    • Bronchial response to nebulized antibiotics in children with cystic fibrosis
    • Chua H.L., Collis G.G., and Le Souef P.N. Bronchial response to nebulized antibiotics in children with cystic fibrosis. Eur Respir J 3 (1990) 1114-1116
    • (1990) Eur Respir J , vol.3 , pp. 1114-1116
    • Chua, H.L.1    Collis, G.G.2    Le Souef, P.N.3
  • 35
    • 0027216541 scopus 로고
    • Effect of amiloride and saline on nasal mucociliary clearance and potential difference in cystic fibrosis and normal subjects
    • Middleton P.G., Geddes D.M., and Alton E.W. Effect of amiloride and saline on nasal mucociliary clearance and potential difference in cystic fibrosis and normal subjects. Thorax 48 (1993) 812-816
    • (1993) Thorax , vol.48 , pp. 812-816
    • Middleton, P.G.1    Geddes, D.M.2    Alton, E.W.3
  • 36
    • 0037438694 scopus 로고    scopus 로고
    • Increasing concentration of inhaled saline with or without amiloride: Effect on mucociliary clearance in normal subjects
    • Sood N., Bennett W.D., Zeman K., et al. Increasing concentration of inhaled saline with or without amiloride: Effect on mucociliary clearance in normal subjects. Am J Respir Crit Care Med 167 (2003) 158-163
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 158-163
    • Sood, N.1    Bennett, W.D.2    Zeman, K.3
  • 37
    • 0030900726 scopus 로고    scopus 로고
    • Mucociliary clearance and buffered hypertonic saline solution
    • Talbot A.R., Herr T.M., and Parsons D.S. Mucociliary clearance and buffered hypertonic saline solution. Laryngoscope 107 (1997) 500-503
    • (1997) Laryngoscope , vol.107 , pp. 500-503
    • Talbot, A.R.1    Herr, T.M.2    Parsons, D.S.3
  • 38
    • 0027511938 scopus 로고
    • Reduced effect of inhaled beta 2-adrenergic agonists on lung mucociliary clearance in patients with cystic fibrosis
    • Mortensen J., Hansen A., Falk M., Nielsen I.K., and Groth S. Reduced effect of inhaled beta 2-adrenergic agonists on lung mucociliary clearance in patients with cystic fibrosis. Chest 103 (1993) 805-811
    • (1993) Chest , vol.103 , pp. 805-811
    • Mortensen, J.1    Hansen, A.2    Falk, M.3    Nielsen, I.K.4    Groth, S.5
  • 40
    • 0030845454 scopus 로고    scopus 로고
    • Rheology of cystic fibrosis sputum after in vitro treatment with hypertonic saline alone and in combination with recombinant human deoxyribonuclease I
    • King M., Dasgupta B., Tomkiewicz R.P., and Brown N.E. Rheology of cystic fibrosis sputum after in vitro treatment with hypertonic saline alone and in combination with recombinant human deoxyribonuclease I. Am J Respir Crit Care Med 156 (1997) 173-177
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 173-177
    • King, M.1    Dasgupta, B.2    Tomkiewicz, R.P.3    Brown, N.E.4
  • 41
    • 0031018453 scopus 로고    scopus 로고
    • Sodium chloride increases the ciliary transportability of cystic fibrosis and bronchiectasis sputum on the mucus-depleted bovine trachea
    • Wills P.J., Hall R.L., Chan W.-M., and Cole P.J. Sodium chloride increases the ciliary transportability of cystic fibrosis and bronchiectasis sputum on the mucus-depleted bovine trachea. J Clin Invest 99 (1997) 9-13
    • (1997) J Clin Invest , vol.99 , pp. 9-13
    • Wills, P.J.1    Hall, R.L.2    Chan, W.-M.3    Cole, P.J.4
  • 42
    • 34047181916 scopus 로고    scopus 로고
    • Reduction of Pseudomonas aeruginosa biofilm formation under osmotic stress
    • (A317)
    • Anderson G.G., Aspedon A., Palmer K., Whiteley M., and O'Toole G. Reduction of Pseudomonas aeruginosa biofilm formation under osmotic stress. Pediatr Pulmonol S29 (2006) 319 (A317)
    • (2006) Pediatr Pulmonol , vol.S29 , pp. 319
    • Anderson, G.G.1    Aspedon, A.2    Palmer, K.3    Whiteley, M.4    O'Toole, G.5
  • 43
    • 0029916071 scopus 로고    scopus 로고
    • Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis
    • Robinson M., Regnis J.A., Bailey D.L., King M., Bautovich G.J., and Bye P.T. Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis. Am J Respir Crit Care Med 153 (1996) 1503-1509
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 1503-1509
    • Robinson, M.1    Regnis, J.A.2    Bailey, D.L.3    King, M.4    Bautovich, G.J.5    Bye, P.T.6
  • 44
    • 0030784262 scopus 로고    scopus 로고
    • Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis
    • Robinson M., Hemming A.L., Regnis J.A., et al. Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis. Thorax 52 (1997) 900-903
    • (1997) Thorax , vol.52 , pp. 900-903
    • Robinson, M.1    Hemming, A.L.2    Regnis, J.A.3
  • 45
    • 0022923921 scopus 로고
    • The effect of airflow on mucus secretion into the trachea of the cat
    • Peatfield A.C., Richardson P.S., and Wells U.M. The effect of airflow on mucus secretion into the trachea of the cat. J Physiol 380 (1986) 429-439
    • (1986) J Physiol , vol.380 , pp. 429-439
    • Peatfield, A.C.1    Richardson, P.S.2    Wells, U.M.3
  • 46
    • 0027246418 scopus 로고
    • Osmolality affects ion and water fluxes and secretion in the ferret trachea
    • Price A.M., Webber S.E., and Widdicombe J.G. Osmolality affects ion and water fluxes and secretion in the ferret trachea. J Appl Physiol 74 (1993) 2788-2794
    • (1993) J Appl Physiol , vol.74 , pp. 2788-2794
    • Price, A.M.1    Webber, S.E.2    Widdicombe, J.G.3
  • 48
    • 0036208055 scopus 로고    scopus 로고
    • Mucociliary clearance in cystic fibrosis
    • Robinson M., and Bye P.T. Mucociliary clearance in cystic fibrosis. Pediatr Pulmonol 33 (2002) 293-306
    • (2002) Pediatr Pulmonol , vol.33 , pp. 293-306
    • Robinson, M.1    Bye, P.T.2
  • 50
    • 30944466084 scopus 로고    scopus 로고
    • The National Hypertonic Saline in Cystic Fibrosis Study Group. A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis
    • Elkins M.R., Robinson M., Rose B.R., et al. The National Hypertonic Saline in Cystic Fibrosis Study Group. A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. N Engl J Med 354 (2006) 229-240
    • (2006) N Engl J Med , vol.354 , pp. 229-240
    • Elkins, M.R.1    Robinson, M.2    Rose, B.R.3
  • 51
    • 0026877917 scopus 로고
    • The MOS 36-item short-form health survey: conceptual framework and item selection
    • Ware J., and Sherbourne C. The MOS 36-item short-form health survey: conceptual framework and item selection. Med Care 30 (1992) 473-481
    • (1992) Med Care , vol.30 , pp. 473-481
    • Ware, J.1    Sherbourne, C.2
  • 52
    • 0033806096 scopus 로고    scopus 로고
    • Translation and linguistic validation of a disease-specific quality of life measure for cystic fibrosis
    • Quittner A.L., Sweeny S., Watrous M., et al. Translation and linguistic validation of a disease-specific quality of life measure for cystic fibrosis. J Pediatr Psychol 25 (2000) 403-414
    • (2000) J Pediatr Psychol , vol.25 , pp. 403-414
    • Quittner, A.L.1    Sweeny, S.2    Watrous, M.3
  • 53
    • 0347812929 scopus 로고    scopus 로고
    • Aerosolized antibiotics in cystic fibrosis
    • Sexauer W.P., and Fiel S.B. Aerosolized antibiotics in cystic fibrosis. Semin Respir Crit Care Med 24 (2003) 717-726
    • (2003) Semin Respir Crit Care Med , vol.24 , pp. 717-726
    • Sexauer, W.P.1    Fiel, S.B.2
  • 54
    • 0030008837 scopus 로고    scopus 로고
    • Airway responsiveness to hyperosmolar saline challenge in cystic fibrosis: a pilot study
    • Rodwell L.T., and Anderson S.D. Airway responsiveness to hyperosmolar saline challenge in cystic fibrosis: a pilot study. Pediatr Pulmonol 21 (1996) 282-289
    • (1996) Pediatr Pulmonol , vol.21 , pp. 282-289
    • Rodwell, L.T.1    Anderson, S.D.2
  • 55
    • 0036123981 scopus 로고    scopus 로고
    • Hypertonic saline and recombinant human DNase: a randomised cross-over pilot study in patients with cystic fibrosis
    • Ballmann M., and von der Hardt H. Hypertonic saline and recombinant human DNase: a randomised cross-over pilot study in patients with cystic fibrosis. J Cystic Fibrosis 1 (2002) 35-37
    • (2002) J Cystic Fibrosis , vol.1 , pp. 35-37
    • Ballmann, M.1    von der Hardt, H.2
  • 56
    • 0033927351 scopus 로고    scopus 로고
    • Sputum induction in young cystic fibrosis patients
    • De Boeck K., Alifier M., and Vandeputte S. Sputum induction in young cystic fibrosis patients. Eur Respir J 16 (2000) 91-94
    • (2000) Eur Respir J , vol.16 , pp. 91-94
    • De Boeck, K.1    Alifier, M.2    Vandeputte, S.3
  • 57
    • 0035060298 scopus 로고    scopus 로고
    • Sputum induction as a research tool for sampling the airways of subjects with cystic fibrosis
    • Henig N.R., Tonelli M.R., Pier M.V., Burns J.L., and Aitken M.L. Sputum induction as a research tool for sampling the airways of subjects with cystic fibrosis. Thorax 56 (2001) 306-311
    • (2001) Thorax , vol.56 , pp. 306-311
    • Henig, N.R.1    Tonelli, M.R.2    Pier, M.V.3    Burns, J.L.4    Aitken, M.L.5
  • 58
    • 9144237586 scopus 로고    scopus 로고
    • Inflammatory and microbiologic markers in induced sputum after intravenous antibiotics in cystic fibrosis
    • Ordonez C.L., Henig C.R., Mayer-Hamblett N., et al. Inflammatory and microbiologic markers in induced sputum after intravenous antibiotics in cystic fibrosis. Am J Respir Crit Care Med 168 (2003) 1471-1475
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 1471-1475
    • Ordonez, C.L.1    Henig, C.R.2    Mayer-Hamblett, N.3
  • 59
    • 0035922668 scopus 로고    scopus 로고
    • Comparison of hypertonic saline and alternate-day or daily recombinant human deoxyribonuclease in children with cystic fibrosis: a randomised trial
    • Suri R., Metcalfe C., Lees B., et al. Comparison of hypertonic saline and alternate-day or daily recombinant human deoxyribonuclease in children with cystic fibrosis: a randomised trial. Lancet 358 (2001) 1316-1321
    • (2001) Lancet , vol.358 , pp. 1316-1321
    • Suri, R.1    Metcalfe, C.2    Lees, B.3
  • 60
    • 33750372715 scopus 로고    scopus 로고
    • Inhaled hypertonic saline as a therapy for cystic fibrosis
    • Elkins M.R., and Bye P.T. Inhaled hypertonic saline as a therapy for cystic fibrosis. Curr Opin Pulm Med 12 (2006) 445-452
    • (2006) Curr Opin Pulm Med , vol.12 , pp. 445-452
    • Elkins, M.R.1    Bye, P.T.2
  • 61
    • 0030783036 scopus 로고    scopus 로고
    • A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol
    • Anderson S.D., Brannan J.D., Spring J., et al. A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol. Am J Respir Crit Care Med 156 (1997) 758-765
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 758-765
    • Anderson, S.D.1    Brannan, J.D.2    Spring, J.3
  • 62
    • 0035108104 scopus 로고    scopus 로고
    • Ion transport and regulation of respiratory tract fluid output in dogs
    • Chen B.T., and Yeates D.B. Ion transport and regulation of respiratory tract fluid output in dogs. J Appl Physiol 90 (2001) 821-831
    • (2001) J Appl Physiol , vol.90 , pp. 821-831
    • Chen, B.T.1    Yeates, D.B.2
  • 64
    • 0042380075 scopus 로고    scopus 로고
    • Evidence of mast cell activation and leukotriene release after mannitol inhalation
    • Brannan J.D., Gulliksson M., Anderson S.D., Chew N., and Kumlin M. Evidence of mast cell activation and leukotriene release after mannitol inhalation. Eur Respir J 22 (2003) 491-496
    • (2003) Eur Respir J , vol.22 , pp. 491-496
    • Brannan, J.D.1    Gulliksson, M.2    Anderson, S.D.3    Chew, N.4    Kumlin, M.5
  • 65
    • 0037027914 scopus 로고    scopus 로고
    • Pharmacological approaches to discovery and development of new mucolytic agents
    • King M., and Rubin B.K. Pharmacological approaches to discovery and development of new mucolytic agents. Adv Drug Delivery Rev 54 (2002) 1475-1490
    • (2002) Adv Drug Delivery Rev , vol.54 , pp. 1475-1490
    • King, M.1    Rubin, B.K.2
  • 66
    • 84889477956 scopus 로고    scopus 로고
    • Ciliary transportability is governed by its osmolality
    • Baum G.L., Priel A., Roth Y., Liron N., and Ostfield E.J. (Eds), Marcel Dekker Inc, New York
    • Wills P.J., Chan W.M., Hall R.L., and Cole P.J. Ciliary transportability is governed by its osmolality. In: Baum G.L., Priel A., Roth Y., Liron N., and Ostfield E.J. (Eds). Cilia, mucus and mucociliary interactions (1998), Marcel Dekker Inc, New York 281-284
    • (1998) Cilia, mucus and mucociliary interactions , pp. 281-284
    • Wills, P.J.1    Chan, W.M.2    Hall, R.L.3    Cole, P.J.4
  • 67
    • 0032834277 scopus 로고    scopus 로고
    • The effect of inhaled mannitol on bronchial mucus clearance in cystic fibrosis patients: a pilot study
    • Robinson M., Daviskas E., Eberl S., Baker J., Chan H.K., Anderson S.D., and Bye P.T. The effect of inhaled mannitol on bronchial mucus clearance in cystic fibrosis patients: a pilot study. Eur Respir J 14 (1999) 678-685
    • (1999) Eur Respir J , vol.14 , pp. 678-685
    • Robinson, M.1    Daviskas, E.2    Eberl, S.3    Baker, J.4    Chan, H.K.5    Anderson, S.D.6    Bye, P.T.7
  • 68
    • 0030188736 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa and epithelial permeability: role of virulence factors elastase and exotoxin A
    • Azghani A.O. Pseudomonas aeruginosa and epithelial permeability: role of virulence factors elastase and exotoxin A. Am J Respir Cell Mol Biol 15 (1996) 132-140
    • (1996) Am J Respir Cell Mol Biol , vol.15 , pp. 132-140
    • Azghani, A.O.1
  • 70
    • 0014799995 scopus 로고
    • Transport and phosphorylation of glucose, fructose and mannitol by Pseudomonas aeruginosa
    • Phibbs P.V., and Eagon R.G. Transport and phosphorylation of glucose, fructose and mannitol by Pseudomonas aeruginosa. Arch Biochem Biophys 138 (1970) 470-482
    • (1970) Arch Biochem Biophys , vol.138 , pp. 470-482
    • Phibbs, P.V.1    Eagon, R.G.2
  • 71
    • 0015114454 scopus 로고
    • Kinetics of transport of glucose, fructose and mannitol by Pseudomonas aeruginosa
    • Eagon R.G., and Phibbs P.V. Kinetics of transport of glucose, fructose and mannitol by Pseudomonas aeruginosa. Can J Biochem 49 (1971) 1031-1041
    • (1971) Can J Biochem , vol.49 , pp. 1031-1041
    • Eagon, R.G.1    Phibbs, P.V.2
  • 72
    • 0020070286 scopus 로고
    • Utilization of human respiratory secretions by mucoid Pseudomonas aeruginosa of cystic fibrosis origin
    • Ohman D.E., and Chakrabarty A.M. Utilization of human respiratory secretions by mucoid Pseudomonas aeruginosa of cystic fibrosis origin. Infect Immun 37 (1982) 662-669
    • (1982) Infect Immun , vol.37 , pp. 662-669
    • Ohman, D.E.1    Chakrabarty, A.M.2
  • 73
    • 0034633688 scopus 로고    scopus 로고
    • The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing
    • Zabner J., Seiler M.P., Launspach J.L., et al. The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing. Proc Nat Acad Sci USA 97 (2000) 11614-11619
    • (2000) Proc Nat Acad Sci USA , vol.97 , pp. 11614-11619
    • Zabner, J.1    Seiler, M.P.2    Launspach, J.L.3
  • 74
    • 33645468082 scopus 로고    scopus 로고
    • Hyperosmolar agents and clearance of mucus in the diseased airway
    • Daviskas E., and Anderson S.D. Hyperosmolar agents and clearance of mucus in the diseased airway. J Aerosol Med 19 (2006) 100-109
    • (2006) J Aerosol Med , vol.19 , pp. 100-109
    • Daviskas, E.1    Anderson, S.D.2
  • 75
    • 0037027952 scopus 로고    scopus 로고
    • Altering airway surface liquid volume: inhalation therapy with amiloride and hyperosmotic agents
    • Hirsh A.J. Altering airway surface liquid volume: inhalation therapy with amiloride and hyperosmotic agents. Adv Drug Del Rev 54 (2002) 1445-1462
    • (2002) Adv Drug Del Rev , vol.54 , pp. 1445-1462
    • Hirsh, A.J.1
  • 76
    • 0025874599 scopus 로고
    • Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis
    • Knowles M.R., Clarke L.L., and Boucher R.C. Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis. N Engl J Med 325 (1991) 533-538
    • (1991) N Engl J Med , vol.325 , pp. 533-538
    • Knowles, M.R.1    Clarke, L.L.2    Boucher, R.C.3
  • 77
    • 0034537007 scopus 로고    scopus 로고
    • + absorption by extracellular nucleotides in human normal and cystic fibrosis airways
    • + absorption by extracellular nucleotides in human normal and cystic fibrosis airways. Am J Respir Cell Mol Biol 23 (2000) 755-761
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 755-761
    • Mall, M.1    Wissner, A.2    Gonska, T.3
  • 78
    • 0032899770 scopus 로고    scopus 로고
    • + absorption in wild-type and Delta F508 CFTR-expressing human bronchial epithelia
    • + absorption in wild-type and Delta F508 CFTR-expressing human bronchial epithelia. Am J Physiol Cell Physiol 276 (1999) C827-C837
    • (1999) Am J Physiol Cell Physiol , vol.276
    • Devor, D.C.1    Pilewski, J.M.2
  • 79
    • 0029871912 scopus 로고    scopus 로고
    • Nucleotide-induced mucin release from primary hamster tracheal surface epithelial cells involves the P2u purinoceptor
    • Kim K.C., Park H.R., Shin C.Y., Akiyama T., and Ko K.H. Nucleotide-induced mucin release from primary hamster tracheal surface epithelial cells involves the P2u purinoceptor. Eur Respir J 9 (1996) 542-548
    • (1996) Eur Respir J , vol.9 , pp. 542-548
    • Kim, K.C.1    Park, H.R.2    Shin, C.Y.3    Akiyama, T.4    Ko, K.H.5
  • 80
    • 0034988651 scopus 로고    scopus 로고
    • Differential effects of UTP, ATP, and adenosine on ciliary activity of human nasal epithelial cells
    • Morse D.M., Smullen J.L., and Davis C.W. Differential effects of UTP, ATP, and adenosine on ciliary activity of human nasal epithelial cells. Am J Physiol Cell Physiol 280 (2001) C1485-C1497
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Morse, D.M.1    Smullen, J.L.2    Davis, C.W.3
  • 81
    • 0027937736 scopus 로고
    • P2u purinoceptor stimulation of surfactant secretion coupled to phosphatidylcholine hydrolysis in type II cells
    • Gobran L.I., Xu Z.X., Lu Z., and Rooney S.A. P2u purinoceptor stimulation of surfactant secretion coupled to phosphatidylcholine hydrolysis in type II cells. Am J Physiol Lung Cell Mol Physiol 267 (1994) L625-L633
    • (1994) Am J Physiol Lung Cell Mol Physiol , vol.267
    • Gobran, L.I.1    Xu, Z.X.2    Lu, Z.3    Rooney, S.A.4
  • 83
    • 20144363443 scopus 로고    scopus 로고
    • 2 receptor agonist: Results of a phase 1/phase 2 multicenter study in mild to moderate cystic fibrosis
    • for the Cystic Fibrosis Foundation Therapeutics Development Network
    • 2 receptor agonist: Results of a phase 1/phase 2 multicenter study in mild to moderate cystic fibrosis. Pediatr Pulmonol 39 (2005) 339-348
    • (2005) Pediatr Pulmonol , vol.39 , pp. 339-348
    • Deterding, R.1    Retsch-Bogart, G.2    Milgram, L.3
  • 84
    • 18344392104 scopus 로고    scopus 로고
    • Safety and efficacy of INS37217 inhalation solution, a novel P2Y2 receptor agonist, in patients with mild cystic fibrosis: Results of a phase 2 multi-center study
    • (A177)
    • Deterding R., LaVange L., Mathews D., et al. Safety and efficacy of INS37217 inhalation solution, a novel P2Y2 receptor agonist, in patients with mild cystic fibrosis: Results of a phase 2 multi-center study. Pediatr Pulmonol 38 (2004) 249 (A177)
    • (2004) Pediatr Pulmonol , vol.38 , pp. 249
    • Deterding, R.1    LaVange, L.2    Mathews, D.3
  • 85
    • 34047164879 scopus 로고    scopus 로고
    • Safety and tolerability of denufosol inhalation solution: Results of a 28-day phase 2 study in 5-7 year old patients in CF
    • (A284)
    • Deterding R., Milla C., Barnes M.L., et al. Safety and tolerability of denufosol inhalation solution: Results of a 28-day phase 2 study in 5-7 year old patients in CF. Pediatr Pulmonol 41 (2006) 306 (A284)
    • (2006) Pediatr Pulmonol , vol.41 , pp. 306
    • Deterding, R.1    Milla, C.2    Barnes, M.L.3
  • 86
    • 0022263413 scopus 로고
    • Clearance of mucus by simulated cough
    • King M., Brock G., and Lundell C. Clearance of mucus by simulated cough. J Appl Physiol 58 (1985) 1776-1782
    • (1985) J Appl Physiol , vol.58 , pp. 1776-1782
    • King, M.1    Brock, G.2    Lundell, C.3
  • 87
    • 0024378201 scopus 로고
    • The role of mucus gel viscosity, spinnability, and adhesive properties in clearance simulated cough
    • King M., Zahm J.M., Pierrot D., Vaquez-Girod S., and Puchelle E. The role of mucus gel viscosity, spinnability, and adhesive properties in clearance simulated cough. Biorheology 26 (1989) 737-745
    • (1989) Biorheology , vol.26 , pp. 737-745
    • King, M.1    Zahm, J.M.2    Pierrot, D.3    Vaquez-Girod, S.4    Puchelle, E.5
  • 88
    • 0022973473 scopus 로고
    • + transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation
    • + transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation. J Clin Invest 78 (1986) 1245-1252
    • (1986) J Clin Invest , vol.78 , pp. 1245-1252
    • Boucher, R.C.1    Stutts, M.J.2    Knowles, M.R.3    Cantley, L.4    Gatzy, J.T.5
  • 90
    • 0022518142 scopus 로고
    • Chloride and potassium channels in cystic fibrosis airway epithelia
    • Welsh M.J., and Liedtke C.M. Chloride and potassium channels in cystic fibrosis airway epithelia. Nature 322 (1986) 467-470
    • (1986) Nature , vol.322 , pp. 467-470
    • Welsh, M.J.1    Liedtke, C.M.2
  • 91
    • 0030017497 scopus 로고    scopus 로고
    • The effects of albuterol on the lung function of hospitalized patients with cystic fibrosis
    • Hordvik N.L., Sammut P.H., Judy C.G., Strizek S.J., and Colombo J.L. The effects of albuterol on the lung function of hospitalized patients with cystic fibrosis. Am J Respir Crit Care Med 154 (1996) 156-160
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 156-160
    • Hordvik, N.L.1    Sammut, P.H.2    Judy, C.G.3    Strizek, S.J.4    Colombo, J.L.5
  • 92
    • 0036344712 scopus 로고    scopus 로고
    • "CF asthma": what is it and what do we do about it?
    • Balfour-Lynn I.M., and Elborn J.S. "CF asthma": what is it and what do we do about it?. Thorax 57 (2002) 742-748
    • (2002) Thorax , vol.57 , pp. 742-748
    • Balfour-Lynn, I.M.1    Elborn, J.S.2
  • 93
    • 0035991740 scopus 로고    scopus 로고
    • Airways reactivity in patients with CF
    • Weinberger M. Airways reactivity in patients with CF. Clin Rev Allergy Immunol 23 (2002) 77-85
    • (2002) Clin Rev Allergy Immunol , vol.23 , pp. 77-85
    • Weinberger, M.1
  • 95
    • 0019420747 scopus 로고
    • Variability of airways hyper-reactivity and allergy in cystic fibrosis
    • Holzer F.J., Olinsky A., and Phelan P.D. Variability of airways hyper-reactivity and allergy in cystic fibrosis. Arch Dis Child 56 (1981) 455-459
    • (1981) Arch Dis Child , vol.56 , pp. 455-459
    • Holzer, F.J.1    Olinsky, A.2    Phelan, P.D.3
  • 96
    • 0015620179 scopus 로고
    • The variable effect of a bronchodilating agent on pulmonary function in cystic fibrosis
    • Landau L.I., and Phelan P.D. The variable effect of a bronchodilating agent on pulmonary function in cystic fibrosis. J Pediatr 82 (1973) 863-868
    • (1973) J Pediatr , vol.82 , pp. 863-868
    • Landau, L.I.1    Phelan, P.D.2
  • 97
    • 33745130682 scopus 로고    scopus 로고
    • Multicenter randomized controlled trial of withdrawal of inhaled corticosteroids in cystic fibrosis
    • on behalf of the CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators
    • Balfour-Lynn I.M., Lees B., Hall P., et al., on behalf of the CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators. Multicenter randomized controlled trial of withdrawal of inhaled corticosteroids in cystic fibrosis. Am J Respir Crit Care Med 173 (2006) 1356-1362
    • (2006) Am J Respir Crit Care Med , vol.173 , pp. 1356-1362
    • Balfour-Lynn, I.M.1    Lees, B.2    Hall, P.3
  • 98
    • 84969497970 scopus 로고    scopus 로고
    • Halfhide C, Evans HJ, Couriel J. Inhaled bronchodilators for cystic fibrosis. The Cochrane Library 2007(1).
  • 99
    • 0021848184 scopus 로고
    • Bronchodilators increase airway instability in cystic fibrosis
    • Zach M.S., Oberwaldner B., Forche G., and Polgar G. Bronchodilators increase airway instability in cystic fibrosis. Am Rev Respir Dis 131 (1985) 537-543
    • (1985) Am Rev Respir Dis , vol.131 , pp. 537-543
    • Zach, M.S.1    Oberwaldner, B.2    Forche, G.3    Polgar, G.4
  • 100
    • 0037464736 scopus 로고    scopus 로고
    • Design of clinical trials in cystic fibrosis
    • Southern K.W., and Smyth R.L. Design of clinical trials in cystic fibrosis. Lancet 361 (2003) 349-350
    • (2003) Lancet , vol.361 , pp. 349-350
    • Southern, K.W.1    Smyth, R.L.2


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