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53
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85085844498
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note
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4 also promoted the addition (39% yield, dr 1.5:1).
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57
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33947680306
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note
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The N-N fragmentation product (1e) was observed in large amounts (ca. 1:1 with product) in the crude product mixture from 2h. In the other reactions, 1 was observed only in small amounts (from 2e, 2g, 2j, 2k) or not at all (from 2a, 2f, 2i, 21). No reduction in yield occurred when the reaction of 2e is extended from 2 d (46%) to 7 d (48%). These observations suggest that diastereoselective decomposition, though not rigorously excluded, is unlikely to account for the high selectivity.
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59
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33947661000
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Wiley, York
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Shriner, R.L.1
Fuson, R.C.2
Curtin, D.Y.3
Morrill, T.C.4
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