Hypertonic saline and recombinant human DNase: A randomised cross-over pilot study in patients with cystic fibrosis

Journal of Cystic Fibrosis

Volumn 1, Issue 1, 2002, Pages 35-37

  Ballmann, Manfred ^a   Von Der Hardt, Horst ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Acceptance; Costs; Cystic fibrosis; Treatment effect

Indexed keywords

COLISTIN; DEOXYRIBONUCLEASE; EXPECTORANT AGENT; RECOMBINANT DEOXYRIBONUCLEASE; SALBUTAMOL; SODIUM CHLORIDE; TOBRAMYCIN; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; BRONCHOSPASM; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION FUNCTION; CROSSOVER PROCEDURE; CYSTIC FIBROSIS; DRUG COST; FEMALE; HEALTH CARE SYSTEM; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG DISEASE; LUNG FUNCTION TEST; MALE; NEBULIZER; PILOT STUDY; PROFIT; PSEUDOMONAS AERUGINOSA; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTION; SCORING SYSTEM; STORAGE; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; ADOLESCENT; CHILD; CROSS-OVER STUDIES; CYSTIC FIBROSIS; DEOXYRIBONUCLEASES; EXPECTORANTS; FEMALE; HUMANS; LUNG DISEASES; MALE; PILOT PROJECTS; RESPIRATORY FUNCTION TESTS; SALINE SOLUTION, HYPERTONIC; TREATMENT OUTCOME;

EID: 0036123981     PISSN: 15691993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1569-1993(01)00009-1     Document Type: Article

References (12)

1. Efficacy and safety of short-term administration of aerosolized recombinant human deoxyribonuclease in patients with cystic fibrosis
2. Short-term efficacy of ultrasonically nebulized hypertonic saline in cystic fibrosis
3. Use of non-parametric methods in the statistical analysis of the two-period change-over design
4. Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis
5. Rheology of cystic fibrosis sputum after in vitro treatment with hypertonic saline alone and in combination with recombinant human deoxyribonuclease I
6. Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis
7. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid
8. Elemental composition of human airway surface fluid in healthy and diseased airways
9. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
10. Elemental content of airway surface liquid from infants with cystic fibrosis
11. Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects
12. Salt-independent abnormality of antimicrobial activity in Cystic Fibrosis airway surface fluid